Fibrinolytic therapy in bacterial endocarditis: experimental studies in dogs.

Abstract:

:An investigation was undertaken to assess the value of adding streptokinase therapy to standard penicillin treatment of artificially induced infective endocarditis due to Streptococcus sanguis. In pigs a low-grade infection could be induced which closely simulated streptococcal endocarditis in man, but for technical reasons this model proved unsatisfactory for further experimentation. In dogs the induction of S. sanguis endocarditis produced a more severe illness with a short natural history. Dogs were divided into two groups, one treated with penicillin alone, the other with penicillin and streptokinase. A five-day course, in which twice daily injections of an acylated streptokinase-plasminogen complex were given, caused a substantial reduction in the size of vegetations and possibly a higher proportion of cures and less damage to the valves. Infarction of the brain, almost certainly due to embolism, was significantly greater in the streptokinase treated group, but the same was not true of the kidneys. The possible value of such treatment for certain kinds of bacterial endocarditis in man, especially in the right side of the heart, is discussed.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Dewar HA,Jones MR,Barnes WS,Griffin SG

doi

10.1093/oxfordjournals.eurheartj.a062100

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

520-7

issue

6

eissn

0195-668X

issn

1522-9645

journal_volume

7

pub_type

临床试验,杂志文章
  • Heart rate variability and ischaemia in patients with coronary heart disease and stable angina pectoris; influence of drug therapy and prognostic value. TIBBS Investigators Group. Total Ischemic Burden Bisoprolol Study.

    abstract:AIMS:Determination of the influence of therapy with bisoprolol and nifedipine on the heart rate variability of patients from the Total Ischemic Burden Bisoprolol Study and examination of the prognostic value. METHODS AND RESULTS:Four hundred and twenty-two patients with stable angina were included. The heart rate vari...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.1998.1272

    authors: Weber F,Schneider H,von Arnim T,Urbaszek W

    更新日期:1999-01-01 00:00:00

  • Impact of final coronary flow velocity reserve on late outcome following stent implantation.

    abstract::Aims To assess whether coronary flow velocity reserve following stent implantation is predictive of the subsequent need of target lesion revascularization. Methods and Results The outcome was examined of 417 patients enrolled in a multicentre prospective randomized study (DESTINI), who received a successful single ves...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.2001.2734

    authors: Nishida T,Di Mario C,Kern MJ,Anderson TJ,Moussa I,Bonan R,Muramatsu T,Jain AC,Suarez de Lezo J,Cho SY,Meredith IT,Moses JW,Colombo A

    更新日期:2002-02-01 00:00:00

  • Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea.

    abstract:AIMS:Delayed lipoprotein clearance is associated with atherosclerosis. This study examined whether chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnoea (OSA), can lead to hyperlipidaemia by inhibiting clearance of triglyceride rich lipoproteins (TRLP). METHODS AND RESULTS:Male C57BL/6J mice on hi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr097

    authors: Drager LF,Li J,Shin MK,Reinke C,Aggarwal NR,Jun JC,Bevans-Fonti S,Sztalryd C,O'Byrne SM,Kroupa O,Olivecrona G,Blaner WS,Polotsky VY

    更新日期:2012-03-01 00:00:00

  • Evaluation of three methods for quantifying valvular regurgitation using gated equilibrium radionuclide ventriculography.

    abstract::The non-invasive quantification of mitral and aortic regurgitation using the left-to-right stroke count ratio (SCR) calculated with gated equilibrium radionuclide ventriculography (RNV), is affected by the overlap of atria and ventricles and the consequent difficult definition of the ventricular regions of interest (R...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062176

    authors: Sciagrà R,Voth E,Tebbe U,Schicha H,Neuhaus KL

    更新日期:1987-10-01 00:00:00

  • Report of a European Society of Cardiology-European Association of Percutaneous Cardiovascular Interventions task force on the evaluation of coronary stents in Europe: executive summary.

    abstract::The evaluation for European Union market approval of coronary stents falls under the Medical Device Directive that was adopted in 1993. Specific requirements for the assessment of coronary stents are laid out in supplementary advisory documents. In response to a call by the European Commission to make recommendations ...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehv203

    authors: Byrne RA,Serruys PW,Baumbach A,Escaned J,Fajadet J,James S,Joner M,Oktay S,Jüni P,Kastrati A,Sianos G,Stefanini GG,Wijns W,Windecker S

    更新日期:2015-10-07 00:00:00

  • Effects of ranolazine on exercise tolerance and HbA1c in patients with chronic angina and diabetes.

    abstract:AIMS:The anti-anginal efficacy and safety of ranolazine in diabetic and non-diabetic patients included in the Combination Assessment of Ranolazine In Stable Angina (CARISA) trial (JAMA 2004;291:309) were studied. Glycaemic control was also assessed in CARISA and its long-term open-label extension study. METHODS AND RE...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehi495

    authors: Timmis AD,Chaitman BR,Crager M

    更新日期:2006-01-01 00:00:00

  • Is the A1166C polymorphism of the angiotensin II type 1 receptor involved in cardiovascular disease?

    abstract::Peptides produced by the renin-angiotensin system play a major role in the development and progression of various cardiovascular diseases. One of these peptides, angiotensin II, is a potent vasoconstrictor that exerts most of its effects through the human AT1 receptor. Following the discovery of a functional variation...

    journal_title:European heart journal

    pub_type: 杂志文章,评审

    doi:

    authors: van Geel PP,Pinto YM,Buikema H,van Gilst WH

    更新日期:1998-07-01 00:00:00

  • A comparison between coronary artery bypass grafting surgery and drug eluting stent for the treatment of unprotected left main coronary artery disease in elderly patients (aged > or =75 years).

    abstract:AIMS:In this study, we compared the clinical outcomes of elderly patients with unprotected left main coronary artery (ULMCA) stenosis treated with either coronary artery bypass grafting (CABG) or drug-eluting stent (DES). METHODS AND RESULTS:From January 2003 to April 2006, 259 patients with ULMCA stenosis and age > o...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehm403

    authors: Palmerini T,Barlocco F,Santarelli A,Bacchi-Reggiani L,Savini C,Baldini E,Alessi L,Ruffini M,Di Credico G,Piovaccari G,Di Bartolomeo R,Marzocchi A,Branzi A,De Servi S

    更新日期:2007-11-01 00:00:00

  • Effect of breathing oxygen-enriched air on exercise performance in patients with precapillary pulmonary hypertension: randomized, sham-controlled cross-over trial.

    abstract:Aims:The purpose of the current trial was to test the hypothesis that breathing oxygen-enriched air increases exercise performance of patients with pulmonary arterial or chronic thrombo-embolic pulmonary hypertension (PAH/CTEPH) and to investigate involved mechanisms. Methods and results:Twenty-two patients with PAH/C...

    journal_title:European heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurheartj/ehx099

    authors: Ulrich S,Hasler ED,Saxer S,Furian M,Müller-Mottet S,Keusch S,Bloch KE

    更新日期:2017-04-14 00:00:00

  • First month course of left ventricular asynergy after intracoronary thrombolysis in acute myocardial infarction. A longitudinal echocardiographic study.

    abstract::Can intracoronary thrombolytic therapy (ITT) reduce the infarct size and improve regional and global left ventricular function and if so how long after recanalization does this improvement develop? 42 patients were treated with ITT, of whom 25 showed successful recanalization (group A) and 17 had persistent occlusion ...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061937

    authors: Widimský P,Cervenka V,Gregor P,Vísek V,Sládková T,Dvorák J,Hrdlicka S

    更新日期:1985-09-01 00:00:00

  • Contractile function of right ventricular papillary muscle after left ventricular infarction in rats: effects of early and late inhibition of angiotensin converting enzyme.

    abstract::Alterations in the right ventricular function may or may not contribute to progressive cardiac dysfunction after left ventricular infarction. Ligation of the left coronary artery (LCAL) was lethal within 24 h for 25% of 100 rats, whereas none of 21 sham-operated rats died. No rats died during the following 4 weeks, af...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/14.11.1554

    authors: Christiansen EH,Tian R,Böttcher M,Andreasen F

    更新日期:1993-11-01 00:00:00

  • Another step on the road to a European Council for Health Research.

    abstract::The Alliance for Biomedical Research in Europe, co-founded by the European Society of Cardiology, has persuaded the European Parliament to move towards European Union-wide means of better directing and coordinating biomedical research, from the laboratory bench to the marketplace. ...

    journal_title:European heart journal

    pub_type: 新闻

    doi:

    authors: Shurlock B

    更新日期:2014-04-01 00:00:00

  • The relationship between diuretic dose, and the haemodynamic response to captopril in patients with cardiac failure.

    abstract::The effect of diuretic dose on the haemodynamic response to captopril was assessed in nine patients with chronic cardiac failure. Each patient was given an intravenous dose of captopril while maintained on (a) a low dose diuretic regime, and (b) a high dose diuretic regime. Activity of the renin angiotensin aldosteron...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060302

    authors: Flapan AD,Davies E,Williams BC,Shaw TR,Edwards CR

    更新日期:1992-07-01 00:00:00

  • Comparative study on the effects of intracoronary nicorandil and nitroglycerin in ischaemic, reperfused porcine hearts.

    abstract::The direct cardioprotective properties of nitroglycerin and nicorandil were compared in regionally ischaemic (45 min), reperfused (24 h) porcine hearts. Intracoronary treatments, which were started 15 min prior to occlusion of the distal left anterior descending coronary artery (LAD), were continuously administered fo...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060962

    authors: Klein HH,Pich S,Lindert-Heimberg S,Schade-Brittinger C,Maisch B,Nebendahl K

    更新日期:1995-05-01 00:00:00

  • Serum amyloid A: high-density lipoproteins interaction and cardiovascular risk.

    abstract:AIMS:High-density lipoproteins (HDLs) are considered as anti-atherogenic. Recent experimental findings suggest that their biological properties can be modified in certain clinical conditions by accumulation of serum amyloid A (SAA). The effect of SAA on the association between HDL-cholesterol (HDL-C) and cardiovascular...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehv352

    authors: Zewinger S,Drechsler C,Kleber ME,Dressel A,Riffel J,Triem S,Lehmann M,Kopecky C,Säemann MD,Lepper PM,Silbernagel G,Scharnagl H,Ritsch A,Thorand B,de las Heras Gala T,Wagenpfeil S,Koenig W,Peters A,Laufs U,Wanner C,

    更新日期:2015-11-14 00:00:00

  • Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study.

    abstract:Aims:To determine tolerability and the optimal dose regimen of the soluble guanylate cyclase stimulator vericiguat in patients with chronic heart failure and preserved ejection fraction (HFpEF). Methods and results:SOCRATES-PRESERVED was a prospective, randomized, placebo-controlled double-blind, Phase 2b dose-finding...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurheartj/ehw593

    authors: Pieske B,Maggioni AP,Lam CSP,Pieske-Kraigher E,Filippatos G,Butler J,Ponikowski P,Shah SJ,Solomon SD,Scalise AV,Mueller K,Roessig L,Gheorghiade M

    更新日期:2017-04-14 00:00:00

  • Surgery of prosthetic valve thrombosis.

    abstract::From January 1978 to August 1983, 41 prosthetic valve thromboses in 34 patients were operated upon in our service. They comprised 15 aortic, 25 mitral and one tricuspid valve thromboses. Seven patients had massive thrombus with dysfunction of the prosthesis; others had small and disseminated thrombi on their prosthesi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/5.suppl_d.39

    authors: Pavie A,Bors V,Baud F,Gandjbakhch I,Cabrol C

    更新日期:1984-10-01 00:00:00

  • Impact of early vs. late microvascular obstruction assessed by magnetic resonance imaging on long-term outcome after ST-elevation myocardial infarction: a comparison with traditional prognostic markers.

    abstract:AIMS:Early and late microvascular obstruction (MO) assessed by magnetic resonance imaging (MRI) are prognostic markers for combined clinical endpoints after ST-elevation myocardial infarction (STEMI). However, there are only limited data for hard endpoints and no consensus exists which of the two best predicts clinical...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehq247

    authors: de Waha S,Desch S,Eitel I,Fuernau G,Zachrau J,Leuschner A,Gutberlet M,Schuler G,Thiele H

    更新日期:2010-11-01 00:00:00

  • Thin-cap fibroatheroma and microchannel findings in optical coherence tomography correlate with subsequent progression of coronary atheromatous plaques.

    abstract:AIMS:Morphological characteristics of non-significant coronary plaques (NSCPs) that develop rapid progression have not been fully elucidated. The aim of this study was to clarify the morphological characteristics of NSCPs in patients with coronary artery disease (CAD) using intravascular optical coherence tomography (O...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehr284

    authors: Uemura S,Ishigami K,Soeda T,Okayama S,Sung JH,Nakagawa H,Somekawa S,Takeda Y,Kawata H,Horii M,Saito Y

    更新日期:2012-01-01 00:00:00

  • Acute vascular toxicity after combination chemotherapy with cisplatin, vinblastine, and bleomycin for testicular cancer.

    abstract::Twenty-one consecutive patients with testicular cancer treated with bleomycin, vinblastine, and cisplatin (PVB) were evaluated for acute vascular ischaemic events during chemotherapy. Angina pectoris occurred in 8/21 (38%) patients, a median 5.6 weeks after initiation of chemotherapy and persisted for 2-7 days. Raynau...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a062542

    authors: Stefenelli T,Kuzmits R,Ulrich W,Glogar D

    更新日期:1988-05-01 00:00:00

  • Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries.

    abstract:AIMS:To investigate the association of estimated total daily sleep duration and daytime nap duration with deaths and major cardiovascular events. METHODS AND RESULTS:We estimated the durations of total daily sleep and daytime naps based on the amount of time in bed and self-reported napping time and examined the assoc...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehy695

    authors: Wang C,Bangdiwala SI,Rangarajan S,Lear SA,AlHabib KF,Mohan V,Teo K,Poirier P,Tse LA,Liu Z,Rosengren A,Kumar R,Lopez-Jaramillo P,Yusoff K,Monsef N,Krishnapillai V,Ismail N,Seron P,Dans AL,Kruger L,Yeates K,Leach

    更新日期:2019-05-21 00:00:00

  • Acute and subacute stent occlusion; risk-reduction by ionic contrast media.

    abstract:AIMS:Current data concerning the influence of X-ray contrast media on the incidence of thrombotic complications in interventional cardiology are controversial. The effect of ionic contrast media on acute (< or =72 h) and subacute (< or =30 days) stent thrombosis has not been investigated. METHODS:Three thousand, nine ...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1053/euhj.2000.2319

    authors: Scheller B,Hennen B,Pohl A,Schieffer H,Markwirth T

    更新日期:2001-03-01 00:00:00

  • Outbursts of anger as a trigger of acute cardiovascular events: a systematic review and meta-analysis.

    abstract:AIM:Short-term psychological stress is associated with an immediate physiological response and may be associated with a transiently higher risk of cardiovascular events. The aim of this study was to determine whether brief episodes of anger trigger the onset of acute myocardial infarction (MI), acute coronary syndromes...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehu033

    authors: Mostofsky E,Penner EA,Mittleman MA

    更新日期:2014-06-01 00:00:00

  • Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle-aged men and women.

    abstract:AIMS:Serum gamma-glutamyltransferase (GGT) concentration may be involved in atherosclerosis. This study examined if serum GGT predicted coronary heart disease (CHD), especially differentiating non-fatal myocardial infarction (MI) and fatal CHD event, among the general population or participants with type-2 diabetes. M...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehl086

    authors: Lee DH,Silventoinen K,Hu G,Jacobs DR Jr,Jousilahti P,Sundvall J,Tuomilehto J

    更新日期:2006-09-01 00:00:00

  • Dipyridamole in chronic stable angina pectoris; a randomized, double blind, placebo-controlled, parallel group study.

    abstract:BACKGROUND:Oral dipyridamole induces accumulation of endogenous adenosine, which in a hypoxic milieu exerts experimentally an angiogenic effect on coronary collateral circulation. A meta-analysis of 13 randomized placebo-controlled trials published between 1960 and 1992 showed evidence of benefit for dipyridamole in th...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/euhj.2001.2623

    authors: Picano E,PISA (Persantin In Stable Angina) study group.

    更新日期:2001-10-01 00:00:00

  • Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs.

    abstract:AIM:Heart disease is recognized as a consequence of dysregulation of cardiac gene regulatory networks. Previously, unappreciated components of such networks are the long non-coding RNAs (lncRNAs). Their roles in the heart remain to be elucidated. Thus, this study aimed to systematically characterize the cardiac long no...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/ehu180

    authors: Ounzain S,Micheletti R,Beckmann T,Schroen B,Alexanian M,Pezzuto I,Crippa S,Nemir M,Sarre A,Johnson R,Dauvillier J,Burdet F,Ibberson M,Guigó R,Xenarios I,Heymans S,Pedrazzini T

    更新日期:2015-02-07 00:00:00

  • Fibrinogen and cerebrovascular disease.

    abstract::The importance of fibrinogen has been identified in two prospective observational studies. Reactive elevations in fibrinogen levels that occur within hours of a major stroke invalidate most cross-sectional case-control studies evaluating fibrinogen as a risk factor. However, as no elevation is seen following fresh epi...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/eurheartj/16.suppl_a.42

    authors: Qizilbash N

    更新日期:1995-03-01 00:00:00

  • High-grade atrioventricular block in acute coronary syndromes: insights from the Global Registry of Acute Coronary Events.

    abstract:BACKGROUND:While prior work has suggested that a high-grade atrioventricular block (HAVB) in the setting of an acute coronary syndrome (ACS) is associated with in-hospital death, limited information is available on the incidence of, and death associated with, HAVB in ACS patients receiving contemporary management. MET...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurheartj/ehu357

    authors: Singh SM,FitzGerald G,Yan AT,Brieger D,Fox KA,López-Sendón J,Yan RT,Eagle KA,Steg PG,Budaj A,Goodman SG

    更新日期:2015-04-21 00:00:00

  • The QRS score: a promising new exercise score for detecting coronary artery disease based on exercise-induced changes of Q-, R- and S-waves: a relationship with myocardial ischaemia.

    abstract:BACKGROUND:Recently, a new exercise test criterion diagnosing coronary artery disease was proposed, based on a composite of changes in Q-, R- and S-waves: the QRS score. We compared this new criterion with conventional ST-segment depression and other compositions of Q-, R- and S-wave changes in patients and normals and...

    journal_title:European heart journal

    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a014936

    authors: van Campen CM,Visser FC,Visser CA

    更新日期:1996-05-01 00:00:00

  • Angiographic follow-up results of a randomized study on angioplasty versus bypass surgery (GABI trial). GABI Study Group.

    abstract::Although several randomized trials have been performed to compare the outcomes of percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass surgery (CABG) in patients with multivessel disease, there is little data available on angiographic follow-up results. The present substudy of the German an...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1093/oxfordjournals.eurheartj.a015036

    authors: Rupprecht HJ,Hamm C,Ischinger T,Dietz U,Reimers J,Meyer J

    更新日期:1996-08-01 00:00:00