Biliary atresia: recent progress.

Abstract:

:Extrahepatic biliary atresia (EHBA), an inflammatory sclerosing cholangiopathy, is the leading indication for liver transplantation in children. The cause is still unknown, although possible infectious, genetic, and immunologic etiologies have received much recent focus. These theories are often dependent on each other for secondary or coexisting mechanisms. Concern for EHBA is raised by a cholestatic infant, but the differential diagnosis is large and the path to diagnosis remains varied. Current treatment is surgical with an overall survival rate of approximately 90%. The goals of this article are to review the important clinical aspects of EHBA and to highlight some of the more recent scientific and clinical developments contributing to our understanding of this condition.

journal_name

J Clin Gastroenterol

authors

Bassett MD,Murray KF

doi

10.1097/MCG.0b013e3181646730

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

720-9

issue

6

eissn

0192-0790

issn

1539-2031

journal_volume

42

pub_type

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