Hepatotoxicity due to antituberculosis therapy. Clinical profile and reintroduction of therapy.


:The clinical profile of antituberculosis treatment (ATT)-induced hepatotoxicity is variable, and the reintroduction of ATT in patients who have developed such injury is controversial. We conducted a prospective study to determine the clinical profile in patients with ATT-induced hepatotoxicity and to test a predefined strategy of reintroduction of ATT. Seventy-two consecutive patients with clinical evidence of ATT-induced hepatotoxicity were included. Jaundice was the presenting symptom in 44 (61%) patients; prodromal symptoms were present in 28 (39%). Serious complications developed in 12 (16.6%) patients (fulminant hepatic failure in seven, subacute hepatic failure in four, hepatic encephalopathy in one). Nine patients (three males, six females) died from these complications. The mean duration of treatment before the onset of hepatitis was significantly longer in the group that died (53.22 +/- 36.22 days) than in the rest of the patients (31.07 +/- 30.30 days; p < 0.01). Malnutrition was present in 37 of the 72 patients. After resolution of drug induced hepatitis, reintroduction of isoniazid and rifampicin was possible in 41 of 44 patients. Thus, our results showed that ATT-induced hepatitis carried significant morbidity and mortality, that malnutrition was common in patients with ATT-related hepatitis, and that potentially hepatotoxic antituberculosis agents could be safely reintroduced after recovery from hepatitis.


J Clin Gastroenterol


Singh J,Garg PK,Tandon RK




Has Abstract


1996-04-01 00:00:00












  • Clarithromycin for the eradication of Helicobacter pylori.

    abstract::Helicobacter pylori infection has proven to be extraordinarily difficult to eradicate. Antimicrobial monotherapies have been particularly disappointing, with most eradication rates in the range of 0-15%. Clarithromycin has potential advantages over other macrolides to which H. pylori is susceptible because of its acid...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Graham DY,Opekun AR,Klein PD

    更新日期:1993-06-01 00:00:00

  • Allergen-free probiotics.

    abstract::Food sensitivities are constantly increasing in "westernized" countries and may pose serious health risks to sensitized individuals. Severe allergy episodes have also been reported after the intake of probiotic products containing milk protein residues, especially in children. The need for safe and effective probiotic...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Mogna G,Strozzi GP,Mogna L

    更新日期:2008-09-01 00:00:00

  • Endoscopic ultrasound-guided endotherapy.

    abstract::Over the last 2 decades, endoscopic ultrasound (EUS) has evolved from a noninvasive diagnostic tool to a combined diagnostic and therapeutic modality. The use of EUS complementary to endoscopic retrograde cholangiopancreatography (ERCP) has made possible biliary and pancreatic drainage in situations where conventional...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Gavini H,Lee JH

    更新日期:2015-03-01 00:00:00

  • The symptomatic and histologic response to a gluten-free diet in patients with borderline enteropathy.

    abstract:GOALS:A clinical problem is posed by patients with symptoms suggestive of gluten sensitivity (diarrhea, weight loss, unresponsive iron-deficiency anemia, etc.); however, small intestinal biopsies reveal only minor abnormalities, such as lymphocytosis with or without crypt hyperplasia (Marsh I-II). Our aim was to assess...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Tursi A,Brandimarte G

    更新日期:2003-01-01 00:00:00

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    abstract::Despite the successful FDA approval of sorafenib as the standard of care therapy in patients with advanced hepatocellular carcinoma (HCC), its clinical benefits have been modest. The mortality rate remains high and prognosis poor for patients with advanced-stage HCC. The exact mechanism of sorafenib in the treatment o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Lee JK,Abou-Alfa GK

    更新日期:2013-07-01 00:00:00

  • Corrosive ingestion in adults.

    abstract::Ingestion of a corrosive substance can produce severe injury to the gastrointestinal tract and can even result in death. The degree and extent of damage depends on several factors like the type of substance, the morphologic form of the agent, the quantity, and the intent. In the acute stage, perforation and necrosis m...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Ramasamy K,Gumaste VV

    更新日期:2003-08-01 00:00:00

  • Peritoneal mesothelioma in recurrent familial peritonitis.

    abstract::A 39-year-old man had a 2-year history of fatigue, weight loss, drug-resistant ascites, and decreased intestinal motility. During adolescence he began to suffer frequent episodes of acute benign peritonitis that spontaneously subsided at age 35. The fact that his younger brother was taking colchicine for the same symp...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Gentiloni N,Febbraro S,Barone C,Lemmo G,Neri G,Zannoni G,Capelli A,Gasbarrini G

    更新日期:1997-06-01 00:00:00

  • Predictive Model for Neoplastic Potential of Gallbladder Polyp.

    abstract:GOAL:To provide the statistical predictive model for neoplastic potential of gallbladder polyp (GBP). BACKGROUND:Many studies have attempted to define the risk factors for neoplastic potential of GBP. It remains difficult to precisely adapt the reported risk factors for the decision of surgery. Estimating the probabil...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Yang JI,Lee JK,Ahn DG,Park JK,Lee KH,Lee KT,Chi SA,Jung SH

    更新日期:2018-03-01 00:00:00

  • Meta-analysis of antisecretory and gastrokinetic compounds in functional dyspepsia.

    abstract::In view of therapeutic advances, we carried out meta-analysis of results from 18 randomized, controlled clinical studies to update a previous meta-analysis and to provide an overview of clinical trials involving treatment of functional dyspepsia. The studies were included only if they satisfied inclusion and exclusion...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析


    authors: Finney JS,Kinnersley N,Hughes M,O'Bryan-Tear CG,Lothian J

    更新日期:1998-06-01 00:00:00

  • The management of postoperative chylous ascites. A case report and literature review.

    abstract::Chylous ascites remains rare as a complication of surgical intervention. Although therapeutic manoeuvres to control chylous ascites have been developed over the past 20 years, its pathophysiology is poorly understood. Conservative approaches involving dietary restriction of long-chain triglycerides and salt, together ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Ohri SK,Patel T,Desa LA,Spencer J

    更新日期:1990-12-01 00:00:00

  • Terminal ileum resection is associated with higher plasma homocysteine levels in Crohn's disease.

    abstract:BACKGROUND:Elevated plasma total homocysteine (tHcy) is associated with a higher risk of thrombosis. Crohn's disease (CD) is associated with hypercoagulability of undefined etiology. We investigated tHcy in patients with CD and its relationship with vitamin status, disease activity, location, duration, and history of t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Vasilopoulos S,Saiean K,Emmons J,Berger WL,Abu-Hajir M,Seetharam B,Binion DG

    更新日期:2001-08-01 00:00:00

  • Osteoporotic Fracture Risk and Health Care Burden in Patients With Cirrhosis.

    abstract:BACKGROUND AND AIMS:Risk factors for osteoporotic fracture as well as inpatient utilization and mortality have not been thoroughly studied in patients with cirrhosis. We analyzed data from a national database to determine fracture risk in patients with cirrhosis, specific risk factors, and the effect of fractures on he...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Patel A,Silverman S,Baghdadi J,Shah O,Sundaram V

    更新日期:2019-08-01 00:00:00

  • Celiac sprue-associated immune complex glomerulonephritis.

    abstract::A 35-year-old man developed leg edema, marked hypoalbuminemia, and proteinuria. Subsequent renal biopsy revealed a diffuse membranoproliferative glomerulonephritis and, on electron microscopy, typical electron-dense deposits characteristic of an immune complex pathogenesis. Although protein wasting might have readily ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Scholey J,Freeman HJ

    更新日期:1986-04-01 00:00:00

  • Immunoproliferative small intestinal disease in a 16-year-old boy presenting as severe malabsorption with excellent response to tetracycline treatment.

    abstract::Immunoproliferative small intestinal disease (IPSID) is a rare lympho-proliferative disorder of the upper small intestine. It is considered a special form of MALT lymphoma with propensity to malignant transformation. This disorder is rare in pediatric literature. We report a case of IPSID in a 16-year-old boy with low...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Zamir A,Parasher G,Moukarzel AA,Guarini L,Zeien L,Feldman F

    更新日期:1998-07-01 00:00:00

  • Histologic findings and Helicobacter pylori in duodenal biopsies.

    abstract::We have studied the morphologic aspects of the duodenal bulb in relation to Helicobacter pylori infection in a large group of patients with endoscopically assessed duodenitis to learn more about the pathogenesis of nonspecific duodenitis (bulbitis) and to clarify the specific role of H. pylori. Eight duodenal biopsy s...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Caselli M,Gaudio M,Chiamenti CM,Trevisani L,Sartori S,Saragoni L,Boldrini P,Dentale A,Ruina M,Alvisi V

    更新日期:1998-01-01 00:00:00

  • Biliary tract obstruction secondary to mycosis fungoides: a case report.

    abstract::Mycosis fungoides is a cutaneous T-cell lymphoma that can disseminate to multiple organs. We report a patient who presented with obstructive jaundice caused by isolated involvement of the extrahepatic biliary tree by mycosis fungoides. Initially, endoscopic examinations and biopsies of the biliary tree and liver faile...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Madsen JA,Tallini G,Glusac EJ,Salem RR,Braverman I,Robert ME

    更新日期:1999-01-01 00:00:00

  • Progression to cirrhosis in Latinos with chronic hepatitis C: differences in Puerto Ricans with and without human immunodeficiency virus coinfection and along gender.

    abstract:BACKGROUND:Hepatitis C virus (HCV) infection is prevalent in Latinos. There is some evidence that progression to cirrhosis is more rapid. END POINTS:To calculate time of cirrhosis from time of HCV infection in a large Latino population. Other end points were to assess variables that predict cirrhosis and the effect of...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Rodríguez-Torres M,Ríos-Bedoya CF,Rodríguez-Orengo J,Fernández-Carbia A,Marxuach-Cuétara AM,López-Torres A,Salgado-Mercado R,Bräu N

    更新日期:2006-04-01 00:00:00

  • Issues in hyperlipidemic pancreatitis.

    abstract::Hypertriglyceridemia (HTG) is a rare cause of pancreatitis. Pancreatitis secondary to HTG, presents typically as an episode of acute pancreatitis (AP) or recurrent AP, rarely as chronic pancreatitis. A serum triglyceride (TG) level of more than 1,000 to 2,000 mg/dL in patients with type I, IV, or V hyperlipidemia (Fre...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Yadav D,Pitchumoni CS

    更新日期:2003-01-01 00:00:00

  • Role of Gut Microbiota in Liver Disease.

    abstract::Many lines of research have established a relationship between the gut microbiome and patients with liver disease. For example, patients with cirrhosis have increased bacteremia, increased blood levels of lipopolysaccharide, and increased intestinal permeability. Patients with cirrhosis have bacterial overgrowth in th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Brenner DA,Paik YH,Schnabl B

    更新日期:2015-11-01 00:00:00

  • The differential diagnosis of eosinophilic esophagitis.

    abstract::Eosinophilic esophagitis is a morphologic finding that may result from a wide spectrum of clinical conditions. The distinctive histological features accompanying eosinophilic esophagitis may facilitate the diagnosis of the underlying disease entity. Unfortunately, there are no pathognomonic histologic characteristics ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Ahmad M,Soetikno RM,Ahmed A

    更新日期:2000-04-01 00:00:00

  • Calcium and acid rebound: a reappraisal.

    abstract::We review acid rebound, the seemingly paradoxical increase in acid secretion resulting from administration of an antacid. Primarily a laboratory observation, the demonstration of the phenomenon was a major contributing factor to the swift, and possibly unjustified, fall from grace of calcium carbonate in the therapy o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验,评审


    authors: Hade JE,Spiro HM

    更新日期:1992-07-01 00:00:00

  • Nephrolithiasis and intestinal disease.

    abstract::Kidney stones in patients with inflammatory bowel disease are usually composed of calcium oxalate. Two factors are important in the increased absorption of dietary oxalate which is responsible for those stones: 1) increased absorption of oxalate in the presence of steatorrhea, and 2) increased permeability of the colo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Dobbins JW

    更新日期:1985-02-01 00:00:00

  • Acute hepatotoxicity from ingestion of yellow phosphorus-containing fireworks.

    abstract::We reviewed 15 cases of poisoning from ingestion of yellow phosphorus-containing fireworks and analyzed its associated acute hepatotoxic effects. Two patients (13%) had no clinical or biochemical evidence of hepatic damage, four (27%) had subclinical hepatic injury, five (33%) manifested varying degrees of hepatocellu...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Fernandez OU,Canizares LL

    更新日期:1995-09-01 00:00:00

  • Multiple lymphomatous polyposis of the gut.

    abstract::Multiple lymphomatous polyposis is very rare. We report two cases affecting duodenum, small intestine and colon/rectum, both with extensive disease, making radical surgery impossible and chemotherapy the treatment of choice. One patient died 23 days after initial treatment of myocardial infiltration, and the other is ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Norum J,Hovde O,Stalsberg H

    更新日期:1994-09-01 00:00:00

  • Sociodemographic characteristics, life stressors, and peptic ulcer. A prospective study.

    abstract::The role of psychosocial factors in peptic ulcer remains controversial. We have investigated the relationship between socioeconomic status, concrete stressors, and ulcers in a longitudinally followed, population-based cohort, taking confounding risk factors into account. A total of 6,928 adults completed the Alameda C...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Levenstein S,Kaplan GA,Smith M

    更新日期:1995-10-01 00:00:00

  • Resolution of hereditary hemorrhagic telangiectasia and anemia with prolonged alpha-interferon therapy for chronic hepatitis C.

    abstract::Hereditary hemorrhagic telangiectasia is a group of autosomal dominant disorders, characterized by telangiectases that develop in the skin, mucous membranes, and visceral organs. Currently, there is no satisfactory treatment of hereditary hemorrhagic telangiectasia. Interferon has never been used for the treatment of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Massoud OI,Youssef WI,Mullen KD

    更新日期:2004-04-01 00:00:00

  • Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease.

    abstract:BACKGROUND:although azathioprine (AZA) is an effective immunomodulator in treating Crohn's disease, some patients develop leukopenia and risk severe infections. Thiopurine methyltransferase (TPMT) is an enzyme responsible for the metabolism of AZA, and its activity is inversely related to the risk of developing acute l...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Regueiro M,Mardini H

    更新日期:2002-09-01 00:00:00

  • Cytomegalovirus gastritis associated with pseudolymphoma.

    abstract::A man who previously had several episodes of upper gastrointestinal hemorrhage from erosive gastritis developed recurrent hemorrhage. Endoscopy showed punctate hemorrhages in the fundus and body of the stomach, plus a discrete area of thickened folds in the anterior wall. Biopsies revealed a dense mucosal infiltrate t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Zucker GM,Otis C,Korowski K,Navab F

    更新日期:1994-04-01 00:00:00

  • Frequency of HFE mutations among Turkish blood donors according to transferrin saturation: genotype screening for hereditary hemochromatosis among voluntary blood donors in Turkey.

    abstract:BACKGROUND AND GOALS:The C282Y and H63D mutations of HFE gene are associated with hereditary hemochromatosis (HH), the most common autosomal recessive disorder in European population. This is the first Turkish population study of, the prevalence of these mutations. STUDY:2677 healthy volunteer blood donors were screen...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章


    authors: Simsek H,Sumer H,Yilmaz E,Balaban YH,Ozcebe O,Hascelik G,Buyukask Y,Tatar G

    更新日期:2004-09-01 00:00:00

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    abstract::Functional abdominal bloating is a condition dominated by a feeling of abdominal fullness or bloating and without sufficient criteria for another functional gastrointestinal disorder. The currently used therapeutic approaches aim to reduce the volume of intestinal gas, thus increasing intestinal gas elimination or red...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审


    authors: Di Stefano M,Miceli E,Armellini E,Missanelli A,Corazza GR

    更新日期:2004-07-01 00:00:00