Abstract：
:The blood film is one of the world's most widely and frequently used tests and has undergone remarkably few changes since its introduction in the late 1800s. This article gives direction and some standardization in the preparation of blood films used for morphologic evaluation in the clinical laboratory. Methodologies that can be labeled as being state-of-the-art and methods applicable for laboratories in developing countries are quoted.
journal_name
Clin Lab Medjournal_title
Clinics in laboratory medicineauthors
Houwen Bdoi
10.1016/s0272-2712(03)00064-7subject
Has Abstractpub_date
2002-03-01 00:00:00pages
1-14, vissue
1eissn
0272-2712issn
1557-9832pii
S0272-2712(03)00064-7journal_volume
22pub_type
杂志文章,评审abstract：:Electron microscopy offers substantial aid in the diagnosis of gastrointestinal tract tumors, especially small-cell carcinoma and enterochromaffin-cell tumors. Tumors that are most difficult to classify by light microscopy--that is, poorly differentiated ones--may also have ultrastructural features by which the cell o...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：:Diagnosis of invasive fungal pneumonias by conventional culture methods is difficult to assess and often delayed. Nonmolecular fungal markers have emerged as an important adjunctive tool to support their diagnosis in combination with other clinical, radiologic, and microbiological criteria of invasive fungal diseases....
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2014.02.006
更新日期：2014-06-01 00:00:00
abstract：:Modern advances in the diagnosis and treatment of the leukemias and lymphomas make use of dynamic techniques in immunology, genetics, and molecular biology, and, as a result, morphology represents a smaller proportion of the total diagnostic work-up of these diseases today than heretofore. However, morphology still re...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：:Antiretroviral drugs against HIV infection have been developed that inhibit various stages of the HIV replication cycle. Agents other than reverse transcriptase inhibitors are reviewed with particular attention to those under study in clinical trials, including inhibitors of the virus-encoded protease enzyme. In addit...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1994-06-01 00:00:00
abstract：:The development of assay techniques for the analysis of tumor markers in tissue extracts and in the peripheral circulation has had a major impact on the diagnosis and management of patients with endocrine neoplasms. In addition to eutopic and ectopic hormones, a variety of other tumor-derived products, including endoc...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1990-03-01 00:00:00
abstract：:The clinical application of B- and T-cell gene rearrangement analysis is discussed relative to diagnostic problems in specific lymphoproliferative disorders. This article reviews the use of the Southern blot hybridization technique for B- and T-cell gene rearrangement detection in the analysis of various hematopoietic...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Adenocarcinoma of the small intestine is relatively rare in comparison to colorectal carcinoma. Adenocarcinoma of the small intestine arises through the adenoma-carcinoma sequence in the colon. However, adenocarcinomas arising in the background of inflammatory bowel disease develop through the dysplasia-carcinoma sequ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2013.08.007
更新日期：2013-12-01 00:00:00
abstract：:Nephropathy progressing to end-stage renal failure is a common complication of diabetes mellitus. The development of diabetic nephropathy is preceded for many years by minor increases in urine albumin excretion (microalbuminuria), and some diabetologists believe that by reducing or reversing this early abnormality, po...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1988-09-01 00:00:00
abstract：:Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a rapid, reliable, and high-throughput diagnostic tool for the identification of microorganisms. The technology is unique in clinical microbiology, allowing laboratories to definitively identify bacterial and fungal isolates...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2013.03.001
更新日期：2013-09-01 00:00:00
abstract：:This article attempts to define and identify sources of variation in laboratory analysis that occur predominantly "away" from the analytic bench. Problems in the derivation and application of reference ranges are reviewed and sources of non-analytic error are "located" within the entire testing cycle. Reference source...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
abstract：:Noninvasive genomic assessments of the fetus while in utero have been made possible by the analysis of cell-free fetal DNA fragments from the serum of pregnant women, as part of a noninvasive prenatal testing screening strategy. Between 7% and 10% of total cell-free DNA in the maternal blood comes from placental troph...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2016.01.018
更新日期：2016-06-01 00:00:00
abstract：:The authors describe a system for collecting usage metrics from widely distributed automation systems. An application that records and stores usage data centrally, calculates run times, and charts the data was developed. Data were collected over 20 months from at least 28 workstations. The application was used to plot...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：10.1016/j.cll.2006.12.001
更新日期：2007-03-01 00:00:00
abstract：:There is growing evidence supporting the genetic variability outside of HLA system that is contributing to the variation in transplant outcomes. Determining novel predictors could help to identify patients at risk and tailor their immunosuppressive regimens. This article discusses the various single nucleotide polymor...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2018.10.002
更新日期：2019-03-01 00:00:00
abstract：:This article describes a method for evaluating some of the medical, economic, and personal consequences of different policies of monitoring patients for various disorders. The problem is difficult because it is dynamic. Most conditions develop over time, and in many cases the sensitivity of the test as well as the cos...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1982-12-01 00:00:00
abstract：:Respiratory viruses continue to be major causes of morbidity and mortality. Currently available chemotherapy is limited to oral amantadine for uncomplicated influenza A and aerosolized ribavirin for respiratory syncytial virus (RSV) infections. Amantadine is also efficacious for chemoprophylaxis of influenza A virus i...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1987-12-01 00:00:00
abstract：:There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1994-06-01 00:00:00
abstract：:This article has presented information concerning the ultrastructural features and, to a lesser degree, the immunohistochemical characteristics of lung neoplasms. Electron microscopy and immunohistochemistry are useful techniques for diagnosing and understanding common and rare lung tumors. Electron microscopy is part...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：:Laboratory informatics is the application of computers and information systems to information management in the pathology laboratory. Effective information management is crucial to the success of pathologists and laboratorians. Informatics has become one of the key pillars of pathology, and the requirement for skilled...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2007.07.011
更新日期：2007-12-01 00:00:00
abstract：:The importance of food-borne helminthic infections is not well recognized and has not received the same attention as food-borne bacterial infections. Poverty, overpopulation, and cultural practices contribute to conditions that maintain food-borne helminthic infections. The development of better means of transportatio...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1999-09-01 00:00:00
abstract：:FNA cytology has been shown to be highly accurate in diagnosing malignant tumors. In gynecology, an overall accuracy of 94.5% in the differentiation between benign and malignant tumors has been reported. Despite many controversial views regarding its safety, aspiration cytology has been accepted as an innocuous proced...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1995-09-01 00:00:00
abstract：:Salmonella, Shigella, and Yersinia cause a well-characterized spectrum of disease in humans, ranging from asymptomatic carriage to hemorrhagic colitis and fatal typhoidal fever. These pathogens are responsible for millions of cases of food-borne illness in the United States each year, with substantial costs measured i...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2015.02.002
更新日期：2015-06-01 00:00:00
abstract：:Bioregulators are naturally occurring organic compounds that regulate a multitude of biologic processes. Under natural circumstances, bioregulators are synthesized in minute quantities in a variety of living organisms and are essential for physiologic homeostasis. In the wrong hands, these compounds have the capabilit...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2006.03.007
更新日期：2006-06-01 00:00:00
abstract：:To answer the question of whether reference values are useful in clinical decision-making, this article addresses the following major controversies: (1) Are reference subjects representative of the group from which they are selected? (2) To what extent should the process of collecting reference values be standardized ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:Recent studies have brought remarkable progress in the understanding of cellular, subcellular, and molecular mechanisms of endothelial injury and responses to injury, both of which appear to be integral parts of the acute inflammatory response. The possible roles of endothelial surface enzymes in the inflammatory resp...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1983-12-01 00:00:00
abstract：:From the inception of TBS in 1988, it has been well received by the pathology and clinical communities. The need for a unifying system of nomenclature was so great that most of the laboratories in the United States, as well as in numerous countries worldwide, quickly adopted TBS. By 1991, only 2 years after the initia...
journal_title：Clinics in laboratory medicine
pub_type： 共识发展会议,杂志文章,评审
doi：10.1016/s0272-2712(03)00053-2
更新日期：2003-09-01 00:00:00
abstract：:This article reviews the laboratory methodologies used to evaluate acute lymphoblastic leukemia (ALL) in children and their role in establishing a diagnosis and prognosis of this disease. These methodologies are: morphology, flow cytometry, cytogenetics, and molecular diagnostics. Additionally, immunophenotypic classi...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：:DNA testing has revolutionized the forensic sciences. Forensic testing has continued to evolve, and now several methods are in use. The predominant methods of forensic DNA analysis are described, and their application in casework is summarized. The legal acceptance of this testing also is discussed. ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1996-03-01 00:00:00
abstract：:Certain serum autoantibodies serve as useful diagnostic markers in AiLD; however, the etiology and pathogenesis of AiLD remain unknown. Although AiLD is characterized by the presence of autoantibodies and other humoral immune abnormalities, there is significant evidence that cell-mediated immune mechanisms are critica...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1997-09-01 00:00:00
abstract：:Bacteria were the first organisms recognized for their potential as agents of bioaggression and the possibility of their use by a terrorist or rogue nation is considered a significant threat. Five of the more likely agents (anthrax, plague, tularemia, Q fever, and brucellosis) are reviewed with emphasis on their epide...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：2001-09-01 00:00:00
abstract：:The development and adaptation of synthetic substrates has introduced new concepts and methodologies to the coagulation laboratory. Synthetic substrates offer potentially improved standardization over conventional testing, providing a rapid, sensitive, and specific way to measure enzymes directly. ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1984-06-01 00:00:00
