Could alpha 1 antitrypsin deficiency have any role in the development of celiac sprue after gastric operations?

Abstract:

:We report a 50-year-old woman with alpha 1 antitrypsin deficiency (PiSZ phenotype) who developed clinical features of malabsorption after vagotomy and pyloroplasty. The intestinal biopsy demonstrated total villous atrophy with hypertrophy of the crypts. After gluten withdrawal, digestive function and the appearance of the intestinal biopsy returned to normal. We raise the possibility of an association between alpha 1 antitrypsin deficiency and celiac sprue.

journal_name

J Clin Gastroenterol

authors

Pons Romero F,Casafont F,Rodriguez de Lope C,San Miguel G,Artiñano E,Cagigas J

doi

10.1097/00004836-198610000-00014

subject

Has Abstract

pub_date

1986-10-01 00:00:00

pages

559-61

issue

5

eissn

0192-0790

issn

1539-2031

journal_volume

8

pub_type

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