Adjuvant therapy for Helicobacter pylori eradication: role of lansoprazole shown in vitro.

Abstract:

:The recognition of Helicobacter pylori (H. pylori) as a major cause of gastroduodenal diseases has led to the use of antibiotics to treat these diseases. However, antibiotics used alone are not very effective, and adjuvant therapy is required. The most potent adjuvant therapy consists of increasing the stomach pH with proton pump inhibitors (PPIs). In addition to this action on stomach pH, PPIs, and especially lansoprazole, have been found to have antimicrobial activity against H. pylori. At high concentrations, they are even bactericidal. Furthermore, they can inhibit H. pylori urease activity. These properties, as well as their antisecretory activity, provide the grounds for their use in eradication of H. pylori.

journal_name

J Clin Gastroenterol

authors

Mégraud F

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

S24-7

eissn

0192-0790

issn

1539-2031

journal_volume

20 Suppl 1

pub_type

杂志文章,评审
  • The Impact of Stool Consistency on Bowel Movement Satisfaction in Patients With IBS-C or CIC Treated With Linaclotide or Other Medications: Real-World Evidence From the CONTOR Study.

    abstract:GOALS:This study aimed to characterize the impact of stool consistency on patient-reported bowel movement (BM) satisfaction in patients with irritable bowel syndrome with constipation (IBS-C) or chronic idiopathic constipation, with a focus on linaclotide. BACKGROUND:As new medications for constipation become availabl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001245

    authors: Taylor DCA,Abel JL,Doshi JA,Martin C,Goolsby Hunter A,Essoi B,Korrer S,Reasner DS,Carson RT,Chey WD

    更新日期:2019-11-01 00:00:00

  • Heterotopic pancreas mimicking carcinoma of the head of the pancreas: a rare cause of obstructive jaundice.

    abstract::A 61-year-old man developed obstructive jaundice and had ultrasonographic and cholangiopancreatographic findings consistent with carcinoma of the pancreas. However, pathologically the obstruction proved to be from heterotopic pancreatic tissue compressing the common bile duct. This patient and eight previously reporte...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198304000-00014

    authors: O'Reilly DJ,Craig RM,Lorenzo G,Yokoo H

    更新日期:1983-04-01 00:00:00

  • Perspectives of chromo and magnifying endoscopy: how, how much, when, and whom should we stain?

    abstract::The goal of every routine endoscopy in the gut is the early diagnosis of malignant and premalignant changes of the mucosa. Chromo- and magnifying endoscopes are exciting new tools and offer detailed analysis of the colonic mucosal surface and pit pattern architecture. This review summarizes recent advances in endoscop...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-200401000-00004

    authors: Kiesslich R,Jung M,DiSario JA,Galle PR,Neurath MF

    更新日期:2004-01-01 00:00:00

  • Extrahepatic portal venous thrombosis: frequent recognition of associated diseases.

    abstract::Twelve patients with obstruction of the extrahepatic portal venous system were seen at the Tufts-New England Medical Center between 1970 and 1979; a cause for the portal vein thrombosis was detected in 11. These included pancreatic disease (4); hematologic disorders (2); postoperative complications of laparotomy (3); ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198504000-00009

    authors: Brown KM,Kaplan MM,Donowitz M

    更新日期:1985-04-01 00:00:00

  • Celecoxib Monotherapy Maintained Small Intestinal Mucosa Better Compared With Loxoprofen Plus Lansoprazole Treatment: A Double-blind, Randomized, Controlled Trial.

    abstract:GOALS:The aim of this study was to compare celecoxib with loxoprofen for protection of small intestine. BACKGROUND:RCT studies report that COX-2 selective inhibitor celecoxib induces fewer small intestinal injuries than nonselective nonsteroidal anti-inflammatory drugs (NSAIDs). Loxoprofen is a prodrug nonselective NS...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCG.0000000000000372

    authors: Fujimori S,Hanada R,Hayashida M,Sakurai T,Ikushima I,Sakamoto C

    更新日期:2016-03-01 00:00:00

  • Low Risk of Neoplasia and Intraprocedural Adverse Events in Gastric Hyperplastic Polypectomy.

    abstract:GOALS:Assess neoplasia and polypectomy-related adverse event (AE) rates in gastric hyperplastic polyps (GHPs). BACKGROUND:GHPs carry a risk of neoplastic transformation. The rate of neoplastic transformation and the risk of polypectomy-related bleeding are unclear in the West, as data are derived from Asian or small s...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001446

    authors: Bar N,Kinaani F,Sperber AD,Amir-Barak H,Dekel R

    更新日期:2020-10-13 00:00:00

  • Reversible hepatitis associated with diclofenac.

    abstract::We describe the clinical features, liver histology, and ultrastructure in reversible diclofenac-induced hepatitis and review previous reports of this entity. Although rarely reported, diclofenac hepatitis may be severe, and even fatal. Symptoms, which develop from 1 week to 11 months after starting the drug, include j...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199104000-00018

    authors: Ouellette GS,Slitzky BE,Gates JA,Lagarde S,West AB

    更新日期:1991-04-01 00:00:00

  • Meta-analysis of antisecretory and gastrokinetic compounds in functional dyspepsia.

    abstract::In view of therapeutic advances, we carried out meta-analysis of results from 18 randomized, controlled clinical studies to update a previous meta-analysis and to provide an overview of clinical trials involving treatment of functional dyspepsia. The studies were included only if they satisfied inclusion and exclusion...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,meta分析

    doi:10.1097/00004836-199806000-00022

    authors: Finney JS,Kinnersley N,Hughes M,O'Bryan-Tear CG,Lothian J

    更新日期:1998-06-01 00:00:00

  • Primary choledochoduodenostomy for benign obstructive biliary tract disease.

    abstract::Repeated surgical interventions on the biliary ductal system increase morbidity and mortality, particularly in the geriatric patient. In an attempt to prevent these complications, side-to-side choledochoduodenostomy was performed as the primary operative procedure in 54 patients, age 72 +/- 13 years. This was the pati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199008000-00013

    authors: Berlatzky Y,Freund HR

    更新日期:1990-08-01 00:00:00

  • High Rates of Mortality in Geriatric Patients Admitted for Inflammatory Bowel Disease Management.

    abstract:GOAL:The goal of this study was to evaluate the inpatient mortality risk among geriatric patients with inflammatory bowel disease (IBD). BACKGROUND:The challenges of caring for elderly patients with IBD will increase with the aging of the US population. Given the complications of hospitalization, we set to examine if ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001458

    authors: Schwartz J,Stein DJ,Lipcsey M,Li B,Feuerstein JD

    更新日期:2020-11-23 00:00:00

  • Clinical practice: diagnosis and evaluation of dyspepsia.

    abstract::The main issue regarding the approach to the patient with uninvestigated dyspepsia is whether the symptoms are the result of an important clinical illness, which then determines the appropriate management strategy for the treatment of the symptoms. An initial trial of empiric antisecretory drugs is recommended for tho...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181c64c69

    authors: Graham DY,Rugge M

    更新日期:2010-03-01 00:00:00

  • Association Between Helicobacter pylori Infection and Short-segment/Long-segment Barrett's Esophagus in a Japanese Population: A Large Cross-Sectional Study.

    abstract:GOAL:The goal of this study was to investigate the relationship between Helicobacter pylori (H. pylori) infection and short-segment and long-segment Barrett's esophagus (SSBE and LSBE). BACKGROUND:H. pylori infection is reported to be inversely associated with Barrett's esophagus (BE) in western countries. However, th...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001264

    authors: Usui G,Sato H,Shinozaki T,Jinno T,Fujibayashi K,Ishii K,Horiuchi H,Morikawa T,Gunji T,Matsuhashi N

    更新日期:2020-05-01 00:00:00

  • The usefulness of routine small bowel biopsies in evaluation of iron deficiency anemia.

    abstract:BACKGROUND:Iron deficiency anemia (IDA) may be the sole manifestation of celiac disease. The role of routine small bowel biopsies obtained during endoscopy in the evaluation of IDA is unclear. This study assessed the usefulness of routine small bowel biopsies in patients presenting with IDA. STUDY:Evaluation of 103 co...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000139034.38568.51

    authors: Grisolano SW,Oxentenko AS,Murray JA,Burgart LJ,Dierkhising RA,Alexander JA

    更新日期:2004-10-01 00:00:00

  • Efficacy of 5-ASA in the treatment of colonic diverticular disease.

    abstract:OBJECTIVE:To assess the therapeutic efficacy of 5-aminosalicylic acid (5-ASA) in patients with colonic diverticular disease performing a systematic review of the literature. DATA SOURCES:Cochrane Trial Register (until Issue 4, 2008), Medical Literature Analysis and Retrieval System Online (1966 to October 1, 2008), Ex...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e3181a15864

    authors: Gatta L,Vakil N,Vaira D,Pilotto A,Curlo M,Comparato G,Leandro G,Ferro U,Lera M,Milletti S,Di Mario F

    更新日期:2010-02-01 00:00:00

  • Efficacy of sucralfate in the prevention of recurrence of duodenal ulcers.

    abstract::Eighty-four patients who were endoscopically confirmed to have healed duodenal ulcers were entered into this 1-year, double-blind, placebo-controlled trial of sucralfate, 1g twice daily, in the prevention of duodenal ulcer recurrence. Patients remained in the study until recurrence of ulceration was endoscopically con...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198709011-00006

    authors: Behar J,Roufail W,Thomas E,Keller F,Dernbach W,Tesler MA

    更新日期:1987-01-01 00:00:00

  • Histologic findings and Helicobacter pylori in duodenal biopsies.

    abstract::We have studied the morphologic aspects of the duodenal bulb in relation to Helicobacter pylori infection in a large group of patients with endoscopically assessed duodenitis to learn more about the pathogenesis of nonspecific duodenitis (bulbitis) and to clarify the specific role of H. pylori. Eight duodenal biopsy s...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199801000-00020

    authors: Caselli M,Gaudio M,Chiamenti CM,Trevisani L,Sartori S,Saragoni L,Boldrini P,Dentale A,Ruina M,Alvisi V

    更新日期:1998-01-01 00:00:00

  • Enteral self-expandable metal stent for malignant luminal obstruction of the upper and lower gastrointestinal tract: a prospective multicentric study.

    abstract:BACKGROUND:Self-expanding metal stents (SEMSs) are used to treat malignant stenosis of the gastrointestinal (GI) tract, as a safe, feasible, and minimally invasive option for reestablishing luminal patency. However, the literature offers scant prospective data on the clinical outcome of these patients. AIM:To assess t...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCG.0b013e318033d30a

    authors: Masci E,Viale E,Mangiavillano B,Contin G,Lomazzi A,Buffoli F,Gatti M,Repaci G,Teruzzi V,Fasoli R,Ravelli P,Testoni PA

    更新日期:2008-04-01 00:00:00

  • Ulcer healing after treatment with sucralfate emulsion or ranitidine. Randomized controlled study in peptic ulcer disease.

    abstract::A randomized trial with a blind observer compared the efficacy of an emulsion containing micronized sucralfate (1 g four times daily) and ranitidine (150 mg twice daily) in the short-term healing of peptic ulcer. Patients with a minimum ulcer size of 5 mm located in the duodenal bulb, the pyloric canal, or in the prep...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198808000-00006

    authors: Lykkegaard Nielsen MC,Vagn Nielsen O,Moesgaard F

    更新日期:1988-08-01 00:00:00

  • Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease.

    abstract:BACKGROUND:although azathioprine (AZA) is an effective immunomodulator in treating Crohn's disease, some patients develop leukopenia and risk severe infections. Thiopurine methyltransferase (TPMT) is an enzyme responsible for the metabolism of AZA, and its activity is inversely related to the risk of developing acute l...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200209000-00008

    authors: Regueiro M,Mardini H

    更新日期:2002-09-01 00:00:00

  • Probiotic Yogurt for the Prevention of Antibiotic-associated Diarrhea in Adults: A Randomized Double-blind Placebo-controlled Trial.

    abstract:GOAL:To evaluate the effect of yogurt supplemented with probiotic bacteria on the prevention of antibiotic-associated diarrhea (AAD) in hospitalized patients. BACKGROUND:Diarrhea following antibiotic administration is a frequent clinical problem. The usefulness of probiotics for the prevention of AAD in the hospitaliz...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCG.0000000000001131

    authors: Velasco M,Requena T,Delgado-Iribarren A,Peláez C,Guijarro C

    更新日期:2019-11-01 00:00:00

  • Massive vitamin A intoxication with ascites and pleural effusion.

    abstract::Vitamin A intoxication was diagnosed in a 14-year-old girl who presented with massive exudative ascites and right pleural effusion, impaired liver enzymes, and hypertriglyceridemia. Electron microscopy of liver biopsy material demonstrated numerous perisinusoidal lipid-filled Ito cells. The patient had taken 100-200,0...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198508000-00016

    authors: Noseda A,Adler M,Ketelbant P,Baran D,Winand J

    更新日期:1985-08-01 00:00:00

  • Study of Gender Differences in Proton Pump Inhibitor Dose Requirements for GERD: A Double-Blind Randomized Trial.

    abstract:GOALS:To determine the proportion of patients with gastroesophageal reflux disease who are on proton pump inhibitors (PPIs) who could reduce their prior dosage by half, and identify predictors of successful step-down. BACKGROUND:Appropriate hypergastrinemia results from gastric acid inhibition. A gender difference in ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCG.0000000000000542

    authors: Helgadóttir H,Metz DC,Lund SH,Gizurarson S,Jacobsen EI,Asgeirsdóttir GA,Yngadóttir Y,Björnsson ES

    更新日期:2017-07-01 00:00:00

  • Fatal reactivation of hepatitis B virus in a patient who was hepatitis B surface antigen negative and core antibody positive before receiving chemotherapy for non-Hodgkin lymphoma.

    abstract::Patients who are hepatitis B surface antigen (HBsAg) positive are at risk for hepatitis flare when receiving cytotoxic or immunosuppressive therapy. It has been reported that as high as 50% of HBsAg-positive individuals who undergo chemotherapy develop elevation of liver transaminases. According to current Association...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181945942

    authors: Wu JM,Huang YH,Lee PC,Lin HC,Lee SD

    更新日期:2009-05-01 00:00:00

  • Ultrasound diagnosis of fatty liver in patients with chronic liver disease: a retrospective observational study.

    abstract:OBJECTIVES:Hepatic ultrasound (US) is readily available and physicians usually trust the results of an US report suggesting fatty liver, but there are conflicting reports on its accuracy, especially in patients with chronic liver disease (CLD). Therefore, we retrospectively examined liver biopsies in patients with CLD ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000225680.45088.01

    authors: Perez NE,Siddiqui FA,Mutchnick MG,Dhar R,Tobi M,Ullah N,Saksouk FA,Wheeler DE,Ehrinpreis MN

    更新日期:2007-07-01 00:00:00

  • Candida overgrowth after treatment of duodenal ulcer. A comparison of cimetidine, famotidine, and omeprazole.

    abstract::Acid-reducing drugs can cause increased growth of microbes, including fungus, because of high gastric pH. Our purpose was to evaluate the occurrence of mycotic infection in patients with duodenal ulcer on anti-ulcer therapy and to compare the effects of cimetidine, famotidine, and omeprazole. Eighty patients with duod...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-199607000-00003

    authors: Goenka MK,Kochhar R,Chakrabarti A,Kumar A,Gupta O,Talwar P,Mehta SK

    更新日期:1996-07-01 00:00:00

  • A case of sclerosing cholangitis managed by a percutaneous approach.

    abstract::In 1992, a 61-year-old man who complained of recurrent episodes of fever and jaundice was diagnosed as having sclerosing cholangitis. In the three years that followed, the clinical picture progressively worsened; and, in 1995, the patient was hospitalized again for biliary obstruction. A liver transplantation was excl...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200003000-00017

    authors: Tritto G,Iaccarino V,De Martino S,D'Agostino L

    更新日期:2000-03-01 00:00:00

  • Increased Acid Exposure on Pretransplant Impedance-pH Testing Is Associated With Chronic Rejection After Lung Transplantation.

    abstract:GOAL:The goal of this study was to assess the relationship between pretransplant measures of reflux and longer-term outcomes of chronic allograft rejection in lung transplant recipients. BACKGROUND:Bronchiolitis obliterans syndrome (BOS) is a primary measure of morbidity and mortality following lung transplantation, a...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001331

    authors: Lo WK,Moniodis A,Goldberg HJ,Feldman N,Chan WW

    更新日期:2020-07-01 00:00:00

  • Chronic Pneumocystis carinii infection of the liver. A case report and review of the literature.

    abstract::Pneumocystis carinii infection of the liver is being reported with increasing frequency in patients with acquired immune deficiency syndrome (AIDS). The clinical picture typically resembles hepatitis. We report such an occurrence in a patient with persistent elevation of alkaline phosphatase and gamma-glutamyl transpe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199207000-00013

    authors: Merkel IS,Good CB,Nalesnik M,Roseman SR

    更新日期:1992-07-01 00:00:00

  • Effect of Consent and Educational Adjuncts to Consent on Patient Perceptions About Colonoscopy.

    abstract:BACKGROUND AND AIMS:Informed consent is a vital preprocedural step for endoscopy but there are substantial variations in its delivery. We therefore sought to assess a multifaceted intervention to improve the consent process. METHODS:Gastroenterologists at a tertiary center were educated on the recommended components o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001093

    authors: Fudman DI,Papamichael K,Roemi L,Rao V,Falchuk KR,Leffler DA,Feuerstein JD

    更新日期:2019-09-01 00:00:00

  • Ursodeoxycholic acid for adjuvant therapy with extracorporeal shock wave lithotripsy of gallstones.

    abstract::Extracorporeal shock wave lithotripsy (ESWL) of gallstones is a new and experimental treatment. Recent data seem to indicate that the use of ursodeoxycholic acid (UDCA) after ESWL may optimize the results of the shock wave treatment. Most of the published data on the clinical use of such therapy emanate from two studi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Fromm H

    更新日期:1988-01-01 00:00:00