Acute and subacute stent occlusion; risk-reduction by ionic contrast media.


AIMS:Current data concerning the influence of X-ray contrast media on the incidence of thrombotic complications in interventional cardiology are controversial. The effect of ionic contrast media on acute (< or =72 h) and subacute (< or =30 days) stent thrombosis has not been investigated. METHODS:Three thousand, nine hundred and ninety consecutive patients underwent coronary stent placement. Group I (n=1808) received non-ionic contrast media while group II (n=2182) was given the ionic Ioxaglate. All patients were treated with a standard regimen of aspirin and ticlopidine for 4 weeks post intervention. RESULTS:Both acute and subacute stent occlusion occurred more frequently in patients receiving non-ionic contrast media compared to ionic contrast media (acute stent occlusion: 1.3% in group I vs 0.3% in group II, P=0.001; subacute stent occlusion: 2.4% in group I vs 0.7% in group II, P=0.001). The incidence of the combined clinical end-point of coronary artery bypass grafting, target lesion revascularization, and overall mortality within 12 months was significantly reduced by the use of Ioxaglate (22.9% vs 16.3%, P=0.001). CONCLUSIONS:Based upon these data, we recommend the use of Ioxaglate in coronary interventions when stent placement is anticipated.


Eur Heart J


European heart journal


Scheller B,Hennen B,Pohl A,Schieffer H,Markwirth T




Has Abstract


2001-03-01 00:00:00














  • A systematic review and meta-analysis of the prevalence of left ventricular non-compaction in adults.

    abstract:AIMS:To assess the reported prevalence of left ventricular non-compaction (LVNC) in different adult cohorts, taking in to consideration the role of diagnostic criteria and imaging modalities used. METHODS AND RESULTS:A systematic review and meta-analysis of studies reporting LVNC prevalence in adults. Studies were sou...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ross SB,Jones K,Blanch B,Puranik R,McGeechan K,Barratt A,Semsarian C

    更新日期:2020-04-07 00:00:00

  • Aldosterone and heart failure.

    abstract::In untreated congestive heart failure, aldosterone plasma concentrations are elevated in proportion to the severity of the disease and are further increased by the use of diuretic treatment. Angiotensin II, plasma potassium concentration, and corticotropin are the major stimulators of aldosterone synthesis. During ang...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Zannad F

    更新日期:1995-12-01 00:00:00

  • Myocardial damage, inflammation and thrombin inhibition in unstable coronary artery disease.

    abstract:AIM:Unstable coronary artery disease (CAD) is a multifactorial disease involving both thrombotic and inflammatory processes. We have assessed the time-course and the influence of thrombin inhibitors on changes in fibrinogen and C-reactive protein levels, and their relation to myocardial ischaemia in unstable CAD. METH...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Oldgren J,Wallentin L,Grip L,Linder R,Nørgaard BL,Siegbahn A

    更新日期:2003-01-01 00:00:00

  • Stent thrombosis and restenosis: what have we learned and where are we going? The Andreas Grüntzig Lecture ESC 2014.

    abstract::Modern-day stenting procedures leverage advances in pharmacotherapy and device innovation. Patients treated with contemporary antiplatelet agents, peri-procedural antithrombin therapy and new-generation drug-eluting stents (DES) have excellent outcomes over the short to medium term. Indeed, coupled with the reducing c...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Byrne RA,Joner M,Kastrati A

    更新日期:2015-12-14 00:00:00

  • Efficacy and safety of aspirin for primary prevention of cardiovascular events: a meta-analysis and trial sequential analysis of randomized controlled trials.

    abstract:AIMS:The role of aspirin in the primary prevention setting is continuously evolving. Recent randomized trials have challenged the role of aspirin in the primary prevention setting. METHODS AND RESULTS:Electronic databases were searched for randomized trials that compared aspirin vs. placebo (or control) in subjects wi...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析


    authors: Mahmoud AN,Gad MM,Elgendy AY,Elgendy IY,Bavry AA

    更新日期:2019-02-14 00:00:00

  • Ratio of transmitral early filling velocity to early diastolic strain rate predicts long-term risk of cardiovascular morbidity and mortality in the general population.

    abstract:Aims:It has previously been demonstrated that the ratio of early mitral inflow velocity to global diastolic strain rate (E/e'sr) is a significant predictor of cardiac events in specific patient populations. The utility of this measurement to predict cardiovascular events in a general population has not been evaluated. ...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Lassen MCH,Biering-Sørensen SR,Olsen FJ,Skaarup KG,Tolstrup K,Qasim AN,Møgelvang R,Jensen JS,Biering-Sørensen T

    更新日期:2019-02-07 00:00:00

  • When is it appropriate to stop non-vitamin K antagonist oral anticoagulants before catheter ablation of atrial fibrillation? A multicentre prospective randomized study.

    abstract:AIMS:Although a recent expert consensus statement has recommended periprocedural uninterrupted (UI) non-vitamin K antagonist oral anticoagulants (NOACs) during catheter ablation of atrial fibrillation (AF) as a Class I indication, there have been no clear randomized trials. We investigated the safety and efficacy of UI...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Yu HT,Shim J,Park J,Kim TH,Uhm JS,Kim JY,Joung B,Lee MH,Kim YH,Pak HN

    更新日期:2019-05-14 00:00:00

  • Non-invasive estimation of the diastolic elastic and viscoelastic properties of the left ventricle.

    abstract::The present study applies a non-invasive method to the quantitative evaluation of left ventricular stiffness in normal subjects and in patients with ischaemic heart disease (IHD). We have studied 20 patients with IHD and 25 healthy subjects. The third heart sound (S3) was detectable in all patients. We have correlated...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Baracca E,Longhini C,Aggio S,Brunazzi C,Aubert AE,Pansini R

    更新日期:1991-02-01 00:00:00

  • Haemodynamically irrelevant pericardial effusion is associated with increased mortality in patients with chronic heart failure.

    abstract:AIMS:Pericardial effusion (PE) is a common finding in cardiac patients with chronic heart failure. The prognostic relevance of a small, haemodynamically non-compromising PE in such patients, however, remains to be determined. METHODS AND RESULTS:All patients referred to our heart failure clinic and having a baseline e...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Fröhlich GM,Keller P,Schmid F,Wolfrum M,Osranek M,Falk C,Noll G,Enseleit F,Reinthaler M,Meier P,Lüscher TF,Ruschitzka F,Tanner FC

    更新日期:2013-05-01 00:00:00

  • Risk stratification in asymptomatic severe aortic stenosis: a critical appraisal.

    abstract::Aortic stenosis is one of the most common forms of acquired valvular heart disease. The development of symptoms, namely syncope, angina, or heart failure, in patients with severe aortic stenosis predicts a high likelihood of mortality. Aortic valve replacement is the current standard of care. In truly asymptomatic pat...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Bhattacharyya S,Hayward C,Pepper J,Senior R

    更新日期:2012-10-01 00:00:00

  • Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF.

    abstract:Aims:To date, clinical evidence of microvascular dysfunction in patients with heart failure (HF) with preserved ejection fraction (HFpEF) has been limited. We aimed to investigate the prevalence of coronary microvascular dysfunction (CMD) and its association with systemic endothelial dysfunction, HF severity, and myoca...

    journal_title:European heart journal

    pub_type: 杂志文章,多中心研究


    authors: Shah SJ,Lam CSP,Svedlund S,Saraste A,Hage C,Tan RS,Beussink-Nelson L,Ljung Faxén U,Fermer ML,Broberg MA,Gan LM,Lund LH

    更新日期:2018-10-01 00:00:00

  • Is atrial fibrillation an inflammatory disorder?

    abstract::There is mounting evidence to support the influence of inflammation in the pathogenesis of atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory markers, even after adjustment for confounding factors. The renin-angiotensin-aldosterone system (RAAS) appears to play a key role in...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Boos CJ,Anderson RA,Lip GY

    更新日期:2006-01-01 00:00:00

  • Long-term survival in severe heart failure in patients treated with enalapril. Ten year follow-up of CONSENSUS I.

    abstract:BACKGROUND:The CONSENSUS trial was the first study to show prognostic improvement by an ACE inhibitor. Patients in NYHA class IV heart failure were treated with enalapril or placebo. After study completion (average 183 days) all patients were offered open-label enalapril therapy. This paper reports on the survival at t...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Swedberg K,Kjekshus J,Snapinn S

    更新日期:1999-01-01 00:00:00

  • Effects of antianginal therapy with a calcium antagonist and nitrates on dobutamine-atropine stress echocardiography. Comparison with exercise electrocardiography.

    abstract:BACKGROUND:Anti-ischaemic therapy with nitrates and/or calcium channel blockers profoundly affects the results of pharmacological stress echocardiography with coronary vasodilators but the influence on catecholamine stress testing remains unsettled. AIMS:The present study aimed to assess the effects of non-beta-blocke...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dodi C,Pingitore A,Sicari R,Bruno G,Cordovil A,Picano E

    更新日期:1997-02-01 00:00:00

  • The comparative efficacy of bivalirudin is markedly attenuated by use of radial access: insights from Blue Cross Blue Shield of Michigan Cardiovascular Consortium.

    abstract:AIM:The purpose of our study was to evaluate the relative impact of bivalirudin on bleeding outcomes associated with trans-radial interventions (TRI) in real world practice. METHODS AND RESULTS:Data for patients undergoing percutaneous coronary intervention (PCI) between January 2010 and March 2014 at the 47 hospitals...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Perdoncin E,Seth M,Dixon S,Cannon L,Khandelwal A,Riba A,David S,Wohns D,Gurm H

    更新日期:2016-06-21 00:00:00

  • Implantable cardioverter defibrillators for primary prevention of death in left ventricular dysfunction with and without ischaemic heart disease: a meta-analysis of 8567 patients in the 11 trials.

    abstract:Aims:Primary prevention implantable cardioverter defibrillators (ICDs) are established therapy for reducing mortality in patients with left ventricular systolic dysfunction and ischaemic heart disease (IHD). However, their efficacy in patients without IHD has been controversial. We undertook a meta-analysis of the tota...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审


    authors: Shun-Shin MJ,Zheng SL,Cole GD,Howard JP,Whinnett ZI,Francis DP

    更新日期:2017-06-07 00:00:00

  • Doppler ultrasonic measurement of cardiac output: reproducibility and validation.

    abstract::The Doppler ultrasonic estimation of cardiac output in man is reviewed. Minimal requirements for accurate measurements are discussed, and the published results of reproducibility studies and validation studies are summarized and analysed. Analysis of Doppler records has a coefficient of repeat determination of 5-8% fo...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: Coats AJ

    更新日期:1990-12-01 00:00:00

  • Intrapericardial treatment of autoreactive pericardial effusion with triamcinolone; the way to avoid side effects of systemic corticosteroid therapy.

    abstract:AIMS:To evaluate efficacy and safety of intrapericardial treatment with the crystalloid corticosteroid triamcinolone in autoreactive pericardial effusion. METHODS AND RESULTS:Two hundred and sixty consecutive patients with pericarditis/myopericarditis underwent pericardiocentesis, pericardioscopy (Storz-AF1101B1), and...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章


    authors: Maisch B,Ristić AD,Pankuweit S

    更新日期:2002-10-01 00:00:00

  • The circadian pattern of the development of ventricular fibrillation in patients with Brugada syndrome.

    abstract:AIMS:Brugada syndrome is considered to be a distinctive subgroup of idiopathic ventricular fibrillation. Identification of the circadian pattern of ventricular fibrillation would contribute to the elucidation of its underlying pathophysiology, but this pattern remains unknown in patients with Brugada syndrome. METHODS...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Matsuo K,Kurita T,Inagaki M,Kakishita M,Aihara N,Shimizu W,Taguchi A,Suyama K,Kamakura S,Shimomura K

    更新日期:1999-03-01 00:00:00

  • Happy heart syndrome: role of positive emotional stress in takotsubo syndrome.

    abstract:AIMS:Takotsubo syndrome (TTS) is typically provoked by negative stressors such as grief, anger, or fear leading to the popular term 'broken heart syndrome'. However, the role of positive emotions triggering TTS remains unclear. The aim of the present study was to analyse the prevalence and characteristics of patients w...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Ghadri JR,Sarcon A,Diekmann J,Bataiosu DR,Cammann VL,Jurisic S,Napp LC,Jaguszewski M,Scherff F,Brugger P,Jäncke L,Seifert B,Bax JJ,Ruschitzka F,Lüscher TF,Templin C,InterTAK Co-investigators:.

    更新日期:2016-10-01 00:00:00

  • Myocardial infarction and the myocyte IGF1 autocrine system.

    abstract::To determine the effects of acute myocardial infarction on the extent and distribution of mural stress on surviving myocardial tissue, coronary artery occlusion was surgically produced in rats. Following haemodynamic measurements in vivo, the characteristics of cardiac anatomy were determined and found to consist of a...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Anversa P,Reiss K,Kajstura J,Cheng W,Li P,Sonnenblick EH,Olivetti G

    更新日期:1995-12-01 00:00:00

  • Combination of high-dose furosemide and hydrochlorothiazide in the treatment of refractory congestive heart failure.

    abstract:OBJECTIVE:We studied the synergism between high-dose furosemide and hydrochlorothiazide in patients with severe congestive heart failure and impaired renal function showing diuretic resistance to a daily dose of furosemide of at least 250 mg. DESIGN AND SETTING:An open study. A general hospital in The Netherlands. ME...

    journal_title:European heart journal

    pub_type: 临床试验,杂志文章


    authors: Dormans TP,Gerlag PG

    更新日期:1996-12-01 00:00:00

  • Phenotypic variability of cardiovascular manifestations in Marfan Syndrome. Possible role of hyperhomocysteinemia and C677T MTHFR gene polymorphism.

    abstract:AIMS:The aim of this study was to evaluate (1) homocysteinemia and the prevalence of the C677T MTHFR polymorphism in Marfan patients and (2) whether the severity of cardiovascular manifestations is associated with homocysteinemia and/or C677T polymorphism. METHODS AND RESULTS:We studied 107 patients subdivided into th...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Giusti B,Porciani MC,Brunelli T,Evangelisti L,Fedi S,Gensini GF,Abbate R,Sani G,Yacoub M,Pepe G

    更新日期:2003-11-01 00:00:00

  • Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry.

    abstract:AIMS:Calmodulinopathies are rare life-threatening arrhythmia syndromes which affect mostly young individuals and are, caused by mutations in any of the three genes (CALM 1-3) that encode identical calmodulin proteins. We established the International Calmodulinopathy Registry (ICalmR) to understand the natural history,...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Crotti L,Spazzolini C,Tester DJ,Ghidoni A,Baruteau AE,Beckmann BM,Behr ER,Bennett JS,Bezzina CR,Bhuiyan ZA,Celiker A,Cerrone M,Dagradi F,De Ferrari GM,Etheridge SP,Fatah M,Garcia-Pavia P,Al-Ghamdi S,Hamilton RM,Al-H

    更新日期:2019-09-14 00:00:00

  • STEMI and NSTEMI: are they so different? 1 year outcomes in acute myocardial infarction as defined by the ESC/ACC definition (the OPERA registry).

    abstract:AIMS:The ESC/ACC redefined myocardial infarction as any amount of necrosis caused by ischaemia. The aim of this study was to describe the management and outcomes using 'real-world' data taking the new definition of acute myocardial infarction into account. METHODS AND RESULTS:A total of 2,151 consecutive patients (76....

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Montalescot G,Dallongeville J,Van Belle E,Rouanet S,Baulac C,Degrandsart A,Vicaut E,OPERA Investigators.

    更新日期:2007-06-01 00:00:00

  • Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPARγ signature.

    abstract:AIMS:Nuclear receptors and their cofactors regulate key pathophysiological processes in atherosclerosis development. The transcriptional activity of these nuclear receptors is controlled by the nuclear receptor corepressors (NCOR), scaffolding proteins that form the basis of large corepressor complexes. Studies with pr...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Oppi S,Nusser-Stein S,Blyszczuk P,Wang X,Jomard A,Marzolla V,Yang K,Velagapudi S,Ward LJ,Yuan XM,Geiger MA,Guillaumon AT,Othman A,Hornemann T,Rancic Z,Ryu D,Oosterveer MH,Osto E,Lüscher TF,Stein S

    更新日期:2020-03-01 00:00:00

  • Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials.

    abstract:AIMS:The impact on mortality outcomes of beta-blockers and calcium blockers in post-myocardial infarction (MI) has been suggested to be related to resting heart rate (HR) reduction. A meta-regression of randomized clinical trials was carried out to assess this relationship using weighted meta-regression of logarithm of...

    journal_title:European heart journal

    pub_type: 杂志文章,meta分析,评审


    authors: Cucherat M

    更新日期:2007-12-01 00:00:00

  • Restenosis and adverse clinical events after successful percutaneous mitral valvuloplasty: immediate post-procedural mitral valve area as an important prognosticator.

    abstract:AIMS:We sought to investigate the factors associated with restenosis and its potential association with late clinical deterioration after successful percutaneous mitral valvuloplasty (PMV). METHODS AND RESULTS:We analysed echocardiographic (median 74 months) and clinical (median 109 months) follow-up data of 329 patie...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Song JK,Song JM,Kang DH,Yun SC,Park DW,Lee SW,Kim YH,Lee CW,Hong MK,Kim JJ,Park SW,Park SJ

    更新日期:2009-05-01 00:00:00

  • ST segment monitoring before, three weeks and six months after aortocoronary bypass surgery.

    abstract::ST segment monitoring by Holter ECG was conducted in 80 consecutive patients 2-4 weeks before aortocoronary bypass surgery and three weeks and six months after surgery. Preoperatively, all patients were under maximal medical therapy. In 31 out of 80 patients medical therapy could be stopped and thus 24-h ST monitoring...

    journal_title:European heart journal

    pub_type: 杂志文章


    authors: Droste C,Lemmen S,Nitsche R,Betz P,Birnbaum D,Roskamm H

    更新日期:1988-12-01 00:00:00

  • Investigation of impaired coronary vasodilator reserve in the guinea pig heart with pressure induced hypertrophy.

    abstract::Impaired coronary reserve and increased minimal coronary resistance have been documented in several animal models of left ventricular hypertrophy. There is controversy whether the increased minimal coronary resistance is due to vascular or extravascular causes. To test the hypothesis that pressure-overloaded left vent...

    journal_title:European heart journal

    pub_type: 杂志文章,评审


    authors: O'Gorman DJ,Thomas P,Turner MA,Sheridan DJ

    更新日期:1992-05-01 00:00:00