Abstract：
:This article reviews the laboratory methodologies used to evaluate acute lymphoblastic leukemia (ALL) in children and their role in establishing a diagnosis and prognosis of this disease. These methodologies are: morphology, flow cytometry, cytogenetics, and molecular diagnostics. Additionally, immunophenotypic classifications of ALL and criteria for establishing a diagnosis of ALL independent of morphology are described.
journal_name
Clin Lab Medjournal_title
Clinics in laboratory medicineauthors
Melnick SJsubject
Has Abstractpub_date
1999-03-01 00:00:00pages
169-86, viiissue
1eissn
0272-2712issn
1557-9832journal_volume
19pub_type
杂志文章,评审abstract：:Chromosome analysis is the genetic technique useful in evaluating endocrine disease. Indications for cytogenetic studies include suspected sex chromosomal aneuploidies as well as repeated fetal wastage. In patients with ambiguous genitalia, cytogenetic studies are mandatory, not only to provide information for assigni...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1984-12-01 00:00:00
abstract：:After more than 6 decades of clinical practice, the transplant community continues to research noninvasive biomarkers of solid organ injury to help improve patient care. In this review, we discuss the clinical usefulness of selective biomarkers and how they are processed at the laboratory. In addition, we organize the...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2018.11.003
更新日期：2019-03-01 00:00:00
abstract：:Respiratory viruses continue to be major causes of morbidity and mortality. Currently available chemotherapy is limited to oral amantadine for uncomplicated influenza A and aerosolized ribavirin for respiratory syncytial virus (RSV) infections. Amantadine is also efficacious for chemoprophylaxis of influenza A virus i...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1987-12-01 00:00:00
abstract：:Noninvasive genomic assessments of the fetus while in utero have been made possible by the analysis of cell-free fetal DNA fragments from the serum of pregnant women, as part of a noninvasive prenatal testing screening strategy. Between 7% and 10% of total cell-free DNA in the maternal blood comes from placental troph...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2016.01.018
更新日期：2016-06-01 00:00:00
abstract：:Recent developments in the surgical pathology of the vulva include updated classifications of non-neoplastic epithelial disorders and vulvar intraepithelial neoplasias. Several histologic variants of vulvar squamous cell carcinoma (SCC) with distinct clinicopathologic features have been described. The concept of super...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1995-09-01 00:00:00
abstract：:Processing of specimens for mycobacteria need to proceed as rapidly as possible to provide 24 hour turnaround for smears and 21-day turnaround for the identification of Mycobacterium tuberculosis. If these goals are to be accomplished, a broth culture or microcolony plate method must be part of the media and in the pl...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1996-09-01 00:00:00
abstract：:Shiga toxin-producing Escherichia coli (STEC) are important enteric pathogens worldwide, causing diarrhea with or without blood visibly present and hemolytic uremic syndrome. STEC are unique among diarrheogenic E coli in producing Shiga toxin type 1 and type 2, the virulence factors responsible for bloody diarrhea and...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2009.11.001
更新日期：2010-03-01 00:00:00
abstract：:Differentiation between procedure-related necrosis and postprocedural myocardial infarction (MI) is challenging because of the inherent association of these procedures to varying levels of myocardial injury. To improve risk stratification of patients at risk of an acute MI, the universal definition of MI implemented c...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2013.11.013
更新日期：2014-03-01 00:00:00
abstract：:This study uses three unique data sets to show the state of the art of hemoglobin A1c (HbA1c) analyzers in a range of settings and compares their performance against the international guidance set by the International Federation of Clinical Chemistry and Laboratory Medicine task force for HbA1c standardization. The da...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2016.09.006
更新日期：2017-03-01 00:00:00
abstract：:Several major pet-food and human-food safety incidents occurred worldwide between 2003 and 2008, causing illnesses and deaths in children, cats, dogs, and pigs. During the 2007 outbreak of renal failure in dogs and cats in the United States, veterinary diagnostic laboratories helped identify melamine and melamine anal...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：10.1016/j.cll.2010.10.003
更新日期：2011-03-01 00:00:00
abstract：:The development of antimicrobic susceptibility testing is outlined with particular reference to standardization of procedures and organizational developments that have led to substantially improved performance. Special problems continue to be posed by increased proportions of opportunistic pathogens and newly recogniz...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1989-06-01 00:00:00
abstract：:Transgenic mice that contain a proline to leucine mutation at amino acid 101 in the endogenous murine PrP gene have been produced by gene targeting. This line of mice was generated to model the mutation thought to be responsible for P102L GSS, a familial TSE disease in humans. Genetargeted 101LL mice showed no evidenc...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/s0272-2712(02)00067-7
更新日期：2003-03-01 00:00:00
abstract：:The active management of laboratory test utilization appears to be a practical approach to addressing the financial pressures imposed by managed care and capitated reimbursement, and can complement efforts already underway in most laboratories to reduce the unit cost of testing. Managing laboratory utilization takes t...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:The era of prenatal screening for serious birth defects began in the 1970s with the discovery that amniotic fluid and maternal serum levels of alpha-fetoprotein (AFP) were increased in pregnancies affected by fetal open neural tube defects. Since then, prenatal screening has become a part of routine obstetric care. In...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/s0272-2712(03)00032-5
更新日期：2003-06-01 00:00:00
abstract：:Control of human immunodeficiency virus type-1 (HIV-1) infection is the foremost public health challenge at the turn of the millennium. Two decades, 22 million fatalities, and 40 million living victims after its discovery, HIV-1 continues its inexorable spread. Over the past few years, scientists have made tremendous ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：10.1016/s0272-2712(02)00020-3
更新日期：2002-12-01 00:00:00
abstract：:The current success in organ transplantation has been brought about by immunosuppressive therapy. Improvements in transplant outcome using these drugs have stalled, and an understanding of the pharmacogenomics of immunosuppressive dosing and response holds the greatest promise for advancing the use of these agents. ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2008.09.004
更新日期：2008-09-01 00:00:00
abstract：:Laboratory information systems (LISs) supply mission-critical capabilities for the vast array of information-processing needs of modern laboratories. LIS architectures include mainframe, client-server, and thin client configurations. The LIS database software manages a laboratory's data. LIS dictionaries are database ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2015.09.002
更新日期：2016-03-01 00:00:00
abstract：:The pharmacologic field that studies antimicrobial pharmacokinetics and pharmacodynamics (PK/PD) has had a major impact on the choice and dosing regimens used for many antibiotics especially those used in the treatment of respiratory tract infections. PK/PD parameters are particularly important in light of increasing ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2004.03.009
更新日期：2004-06-01 00:00:00
abstract：:B-cell lymphomas represent approximately 20% to 25% of primary cutaneous lymphomas. Within this group, most cases (>99%) are encompassed by 3 diagnostic entities: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type. In this...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2017.05.009
更新日期：2017-09-01 00:00:00
abstract：:DNA testing has revolutionized the forensic sciences. Forensic testing has continued to evolve, and now several methods are in use. The predominant methods of forensic DNA analysis are described, and their application in casework is summarized. The legal acceptance of this testing also is discussed. ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1996-03-01 00:00:00
abstract：:The mean platelet volume measurement can reflect changes in either the level of platelet stimulation or rate of platelet production. The controversy related to whether platelets change volume or density in the circulation is still not clearly resolved, and although the relationship between platelet number and size and...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1993-12-01 00:00:00
abstract：:The blood film is one of the world's most widely and frequently used tests and has undergone remarkably few changes since its introduction in the late 1800s. This article gives direction and some standardization in the preparation of blood films used for morphologic evaluation in the clinical laboratory. Methodologies...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/s0272-2712(03)00064-7
更新日期：2002-03-01 00:00:00
abstract：:To answer the question of whether reference values are useful in clinical decision-making, this article addresses the following major controversies: (1) Are reference subjects representative of the group from which they are selected? (2) To what extent should the process of collecting reference values be standardized ...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1984-03-01 00:00:00
abstract：:There is growing evidence supporting the genetic variability outside of HLA system that is contributing to the variation in transplant outcomes. Determining novel predictors could help to identify patients at risk and tailor their immunosuppressive regimens. This article discusses the various single nucleotide polymor...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2018.10.002
更新日期：2019-03-01 00:00:00
abstract：:Acute accidental iron poisoning is a common serious and potentially fatal intoxication in the young child. Approximately 1 per cent of such poisoning have a fatal outcome, and outcome is closely related to the early onset of coma or shock. Long-term prognosis is excellent for all survivors of the acute episode, althou...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:The recent development and clinical implementation of genomic microarrays has resulted in rapid and significant changes for postnatal studies in the field of cytogenetics. This article discusses the benefits and issues for the use of microarrays for prenatal genetic diagnosis. It includes sections on specimen processi...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2011.08.004
更新日期：2011-12-01 00:00:00
abstract：:The search for clinical outcomes associated with antiphospholipid antibodies (aPL) has been ongoing for a decade. This article focuses on the clinical use of tests for the detection of aPL. A review of the current thinking regarding the pathophysiology of antiphospholipid syndromes is relevant to the discussion of dif...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1995-03-01 00:00:00
abstract：:Diagnosis of invasive fungal pneumonias by conventional culture methods is difficult to assess and often delayed. Nonmolecular fungal markers have emerged as an important adjunctive tool to support their diagnosis in combination with other clinical, radiologic, and microbiological criteria of invasive fungal diseases....
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2014.02.006
更新日期：2014-06-01 00:00:00
abstract：:Severe adverse drug reactions are a common cause of morbidity and mortality. Some of the most severe reactions are immunologically mediated and have been linked to specific HLA alleles. The mechanisms underlying HLA-associated drug hypersensitivity are complex and not fully understood. Recent findings have provided in...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：10.1016/j.cll.2018.08.002
更新日期：2018-12-01 00:00:00
abstract：:In discussing quality assurance in the blood bank, where many of the standard statistical techniques of measuring accuracy simply do not apply, three questions come to mind: How much? How often? Who says? Because of severe changes in the prospective payment plan and a new interest in cost effectiveness, many transfusi...
journal_title：Clinics in laboratory medicine
pub_type： 杂志文章,评审
doi：
更新日期：1986-12-01 00:00:00
