Laboratory diagnosis of antiphospholipid syndromes.

abstract：:At the start of the twenty-first century, a dramatic change occurred in the clinical laboratory community. Concepts from Metrology, the science of measurement, began to be formally applied to clinical laboratory field methods, resulting in a new appreciation of metrological calibrator traceability. It is a change beca...

journal_title：Clinics in laboratory medicine

authors： Armbruster D

更新日期：2017-03-01 00:00:00

abstract：:ALP is a profoundly ubiquitous enzyme that originates in many, if not all, mammalian tissues. The development of a simple ISEF technique has allowed reflection of at least 12 cellular components. Improvements in technique may add further zones of information. The aura of darkness surrounding ALP is being slowly dissip...

journal_title：Clinics in laboratory medicine

authors： Griffiths J

更新日期：1989-12-01 00:00:00

abstract：:Diseases due to nontuberculous mycobacteria are increasing in frequency, especially in patients with compromised immunity. A number of "new" mycobacterial species have been described in the last decade, largely as the result of the use of new tools to identify previously unrecognized mycobacteria found in the environm...

journal_title：Clinics in laboratory medicine

authors： Herdman AV,Steele JC Jr

更新日期：2004-09-01 00:00:00

abstract：:Recent studies have brought remarkable progress in the understanding of cellular, subcellular, and molecular mechanisms of endothelial injury and responses to injury, both of which appear to be integral parts of the acute inflammatory response. The possible roles of endothelial surface enzymes in the inflammatory resp...

journal_title：Clinics in laboratory medicine

authors： Ryan US,Ryan JW

更新日期：1983-12-01 00:00:00

abstract：:The authors describe a system for collecting usage metrics from widely distributed automation systems. An application that records and stores usage data centrally, calculates run times, and charts the data was developed. Data were collected over 20 months from at least 28 workstations. The application was used to plot...

journal_title：Clinics in laboratory medicine

authors： Benn N,Turlais F,Clark V,Jones M,Clulow S

更新日期：2007-03-01 00:00:00

abstract：:To overcome the significant mortality associated with ovarian cancer, a highly sensitive and specific screening test is urgently needed. CA-125 testing is used to monitor response to chemotherapy, detect recurrence, and detect late stage ovarian cancer. However, CA-125 testing, alone or in combination with ultrasonogr...

journal_title：Clinics in laboratory medicine

authors： Kim K,Visintin I,Alvero AB,Mor G

更新日期：2009-03-01 00:00:00

abstract：:Differentiation between procedure-related necrosis and postprocedural myocardial infarction (MI) is challenging because of the inherent association of these procedures to varying levels of myocardial injury. To improve risk stratification of patients at risk of an acute MI, the universal definition of MI implemented c...

journal_title：Clinics in laboratory medicine

authors： Grobben RB,Nathoe HM,Januzzi JL Jr,van Kimmenade RR

更新日期：2014-03-01 00:00:00

abstract：:This article reviews the concept of dysplasia and the distinguishing features of dysplastic nevi, including their premalignant potential, their biologic markers of tumor progression, and their reproducibly recognizable clinical and histologic characteristics. An additional emphasis is placed on describing gray zone m...

journal_title：Clinics in laboratory medicine

authors： Kim JC,Murphy GF

更新日期：2000-12-01 00:00:00

abstract：:Point-of-care testing is an emerging specialty in laboratory medicine and has attracted considerable interest in the medical literature. This article presents a general overview of point-of-care testing including its history, menu, clinical utility, aspects of analytical performance, regulatory issues, and management ...

journal_title：Clinics in laboratory medicine

authors： Lee-Lewandrowski E,Lewandrowski K

更新日期：2001-06-01 00:00:00

abstract：:Market forces and service demands are driving a segment of laboratory testing away from centralized laboratories and closer to the patient's bedside. Placed into a historical perspective, this should be neither surprising nor distressing. Terminology is being clarified and professional societies are beginning to take ...

journal_title：Clinics in laboratory medicine

authors： Handorf CR

更新日期：1994-09-01 00:00:00

abstract：:In discussing quality assurance in the blood bank, where many of the standard statistical techniques of measuring accuracy simply do not apply, three questions come to mind: How much? How often? Who says? Because of severe changes in the prospective payment plan and a new interest in cost effectiveness, many transfusi...

journal_title：Clinics in laboratory medicine

authors： White KK,Silberstein LE

更新日期：1986-12-01 00:00:00

abstract：:During the past 20 years, laboratory systems have evolved to a high degree of complexity. In some cases, continuing addition of new features has adversely affected functionality. There is increasing recognition that the number of features listed on a request for proposal does not necessarily provide an accurate guide ...

journal_title：Clinics in laboratory medicine

authors： Krieg AF

更新日期：1991-03-01 00:00:00

abstract：:From the inception of TBS in 1988, it has been well received by the pathology and clinical communities. The need for a unifying system of nomenclature was so great that most of the laboratories in the United States, as well as in numerous countries worldwide, quickly adopted TBS. By 1991, only 2 years after the initia...

journal_title：Clinics in laboratory medicine

authors： Henry MR

更新日期：2003-09-01 00:00:00

abstract：:This article addresses several fundamental features of clinical flow cytometry. A practical overview of the technical and methodologic aspects of this fast-growing and increasingly important new clinical and investigative field is provided. The use of flow cytometry for the diagnosis and monitoring of various chronic ...

journal_title：Clinics in laboratory medicine

authors： Kipps TJ,Meisenholder G,Robbins BA

更新日期：1992-06-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid, reliable, and high-throughput diagnostic tool for the identification of microorganisms. The technology is unique in clinical microbiology, allowing laboratories to definitively identify bacterial and fungal isolates...

journal_title：Clinics in laboratory medicine

authors： Dingle TC,Butler-Wu SM

更新日期：2013-09-01 00:00:00

abstract：:This article attempts to define and identify sources of variation in laboratory analysis that occur predominantly "away" from the analytic bench. Problems in the derivation and application of reference ranges are reviewed and sources of non-analytic error are "located" within the entire testing cycle. Reference source...

journal_title：Clinics in laboratory medicine

authors： Bachner P

更新日期：1986-12-01 00:00:00

abstract：:Transgenic mice that contain a proline to leucine mutation at amino acid 101 in the endogenous murine PrP gene have been produced by gene targeting. This line of mice was generated to model the mutation thought to be responsible for P102L GSS, a familial TSE disease in humans. Genetargeted 101LL mice showed no evidenc...

journal_title：Clinics in laboratory medicine

authors： Barron RM,Manson JC

更新日期：2003-03-01 00:00:00

abstract：:Susceptibility testing of microorganisms isolated from blood cultures should follow the guidelines of the NCCLS in the selection of antimicrobial agents and the method for testing. Standardized testing can be performed on isolated colonies from pure subcultures of the blood/broth mixture. Direct susceptibility testing...

journal_title：Clinics in laboratory medicine

authors： Mirrett S

更新日期：1994-03-01 00:00:00

abstract：:Nephropathy progressing to end-stage renal failure is a common complication of diabetes mellitus. The development of diabetic nephropathy is preceded for many years by minor increases in urine albumin excretion (microalbuminuria), and some diabetologists believe that by reducing or reversing this early abnormality, po...

journal_title：Clinics in laboratory medicine

authors： Hindmarsh JT

更新日期：1988-09-01 00:00:00

abstract：:Immunology testing is relevant for the diagnosis of many autoimmune conditions. However, diagnostic pitfalls arise owing to incorrect interpretation of results and incomplete understanding of the underlying technique or immune-mediated condition. Here, we review the diagnostic considerations related to commonly used i...

journal_title：Clinics in laboratory medicine

authors： Maher L,Perugino C

更新日期：2019-12-01 00:00:00

abstract：:The importance of the phlogogenic effects of immune complexes in disease pathogenesis has been emphasized, but they also have a role in immunoregulation. We examined the effects of DNA: anti-DNA immune complexes, formed at different antigen:antibody ratios, on the ability of T cells to modulate DNA antibody production...

journal_title：Clinics in laboratory medicine

authors： Clough JD,Calabrese LH,Budervic SA

更新日期：1988-06-01 00:00:00

abstract：:Respiratory viruses continue to be major causes of morbidity and mortality. Currently available chemotherapy is limited to oral amantadine for uncomplicated influenza A and aerosolized ribavirin for respiratory syncytial virus (RSV) infections. Amantadine is also efficacious for chemoprophylaxis of influenza A virus i...

journal_title：Clinics in laboratory medicine

authors： Sperber SJ,Hayden FG

更新日期：1987-12-01 00:00:00

abstract：:Salmonella, Shigella, and Yersinia cause a well-characterized spectrum of disease in humans, ranging from asymptomatic carriage to hemorrhagic colitis and fatal typhoidal fever. These pathogens are responsible for millions of cases of food-borne illness in the United States each year, with substantial costs measured i...

journal_title：Clinics in laboratory medicine

authors： Dekker JP,Frank KM

更新日期：2015-06-01 00:00:00

abstract：:As aerobic creatures, normal living requires that not only are human beings exposed to oxygen but are dependent on oxygen. Humans have evolved mechanisms to cope with living in an aerobic environment; however, modern humans may be more exposed to oxidant stresses. Much indirect evidence implicates reactive oxygen spec...

journal_title：Clinics in laboratory medicine

authors： Bankson DD,Kestin M,Rifai N

更新日期：1993-06-01 00:00:00

abstract：:Cytomorphological examination of aspirate smears remains the basic method to diagnose hematologic disorders and to evaluate treatment-related changes. Last-generation hematological analyzers can count, besides cells normally circulating in peripheral blood, some types of immature and abnormal cells, such as erythrobla...

journal_title：Clinics in laboratory medicine

authors： d'Onofrio G,Zini G

更新日期：2015-03-01 00:00:00

abstract：:This article provides surgical pathologists an overview of health information systems (HISs): what they are, what they do, and how such systems relate to the practice of surgical pathology. Much of this article is dedicated to the electronic medical record. Information, in how it is captured, transmitted, and conveyed...

journal_title：Clinics in laboratory medicine

authors： Sirintrapun SJ,Artz DR

更新日期：2016-03-01 00:00:00

abstract：:Lyme disease in North America is caused by infection with the spirochetal bacterium Borrelia burgdorferi and transmitted by Ixodes scapularis and Ixodes pacificus ticks. These ticks also have the potential to transmit a rapidly expanding list of other pathogenic bacteria, viruses, and parasites, including Anaplasma ph...

journal_title：Clinics in laboratory medicine

authors： Caulfield AJ,Pritt BS

更新日期：2015-12-01 00:00:00

abstract：:An obvious advantage of a combined PAP and PSA measurement is the increased sensitivity of detection. Furthermore, the use of both markers in monitoring patients with prostatic carcinoma offers the advantage of a greater number of patients with objective parameters for follow-up. ...

journal_title：Clinics in laboratory medicine

authors： Saito Y

更新日期：1993-03-01 00:00:00

abstract：:A methodology for computing the maximum expected number of unreliable patient results produced because of an out-of-control condition for a given quality control strategy is presented along with strategies for changing the expected number of unreliable results produced and reported. The expected number of unreliable p...

journal_title：Clinics in laboratory medicine

authors： Yundt-Pacheco J,Parvin CA

更新日期：2013-03-01 00:00:00

abstract：:To leverage the time and expertise of the pathologist, a comprehensive workstation is a useful tool. Because the practice of pathology is so diverse, however, there is no one standard for what constitutes a workstation. The author reviews the several elements and components which must be included (access to your LIS, ...

journal_title：Clinics in laboratory medicine

authors： Aller RD

更新日期：1997-06-01 00:00:00