Abstract:
GOALS:To describe the association of untreated celiac disease with hyperhomocysteinemia and variants of the methylenetetrahydrofolicacid reductase (MTHFR) gene found in clinical practice. STUDY:Case studies with description of associated clinical, biochemical, and genetic findings and review of literature. RESULTS:Five new cases and 7 additional cases found from literature search of hyperhomocysteinemia with celiac sprue are reported. Treatment with gluten-free diet and folic acid led to the variable improvement in homocysteine levels. MTHFR gene variants were present in the each of the new patients described. CONCLUSIONS:Untreated celiac disease may be associated with hyperhomocysteinemia caused by a combination of vitamin deficiencies and variants in the MTHFR gene. Abnormalities do not consistently improve with gluten-free diet. The abnormal findings could result from vitamin deficiencies or variant MTHFR status. Possible clinical implications for patients with celiac disease and hyperhomocysteinemia are reviewed.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Wilcox GM,Mattia ARdoi
10.1097/00004836-200608000-00007subject
Has Abstractpub_date
2006-08-01 00:00:00pages
596-601issue
7eissn
0192-0790issn
1539-2031pii
00004836-200608000-00007journal_volume
40pub_type
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:1994-07-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-198103000-00008
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-199010000-00018
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pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-200003000-00017
更新日期:2000-03-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 临床试验,杂志文章
doi:
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-06-01 00:00:00
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