From Birth to "Immunohealth," Allergies and Enterocolitis.

Abstract:

:Microbial signals stimulate development and maintenance of the neonatal immune system. The process begins in utero, with limited exposure to microbes in the intrauterine environment, as well as maternal immune signals priming the developing immune system. After birth and initial colonization, the immune system must be able to activate against pathogens, but also achieve oral tolerance of food and resident gut microbes. Through microbial signals and appropriate nutrition, the immune system is able to achieve homeostasis. Major challenges to successful colonization and immune system regulation include abnormal microbial inoculi (cesarean section, hygiene) and antibiotics. When normal colonization is interrupted, dysbiosis occurs. This imbalance of microbes and subsequently of the immune system can result in allergic diseases, asthma, or necrotizing enterocolitis. Probiotics and probiotic-derived therapies represent an exciting avenue to replete the population of commensal microbes and to prevent the immune-mediated sequelae of dysbiosis.

journal_name

J Clin Gastroenterol

authors

Houghteling PD,Walker WA

doi

10.1097/MCG.0000000000000355

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

S7-S12

eissn

0192-0790

issn

1539-2031

pii

00004836-201511001-00005

journal_volume

49 Suppl 1

pub_type

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