Temporal data mining.

abstract：:DNA testing has revolutionized the forensic sciences. Forensic testing has continued to evolve, and now several methods are in use. The predominant methods of forensic DNA analysis are described, and their application in casework is summarized. The legal acceptance of this testing also is discussed. ...

journal_title：Clinics in laboratory medicine

authors： Weedn VW

更新日期：1996-03-01 00:00:00

abstract：:Rapidly changing technology in the clinical microbiology laboratory requires a highly skilled workforce. The current clinical microbiology workforce is aging with a wave of retirements currently unfolding. Key competencies that will be needed for the next generation of microbiologists include strong analytical skills,...

journal_title：Clinics in laboratory medicine

authors： Gilligan PH,McGee MH

更新日期：2019-09-01 00:00:00

abstract：:Image processing applications in forensic pathology are becoming increasingly important. This article introduces basic concepts in image processing as applied to problems in forensic pathology in a non-mathematical context. Discussions of contrast enhancement, digital encoding, compression, deblurring, and other topic...

journal_title：Clinics in laboratory medicine

authors： Oliver WR

更新日期：1998-03-01 00:00:00

abstract：:The importance of food-borne helminthic infections is not well recognized and has not received the same attention as food-borne bacterial infections. Poverty, overpopulation, and cultural practices contribute to conditions that maintain food-borne helminthic infections. The development of better means of transportatio...

journal_title：Clinics in laboratory medicine

authors： Bruckner DA

更新日期：1999-09-01 00:00:00

abstract：:Cytomorphological examination of aspirate smears remains the basic method to diagnose hematologic disorders and to evaluate treatment-related changes. Last-generation hematological analyzers can count, besides cells normally circulating in peripheral blood, some types of immature and abnormal cells, such as erythrobla...

journal_title：Clinics in laboratory medicine

authors： d'Onofrio G,Zini G

更新日期：2015-03-01 00:00:00

abstract：:Although most of the diagnostic applications of flow cytometry bring forth examples of leukocyte immunophenotyping for immunodeficiency diseases and leukemia-lymphoma diagnosis, the same technology has improved medical assessment of diseases affecting the red cell and erythropoiesis. Flow cytometric methods were first...

journal_title：Clinics in laboratory medicine

authors： Davis BH

更新日期：2001-12-01 00:00:00

abstract：:Respiratory viruses continue to be major causes of morbidity and mortality. Currently available chemotherapy is limited to oral amantadine for uncomplicated influenza A and aerosolized ribavirin for respiratory syncytial virus (RSV) infections. Amantadine is also efficacious for chemoprophylaxis of influenza A virus i...

journal_title：Clinics in laboratory medicine

authors： Sperber SJ,Hayden FG

更新日期：1987-12-01 00:00:00

abstract：:Antiretroviral failure caused by the development of drug resistance in HIV-1 is an increasingly common clinical problem. Two types of resistance assays are available to clinicians. Genotypic assays determine the presence of mutations associated with drug resistance. The interpretation of mutations is often complicated...

journal_title：Clinics in laboratory medicine

authors： Hanna GJ

更新日期：2002-09-01 00:00:00

abstract：:An exciting era exists as a result of the introduction of novel markers of myocardial damage. The prognostic implications of troponins, even in the setting of "minor myocardial damage," are potentially of immense value to patient care. We need to take the next step and assess the outcomes of interventions in these set...

journal_title：Clinics in laboratory medicine

authors： Tymchak WJ,Armstrong PW

更新日期：1997-12-01 00:00:00

abstract：:FNA cytology has been shown to be highly accurate in diagnosing malignant tumors. In gynecology, an overall accuracy of 94.5% in the differentiation between benign and malignant tumors has been reported. Despite many controversial views regarding its safety, aspiration cytology has been accepted as an innocuous proced...

journal_title：Clinics in laboratory medicine

authors： Ganjei P

更新日期：1995-09-01 00:00:00

abstract：:Drugs ingested in overdose can have altered pharmacokinetics of absorption, distribution, and elimination. The pathophysiologic consequences of overdose can also change a drug's pharmacokinetic properties. Many toxicologic interventions are based on modifying the drug's pharmacokinetics (e.g., impairing absorption or ...

journal_title：Clinics in laboratory medicine

authors： Platt D

更新日期：1990-06-01 00:00:00

abstract：:There is growing evidence supporting the genetic variability outside of HLA system that is contributing to the variation in transplant outcomes. Determining novel predictors could help to identify patients at risk and tailor their immunosuppressive regimens. This article discusses the various single nucleotide polymor...

journal_title：Clinics in laboratory medicine

authors： Jindra PT,Cusick MF

更新日期：2019-03-01 00:00:00

abstract：:Molecular biological techniques have evolved expeditiously and in turn have been applied to the detection of infectious disease. Maturation of these technologies and their coupling with related technological advancement in fluorescence, electronics, digitization, nanodynamics, and sensors among others have afforded cl...

journal_title：Clinics in laboratory medicine

authors： Fairfax MR,Bluth MH,Salimnia H

更新日期：2018-06-01 00:00:00

abstract：:Melanoma represents a substantial source of risk within dermatology and dermatopathology. This article seeks to provide general pathologists, dermatologists and dermatopathologists with an overview of the basics principles of medical malpractice litigation, a review of the essentials of reporting and the importance of...

journal_title：Clinics in laboratory medicine

authors： High WA

更新日期：2008-06-01 00:00:00

abstract：:This article describes a method for evaluating some of the medical, economic, and personal consequences of different policies of monitoring patients for various disorders. The problem is difficult because it is dynamic. Most conditions develop over time, and in many cases the sensitivity of the test as well as the cos...

journal_title：Clinics in laboratory medicine

authors： Eddy DM

更新日期：1982-12-01 00:00:00

abstract：:The recent development and clinical implementation of genomic microarrays has resulted in rapid and significant changes for postnatal studies in the field of cytogenetics. This article discusses the benefits and issues for the use of microarrays for prenatal genetic diagnosis. It includes sections on specimen processi...

journal_title：Clinics in laboratory medicine

authors： Lamb AN

更新日期：2011-12-01 00:00:00

abstract：:To overcome the significant mortality associated with ovarian cancer, a highly sensitive and specific screening test is urgently needed. CA-125 testing is used to monitor response to chemotherapy, detect recurrence, and detect late stage ovarian cancer. However, CA-125 testing, alone or in combination with ultrasonogr...

journal_title：Clinics in laboratory medicine

authors： Kim K,Visintin I,Alvero AB,Mor G

更新日期：2009-03-01 00:00:00

abstract：:The myelodysplastic syndromes are bone marrow stem cell disorders that result in disorderly and ineffective hematopoiesis. They are prognostically heterogenous. Approximately one third of cases evolve to acute myeloid leukemia. Many additional cases terminate in severe bone marrow failure. The French-American-British ...

journal_title：Clinics in laboratory medicine

authors： McKenna RW,Allison PM

更新日期：1990-12-01 00:00:00

abstract：:Screening tests may help or harm the healthy subject and, therefore, must be selected and used carefully. Criteria for selection include characteristics of the disease(s), of the potential screening tests, and of the population(s) to be screened. An understanding of methods used to evaluate tests will allow the invest...

journal_title：Clinics in laboratory medicine

authors： Mulley AG

更新日期：1986-06-01 00:00:00

abstract：:Simple, inexpensive procedures for rapid identification of the common bacterial pathogens are outlined in detail. When the tests are judiciously applied, most isolates can be identified within minutes or hours, and strains that require more extensive testing for accurate identification will be recognized. ...

journal_title：Clinics in laboratory medicine

authors： Barry AL

更新日期：1985-03-01 00:00:00

abstract：:Electron microscopy offers substantial aid in the diagnosis of gastrointestinal tract tumors, especially small-cell carcinoma and enterochromaffin-cell tumors. Tumors that are most difficult to classify by light microscopy--that is, poorly differentiated ones--may also have ultrastructural features by which the cell o...

journal_title：Clinics in laboratory medicine

authors： Cleary KR

更新日期：1987-03-01 00:00:00

abstract：:India is a global leader in diabetes, currently with second largest pool of diabetes in the world. Asian Indian phenotype is uniquely predisposed to develop type 2 diabetes because of strong familial aggregation as well lifestyle factors of imprudent diet and sedentary physical habit. The typical Asian Indian phenotyp...

journal_title：Clinics in laboratory medicine

authors： Joshi SR

更新日期：2012-06-01 00:00:00

abstract：:Extracellular vesicles (EVs) are membranous particles found in a variety of biofluids that encapsulate molecular information from the cell, which they originate from. This rich source of information that is easily obtained can then be mined to find diagnostic biomarkers. This article explores the current biological un...

journal_title：Clinics in laboratory medicine

authors： Strotman LN,Linder MW

更新日期：2016-09-01 00:00:00

abstract：:To date, CRP remains the single standard biochemical marker for predicting the severity of AP. Because the combination of clinico-physiological scores and CRP provides good information at 48 hours, research has focused on the predictive ability of various markers when applied in the initial 24 hours after admission to...

journal_title：Clinics in laboratory medicine

authors： Papachristou GI,Whitcomb DC

更新日期：2005-03-01 00:00:00

abstract：:Mechanisms of immunologic injury causing glomerulonephritis are based on immune complex or autoantibody deposition with activation of complement. Circulating immune complex disease can be diagnosed and monitored with improved assays for immune complexes, DNA antibodies, complement levels, and complement activation pro...

journal_title：Clinics in laboratory medicine

authors： McPherson RA

更新日期：1993-03-01 00:00:00

abstract：:This study uses three unique data sets to show the state of the art of hemoglobin A1c (HbA1c) analyzers in a range of settings and compares their performance against the international guidance set by the International Federation of Clinical Chemistry and Laboratory Medicine task force for HbA1c standardization. The da...

journal_title：Clinics in laboratory medicine

authors： Lenters-Westra E,English E

更新日期：2017-03-01 00:00:00

abstract：:Technical advances in laboratory testing such as sensitive chemical tests and standardized commercial slides have significantly altered our entire approach to urinalysis. In addition, the recognition of the association of microhematuria with urologic neoplasms and the morphologically altered red blood cells with renal...

journal_title：Clinics in laboratory medicine

authors： Shenoy UA

更新日期：1985-06-01 00:00:00

abstract：:The red cell indices of mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration have been standard methods of evaluating anemia since they were developed by Wintrobe in the 1930s. This article discusses the technical variabilities that have rendered the classic red cell indi...

journal_title：Clinics in laboratory medicine

authors： Savage RA

更新日期：1993-12-01 00:00:00

abstract：:The ability to identify specific strains within a given species of pathogen is an important aid in the rational development of effective measures to prevent and control nosocomial infections. The efforts of both microbiologist and hospital epidemiologic are facilitated greatly by the availability of the newer molecula...

journal_title：Clinics in laboratory medicine

authors： Sader HS,Hollis RJ,Pfaller MA

更新日期：1995-06-01 00:00:00

abstract：:Vertical auto profile (VAP) method is a direct single test for measuring comprehensive lipoprotein cholesterol profile. It is based on a well-established method of ultracentrifugation that uses vertical rotor and single density gradient spin. VAP provides cholesterol concentrations of total lipoprotein, high-density l...

journal_title：Clinics in laboratory medicine

authors： Kulkarni KR

更新日期：2006-12-01 00:00:00