Abstract:
:A formal therapeutic drug monitoring consultation service (TDMCS) will enhance the clinical benefits of drug level determinations. It can result in decreased length of stay and improved risk management posture. The successful implementation of a TDMCS requires the coordinated efforts of a multidisciplinary team that may include physicians, pharmacists, nurses, and laboratory personnel. Clinical pathologists and clinical pharmacists are particularly well qualified to direct a TDMCS. Consistent delivery of quality services requires that all procedures related to the consultation process be standardized and documented in a procedures manual. The cost of providing the service may be recovered through both direct and indirect mechanisms.
journal_name
Clin Lab Medjournal_title
Clinics in laboratory medicineauthors
Wilkinson DSsubject
Has Abstractpub_date
1987-06-01 00:00:00pages
473-84issue
2eissn
0272-2712issn
1557-9832journal_volume
7pub_type
杂志文章,评审abstract::This article attempts to define and identify sources of variation in laboratory analysis that occur predominantly "away" from the analytic bench. Problems in the derivation and application of reference ranges are reviewed and sources of non-analytic error are "located" within the entire testing cycle. Reference source...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1986-12-01 00:00:00
abstract::The interpretation of the total serum testosterone concentration is problematic because it is related directly to the serum SHBG concentration.Frequently, an estimate of the serum free testosterone concentration is obtained to better assess the clinical status of the patient. We reviewed five methods for the determina...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2004.01.010
更新日期:2004-03-01 00:00:00
abstract::The development of assay techniques for the analysis of tumor markers in tissue extracts and in the peripheral circulation has had a major impact on the diagnosis and management of patients with endocrine neoplasms. In addition to eutopic and ectopic hormones, a variety of other tumor-derived products, including endoc...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1990-03-01 00:00:00
abstract::The combination of requirements for decreased turnaround time for hematology laboratory results and advances in technology have driven testing closer to the point of patient contact. This article provides an overview of the technologies available to measure hemoglobin, white blood cell counts, differentials, and CD4+ ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2014.10.009
更新日期:2015-03-01 00:00:00
abstract::This study examines the relationship between D-dimer concentration and patient age, gender, race, and renal function, and the role of D-dimer concentration as a predictor of in-hospital mortality, in a critically ill patient population. The results demonstrate there is a correlation between increased D-dimer concentra...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2014.06.015
更新日期:2014-09-01 00:00:00
abstract::Control of human immunodeficiency virus type-1 (HIV-1) infection is the foremost public health challenge at the turn of the millennium. Two decades, 22 million fatalities, and 40 million living victims after its discovery, HIV-1 continues its inexorable spread. Over the past few years, scientists have made tremendous ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:10.1016/s0272-2712(02)00020-3
更新日期:2002-12-01 00:00:00
abstract::One of the most vital functions of the vertebrates is to maintain hemostasis through coagulation and fibrinolysis. This is achieved by the interaction of vascular walls with blood components such as cells and proteins (coagulation factors, immunoglobulins, and complement). Deficiency of coagulation factors results in ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1986-03-01 00:00:00
abstract::Certain serum autoantibodies serve as useful diagnostic markers in AiLD; however, the etiology and pathogenesis of AiLD remain unknown. Although AiLD is characterized by the presence of autoantibodies and other humoral immune abnormalities, there is significant evidence that cell-mediated immune mechanisms are critica...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1997-09-01 00:00:00
abstract::The last decade has witnessed the transformation of first-trimester Down syndrome screening from an aspiration to a clinical reality. First-trimester screening now equals or exceeds the diagnostic accuracy of conventional midtrimester screen while realizing an important desire of pregnant women for early diagnosis. Be...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2010.05.001
更新日期:2010-09-01 00:00:00
abstract::Methodologic aspects including causes of factitious hyperphosphatemia and hypophosphatemia are summarized. The differential diagnosis of hyperphosphatemia is reviewed under its three broad causes: decreased glomerular filtration rate, increased exogenous or endogenous phosphate load, and increased renal tubular phosph...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1993-03-01 00:00:00
abstract::During the past 20 years, laboratory systems have evolved to a high degree of complexity. In some cases, continuing addition of new features has adversely affected functionality. There is increasing recognition that the number of features listed on a request for proposal does not necessarily provide an accurate guide ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1991-03-01 00:00:00
abstract::Seven different mycoplasmas have been isolated from the human genitourinary tract. The diseases they cause or with which they have been associated are described. Diagnosis of infection by cultural and noncultural (antigen detection, DNA probes) methods is discussed in detail. The more useful serologic procedures are i...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1989-09-01 00:00:00
abstract::At the present time, the use of molecular techniques for diagnosing the neurologic porphyrias is limited mainly to those laboratories doing research in the area. Because any of four genes may be involved, it is important to confirm the diagnosis in the index case before undertaking molecular investigation. With advanc...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1997-03-01 00:00:00
abstract::Transfusion medicine is a rapidly evolving specialty, and efforts are ongoing to improve the safety and quality of blood component therapy. Leukocytes are known to be the cause of numerous adverse effects of transfusion therapy, and their removal from red cells and platelet components may be desirable in a variety of ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00
abstract::Screening tests may help or harm the healthy subject and, therefore, must be selected and used carefully. Criteria for selection include characteristics of the disease(s), of the potential screening tests, and of the population(s) to be screened. An understanding of methods used to evaluate tests will allow the invest...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1986-06-01 00:00:00
abstract::Normal thermogenesis requires a complex interaction between systems that generate and dissipate heat. Serving as director of thermogenesis, the hypothalamus activates the sympathetic nervous system along with the thyroid and adrenal glands to respond to changes in body temperature. Working in concert, these systems re...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2006.01.007
更新日期:2006-03-01 00:00:00
abstract::In discussing quality assurance in the blood bank, where many of the standard statistical techniques of measuring accuracy simply do not apply, three questions come to mind: How much? How often? Who says? Because of severe changes in the prospective payment plan and a new interest in cost effectiveness, many transfusi...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1986-12-01 00:00:00
abstract::Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid, reliable, and high-throughput diagnostic tool for the identification of microorganisms. The technology is unique in clinical microbiology, allowing laboratories to definitively identify bacterial and fungal isolates...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2013.03.001
更新日期:2013-09-01 00:00:00
abstract::The improvement of quality in clinical care can greatly benefit form continuous benchmarking with information based on laboratory data. To be most effective, the information is best provided in the form of real-time disease management decision support. Such an approach requires advances in the implementation of hospit...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1999-12-01 00:00:00
abstract::The pharmacologic field that studies antimicrobial pharmacokinetics and pharmacodynamics (PK/PD) has had a major impact on the choice and dosing regimens used for many antibiotics especially those used in the treatment of respiratory tract infections. PK/PD parameters are particularly important in light of increasing ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2004.03.009
更新日期:2004-06-01 00:00:00
abstract::The recent development and clinical implementation of genomic microarrays has resulted in rapid and significant changes for postnatal studies in the field of cytogenetics. This article discusses the benefits and issues for the use of microarrays for prenatal genetic diagnosis. It includes sections on specimen processi...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2011.08.004
更新日期:2011-12-01 00:00:00
abstract::Clinical decision support (CDS) can greatly enhance patient blood management through optimizing ordering and providing patient-specific information. At present, modeling and prediction have small roles in inventory management; they will likely have increasing applications to help guide donor center collections based o...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2019.01.006
更新日期:2019-06-01 00:00:00
abstract::Considerable advances have been made in identifying women whose pregnancies are at the greatest risk for fetal Down syndrome and other aneuploidies. Maternal serum tests and ultrasonography in either the first or second trimester provide effective prenatal screening. However, the most efficacious protocols are based o...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2010.04.013
更新日期:2010-09-01 00:00:00
abstract::Diseases due to nontuberculous mycobacteria are increasing in frequency, especially in patients with compromised immunity. A number of "new" mycobacterial species have been described in the last decade, largely as the result of the use of new tools to identify previously unrecognized mycobacteria found in the environm...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2004.05.011
更新日期:2004-09-01 00:00:00
abstract::Yellow fever (YF) is a viral disease, endemic to tropical regions of Africa and the Americas, which principally affects humans and nonhuman primates and is transmitted via the bite of infected mosquitoes. Yellow fever virus (YFV) can cause devastating epidemics of potentially fatal, hemorrhagic disease. Despite mass v...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2010.01.001
更新日期:2010-03-01 00:00:00
abstract::To answer the question of whether reference values are useful in clinical decision-making, this article addresses the following major controversies: (1) Are reference subjects representative of the group from which they are selected? (2) To what extent should the process of collecting reference values be standardized ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::Point-of-care testing is an emerging specialty in laboratory medicine and has attracted considerable interest in the medical literature. This article presents a general overview of point-of-care testing including its history, menu, clinical utility, aspects of analytical performance, regulatory issues, and management ...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:2001-06-01 00:00:00
abstract::A decision model was developed to evaluate the costs and benefits of further reducing the risk of transfusion-transmitted disease. The model addresses recipient risk factors as well as operational considerations. Application of the model to prior risk reduction decisions documents its validity as a decision-making too...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract::The mean platelet volume measurement can reflect changes in either the level of platelet stimulation or rate of platelet production. The controversy related to whether platelets change volume or density in the circulation is still not clearly resolved, and although the relationship between platelet number and size and...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:
更新日期:1993-12-01 00:00:00
abstract::"Bath salts" has attracted young adults primarily due to its stimulatory and hallucinogenic effects akin to amphetamines and cocaine. Although other designer amines have been incorporated to newer generation "bath salts", synthetic cathinones remain to be their major component. This article discusses our current under...
journal_title:Clinics in laboratory medicine
pub_type: 杂志文章,评审
doi:10.1016/j.cll.2012.07.010
更新日期:2012-09-01 00:00:00