Insulinoma after streptozotocin therapy for metastatic gastrinoma: natural history or iatrogenic complication?

Abstract:

:Islet cell carcinoma frequently produces more than one chemical product, although its clinical expression is usually restricted to a single hormone. We describe an unusual patient who presented with full-blown metastasizing gastrinoma. He was treated with cimetidine for five years and then streptozotocin therapy, which resulted in a regression in hepatomegaly and a fall in serum gastrin levels. Following one year's therapy with streptozotocin, he was admitted in hyperinsulinemic hypoglycemic stupor. This appears to be the first reported case of a "shift" from clinical gastrinoma to insulinoma possibly related to prolonged streptozotocin therapy.

journal_name

J Clin Gastroenterol

authors

Bar M,Burke M,Isakov A,Almog C

doi

10.1097/00004836-199010000-00018

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

579-80

issue

5

eissn

0192-0790

issn

1539-2031

journal_volume

12

pub_type

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