Development of an Ex Vivo Organ Culture Technique to Evaluate Probiotic Utilization in IBD.

Abstract:

:The consistent technical and conceptual progress in the study of the microbiota has led novel impulse to the research for therapeutical application of probiotic bacteria in human pathologies, such as inflammatory bowel disease (IBD). Considering the heterogenous results of probiotics in clinical studies, the model of translational medicine may lead to a more specific and efficacious utilization of probiotic bacteria in IBD. In this regard, the selection and utilization of appropriate experimental models may drive the transition from pure in vitro systems to practical clinical application. We developed a simple and reproducible ex vivo organ culture method with potential utilization for the evaluation of probiotic bacteria efficacy in IBD patients.

journal_name

J Clin Gastroenterol

authors

Pagnini C,Martorelli M,Lanini C,Delle Fave G

doi

10.1097/MCG.0000000000000698

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

S179-S182

eissn

0192-0790

issn

1539-2031

pii

00004836-201611001-00021

journal_volume

50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015

pub_type

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