Malpractice in dermatopathology: principles, risk mitigation, and opportunities for improved care for the histologic diagnosis of melanoma and pigmented lesions.

abstract：:The red cell indices of mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration have been standard methods of evaluating anemia since they were developed by Wintrobe in the 1930s. This article discusses the technical variabilities that have rendered the classic red cell indi...

journal_title：Clinics in laboratory medicine

authors： Savage RA

更新日期：1993-12-01 00:00:00

abstract：:Vertical auto profile (VAP) method is a direct single test for measuring comprehensive lipoprotein cholesterol profile. It is based on a well-established method of ultracentrifugation that uses vertical rotor and single density gradient spin. VAP provides cholesterol concentrations of total lipoprotein, high-density l...

journal_title：Clinics in laboratory medicine

authors： Kulkarni KR

更新日期：2006-12-01 00:00:00

abstract：:Immunology testing is relevant for the diagnosis of many autoimmune conditions. However, diagnostic pitfalls arise owing to incorrect interpretation of results and incomplete understanding of the underlying technique or immune-mediated condition. Here, we review the diagnostic considerations related to commonly used i...

journal_title：Clinics in laboratory medicine

authors： Maher L,Perugino C

更新日期：2019-12-01 00:00:00

abstract：:Breast cancer is the leading cause of cancer mortality among women in developing countries. Timely and accurate histopathological diagnosis of breast cancer is critical to delivering high-quality breast cancer care to patients in low- and middle-income countries (LMIC). The most important prognostic factors in breast ...

journal_title：Clinics in laboratory medicine

authors： Martei YM,Pace LE,Brock JE,Shulman LN

更新日期：2018-03-01 00:00:00

abstract：:Yellow fever (YF) is a viral disease, endemic to tropical regions of Africa and the Americas, which principally affects humans and nonhuman primates and is transmitted via the bite of infected mosquitoes. Yellow fever virus (YFV) can cause devastating epidemics of potentially fatal, hemorrhagic disease. Despite mass v...

journal_title：Clinics in laboratory medicine

authors： Gardner CL,Ryman KD

更新日期：2010-03-01 00:00:00

abstract：:Diagnosis of invasive fungal pneumonias by conventional culture methods is difficult to assess and often delayed. Nonmolecular fungal markers have emerged as an important adjunctive tool to support their diagnosis in combination with other clinical, radiologic, and microbiological criteria of invasive fungal diseases....

journal_title：Clinics in laboratory medicine

authors： Lamoth F,Alexander BD

更新日期：2014-06-01 00:00:00

abstract：:Direct-to-consumer genetic testing came on the scene 2 decades ago as a means for allowing consumers to access their genetic information without the involvement of a physician or genetic counselor. Results are delivered directly to the consumer, often leading to misinterpretation and needless medical interventions or ...

journal_title：Clinics in laboratory medicine

authors： Dinulos MBP,Vallee SE

更新日期：2020-03-01 00:00:00

abstract：:Acute erythroleukemia is an aggressive leukemia derived from a multipotential stem cell. Three subtypes have been described: (1) M6a with greater than or equal to 30% blasts of the nonerythrocytic component, (2) M6b with greater than or equal to 30% pronormoblasts of the erythrocytic elements, and (3) M6c with greater...

journal_title：Clinics in laboratory medicine

authors： Mazzella FM,Alvares C,Kowal-Vern A,Schumacher HR

更新日期：2000-03-01 00:00:00

abstract：:Nephropathy progressing to end-stage renal failure is a common complication of diabetes mellitus. The development of diabetic nephropathy is preceded for many years by minor increases in urine albumin excretion (microalbuminuria), and some diabetologists believe that by reducing or reversing this early abnormality, po...

journal_title：Clinics in laboratory medicine

authors： Hindmarsh JT

更新日期：1988-09-01 00:00:00

abstract：:Advances in cellular therapies for pediatric patients have created many opportunities for improved survival with reduced morbidity. This article reviews current cellular therapies in pediatric hematological malignancy, including the most updated practices in hematopoietic stem cell transplant and the use of chimeric a...

journal_title：Clinics in laboratory medicine

authors： Kuldanek S,Pasko B,DomBourian M,Annen K

更新日期：2021-03-01 00:00:00

abstract：:Autoimmune aPL are associated with a well-defined clinical syndrome of vascular thromboses, recurrent fetal loss, thrombocytopenia, livedo reticularis, and valvular and neurologic abnormalities. A clinical diagnosis of SLE need not be present, and aPL syndrome in the absence of other well-defined autoimmune disease is...

journal_title：Clinics in laboratory medicine

authors： Sammaritano LR,Gharavi AE

更新日期：1992-03-01 00:00:00

abstract：:The most efficacious and practical means of diagnosing human schistosomiasis is based on the detection of infection-specific antibodies. Because of their high sensitivity, antibody assays remain the most practical assays for epidemiologic studies and patient management. Initial screening may be performed in the field ...

journal_title：Clinics in laboratory medicine

authors： Tsang VC,Wilkins PP

更新日期：1991-12-01 00:00:00

abstract：:Laboratory information systems (LISs) supply mission-critical capabilities for the vast array of information-processing needs of modern laboratories. LIS architectures include mainframe, client-server, and thin client configurations. The LIS database software manages a laboratory's data. LIS dictionaries are database ...

journal_title：Clinics in laboratory medicine

authors： Henricks WH

更新日期：2016-03-01 00:00:00

abstract：:Lyme disease in North America is caused by infection with the spirochetal bacterium Borrelia burgdorferi and transmitted by Ixodes scapularis and Ixodes pacificus ticks. These ticks also have the potential to transmit a rapidly expanding list of other pathogenic bacteria, viruses, and parasites, including Anaplasma ph...

journal_title：Clinics in laboratory medicine

authors： Caulfield AJ,Pritt BS

更新日期：2015-12-01 00:00:00

abstract：:In discussing quality assurance in the blood bank, where many of the standard statistical techniques of measuring accuracy simply do not apply, three questions come to mind: How much? How often? Who says? Because of severe changes in the prospective payment plan and a new interest in cost effectiveness, many transfusi...

journal_title：Clinics in laboratory medicine

authors： White KK,Silberstein LE

更新日期：1986-12-01 00:00:00

abstract：:Lipoprotein-associated phospholipase A2 (LP-PLA2) is an emerging inflammatory marker that is used to assess the risk for cardiovascular disease (CVD) and associated events. Several epidemiologic studies have demonstrated an independent association between plasma Lp-PLA2 concentration and risk for cardiovascular events...

journal_title：Clinics in laboratory medicine

authors： McConnell JP,Hoefner DM

更新日期：2006-09-01 00:00:00

abstract：:A rapidly increasing body of evidence links human papillomavirus (HPV) to cervical neoplasia through epidemiologic associations, pathologic features, molecular detection, and mechanisms of oncogenesis. HPV is now accepted as the primary cause of cervical neoplasia and accounts for most of the risk factors traditionall...

journal_title：Clinics in laboratory medicine

authors： McLachlin CM

更新日期：2000-06-01 00:00:00

abstract：:There are many types of ANA and they may react with different nuclear components varying from nucleic acids to both basic and acidic nuclear proteins. Recent investigations have demonstrated that it is important not only to detect the presence and quantity of the ANA, but also to identify the immunologic specificities...

journal_title：Clinics in laboratory medicine

authors： Nakamura RM,Tan EM

更新日期：1986-03-01 00:00:00

abstract：:To meet the challenges of diagnosis and management of infectious diseases, clinical pathology residents must receive comprehensive training in microbiology, learn to think critically, develop problem-solving skills, and take active roles as laboratory consultants. Residents well trained in clinical microbiology become...

journal_title：Clinics in laboratory medicine

authors： Haller BL

更新日期：2007-06-01 00:00:00

abstract：:The importance of the phlogogenic effects of immune complexes in disease pathogenesis has been emphasized, but they also have a role in immunoregulation. We examined the effects of DNA: anti-DNA immune complexes, formed at different antigen:antibody ratios, on the ability of T cells to modulate DNA antibody production...

journal_title：Clinics in laboratory medicine

authors： Clough JD,Calabrese LH,Budervic SA

更新日期：1988-06-01 00:00:00

abstract：:There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1...

journal_title：Clinics in laboratory medicine

authors： Laughlin MA,Pomerantz RJ

更新日期：1994-06-01 00:00:00

abstract：:Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger...

journal_title：Clinics in laboratory medicine

authors： Shi M,Nguyen P,Jevremovic D

更新日期：2017-12-01 00:00:00

abstract：:From the inception of TBS in 1988, it has been well received by the pathology and clinical communities. The need for a unifying system of nomenclature was so great that most of the laboratories in the United States, as well as in numerous countries worldwide, quickly adopted TBS. By 1991, only 2 years after the initia...

journal_title：Clinics in laboratory medicine

authors： Henry MR

更新日期：2003-09-01 00:00:00

abstract：:Automated image processing analysis for leukocyte differential counting started 30 years ago principally as a mimic of the traditional microscopic method. Several types of systems were used in the 1970s and 1980s. In the late 1990s, two new image processing systems were developed with new technology for cell image ana...

journal_title：Clinics in laboratory medicine

authors： Tatsumi N,Pierre RV

更新日期：2002-03-01 00:00:00

abstract：:An ideal immunohistochemical screening panel would be one in which each antibody is 100% sensitive and specific for the target cell type (e.g., markers for epithelial neoplasms, lymphomas, sarcomas, etc.). Anyone who has practiced immunochemistry is well aware that this situation does not exist. High sensitivity is hi...

journal_title：Clinics in laboratory medicine

authors： Linder J

更新日期：1990-03-01 00:00:00

abstract：:To leverage the time and expertise of the pathologist, a comprehensive workstation is a useful tool. Because the practice of pathology is so diverse, however, there is no one standard for what constitutes a workstation. The author reviews the several elements and components which must be included (access to your LIS, ...

journal_title：Clinics in laboratory medicine

authors： Aller RD

更新日期：1997-06-01 00:00:00

abstract：:Disturbed liver parenchymal cell function adversely impacts on the hemostasis system, the extent of which correlates with the degree of liver disease. Because liver parenchymal cells synthesize most factors of the clotting and the fibrinolytic systems, levels of these procoagulant and anticoagulant as well as profibri...

journal_title：Clinics in laboratory medicine

authors： Mammen EF

更新日期：1994-12-01 00:00:00

abstract：:The pharmacologic field that studies antimicrobial pharmacokinetics and pharmacodynamics (PK/PD) has had a major impact on the choice and dosing regimens used for many antibiotics especially those used in the treatment of respiratory tract infections. PK/PD parameters are particularly important in light of increasing ...

journal_title：Clinics in laboratory medicine

authors： Andes D,Anon J,Jacobs MR,Craig WA

更新日期：2004-06-01 00:00:00

abstract：:This article reviews the concept of dysplasia and the distinguishing features of dysplastic nevi, including their premalignant potential, their biologic markers of tumor progression, and their reproducibly recognizable clinical and histologic characteristics. An additional emphasis is placed on describing gray zone m...

journal_title：Clinics in laboratory medicine

authors： Kim JC,Murphy GF

更新日期：2000-12-01 00:00:00

abstract：:Bioregulators are naturally occurring organic compounds that regulate a multitude of biologic processes. Under natural circumstances, bioregulators are synthesized in minute quantities in a variety of living organisms and are essential for physiologic homeostasis. In the wrong hands, these compounds have the capabilit...

journal_title：Clinics in laboratory medicine

authors： Kagan E

更新日期：2006-06-01 00:00:00