Tumors of the alimentary tract.

abstract：:Bioregulators are naturally occurring organic compounds that regulate a multitude of biologic processes. Under natural circumstances, bioregulators are synthesized in minute quantities in a variety of living organisms and are essential for physiologic homeostasis. In the wrong hands, these compounds have the capabilit...

journal_title：Clinics in laboratory medicine

authors： Kagan E

更新日期：2006-06-01 00:00:00

abstract：:B-cell lymphomas represent approximately 20% to 25% of primary cutaneous lymphomas. Within this group, most cases (>99%) are encompassed by 3 diagnostic entities: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type. In this...

journal_title：Clinics in laboratory medicine

authors： Hope CB,Pincus LB

更新日期：2017-09-01 00:00:00

abstract：:This article describes a method for evaluating some of the medical, economic, and personal consequences of different policies of monitoring patients for various disorders. The problem is difficult because it is dynamic. Most conditions develop over time, and in many cases the sensitivity of the test as well as the cos...

journal_title：Clinics in laboratory medicine

authors： Eddy DM

更新日期：1982-12-01 00:00:00

abstract：:Standard business inventory procedures can be cost effective when they are adapted to hospital laboratory inventory management in a 500-bed hospital. The investment in a central laboratory store-room and one additional employee yields financial benefits and indirect service benefits. The system requires consistent use...

journal_title：Clinics in laboratory medicine

authors： Weinstein W,Wenk RE

更新日期：1985-12-01 00:00:00

abstract：:Molecular biological techniques have evolved expeditiously and in turn have been applied to the detection of infectious disease. Maturation of these technologies and their coupling with related technological advancement in fluorescence, electronics, digitization, nanodynamics, and sensors among others have afforded cl...

journal_title：Clinics in laboratory medicine

authors： Fairfax MR,Bluth MH,Salimnia H

更新日期：2018-06-01 00:00:00

abstract：:The recent development and clinical implementation of genomic microarrays has resulted in rapid and significant changes for postnatal studies in the field of cytogenetics. This article discusses the benefits and issues for the use of microarrays for prenatal genetic diagnosis. It includes sections on specimen processi...

journal_title：Clinics in laboratory medicine

authors： Lamb AN

更新日期：2011-12-01 00:00:00

abstract：:Fine needle aspiration biopsy (FNAB) is the diagnostic procedure of choice for evaluation of liver lesions. Although primarily applied to malignant disease, it is also used in the evaluation of benign conditions. Improvements in imaging techniques and advances in cytologic interpretations, as well as production of new...

journal_title：Clinics in laboratory medicine

authors： Pitman MB

更新日期：1998-09-01 00:00:00

abstract：:The search for clinical outcomes associated with antiphospholipid antibodies (aPL) has been ongoing for a decade. This article focuses on the clinical use of tests for the detection of aPL. A review of the current thinking regarding the pathophysiology of antiphospholipid syndromes is relevant to the discussion of dif...

journal_title：Clinics in laboratory medicine

authors： Reyes H,Dearing L,Bick RL,Shoenfeld Y,Peter JB

更新日期：1995-03-01 00:00:00

abstract：:An exciting era exists as a result of the introduction of novel markers of myocardial damage. The prognostic implications of troponins, even in the setting of "minor myocardial damage," are potentially of immense value to patient care. We need to take the next step and assess the outcomes of interventions in these set...

journal_title：Clinics in laboratory medicine

authors： Tymchak WJ,Armstrong PW

更新日期：1997-12-01 00:00:00

abstract：:Nephropathy progressing to end-stage renal failure is a common complication of diabetes mellitus. The development of diabetic nephropathy is preceded for many years by minor increases in urine albumin excretion (microalbuminuria), and some diabetologists believe that by reducing or reversing this early abnormality, po...

journal_title：Clinics in laboratory medicine

authors： Hindmarsh JT

更新日期：1988-09-01 00:00:00

abstract：:The principles, technique of measurement, and clinical significance of free drugs are reviewed. Albumin, alpha-1-acid glycoprotein, and lipoprotein are the main drug-binding proteins in blood. Variations of the concentrations of these proteins owing to disease would result in changes in the free drug levels. These lev...

journal_title：Clinics in laboratory medicine

authors： Chan S,Gerson B

更新日期：1987-06-01 00:00:00

abstract：:The blood film is one of the world's most widely and frequently used tests and has undergone remarkably few changes since its introduction in the late 1800s. This article gives direction and some standardization in the preparation of blood films used for morphologic evaluation in the clinical laboratory. Methodologies...

journal_title：Clinics in laboratory medicine

authors： Houwen B

更新日期：2002-03-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid, reliable, and high-throughput diagnostic tool for the identification of microorganisms. The technology is unique in clinical microbiology, allowing laboratories to definitively identify bacterial and fungal isolates...

journal_title：Clinics in laboratory medicine

authors： Dingle TC,Butler-Wu SM

更新日期：2013-09-01 00:00:00

abstract：:Melanoma represents a substantial source of risk within dermatology and dermatopathology. This article seeks to provide general pathologists, dermatologists and dermatopathologists with an overview of the basics principles of medical malpractice litigation, a review of the essentials of reporting and the importance of...

journal_title：Clinics in laboratory medicine

authors： High WA

更新日期：2008-06-01 00:00:00

abstract：:Although most of the diagnostic applications of flow cytometry bring forth examples of leukocyte immunophenotyping for immunodeficiency diseases and leukemia-lymphoma diagnosis, the same technology has improved medical assessment of diseases affecting the red cell and erythropoiesis. Flow cytometric methods were first...

journal_title：Clinics in laboratory medicine

authors： Davis BH

更新日期：2001-12-01 00:00:00

abstract：:Cyclosporine (CsA) monitoring has remained controversial since the advent of the use of CsA in organ transplantation in the early 1980s. This article attempts to clarify for the clinical laboratory worker many of the vagaries associated with CsA monitoring by considering choice of sample matrix, the nature of metaboli...

journal_title：Clinics in laboratory medicine

authors： Napoli KL,Kahan BD

更新日期：1991-09-01 00:00:00

abstract：:The last decade has witnessed the transformation of first-trimester Down syndrome screening from an aspiration to a clinical reality. First-trimester screening now equals or exceeds the diagnostic accuracy of conventional midtrimester screen while realizing an important desire of pregnant women for early diagnosis. Be...

journal_title：Clinics in laboratory medicine

authors： Bahado-Singh RO,Argoti P

更新日期：2010-09-01 00:00:00

abstract：:With the US Food and Drug Administration's recent label change of warfarin to include genetic testing for warfarin sensitivity, manufacturers are developing assays, and laboratories are offering testing. This article describes the genetic variants for which testing is available. Current technologies and assays are com...

journal_title：Clinics in laboratory medicine

authors： Lyon E,McMillin G,Melis R

更新日期：2008-12-01 00:00:00

abstract：:Variation in the genome of hepatitis B virus has been associated with a number of clinical parameters, but there is a paucity of functional data to show a causal relationship. For example, variants of the core and X genes have been linked with the pathogenesis of chronic hepatitis, viral replication efficiency, and se...

journal_title：Clinics in laboratory medicine

authors： Carman WF

更新日期：1996-06-01 00:00:00

abstract：:This article addresses several fundamental features of clinical flow cytometry. A practical overview of the technical and methodologic aspects of this fast-growing and increasingly important new clinical and investigative field is provided. The use of flow cytometry for the diagnosis and monitoring of various chronic ...

journal_title：Clinics in laboratory medicine

authors： Kipps TJ,Meisenholder G,Robbins BA

更新日期：1992-06-01 00:00:00

abstract：:Disturbed liver parenchymal cell function adversely impacts on the hemostasis system, the extent of which correlates with the degree of liver disease. Because liver parenchymal cells synthesize most factors of the clotting and the fibrinolytic systems, levels of these procoagulant and anticoagulant as well as profibri...

journal_title：Clinics in laboratory medicine

authors： Mammen EF

更新日期：1994-12-01 00:00:00

abstract：:Screening tests may help or harm the healthy subject and, therefore, must be selected and used carefully. Criteria for selection include characteristics of the disease(s), of the potential screening tests, and of the population(s) to be screened. An understanding of methods used to evaluate tests will allow the invest...

journal_title：Clinics in laboratory medicine

authors： Mulley AG

更新日期：1986-06-01 00:00:00

abstract：:Salmonella, Shigella, and Yersinia cause a well-characterized spectrum of disease in humans, ranging from asymptomatic carriage to hemorrhagic colitis and fatal typhoidal fever. These pathogens are responsible for millions of cases of food-borne illness in the United States each year, with substantial costs measured i...

journal_title：Clinics in laboratory medicine

authors： Dekker JP,Frank KM

更新日期：2015-06-01 00:00:00

abstract：:Vitamin D has been associated with many health conditions. Because of widespread deficiency in the general population, laboratory testing of vitamin D has increased exponentially in recent years. Currently, 25-hydroxyvitamin D (25[OH]D) is considered the best marker of vitamin D status. Automated immunoassays and tand...

journal_title：Clinics in laboratory medicine

authors： Garg U

更新日期：2018-09-01 00:00:00

abstract：:Automated image processing analysis for leukocyte differential counting started 30 years ago principally as a mimic of the traditional microscopic method. Several types of systems were used in the 1970s and 1980s. In the late 1990s, two new image processing systems were developed with new technology for cell image ana...

journal_title：Clinics in laboratory medicine

authors： Tatsumi N,Pierre RV

更新日期：2002-03-01 00:00:00

abstract：:Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger...

journal_title：Clinics in laboratory medicine

authors： Shi M,Nguyen P,Jevremovic D

更新日期：2017-12-01 00:00:00

abstract：:The authors describe a system for collecting usage metrics from widely distributed automation systems. An application that records and stores usage data centrally, calculates run times, and charts the data was developed. Data were collected over 20 months from at least 28 workstations. The application was used to plot...

journal_title：Clinics in laboratory medicine

authors： Benn N,Turlais F,Clark V,Jones M,Clulow S

更新日期：2007-03-01 00:00:00

abstract：:This article reviews the laboratory methodologies used to evaluate acute lymphoblastic leukemia (ALL) in children and their role in establishing a diagnosis and prognosis of this disease. These methodologies are: morphology, flow cytometry, cytogenetics, and molecular diagnostics. Additionally, immunophenotypic classi...

journal_title：Clinics in laboratory medicine

authors： Melnick SJ

更新日期：1999-03-01 00:00:00

abstract：:Revolutionary changes in the computer industry brought about in part by the introduction of personal computers are now reaching into clinical laboratories everywhere. Although the true justification for any computer tool may be an intangible one such as improvement in service, such tools can typically be cost justifie...

journal_title：Clinics in laboratory medicine

authors： Hendricks EJ

更新日期：1985-12-01 00:00:00

abstract：:Antiretroviral drugs against HIV infection have been developed that inhibit various stages of the HIV replication cycle. Agents other than reverse transcriptase inhibitors are reviewed with particular attention to those under study in clinical trials, including inhibitors of the virus-encoded protease enzyme. In addit...

journal_title：Clinics in laboratory medicine

authors： Kaplan JC,Hirsch MS

更新日期：1994-06-01 00:00:00