Abstract:
:Acute erythroleukemia is an aggressive leukemia derived from a multipotential stem cell. Three subtypes have been described: (1) M6a with greater than or equal to 30% blasts of the nonerythrocytic component, (2) M6b with greater than or equal to 30% pronormoblasts of the erythrocytic elements, and (3) M6c with greater than or equal to 30% blasts and greater than or equal to 30% pronormoblasts by the aforementioned exclusion criteria. The poor prognosis associated with this disorder positively correlates with a high pronormoblast:myeloblast ratio; unfavorable cytogenetic aberrations; a high proliferative index; and the presence of P-glycoprotein expression (multidrug resistance phenotype). Chemotherapeutic regimens directed toward these specific parameters should be devised in order to improve the characteristically poor outcome of this patient population.
journal_name
Clin Lab Medjournal_title
Clinics in laboratory medicineauthors
Mazzella FM,Alvares C,Kowal-Vern A,Schumacher HRsubject
Has Abstractpub_date
2000-03-01 00:00:00pages
119-37issue
1eissn
0272-2712issn
1557-9832journal_volume
20pub_type
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
pub_type: 历史文章,杂志文章,评审
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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