Is the A1166C polymorphism of the angiotensin II type 1 receptor involved in cardiovascular disease?

abstract：:Large-scale randomized clinical trials have established the efficacy of cholesterol-lowering, blood pressure-lowering, and anti-platelet therapy to prevent cardiovascular diseases. A challenge for clinicians is to apply group-level evidence from these trials to individual patients. Trials typically report a single tre...

journal_title：European heart journal

authors： van der Leeuw J,Ridker PM,van der Graaf Y,Visseren FL

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Electrocardiographic abnormalities and premature ventricular contractions are common in athletes and are generally benign. However, the specific outcome of high-level endurance athletes with frequent and complex ventricular arrhythmias is unclear. Also, information on the predictive accuracy of different inv...

journal_title：European heart journal

authors： Heidbüchel H,Hoogsteen J,Fagard R,Vanhees L,Ector H,Willems R,Van Lierde J

更新日期：2003-08-01 00:00:00

abstract：:We investigated whether left ventricular hypertrophy in elite cyclists is associated with functional changes or abnormal energy metabolism. Left ventricular hypertrophy is a powerful risk factor for sudden cardiac death with different prognostic significance among the various geometric forms. Cyclists may have a combi...

journal_title：European heart journal

authors： Pluim BM,Chin JC,De Roos A,Doornbos J,Siebelink HM,Van der Laarse A,Vliegen HW,Lamerichs RM,Bruschke AV,Van der Wall EE

更新日期：1996-08-01 00:00:00

abstract：AIM:To investigate fatalities from myocardial infarction at 28 days and one-year among patients aged 35-64 years in the Nordic and Lithuanian centres participating in the World Health Organization MONICA (Monitoring of Trends and Determinants of Cardiovascular Disease) Project. METHODS AND RESULTS:Altogether 9100 myoc...

journal_title：European heart journal

authors： Salomaa VV,Lundberg V,Agnarsson U,Radisauskas R,Kirchhoff M,Wilhelmsen L

更新日期：1997-01-01 00:00:00

abstract：:Morphological changes in human myocardium associated with pressure overload-induced left ventricular hypertrophy were studied in 22 normal and 21 hypertrophic hearts obtained at autopsy. Samples were obtained from the left lateral ventricular wall, half way between the apex and the base. Myocyte dimensions, polyploidi...

journal_title：European heart journal

authors： Vliegen HW,van der Laarse A,Cornelisse CJ,Eulderink F

更新日期：1991-04-01 00:00:00

abstract：:This study analyses the immediate outcome and the risk of recurrent restenosis in patients who, at the time of repeat coronary angioplasty for a first restenosis, had unstable (n = 50), 19%) or stable (n = 218, 81%) angina. Successful angioplasty was accomplished in 250 (93%) patients, 222 (89%) of whom had follow-up ...

journal_title：European heart journal

authors： Bauters C,Lablanche JM,McFadden EP,Leroy F,Bertrand ME

更新日期：1993-02-01 00:00:00

abstract：AIMS:To assess EuroSCORE performance in predicting in-hospital mortality in on-pump coronary artery bypass grafting (CABG) and off-pump coronary artery bypass grafting (OPCAB). METHODS AND RESULTS:Additive and logistic EuroSCORE were computed for consecutive patients undergoing CABG (n = 3440, 75%) or OPCAB (n = 1140,...

journal_title：European heart journal

authors： Parolari A,Pesce LL,Trezzi M,Loardi C,Kassem S,Brambillasca C,Miguel B,Tremoli E,Biglioli P,Alamanni F

更新日期：2009-02-01 00:00:00

abstract：:Percutaneous excimer laser coronary angioplasty (ELCA) was performed in a first group of 20 patients with stable angina pectoris caused by significant coronary stenosis, and long-term follow-up was evaluated. Prototype 4 to 5.5 French multifibre catheters with 18-20 quartz fibres of 100 microns diameter, concentricall...

journal_title：European heart journal

authors： Kochs M,Haerer W,Eggeling T,Hoeher M,Schmidt A,Hombach V

更新日期：1992-03-01 00:00:00

abstract：AIMS:The cardiac extracellular matrix is highly involved in regulating inflammation, remodelling, and function of the heart. Whether matrix alterations relate to the degree of inflammation, fibrosis, and overall rejection in the human transplanted heart remained, until now, unknown. METHODS AND RESULTS:Expression of m...

journal_title：European heart journal

authors： Vanhoutte D,van Almen GC,Van Aelst LN,Van Cleemput J,Droogné W,Jin Y,Van de Werf F,Carmeliet P,Vanhaecke J,Papageorgiou AP,Heymans S

更新日期：2013-07-01 00:00:00

abstract：AIMS:Adverse left ventricular (LV) remodelling after myocardial infarction (MI) frequently leads to congestive heart failure (CHF). We have previously shown that myocardial beta-adrenoceptor density (beta-ARD) is reduced soon after acute MI and correlates with LV dilatation in the short term. The aim of the present stu...

journal_title：European heart journal

authors： Gaemperli O,Liga R,Spyrou N,Rosen SD,Foale R,Kooner JS,Rimoldi OE,Camici PG

更新日期：2010-07-01 00:00:00

abstract：:Sequential alterations of left ventricular volumes and haemodynamics were studied in 29 patients between 4 days and 4 weeks after myocardial infarction. Left ventricular volume was determined by single photon emission computerized tomography (SPECT), infarct size by creatine kinase (CK) analysis, angiography and thall...

journal_title：European heart journal

authors： Gaudron P,Eilles C,Ertl G,Kochsiek K

更新日期：1990-04-01 00:00:00

abstract：AIMS:Myocarditis is a potentially fatal complication of immune checkpoint inhibitors (ICI). Sparse data exist on the use of cardiovascular magnetic resonance (CMR) in ICI-associated myocarditis. In this study, the CMR characteristics and the association between CMR features and cardiovascular events among patients with...

journal_title：European heart journal

authors： Zhang L,Awadalla M,Mahmood SS,Nohria A,Hassan MZO,Thuny F,Zlotoff DA,Murphy SP,Stone JR,Golden DLA,Alvi RM,Rokicki A,Jones-O'Connor M,Cohen JV,Heinzerling LM,Mulligan C,Armanious M,Barac A,Forrestal BJ,Sullivan RJ,

更新日期：2020-05-07 00:00:00

abstract：:Modern-day stenting procedures leverage advances in pharmacotherapy and device innovation. Patients treated with contemporary antiplatelet agents, peri-procedural antithrombin therapy and new-generation drug-eluting stents (DES) have excellent outcomes over the short to medium term. Indeed, coupled with the reducing c...

journal_title：European heart journal

authors： Byrne RA,Joner M,Kastrati A

更新日期：2015-12-14 00:00:00

abstract：:Orally active angiotensin converting enzyme (ACE) inhibitors have been successfully used in the treatment of congestive heart failure and hypertension. However, adverse skin reactions, such as angioneurotic oedema have been reported following such medication. Furthermore, these drugs have been associated with a persis...

journal_title：European heart journal

authors： Andersson RG,Persson K

更新日期：1994-08-01 00:00:00

abstract：AIMS:we investigated the relationship between sublingual perfused capillary density (PCD) as a measure of tissue perfusion and outcome (i.e. occurrence of organ failure and mortality) in patients with cardiogenic shock from acute myocardial infarction. METHODS AND RESULTS:we performed a prospective study in 68 patient...

journal_title：European heart journal

authors： den Uil CA,Lagrand WK,van der Ent M,Jewbali LS,Cheng JM,Spronk PE,Simoons ML

更新日期：2010-12-01 00:00:00

abstract：AIMS:Induced pluripotent stem cells (iPSCs) provide a unique opportunity for the generation of patient-specific cells for use in disease modelling, drug screening, and regenerative medicine. The aim of this study was to compare human-induced pluripotent stem cells (hiPSCs) derived from different somatic cell sources re...

journal_title：European heart journal

authors： Streckfuss-Bömeke K,Wolf F,Azizian A,Stauske M,Tiburcy M,Wagner S,Hübscher D,Dressel R,Chen S,Jende J,Wulf G,Lorenz V,Schön MP,Maier LS,Zimmermann WH,Hasenfuss G,Guan K

更新日期：2013-09-01 00:00:00

abstract：AIMS:This investigation was set up to study the prevalence of left ventricular hypertrophy in a hypertensive population with reference to a normotensive control group. From the general population 3498 men and women aged 35, 45, 55 and 65 years old were invited to a health examination. Participants with blood pressure a...

journal_title：European heart journal

authors： Tingleff J,Munch M,Jakobsen TJ,Torp-Pedersen C,Olsen ME,Jensen KH,Jørgensen T,Kirchoff M

更新日期：1996-01-01 00:00:00

abstract：:In order to compare different criteria for the definition of late potentials in patients after myocardial infarction, three signal averaged ECG variables, duration of the signal-averaged QRS complex (QRS), root-mean-square voltage of the terminal 40 ms (RMS-40), and the duration of low amplitude signals less than 40 m...

journal_title：European heart journal

authors： Malik M,Odemuyiwa O,Poloniecki J,Kulakowski P,Farrell T,Staunton A,Camm AJ

更新日期：1992-05-01 00:00:00

abstract：:In the adult cardiac myocyte the functional and structural integrity of the sarcolemma depends on the presence of calcium ions in the extracellular fluid. Ultrastructural damage to the myocardial cell after Ca is repleted following brief periods of Ca depletion includes (1) sarcolemmal disruption, (2) mitochondrial da...

journal_title：European heart journal

authors： Frank JS

更新日期：1983-12-01 00:00:00

abstract：AIMS:We investigated the influence of type one cannabinoid receptor (CB1) deficiency on acute heart failure (AHF) and the underlying mechanism. Acute heart failure syndrome is an important clinical problem because of its high morbidity and mortality rates. Activation of CB1 induces vascular dilation and reinforces the ...

journal_title：European heart journal

authors： Liao Y,Bin J,Asakura M,Xuan W,Chen B,Huang Q,Xu D,Ledent C,Takashima S,Kitakaze M

更新日期：2012-12-01 00:00:00

abstract：AIMS:The relative benefits of computed tomography coronary angiography (CTCA)-guided management in women and men with suspected angina due to coronary heart disease (CHD) are uncertain. METHODS AND RESULTS:In this post hoc analysis of an open-label parallel-group multicentre trial, we recruited 4146 patients referred ...

journal_title：European heart journal

authors： Mangion K,Adamson PD,Williams MC,Hunter A,Pawade T,Shah ASV,Lewis S,Boon NA,Flather M,Forbes J,McLean S,Roditi G,van Beek EJR,Timmis AD,Newby DE,McAllister DA,Berry C

更新日期：2020-04-01 00:00:00

abstract：:Clinical reports show that electrical stimulation of the spinal cord reduces symptoms of angina pectoris, but so far have not provided evidence on the mechanisms involved. The hypothesis for this study was that inhibition of spinothalamic tract transmission may account for this result. Extracellular potentials of 28 s...

journal_title：European heart journal

authors： Chandler MJ,Brennan TJ,Garrison DW,Kim KS,Schwartz PJ,Foreman RD

更新日期：1993-01-01 00:00:00

abstract：:The electrocardiographic patterns, observed during 24-h Holter monitoring, of 10 patients (mean age 35 +/- 22 years) with first and second degree A-V block due to dual A-V nodal pathways are reported. Recordings were selected according to the presence of: sudden and persistent prolongation of the PR interval: sudden n...

journal_title：European heart journal

authors： Di Biase M,Tritto M,Sabato G,Pitzalis MV,Rizzon P

更新日期：1991-03-01 00:00:00

abstract：AIMS:No-reflow after a primary percutaneous coronary intervention (PCI) is associated with a high incidence of left ventricular (LV) failure and a poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and an important modulator of neutrophil function. Elevated systemic ET-1 levels ...

journal_title：European heart journal

authors： Niccoli G,Lanza GA,Shaw S,Romagnoli E,Gioia D,Burzotta F,Trani C,Mazzari MA,Mongiardo R,De Vita M,Rebuzzi AG,Lüscher TF,Crea F

更新日期：2006-08-01 00:00:00

abstract：AIM:The purpose of this study was to assess the relationship between pulse pressure (PP) and cardiovascular outcomes in a large, elderly, coronary artery disease (CAD) population with hypertension, and compare the predictive power of PP with other blood pressure measures. METHODS AND RESULTS:In INternational VErapamil...

journal_title：European heart journal

authors： Bangalore S,Messerli FH,Franklin SS,Mancia G,Champion A,Pepine CJ

更新日期：2009-06-01 00:00:00

abstract：AIMS:Coronary plaque characteristics are associated with ischaemia. Differences in plaque volumes and composition may explain the discordance between coronary stenosis severity and ischaemia. We evaluated the association between coronary stenosis severity, plaque characteristics, coronary computed tomography angiograph...

journal_title：European heart journal

authors： Gaur S,Øvrehus KA,Dey D,Leipsic J,Bøtker HE,Jensen JM,Narula J,Ahmadi A,Achenbach S,Ko BS,Christiansen EH,Kaltoft AK,Berman DS,Bezerra H,Lassen JF,Nørgaard BL

更新日期：2016-04-14 00:00:00

abstract：:Echocardiographic parameters of left ventricular (LV) function were compared with the electrocardiographic findings in 40 patients with chronic severe aortic regurgitation. Total 12-lead QRS amplitude was linearly correlated with LV mass and its 'relative reduction' (less than 250 mm) indicated LV hypertrophy. Patient...

journal_title：European heart journal

authors： Scognamiglio R,Fasoli G,Bruni A,Dalla-Volta S

更新日期：1988-01-01 00:00:00

abstract：:To assess the prevalence of asymmetric septal hypertrophy (ASH) in hypertensive patients, 613 echocardiographic examinations performed over a period of one year were reviewed. Asymmetric septal hypertrophy (defined by an echocardiographic interventricular septum to left ventricular free wall thickness ratio of greater...

journal_title：European heart journal

authors： Wicker P,Roudaut R,Haissaguere M,Villega-Arino P,Clementy J,Dallocchio M

更新日期：1983-11-01 00:00:00

abstract：AIMS:Although embolic protection devices reduce complications during saphenous vein graft (SVG) stenting, adverse events still occur in approximately 10% of patients. IIb/IIIa antagonists have not been proven effective during SVG intervention. We hypothesized that adjunctive use of these agents might enhance the effica...

journal_title：European heart journal

authors： Jonas M,Stone GW,Mehran R,Hermiller J,Feldman R,Herrmann HC,Cox DA,Kuntz RE,Popma JJ,Rogers C,FilterWire EX Randomized Evalulation (FIRE) Investigators.

更新日期：2006-04-01 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) represents an important phenotype among the broader spectrum of patients with heart failure with preserved ejection fraction (HFpEF), but its mechanistic basis remains unclear. We hypothesized that activation of endothelin and adrenomedullin, two counterregulatory pathways important in ...

journal_title：European heart journal

authors： Obokata M,Kane GC,Reddy YNV,Melenovsky V,Olson TP,Jarolim P,Borlaug BA

更新日期：2019-12-01 00:00:00