Celiac sprue, hyperhomocysteinemia, and MTHFR gene variants.

Abstract:

GOALS:To describe the association of untreated celiac disease with hyperhomocysteinemia and variants of the methylenetetrahydrofolicacid reductase (MTHFR) gene found in clinical practice. STUDY:Case studies with description of associated clinical, biochemical, and genetic findings and review of literature. RESULTS:Five new cases and 7 additional cases found from literature search of hyperhomocysteinemia with celiac sprue are reported. Treatment with gluten-free diet and folic acid led to the variable improvement in homocysteine levels. MTHFR gene variants were present in the each of the new patients described. CONCLUSIONS:Untreated celiac disease may be associated with hyperhomocysteinemia caused by a combination of vitamin deficiencies and variants in the MTHFR gene. Abnormalities do not consistently improve with gluten-free diet. The abnormal findings could result from vitamin deficiencies or variant MTHFR status. Possible clinical implications for patients with celiac disease and hyperhomocysteinemia are reviewed.

journal_name

J Clin Gastroenterol

authors

Wilcox GM,Mattia AR

doi

10.1097/00004836-200608000-00007

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

596-601

issue

7

eissn

0192-0790

issn

1539-2031

pii

00004836-200608000-00007

journal_volume

40

pub_type

杂志文章
  • Pseudolipoma of Glisson's capsule. Report of six cases and review of the literature.

    abstract::We report six cases of pseudolipoma of Glisson's capsule. The patients ranged from 53 to 83 years old (mean 67.7 years), and all were men. Pseudolipoma of Glisson's capsule was detected by imaging studies before operation in two cases, and noted incidentally in the remaining four. Computed tomography demonstrated a su...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Sasaki M,Harada K,Nakanuma Y,Watanabe K

    更新日期:1994-07-01 00:00:00

  • Ultrasonography-guided percutaneous radiofrequency ablation for treatment of a huge symptomatic hepatic cavernous hemangioma.

    abstract::Hepatic cavernous hemangioma is the most common benign tumor of the liver. Appropriate management of this tumor remains a controversial topic. We have accumulated a number of cases with successful management of local hepatic tumors. Here we report a case where we performed an ultrasound-guided percutaneous radiofreque...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000196404.07487.1d

    authors: Tak WY,Park SY,Jeon SW,Cho CM,Kweon YO,Kim SK,Choi YH,Chung JM

    更新日期:2006-02-01 00:00:00

  • Hydrogen peroxide colitis: a report of three patients.

    abstract::We have seen three patients with acute ulcerative colitis after hydrogen peroxide enemas. The colitis is probably the result of the explosive entrance of gas into the loose connective tissues of the mucosa and submucosa of the rectum and sigmoid. Fortunately, it is transitory in nature, but it should be distinguished ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198103000-00008

    authors: Meyer CT,Brand M,DeLuca VA,Spiro HM

    更新日期:1981-03-01 00:00:00

  • Carcinoma of the colon, sclerosing cholangitis, pericholangitis, and bronchiectasis in a patient with chronic ulcerative colitis.

    abstract::We report a patient with long-standing ulcerative colitis who developed carcinoma of the colon, sclerosing cholangitis, pericholangitis, and bronchiectasis over the course of 10-15 years. Occurrence of these rare conditions in the same patient supports their reported association and reemphasizes that there may be mult...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Pang JA,Vicary FR

    更新日期:1984-08-01 00:00:00

  • Noncardiac chest pain.

    abstract:GOALS:Review of research directions in the etiology, evaluation, and treatment of patients with noncardiac chest pain. The author proposes a combined practical approach to noncardiac chest pain that incorporates these findings, which is useful in a clinical practice setting. BACKGROUND:Several major schools of thought...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200201000-00004

    authors: Botoman VA

    更新日期:2002-01-01 00:00:00

  • Perspectives of chromo and magnifying endoscopy: how, how much, when, and whom should we stain?

    abstract::The goal of every routine endoscopy in the gut is the early diagnosis of malignant and premalignant changes of the mucosa. Chromo- and magnifying endoscopes are exciting new tools and offer detailed analysis of the colonic mucosal surface and pit pattern architecture. This review summarizes recent advances in endoscop...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200401000-00004

    authors: Kiesslich R,Jung M,DiSario JA,Galle PR,Neurath MF

    更新日期:2004-01-01 00:00:00

  • The economic impact of irritable bowel syndrome in a managed care setting.

    abstract:GOALS:To compare the healthcare resource consumption of patients who have irritable bowel syndrome (IBS) with an age-, gender-, and comorbidity-matched cohort of patients without IBS from a managed care perspective. STUDY:Retrospective cohort analysis. Data were obtained electronically through the Henry Ford Health Sy...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200207000-00005

    authors: Patel RP,Petitta A,Fogel R,Peterson E,Zarowitz BJ

    更新日期:2002-07-01 00:00:00

  • Insulinoma after streptozotocin therapy for metastatic gastrinoma: natural history or iatrogenic complication?

    abstract::Islet cell carcinoma frequently produces more than one chemical product, although its clinical expression is usually restricted to a single hormone. We describe an unusual patient who presented with full-blown metastasizing gastrinoma. He was treated with cimetidine for five years and then streptozotocin therapy, whic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199010000-00018

    authors: Bar M,Burke M,Isakov A,Almog C

    更新日期:1990-10-01 00:00:00

  • Silent celiac disease in chronic hepatitis C: impact of interferon treatment on the disease onset and clinical outcome.

    abstract:GOALS:To assess the impact of interferon treatment on celiac disease onset in hepatitis C patients and to clarify its clinical relevance and outcome. BACKGROUND:Hepatitis C is associated with autoimmunity, which can be exacerbated by interferon treatment. Cases of celiac disease activation during interferon treatment ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200411000-00014

    authors: Durante-Mangoni E,Iardino P,Resse M,Cesaro G,Sica A,Farzati B,Ruggiero G,Adinolfi LE

    更新日期:2004-11-01 00:00:00

  • Positive predictive value of endoscopic features deemed typical of gastric fundic gland polyps.

    abstract:BACKGROUND:Fundic gland polyps (FGPs) are now the most common gastric polyp encountered by endoscopists. However, they have minimal clinical significance. If they could be reliably predicted by endoscopic features, it might prevent the need for and cost of biopsy. GOALS:To determine the positive predictive value of en...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200305000-00007

    authors: Weston BR,Helper DJ,Rex DK

    更新日期:2003-05-01 00:00:00

  • Celiac Disease is Misdiagnosed Based on Serology Only in a Substantial Proportion of Patients.

    abstract:BACKGROUND:Although the diagnostic process in celiac disease (CeD) has been addressed in several international guidelines, little is known about the actual proceeding in current clinical practice. This study investigated the initial presentation, the diagnostic process, follow-up evaluations, and adherence to a gluten-...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000676

    authors: Vavricka SR,Stelzer T,Lattmann J,Stotz M,Lehmann R,Zeitz J,Scharl M,Misselwitz B,Pohl D,Fried M,Tutuian R,Fasano A,Schoepfer AM,Rogler G,Biedermann L,Greuter T

    更新日期:2018-01-01 00:00:00

  • Lactic acidosis associated with cirrhosis, hepatoma, hemoperitoneum, and hyperphosphatemia.

    abstract::A patient with cirrhosis developed hemoperitoneum, lactic acidosis, and hyperphosphatemia in the absence of shock. At post-mortem examination occult multicentric hepatocellular carcinoma eroding the liver capsule was present. The case emphasizes the central role of the liver in lactic acidosis, indicates that hemoperi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198604000-00025

    authors: Berenson MM,Lee RG

    更新日期:1986-04-01 00:00:00

  • The cost of knowing the truth-limitations to a cost-benefit analysis of upper GI endoscopy.

    abstract::In a prospective series of 284 upper gastrointestinal (GI) endoscopies, outcome was evaluated by a cost-benefit analysis. Two-thirds of the endoscopies had a negative result, or a diagnosis was found which was not worth the costs of the endoscopy. The overall diagnostic gain of 284 endoscopies, however, outweighed the...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198204000-00003

    authors: Sonnenberg A,Blum AL

    更新日期:1982-04-01 00:00:00

  • Could alpha 1 antitrypsin deficiency have any role in the development of celiac sprue after gastric operations?

    abstract::We report a 50-year-old woman with alpha 1 antitrypsin deficiency (PiSZ phenotype) who developed clinical features of malabsorption after vagotomy and pyloroplasty. The intestinal biopsy demonstrated total villous atrophy with hypertrophy of the crypts. After gluten withdrawal, digestive function and the appearance of...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198610000-00014

    authors: Pons Romero F,Casafont F,Rodriguez de Lope C,San Miguel G,Artiñano E,Cagigas J

    更新日期:1986-10-01 00:00:00

  • Is there a role for dietary essential fatty acids in gastroduodenal mucosal protection?

    abstract::A great deal is known about methods to diminish intragastric acid concentration, but far less is known about the ability of the gastroduodenal mucosa to resist injury or accelerate its healing. One group of compounds that plays a key role in the endogenous ability of the mucosa to protect itself against injury and per...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199112001-00012

    authors: Hollander D,Tarnawski A

    更新日期:1991-01-01 00:00:00

  • Confocal endomicroscopic examination of malignant biliary strictures and histologic correlation with lymphatics.

    abstract:BACKGROUND AND AIMS:Current methods to diagnose malignant biliary strictures are of low sensitivity. Confocal endomicroscopy is a new approach that may improve the diagnosis of indeterminate biliary strictures. The purpose of this study was to evaluate indeterminate biliary strictures using probe-based confocal laser e...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181fbdc38

    authors: Loeser CS,Robert ME,Mennone A,Nathanson MH,Jamidar P

    更新日期:2011-03-01 00:00:00

  • Elevated Serum Triglycerides in the Prognostic Assessment of Acute Pancreatitis: A Systematic Review and Meta-Analysis of Observational Studies.

    abstract:BACKGROUND:Hypertriglyceridemia has been positively associated with the risk of acute pancreatitis (AP), but whether increased triglyceride (TG) levels are associated with the severity of AP remains unknown. To this, a meta-analysis was conducted to assess the effect of elevated serum TG on the prognosis of AP. METHOD...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCG.0000000000000846

    authors: Wang Q,Wang G,Qiu Z,He X,Liu C

    更新日期:2017-08-01 00:00:00

  • A case of sclerosing cholangitis managed by a percutaneous approach.

    abstract::In 1992, a 61-year-old man who complained of recurrent episodes of fever and jaundice was diagnosed as having sclerosing cholangitis. In the three years that followed, the clinical picture progressively worsened; and, in 1995, the patient was hospitalized again for biliary obstruction. A liver transplantation was excl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200003000-00017

    authors: Tritto G,Iaccarino V,De Martino S,D'Agostino L

    更新日期:2000-03-01 00:00:00

  • Multiple abscesses of the liver caused by Campylobacter jejuni.

    abstract::A 37-year-old woman developed multiple liver abscesses caused by Campylobacter jejuni, as a consequence of unrecognized and inadequately treated Campylobacter enteritis. The diagnosis was established by isolation of Campylobacter jejuni from blood and pus obtained from one of the liver abscesses during laparoscopy. Th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199506000-00011

    authors: Brmbolić B

    更新日期:1995-06-01 00:00:00

  • Treating Budd-Chiari Syndrome: making rational choices from a myriad of options.

    abstract::Budd-Chiari syndrome represents a spectrum of disorders characterized by obstruction to hepatic venous drainage. Originally described as an "obliterating endophlebitis of the hepatic veins," this condition has come to refer to the manifestations of hepatic venous outflow obstruction anywhere above the level of the hep...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200003000-00007

    authors: Olzinski AT,Sanyal AJ

    更新日期:2000-03-01 00:00:00

  • Probiotics and functional abdominal bloating.

    abstract::Functional abdominal bloating is a condition dominated by a feeling of abdominal fullness or bloating and without sufficient criteria for another functional gastrointestinal disorder. The currently used therapeutic approaches aim to reduce the volume of intestinal gas, thus increasing intestinal gas elimination or red...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcg.0000128939.40458.25

    authors: Di Stefano M,Miceli E,Armellini E,Missanelli A,Corazza GR

    更新日期:2004-07-01 00:00:00

  • Impaired plasma cyclic AMP response to exogenous glucagon in acute liver injury.

    abstract::The response of plasma cyclic AMP to glucagon was investigated in 18 patients with acute liver injury to determine its value as a marker for the severity of the hepatic damage. We also investigated the interrelationship between plasma cyclic AMP response and the hyperglucagonemia often seen in this disease. Plasma cyc...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Miyakoshi H,Noda Y,Uchida S,Tanaka N,Noto Y,Kato Y,Kawai K,Hayakawa H,Kobayashi K,Hattori N

    更新日期:1984-08-01 00:00:00

  • Calcitonin gene-related peptide in hepatorenal syndrome. A possible mediator of peripheral vasodilation?

    abstract::In advanced cirrhosis and hepatorenal syndrome, peripheral vasodilation is a prominent feature and may be pathophysiologically relevant. To determine whether the potent vasodilator, calcitonin gene-related peptide (CGRP), circulates at abnormal levels in patients with these disorders, we observed eight patients with a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199203000-00010

    authors: Gupta S,Morgan TR,Gordan GS

    更新日期:1992-03-01 00:00:00

  • Atypical cystic carcinoid tumors of the liver.

    abstract::Carcinoid metastases in the liver are typically solid, hypervascular lesions. We report 3 cases of cystic carcinoid tumors in the liver with radiographic findings. Two were metastatic from primary carcinoid tumors of the small intestine and one was not associated with any extra hepatic lesion at presentation or during...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181da7714

    authors: Salamone L,McCarthy S,Salem RR

    更新日期:2010-11-01 00:00:00

  • Sigmoid volvulus in adolescence.

    abstract::Sigmoid volvulus in young adults is rare. It usually presents as chronic recurrent attacks of abdominal pain. The diagnosis is usually delayed because of a low level of suspicion. We present the case of a 17-year-old girl with recurrent episodes of sigmoid volvulus, to illustrate the problem. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198708000-00023

    authors: Krupsky S,Halevy A,Orda R

    更新日期:1987-08-01 00:00:00

  • Motility of the transverse colon used for esophageal replacement.

    abstract::The authors studied the motility of transverse colon used for reconstruction of the pharyngogastric transit after esophagectomy. The study included 10 patients who underwent esophagectomy 15 to 201 months (median, 48.5 months) before motility evaluation. Nine patients underwent operation because of caustic injury and ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200203000-00005

    authors: Dantas RO,Mamede RC

    更新日期:2002-03-01 00:00:00

  • Detection and localization of active gastrointestinal bleeding with multidetector row computed tomography angiography: a 5-year prospective study in one medical center.

    abstract:GOAL:To prospectively assess the utility of multidetector row computed tomography angiography (MDCTA) in the diagnosis of active gastrointestinal bleeding (GIB). BACKGROUND:MDCTA is a relatively recent advance in CT scanning technology enabling excellent vascular visualization and detection of various vascular abnorma...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31823337ee

    authors: Sun H,Jin Z,Li X,Qian J,Yu J,Zhu F,Zhu H

    更新日期:2012-01-01 00:00:00

  • Acceptance of telemanagement is high in patients with inflammatory bowel disease.

    abstract:GOALS:Assess acceptance and attitudes regarding telemanagement (HAT) in patients with inflammatory bowel disease (IBD). BACKGROUND:Noncompliance is a barrier to successful outcomes in patients with IBD. Novel methods for monitoring and assessing compliance are needed. STUDY:HAT consists of a laptop connected to a wei...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200603000-00006

    authors: Cross RK,Arora M,Finkelstein J

    更新日期:2006-03-01 00:00:00

  • Body position affects recumbent postprandial reflux.

    abstract::There is a lack of consensus as to whether there is a difference in the amount of gastroesophageal reflux when lying with the right versus the left side down. In an attempt to answer this question we conducted a two-part study. The first consisted of a questionnaire distributed to 103 gastroenterologists with a specia...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-199406000-00004

    authors: Katz LC,Just R,Castell DO

    更新日期:1994-06-01 00:00:00

  • Altered Expression of the Epithelial Mucin MUC1 Accompanies Endoscopic Recurrence of Postoperative Crohn's Disease.

    abstract:BACKGROUND:MUC1-glycoprotein is expressed at low levels and in fully glycosylated form on epithelial cells. Inflammation causes MUC1 overexpression and hypoglycosylation. We hypothesized that overexpression of hypoglycosylated MUC1 would be found in postoperative Crohn's disease (CD) recurrence and could be considered ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001340

    authors: Hashash JG,Beatty PL,Critelli K,Hartman DJ,Regueiro M,Tamim H,Regueiro MD,Binion DG,Finn OJ

    更新日期:2021-02-01 00:00:00