Abstract:
:This article reviews congenital melanocytic nevi (CMN), which are present at birth or appear shortly thereafter, and their main histologic features. Several histologic variants and histopathologic criteria that differentiate CMN from other nevi, such as atypical or dysplastic nevi, and from nevoid malignant melanoma, are discussed. Histologic pitfalls in the correct identification of lentiginous melanocytic hyperplasia, pagetoid scatter, and proliferative nodules in the context of CMN are discussed. The risk for development of malignant melanoma in association with a congenital melanocytic nevus and variable causes for changing mole are discussed.
journal_name
Clin Lab Medjournal_title
Clinics in laboratory medicineauthors
Zayour M,Lazova Rdoi
10.1016/j.cll.2011.03.004subject
Has Abstractpub_date
2011-06-01 00:00:00pages
267-80issue
2eissn
0272-2712issn
1557-9832pii
S0272-2712(11)00025-4journal_volume
31pub_type
杂志文章,评审abstract::This article describes a method for evaluating some of the medical, economic, and personal consequences of different policies of monitoring patients for various disorders. The problem is difficult because it is dynamic. Most conditions develop over time, and in many cases the sensitivity of the test as well as the cos...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1982-12-01 00:00:00
abstract::An obvious advantage of a combined PAP and PSA measurement is the increased sensitivity of detection. Furthermore, the use of both markers in monitoring patients with prostatic carcinoma offers the advantage of a greater number of patients with objective parameters for follow-up. ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
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abstract::A formal therapeutic drug monitoring consultation service (TDMCS) will enhance the clinical benefits of drug level determinations. It can result in decreased length of stay and improved risk management posture. The successful implementation of a TDMCS requires the coordinated efforts of a multidisciplinary team that m...
journal_title:Clinics in laboratory medicine
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abstract::The development of assay techniques for the analysis of tumor markers in tissue extracts and in the peripheral circulation has had a major impact on the diagnosis and management of patients with endocrine neoplasms. In addition to eutopic and ectopic hormones, a variety of other tumor-derived products, including endoc...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1990-03-01 00:00:00
abstract::To overcome the significant mortality associated with ovarian cancer, a highly sensitive and specific screening test is urgently needed. CA-125 testing is used to monitor response to chemotherapy, detect recurrence, and detect late stage ovarian cancer. However, CA-125 testing, alone or in combination with ultrasonogr...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2009.02.001
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abstract::Adenocarcinoma of the small intestine is relatively rare in comparison to colorectal carcinoma. Adenocarcinoma of the small intestine arises through the adenoma-carcinoma sequence in the colon. However, adenocarcinomas arising in the background of inflammatory bowel disease develop through the dysplasia-carcinoma sequ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2013.08.007
更新日期:2013-12-01 00:00:00
abstract::Fine needle aspiration biopsy (FNAB) is the diagnostic procedure of choice for evaluation of liver lesions. Although primarily applied to malignant disease, it is also used in the evaluation of benign conditions. Improvements in imaging techniques and advances in cytologic interpretations, as well as production of new...
journal_title:Clinics in laboratory medicine
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abstract::The clinical application of B- and T-cell gene rearrangement analysis is discussed relative to diagnostic problems in specific lymphoproliferative disorders. This article reviews the use of the Southern blot hybridization technique for B- and T-cell gene rearrangement detection in the analysis of various hematopoietic...
journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2014.06.015
更新日期:2014-09-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2007.05.013
更新日期:2007-09-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:10.1016/j.cll.2010.07.004
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abstract::Electron microscopy offers substantial aid in the diagnosis of gastrointestinal tract tumors, especially small-cell carcinoma and enterochromaffin-cell tumors. Tumors that are most difficult to classify by light microscopy--that is, poorly differentiated ones--may also have ultrastructural features by which the cell o...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::In marked contrast to their historical classification as relatively harmless, common cold-causing, respiratory pathogens, human coronaviruses (HCoVs) are associated with more severe clinical complications, as emphasized by the discovery of severe acute respiratory syndrome-associated CoV (SARS-CoV) in 2003. Still, the...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2009.07.007
更新日期:2009-12-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2009.11.001
更新日期:2010-03-01 00:00:00
abstract::Recent studies have brought remarkable progress in the understanding of cellular, subcellular, and molecular mechanisms of endothelial injury and responses to injury, both of which appear to be integral parts of the acute inflammatory response. The possible roles of endothelial surface enzymes in the inflammatory resp...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1983-12-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
abstract::The most efficacious and practical means of diagnosing human schistosomiasis is based on the detection of infection-specific antibodies. Because of their high sensitivity, antibody assays remain the most practical assays for epidemiologic studies and patient management. Initial screening may be performed in the field ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1991-12-01 00:00:00
abstract::Normal thermogenesis requires a complex interaction between systems that generate and dissipate heat. Serving as director of thermogenesis, the hypothalamus activates the sympathetic nervous system along with the thyroid and adrenal glands to respond to changes in body temperature. Working in concert, these systems re...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2006.01.007
更新日期:2006-03-01 00:00:00
abstract::Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid, reliable, and high-throughput diagnostic tool for the identification of microorganisms. The technology is unique in clinical microbiology, allowing laboratories to definitively identify bacterial and fungal isolates...
journal_title:Clinics in laboratory medicine
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doi:10.1016/j.cll.2013.03.001
更新日期:2013-09-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2013.03.024
更新日期:2013-06-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1993-03-01 00:00:00
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1995-12-01 00:00:00
abstract::Vertical auto profile (VAP) method is a direct single test for measuring comprehensive lipoprotein cholesterol profile. It is based on a well-established method of ultracentrifugation that uses vertical rotor and single density gradient spin. VAP provides cholesterol concentrations of total lipoprotein, high-density l...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2007.12.006
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journal_title:Clinics in laboratory medicine
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journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::Simple, inexpensive procedures for rapid identification of the common bacterial pathogens are outlined in detail. When the tests are judiciously applied, most isolates can be identified within minutes or hours, and strains that require more extensive testing for accurate identification will be recognized. ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:
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journal_title:Clinics in laboratory medicine
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