Potential animal models of lacunar stroke: a systematic review.

abstract：BACKGROUND AND PURPOSE:Autopsy series of patients with AIDS have found a 4% to 29% prevalence of cerebral infarction. Little is known of the prevalence of cerebral infarction when not associated with non-HIV central nervous system (CNS) infection, lymphoma, or cardioembolic sources. Clinical correlation has seldom been...

journal_title：Stroke

authors： Connor MD,Lammie GA,Bell JE,Warlow CP,Simmonds P,Brettle RD

更新日期：2000-09-01 00:00:00

abstract：:Background and Purpose- The aim of the present study was to evaluate the relationship between normal-appearing white matter (NAWM) integrity and postischemic stroke recovery in 4 main domains including cognition, mood, gait, and dependency. Methods- A prospective study was conducted, including patients diagnosed for a...

journal_title：Stroke

authors： Sagnier S,Catheline G,Dilharreguy B,Linck PA,Coupé P,Munsch F,Bigourdan A,Debruxelles S,Poli M,Olindo S,Renou P,Rouanet F,Dousset V,Berthoz S,Tourdias T,Sibon I

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Disturbed cerebral autoregulation has been reported to correlate with an unfavorable outcome after head injury. Using transcranial Doppler ultrasonography, we investigated whether hemodynamic responses to spontaneous variations of cerebral perfusion pressure (CPP) provide reliable information on ...

journal_title：Stroke

authors： Czosnyka M,Smielewski P,Kirkpatrick P,Menon DK,Pickard JD

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between nimodipine-induced reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to confirm this correlation with and without adjustment for prognostic variables and to investigate ...

journal_title：Stroke

authors： Ahmed N,Näsman P,Wahlgren NG

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuroradiological characteristics and functional outcomes of patients with intracerebral hemorrhage (ICH) during novel oral anticoagulant treatment were not well defined. We examined these in comparison with those during warfarin treatment. METHODS:The consecutive 585 patients with ICH admitted ...

journal_title：Stroke

authors： Hagii J,Tomita H,Metoki N,Saito S,Shiroto H,Hitomi H,Kamada T,Seino S,Takahashi K,Baba Y,Sasaki S,Uchizawa T,Iwata M,Matsumoto S,Osanai T,Yasujima M,Okumura K

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The results of previous studies suggest that early goal-directed fluid therapy (EGDT) reduces delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage, but the effects of EGDT on clinical outcomes are still unclear. This study aimed to determine whether EGDT improves outcomes comp...

journal_title：Stroke

authors： Mutoh T,Kazumata K,Terasaka S,Taki Y,Suzuki A,Ishikawa T

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of fibrinolysis, and high levels may increase the risk of cardiovascular disease. The 4G/5G polymorphism affects PAI-1 gene transcription with lower levels of plasma PAI-1 in the presence of the 5G allele. We investigated whethe...

journal_title：Stroke

authors： Hoekstra T,Geleijnse JM,Kluft C,Giltay EJ,Kok FJ,Schouten EG

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:It is known that atherosclerosis does not involve both carotid arteries to the same extent. Pathological investigations have demonstrated that lesions develop in regions of low wall shear stress. The aims of the present study were to verify the degree of carotid atherosclerosis asymmetry in a pop...

journal_title：Stroke

authors： Gnasso A,Irace C,Carallo C,De Franceschi MS,Motti C,Mattioli PL,Pujia A

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Silent cerebrovascular disease (CVD) has been proposed as a predisposing condition for clinically overt stroke and vascular dementia. Recently, we found increased thrombin generation in silent CVD patients. Here, we report the effect of thrombin inhibition using a potent selective thrombin inhibi...

journal_title：Stroke

authors： Kario K,Matsuo T,Hoshide S,Umeda Y,Shimada K

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The current work is based on our previous finding that in neuronal cells, nmol/L concentrations of alpha-tocotrienol (TCT), but not alpha-tocopherol (TCP), blocked glutamate-induced death by suppressing early activation of c-Src kinase and 12-lipoxygenase. METHODS:The single neuron microinjectio...

journal_title：Stroke

authors： Khanna S,Roy S,Slivka A,Craft TK,Chaki S,Rink C,Notestine MA,DeVries AC,Parinandi NL,Sen CK

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Previous research has reported worse outcomes after stroke for women and for African Americans, but few prospective population-based studies have systematically examined demographic differences on long-term stroke outcomes. Race and gender differences in 1-year stroke outcomes were examined using...

journal_title：Stroke

authors： Roth DL,Haley WE,Clay OJ,Perkins M,Grant JS,Rhodes JD,Wadley VG,Kissela B,Howard G

更新日期：2011-03-01 00:00:00

abstract：:The nature of alpha-adrenergic receptors in human cerebral arteries was characterized, and alteration of these receptors after subarachnoid hemorrhage was examined using a radioligand binding assay. Norepinephrine content of control arteries was also analyzed and compared with that of arteries after subarachnoid hemor...

journal_title：Stroke

authors： Tsukahara T,Taniguchi T,Miwa S,Shimohama S,Fujiwara M,Nishikawa M,Handa H

更新日期：1988-01-01 00:00:00

abstract：:The double subarachnoid hemorrhage canine model was used to test the prophylactic value of immunosuppression in the prevention of cerebral vasospasm after subarachnoid hemorrhage. Dogs treated with cyclosporine A following the regimen prescribed for organ transplant procedures in patients showed a significant reductio...

journal_title：Stroke

authors： Peterson JW,Nishizawa S,Hackett JD,Bun T,Teramura A,Zervas NT

更新日期：1990-01-01 00:00:00

abstract：:We devised the present experiments to assess the effects of ischemia on the production of dopamine in the caudate nucleus of spontaneously hypertensive stroke-resistant rats. Ringer's solution was continuously perfused at a rate of 10 microliters/min through 0.2-mm-diameter dialysis tubing implanted in the rat's cauda...

journal_title：Stroke

authors： Kawano T,Tsutsumi K,Miyake H,Mori K

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials evaluated the safety and efficacy of thrombectomy in the treatment of intracranial arterial occlusions within 8 hours of symptom onset. We sought to determine the predictors of clinical and angiographic outcomes in...

journal_title：Stroke

authors： Nogueira RG,Liebeskind DS,Sung G,Duckwiler G,Smith WS,MERCI.,Multi MERCI Writing Committee.

更新日期：2009-12-01 00:00:00

abstract：:Five patients studied by the authors and 28 mentioned in the literature indicate that recurrent stenosis occurs in no less than 0.6% of patients after carotid endarterectomy. The pathology of the recurrent stenosis was stated in only 10 cases indicating atherosclerotic disease in various stages of development in 7 and...

journal_title：Stroke

authors： French BN,Rewcastle NB

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Vertebrobasilar territory ischemia (VBI) leads to disabling neurological symptoms and poses a risk for stroke by an embolic or flow-related mechanism. We present our clinical experience in the endovascular treatment of patients with symptomatic VBI from severe atherosclerosis or dissection of the...

journal_title：Stroke

authors： Malek AM,Higashida RT,Phatouros CC,Lempert TE,Meyers PM,Gress DR,Dowd CF,Halbach VV

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Hyperpolarization of vascular muscle in response to activation of potassium channels is a major mechanism of vasodilatation. In cerebral blood vessels, four different potassium channels have been described: ATP-sensitive potassium channels, calcium-activated potassium channels, delayed rectifier potassium ch...

journal_title：Stroke

authors： Kitazono T,Faraci FM,Taguchi H,Heistad DD

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:We aimed to clarify the association of chronic kidney disease (CKD) with carotid atherosclerosis and the impact of CKD on carotid atherosclerosis according to blood pressure categories in an urban general population. METHODS:We studied 3466 Japanese individuals (35-93 years old) in the Suita Stu...

journal_title：Stroke

authors： Ohara T,Kokubo Y,Toyoda K,Watanabe M,Koga M,Nakamura S,Nagatsuka K,Minematsu K,Nakagawa M,Miyamoto Y

更新日期：2013-12-01 00:00:00

abstract：:Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experienc...

journal_title：Stroke

authors： Yenari MA,Hemmen TM

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The pressure-flow relation has been characterized in normal cerebrum, but it has not been studied in cerebrum dependent on collateral flow. The purpose of this investigation was to examine the relation between systemic pressure, regional cerebral blood flow, and middle cerebral artery branch pres...

journal_title：Stroke

authors： Muhonen MG,Sawin PD,Loftus CM,Heistad DD

更新日期：1992-07-01 00:00:00

abstract：:Background and Purpose- Although obesity is an established risk factor for cardiovascular disease and stroke, studies have shown evidence of an obesity paradox-a protective effect of obesity in patients who already have these disease states. Data on the obesity paradox in intracerebral hemorrhage is limited. Methods- ...

journal_title：Stroke

authors： Persaud SR,Lieber AC,Donath E,Stingone JA,Dangayach NS,Zhang X,Mocco J,Kellner CP

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Efficacy of intravenous thrombolysis in acute ischemic stroke declines with increasing time to treatment initiation. Previous small-scale studies suggested that the earlier patients arrive, the longer it takes to administer recombinant tissue plasminogen activator. METHODS:Of 32 529 patients wit...

journal_title：Stroke

authors： Ferrari J,Knoflach M,Kiechl S,Willeit J,Matosevic B,Seyfang L,Lang W,Austrian Stroke Unit Registry Collaborators.

更新日期：2010-09-01 00:00:00

abstract：:Perforating branches of the middle cerebral arteries (MCA) were examined on the forebrain hemispheres of fourteen human brains. It was noticed that their intracerebral segments arose from the MCA main trunk, and its terminal and collateral (cortical) branches. They terminated in certain parts of the basal ganglia and ...

journal_title：Stroke

authors： Marinkovic SV,Milisavljevic MM,Kovacevic MS,Stevic ZD

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The consequences of stroke are a major health concern. This study was conducted to compare the health-related quality of life among long-term survivors of stroke with that of the general population. METHODS:Our data are taken from a population-based case-control study of all 6-year survivors of ...

journal_title：Stroke

authors： Hackett ML,Duncan JR,Anderson CS,Broad JB,Bonita R

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND AND PURPOSE:To investigate the incidence of retrograde flow from complex plaques (> or =4-mm-thick, ulcerated, or superimposed thrombi) of the descending aorta (DAo) and its potential role in embolic stroke. METHODS:Ninety-four consecutive acute stroke patients with aortic plaques > or =3-mm-thick in transe...

journal_title：Stroke

authors： Harloff A,Simon J,Brendecke S,Assefa D,Helbing T,Frydrychowicz A,Weber J,Olschewski M,Strecker C,Hennig J,Weiller C,Markl M

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND PURPOSE:On the assumption that the majority of lacunes are caused by small-vessel diseases and that pial artery infarcts arise from cardio-embolic or large-vessel diseases, 194 patients from the Berlin Cerebral Ischemia Data Bank with either lacunar or pial artery infarcts were analyzed for the frequency...

journal_title：Stroke

authors： Mast H,Thompson JL,Völler H,Mohr JP,Marx P

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:A pulsatility index (PI) represents vascular resistance distal to an examined artery. The purpose of the present study was to evaluate an association between plasma total homocysteine (tHcy) and PIs of the cerebral arteries in patients with ischemic stroke. METHODS:Consecutive patients with isch...

journal_title：Stroke

authors： Lim MH,Cho YI,Jeong SK

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Using the dexamethasone suppression test, we studied the suppressibility of the cortisol axis and its clinical determinants at various time points after stroke. A major aim was to examine the dexamethasone test as a diagnostic tool for the diagnosis of major depression in stroke patients. METHOD...

journal_title：Stroke

authors： Aström M,Olsson T,Asplund K

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Because no population-based estimates are available for asymptomatic retinal emboli, we aimed to assess prevalence and associations of this sign in a defined older Australian urban population. METHODS:A total of 3654 persons aged 49 years or older, representing 82% of residents in an urban area ...

journal_title：Stroke

authors： Mitchell P,Wang JJ,Li W,Leeder SR,Smith W

更新日期：1997-01-01 00:00:00