Abstract:
:In healthy volunteers, we studied the effect in intragastric administration of 100 ml 40% alcohol or isotonic saline on the ultrastructure of gastric oxyntic mucosa with emphasis on gastric mucosal microvasculature. We found that a single dose of 40% alcohol produces exfoliation of the surface epithelium, damage to the mucosal microvessels, extravasation of red blood cells and plasma from disrupted microvessels, and extensive edema of superficial lamina propria. The ultrastructural changes were seen as early as 5 min after alcohol administration and occurred in the mucosal areas where glandular cells did not show necrotic changes. Alcohol-induced injury was localized predominantly to interfoveolar mucosal areas and only occasionally extended to the neck areas. This study demonstrates that the mucosal microvasculature is a primary target for alcohol-induced injury of the human gastric mucosa.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Tarnawski A,Stachura J,Gergely H,Hollander Dsubject
Has Abstractpub_date
1988-01-01 00:00:00pages
S53-64eissn
0192-0790issn
1539-2031journal_volume
10 Suppl 1pub_type
临床试验,杂志文章abstract::Mycosis fungoides is a cutaneous T-cell lymphoma that can disseminate to multiple organs. We report a patient who presented with obstructive jaundice caused by isolated involvement of the extrahepatic biliary tree by mycosis fungoides. Initially, endoscopic examinations and biopsies of the biliary tree and liver faile...
journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-199901000-00015
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,多中心研究
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-198308000-00003
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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更新日期:1986-10-01 00:00:00
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abstract::Helicobacter pylori infects only human gastric epithelium, causes gastritis, and is strongly associated with gastroduodenal ulceration and gastric cancer. Colonization of the stomach with H. pylori is accompanied in the acute stage by an increased number of neutrophils in the lamina propria, indicative of gastric infl...
journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
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