Urinary antibody titers to Helicobacter pylori and an impact of clinical characteristics.

Abstract:

:This study evaluates the clinical usefulness of titers of antibody to Helicobacter pylori (Hp) in a urine-based enzyme-linked immunosorbent assay (URINELISA; Otsuka Pharmaceutical, Tokushima, Japan) by comparing values of serum antibody to Hp in an already commercialized kit in a population of 250 asymptomatic individuals. Influences of physical and laboratory characteristics on the relationship between serum and urinary titers of antibody to Hp were also estimated using simple and multiple regression analyses. Specific urine gravity, urine pH, proteinuria, and age of the subjects were regarded as significant factors relating to urinary titers of the anti-Hp antibody on simple regression analyses. Both the urinary and serum titers strongly correlated on simple regression analysis (r = 0.782, P < 0.0001). On multiple regression analysis, an additional two factors, specific urine gravity and urine pH, were picked up, and the correlation coefficient was improved (r = 0.795, P < 0.0001). The present results indicate that URINELISA had not only qualitative but quantitative accuracy. However, careful attention should be paid to cases with abnormalities in urinalysis when used quantitatively.

journal_name

J Clin Gastroenterol

authors

Yamamoto T,Tamura M,Ishii T,Anjiki H,Hattori K,Saitoh M,Sanaka M,Kuyama Y

doi

10.1097/00004836-200304000-00010

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

329-31

issue

4

eissn

0192-0790

issn

1539-2031

journal_volume

36

pub_type

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