Abstract:
:Although most of the diagnostic applications of flow cytometry bring forth examples of leukocyte immunophenotyping for immunodeficiency diseases and leukemia-lymphoma diagnosis, the same technology has improved medical assessment of diseases affecting the red cell and erythropoiesis. Flow cytometric methods were first applied to laboratory hematology with the improvement in reticulocyte counting and the creation of the immature reticulocyte fraction for better anemia evaluation and therapeutic monitoring. A more recent improvement attributable to flow cytometry is accurate detection of fetal red cells in the evaluation of FMH hemorrhage. The same method used in the detection of fetal RBCs based on HbF content measurement using monoclonal antibodies also offers the potential for enumeration of F cells, which promises to have use in therapeutic monitoring of patients with sickle cell disease and the evaluation of other hemoglobinopathies and myelodysplasia. Other clinical uses of flow cytometric RBC analysis include nonisotopic red cell survival studies, sensitive blood group typing, sensitive detection of immune-mediated hemolytic diseases, and evaluation of parasitic diseases whose life cycle involves intracellular RBC infestation. This article summarizes red cell flow cytometry, particularly as it impacts the areas of immunohematology and laboratory hematology, and points to areas of potential future contribution of this technology to diagnostic medicine.
journal_name
Clin Lab Medjournal_title
Clinics in laboratory medicineauthors
Davis BHsubject
Has Abstractpub_date
2001-12-01 00:00:00pages
829-40issue
4eissn
0272-2712issn
1557-9832journal_volume
21pub_type
杂志文章,评审abstract::Normal thermogenesis requires a complex interaction between systems that generate and dissipate heat. Serving as director of thermogenesis, the hypothalamus activates the sympathetic nervous system along with the thyroid and adrenal glands to respond to changes in body temperature. Working in concert, these systems re...
journal_title:Clinics in laboratory medicine
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doi:10.1016/j.cll.2006.01.007
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1998-03-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2004.01.010
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1990-06-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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更新日期:1993-09-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2004.12.003
更新日期:2005-03-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2006.07.004
更新日期:2006-12-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1997-06-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1994-03-01 00:00:00
abstract::Formal medical and public health microbiology (MPHM) fellowship programs play a key role in preparing future clinical microbiology laboratory directors for their leadership and management responsibilities. Given the continually evolving MPHM field, fellowships must remain adaptable to changes in the field, providing t...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2020.08.009
更新日期:2020-12-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2014.10.001
更新日期:2015-03-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1992-06-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1994-06-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2013.03.001
更新日期:2013-09-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1995-09-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
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更新日期:1995-09-01 00:00:00
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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doi:10.1016/j.cll.2011.08.004
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
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abstract::The myelodysplastic syndromes are bone marrow stem cell disorders that result in disorderly and ineffective hematopoiesis. They are prognostically heterogenous. Approximately one third of cases evolve to acute myeloid leukemia. Many additional cases terminate in severe bone marrow failure. The French-American-British ...
journal_title:Clinics in laboratory medicine
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更新日期:1990-12-01 00:00:00
abstract::Granulocytic sarcoma is a variant presentation of acute myeloblastic leukemia, occurring in extramedullary locations. It is uncommon, but it may occur at any site and at any age, which necessitates its inclusion in the differential diagnosis of all undifferentiated tumors. Histology, touch-imprint cytology, cytochemis...
journal_title:Clinics in laboratory medicine
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