Abstract:
:Vitamin A intoxication was diagnosed in a 14-year-old girl who presented with massive exudative ascites and right pleural effusion, impaired liver enzymes, and hypertriglyceridemia. Electron microscopy of liver biopsy material demonstrated numerous perisinusoidal lipid-filled Ito cells. The patient had taken 100-200,000 I.U. vitamin A per day for 15 months. Serum vitamin A level remained elevated for 4 months after vitamin discontinuation. The unusual severity of portal hypertension was documented by a high wedged hepatic vein pressure level. The ascites occurred 2 months after vitamin A had been discontinued, probably owing to particularly slow mobilization of large hepatic stores of vitamin A. Portal hypertension disappeared after a 6-month low vitamin A diet, but the liver biopsy failed to demonstrate any decrease in number or size of Ito cells, suggesting that lipid venous obstruction is unlikely to be the only mechanism responsible for portal hypertension in vitamin A-induced liver disease.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Noseda A,Adler M,Ketelbant P,Baran D,Winand Jdoi
10.1097/00004836-198508000-00016subject
Has Abstractpub_date
1985-08-01 00:00:00pages
344-9issue
4eissn
0192-0790issn
1539-2031journal_volume
7pub_type
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journal_title:Journal of clinical gastroenterology
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