Calculation of the biological effective dose for piecewise defined dose-rate fits.

Abstract:

:An algorithmic solution to the biological effective dose (BED) calculation from the Lea-Catcheside formula for a piecewise defined function is presented. Data from patients treated for metastatic thyroid cancer were used to illustrate the solution. The Lea-Catcheside formula for the G-factor of the BED is integrated numerically using a large number of small trapezoidal fits to each integral. The algorithmically calculated BED is compatible with an analytic calculation for a similarly valued exponentially fitted dose-rate plot and is the only resolution for piecewise defined dose-rate functions.

journal_name

Med Phys

journal_title

Medical physics

authors

Hobbs RF,Sgouros G

doi

10.1118/1.3070587

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

904-7

issue

3

eissn

0094-2405

issn

2473-4209

journal_volume

36

pub_type

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