Reference values: are they useful?

abstract：:Flow cytometry immunophenotyping of the hematopoietic cells from the bone marrow can help with diagnosis, prognosis, and therapy of chronic myeloid neoplasms. Unlike with B-cell neoplasms, there is no simple phenotypic test to substitute for clonality. Therefore, antigen panels to evaluate myeloid neoplasms are larger...

journal_title：Clinics in laboratory medicine

authors： Shi M,Nguyen P,Jevremovic D

更新日期：2017-12-01 00:00:00

abstract：:Cannabis, or marijuana, has been known and used as a drug for many thousands of years. Recent interest in drug abuse and detection has spurred the development of several methodologies for cannabinoid detection. These methods include immunoassays and chromatography. Laboratories routinely performing cannabinoid testing...

journal_title：Clinics in laboratory medicine

authors： King DL,Martel PA,O'Donnell CM

更新日期：1987-09-01 00:00:00

abstract：:Bacteria were the first organisms recognized for their potential as agents of bioaggression and the possibility of their use by a terrorist or rogue nation is considered a significant threat. Five of the more likely agents (anthrax, plague, tularemia, Q fever, and brucellosis) are reviewed with emphasis on their epide...

journal_title：Clinics in laboratory medicine

authors： Martin GJ,Marty AM

更新日期：2001-09-01 00:00:00

abstract：:Contemporary bacterial serology relevant to medicine involves poly- and monoclonal antibodies to study pathogenic bacteria and nonpathogenic organisms useful in controlling infectious diseases. Monoclonal antibody applications include immunodiagnostics, prophylaxis and serotherapy, and microbial biotechnology and mole...

journal_title：Clinics in laboratory medicine

authors： Conway de Macario E,Macario AJ

更新日期：1985-09-01 00:00:00

abstract：:The apoproteins structurally are closely associated with specific lipoproteins, for example, apoprotein B with VLDL and LDL and apoprotein A-I with HDL. The levels of these apoproteins provide information about the plasma concentrations and metabolism of the lipoproteins with which they are associated. The levels of a...

journal_title：Clinics in laboratory medicine

authors： Albers JJ,Brunzell JD,Knopp RH

更新日期：1989-03-01 00:00:00

abstract：:Screening tests may help or harm the healthy subject and, therefore, must be selected and used carefully. Criteria for selection include characteristics of the disease(s), of the potential screening tests, and of the population(s) to be screened. An understanding of methods used to evaluate tests will allow the invest...

journal_title：Clinics in laboratory medicine

authors： Mulley AG

更新日期：1986-06-01 00:00:00

abstract：:There are many types of ANA and they may react with different nuclear components varying from nucleic acids to both basic and acidic nuclear proteins. Recent investigations have demonstrated that it is important not only to detect the presence and quantity of the ANA, but also to identify the immunologic specificities...

journal_title：Clinics in laboratory medicine

authors： Nakamura RM,Tan EM

更新日期：1986-03-01 00:00:00

abstract：:Disturbed liver parenchymal cell function adversely impacts on the hemostasis system, the extent of which correlates with the degree of liver disease. Because liver parenchymal cells synthesize most factors of the clotting and the fibrinolytic systems, levels of these procoagulant and anticoagulant as well as profibri...

journal_title：Clinics in laboratory medicine

authors： Mammen EF

更新日期：1994-12-01 00:00:00

abstract：:Electron microscopy offers substantial aid in the diagnosis of gastrointestinal tract tumors, especially small-cell carcinoma and enterochromaffin-cell tumors. Tumors that are most difficult to classify by light microscopy--that is, poorly differentiated ones--may also have ultrastructural features by which the cell o...

journal_title：Clinics in laboratory medicine

authors： Cleary KR

更新日期：1987-03-01 00:00:00

abstract：:I have reviewed many of the methods available for the assessment of fetal lung maturity. The difficulty of using diagnostic tests for diseases of low prevalence has been discussed. By reviewing the nature of the amniotic fluid surfactant material, and some of the principles underlying analytical methods, the bases of ...

journal_title：Clinics in laboratory medicine

authors： Dubin SB

更新日期：1992-09-01 00:00:00

abstract：:Acute erythroleukemia is an aggressive leukemia derived from a multipotential stem cell. Three subtypes have been described: (1) M6a with greater than or equal to 30% blasts of the nonerythrocytic component, (2) M6b with greater than or equal to 30% pronormoblasts of the erythrocytic elements, and (3) M6c with greater...

journal_title：Clinics in laboratory medicine

authors： Mazzella FM,Alvares C,Kowal-Vern A,Schumacher HR

更新日期：2000-03-01 00:00:00

abstract：:The development of assay techniques for the analysis of tumor markers in tissue extracts and in the peripheral circulation has had a major impact on the diagnosis and management of patients with endocrine neoplasms. In addition to eutopic and ectopic hormones, a variety of other tumor-derived products, including endoc...

journal_title：Clinics in laboratory medicine

authors： DeLellis RA

更新日期：1990-03-01 00:00:00

abstract：:This article describes a method for evaluating some of the medical, economic, and personal consequences of different policies of monitoring patients for various disorders. The problem is difficult because it is dynamic. Most conditions develop over time, and in many cases the sensitivity of the test as well as the cos...

journal_title：Clinics in laboratory medicine

authors： Eddy DM

更新日期：1982-12-01 00:00:00

abstract：:At the present time, the use of molecular techniques for diagnosing the neurologic porphyrias is limited mainly to those laboratories doing research in the area. Because any of four genes may be involved, it is important to confirm the diagnosis in the index case before undertaking molecular investigation. With advanc...

journal_title：Clinics in laboratory medicine

authors： Schreiber WE

更新日期：1997-03-01 00:00:00

abstract：:The classic workup of a patient for possible PA is revisited in light of the vanishing Schilling test. The vagaries of testing for B12 and blocking antibodies are reexamined. The advantages and disadvantages of newer tests such as MMA and serum gastrin levels are catalogued. At this juncture in the evolution of new te...

journal_title：Clinics in laboratory medicine

authors： Ward PC

更新日期：2002-06-01 00:00:00

abstract：:India is a global leader in diabetes, currently with second largest pool of diabetes in the world. Asian Indian phenotype is uniquely predisposed to develop type 2 diabetes because of strong familial aggregation as well lifestyle factors of imprudent diet and sedentary physical habit. The typical Asian Indian phenotyp...

journal_title：Clinics in laboratory medicine

authors： Joshi SR

更新日期：2012-06-01 00:00:00

abstract：:ALP is a profoundly ubiquitous enzyme that originates in many, if not all, mammalian tissues. The development of a simple ISEF technique has allowed reflection of at least 12 cellular components. Improvements in technique may add further zones of information. The aura of darkness surrounding ALP is being slowly dissip...

journal_title：Clinics in laboratory medicine

authors： Griffiths J

更新日期：1989-12-01 00:00:00

abstract：:Laboratory information systems (LISs) supply mission-critical capabilities for the vast array of information-processing needs of modern laboratories. LIS architectures include mainframe, client-server, and thin client configurations. The LIS database software manages a laboratory's data. LIS dictionaries are database ...

journal_title：Clinics in laboratory medicine

authors： Henricks WH

更新日期：2016-03-01 00:00:00

abstract：:Shiga toxin-producing Escherichia coli (STEC) are important enteric pathogens worldwide, causing diarrhea with or without blood visibly present and hemolytic uremic syndrome. STEC are unique among diarrheogenic E coli in producing Shiga toxin type 1 and type 2, the virulence factors responsible for bloody diarrhea and...

journal_title：Clinics in laboratory medicine

authors： Hunt JM

更新日期：2010-03-01 00:00:00

abstract：:Chromosome analysis is the genetic technique useful in evaluating endocrine disease. Indications for cytogenetic studies include suspected sex chromosomal aneuploidies as well as repeated fetal wastage. In patients with ambiguous genitalia, cytogenetic studies are mandatory, not only to provide information for assigni...

journal_title：Clinics in laboratory medicine

authors： Gordon LP

更新日期：1984-12-01 00:00:00

abstract：:Mechanisms of immunologic injury causing glomerulonephritis are based on immune complex or autoantibody deposition with activation of complement. Circulating immune complex disease can be diagnosed and monitored with improved assays for immune complexes, DNA antibodies, complement levels, and complement activation pro...

journal_title：Clinics in laboratory medicine

authors： McPherson RA

更新日期：1993-03-01 00:00:00

abstract：:Osteoporosis (low bone mass) depends on the peak bone mass attained and bone loss after the peak. Sex steroids (estrogens and androgens) have an impact on both processes. In this article the roles and mechanisms of estrogens and androgens are discussed in relation to clinical osteoporosis. Other hormones and hormone-l...

journal_title：Clinics in laboratory medicine

authors： Adler RA

更新日期：2000-09-01 00:00:00

abstract：:Granulocytic sarcoma is a variant presentation of acute myeloblastic leukemia, occurring in extramedullary locations. It is uncommon, but it may occur at any site and at any age, which necessitates its inclusion in the differential diagnosis of all undifferentiated tumors. Histology, touch-imprint cytology, cytochemis...

journal_title：Clinics in laboratory medicine

authors： Hutchison RE,Kurec AS,Davey FR

更新日期：1990-12-01 00:00:00

abstract：:Venous thromboembolism covers a range of conditions from deep vein thrombosis to pulmonary embolism. Treatment aims to alleviate symptoms, minimize acute morbidity and mortality by preventing the extension or potentially fatal embolization of the initial thrombus, and avoid postthrombotic syndrome. Anticoagulant thera...

journal_title：Clinics in laboratory medicine

authors： Al-Badri A,Spyropoulos AC

更新日期：2014-09-01 00:00:00

abstract：:The importance of the phlogogenic effects of immune complexes in disease pathogenesis has been emphasized, but they also have a role in immunoregulation. We examined the effects of DNA: anti-DNA immune complexes, formed at different antigen:antibody ratios, on the ability of T cells to modulate DNA antibody production...

journal_title：Clinics in laboratory medicine

authors： Clough JD,Calabrese LH,Budervic SA

更新日期：1988-06-01 00:00:00

abstract：:With emerging antimicrobial resistance, rapid antimicrobial susceptibility testing (AST) is needed to provide early definitive therapeutic guidance to optimize patient outcome. Genotypic methods are fast, but can identify only a subset of known resistance elements. Phenotypic methods determine clinically predictive mi...

journal_title：Clinics in laboratory medicine

authors： Smith KP,Kirby JE

更新日期：2019-09-01 00:00:00

abstract：:Melanoma represents a substantial source of risk within dermatology and dermatopathology. This article seeks to provide general pathologists, dermatologists and dermatopathologists with an overview of the basics principles of medical malpractice litigation, a review of the essentials of reporting and the importance of...

journal_title：Clinics in laboratory medicine

authors： High WA

更新日期：2008-06-01 00:00:00

abstract：:An obvious advantage of a combined PAP and PSA measurement is the increased sensitivity of detection. Furthermore, the use of both markers in monitoring patients with prostatic carcinoma offers the advantage of a greater number of patients with objective parameters for follow-up. ...

journal_title：Clinics in laboratory medicine

authors： Saito Y

更新日期：1993-03-01 00:00:00

abstract：:Cytomorphological examination of aspirate smears remains the basic method to diagnose hematologic disorders and to evaluate treatment-related changes. Last-generation hematological analyzers can count, besides cells normally circulating in peripheral blood, some types of immature and abnormal cells, such as erythrobla...

journal_title：Clinics in laboratory medicine

authors： d'Onofrio G,Zini G

更新日期：2015-03-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid, reliable, and high-throughput diagnostic tool for the identification of microorganisms. The technology is unique in clinical microbiology, allowing laboratories to definitively identify bacterial and fungal isolates...

journal_title：Clinics in laboratory medicine

authors： Dingle TC,Butler-Wu SM

更新日期：2013-09-01 00:00:00