Different linkage of depression to hypercortisolism early versus late after stroke. A 3-year longitudinal study.

Abstract:

BACKGROUND AND PURPOSE:Using the dexamethasone suppression test, we studied the suppressibility of the cortisol axis and its clinical determinants at various time points after stroke. A major aim was to examine the dexamethasone test as a diagnostic tool for the diagnosis of major depression in stroke patients. METHODS:The dexamethasone suppression test, major depression, functional ability, and disorientation were assessed in a cohort of 70 patients with acute stroke and after 3 months (n = 63) and 3 years (n = 43). RESULTS:Early after stroke, 24% of the patients were nonsuppressors, with about the same proportion at 3 months (22%) and 3 years (21%). None of the controls (17 healthy elderly volunteers) were nonsuppressors. High cortisol levels early after stroke were significantly associated with functional impairment (r = 0.35; p = 0.003) and disorientation (r = 0.27; p = 0.03). Three years after stroke, high postdexamethasone cortisol levels were significantly associated with major depression (r = 0.57; p < 0.001). The sensitivity of the dexamethasone test was 70% and the specificity 97%. In a longitudinal analysis of the long-term survivors (n = 42), postdexamethasone cortisol values at 3 months predicted major depression at 3 years. CONCLUSIONS:Hypercortisolism is associated with major depression late (3 years) but not early (0-3 months) after stroke. Patients with hypercortisolism 3 months after stroke are at risk of major depression later in the course and warrant careful follow-up from a psychiatric viewpoint.

journal_name

Stroke

journal_title

Stroke

authors

Aström M,Olsson T,Asplund K

doi

10.1161/01.str.24.1.52

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

52-7

issue

1

eissn

0039-2499

issn

1524-4628

journal_volume

24

pub_type

杂志文章

相关文献

STROKE文献大全
  • Medial medullary infarction from fibrocartilaginous embolism to the anterior spinal artery.

    abstract::A previously healthy young woman presented with sudden onset of quadriplegia, anesthesia below the C3 dermatome, respiratory paralysis, vertical nystagmus, ocular bobbing and cortical blindness. After partial resolution of the latter deficits, she remained quadriplegic, with a C3 level of anesthesia, and in respirator...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.3.413

    authors: Kase CS,Varakis JN,Stafford JR,Mohr JP

    更新日期:1983-05-01 00:00:00

  • Hemolysate-induced contraction in smooth muscle cells of the guinea pig basilar artery.

    abstract::The hemolysate (10(-5)-10(-2) times dilution; original hemoglobin concentration was 0.83 +/- 0.10 X 10(-3)M) evoked the contraction in a dose dependent manner, and this contraction was composed of low and high sensitive responses as estimated from the Eadie-Hofstee's plot. Indomethacin (10(-7)-10(-5)M) inhibited the l...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.15.3.503

    authors: Fujiwara S,Kuriyama H

    更新日期:1984-05-01 00:00:00

  • Association of Blood Pressure With Short- and Long-Term Functional Outcome After Stroke Thrombectomy: Post Hoc Analysis of the SIESTA Trial.

    abstract:BACKGROUND AND PURPOSE:Outcome after mechanical thrombectomy for ischemic stroke may be influenced by blood pressure (BP). This study aims to assess the association of BP changes during general anesthesia versus conscious sedation with functional outcome after mechanical thrombectomy. METHODS:SIESTA (Sedation vs Intub...

    journal_title:Stroke

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/STROKEAHA.117.019709

    authors: Schönenberger S,Uhlmann L,Ungerer M,Pfaff J,Nagel S,Klose C,Bendszus M,Wick W,Ringleb PA,Kieser M,Möhlenbruch MA,Bösel J

    更新日期:2018-06-01 00:00:00

  • Critical appraisal of the design and reporting of studies of imaging and measurement of carotid stenosis.

    abstract:BACKGROUND AND PURPOSE:Several hundred studies have been published over the last few years on imaging and measurement of carotid stenosis. Despite all this research, there is still no consensus about how best to image and measure stenosis. One possible explanation for this is that many of the studies have not been larg...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/01.str.31.6.1444

    authors: Rothwell PM,Pendlebury ST,Wardlaw J,Warlow CP

    更新日期:2000-06-01 00:00:00

  • Arterial stiffness, cognitive decline, and risk of dementia: the Rotterdam study.

    abstract:BACKGROUND AND PURPOSE:Arterial stiffness is associated with an increased risk of myocardial infarction and stroke, independent of classical vascular risk factors. Vascular factors and stroke are associated with cognitive function and dementia. We examined whether arterial stiffness was independently associated with co...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000257998.33768.87

    authors: Poels MM,van Oijen M,Mattace-Raso FU,Hofman A,Koudstaal PJ,Witteman JC,Breteler MM

    更新日期:2007-03-01 00:00:00

  • Postprandial and orthostatic cardiovascular changes after acute stroke.

    abstract:BACKGROUND AND PURPOSE:Large falls in blood pressure after meals have been demonstrated in fit and frail elderly subjects; these changes may be associated with an increased incidence of stroke. Postprandial falls in BP may be particularly deleterious after acute stroke, when normal baroreflex mechanisms and cerebral au...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.26.10.1811

    authors: Robinson TG,Potter JF

    更新日期:1995-10-01 00:00:00

  • Tumor-Like Presentation of Primary Angiitis of the Central Nervous System.

    abstract:BACKGROUND AND PURPOSE:We aimed to describe the clinical and imaging features of patients with tumor-like presentation of primary angiitis of the central nervous system. METHODS:We retrospectively analyzed 10 patients enrolled in the French primary angiitis of the central nervous system cohort, who initially presented...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.013917

    authors: de Boysson H,Boulouis G,Dequatre N,Godard S,Néel A,Arquizan C,Detante O,Bloch-Queyrat C,Zuber M,Touzé E,Bienvenu B,Aouba A,Guillevin L,Naggara O,Pagnoux C,French Vasculitis Study Group.

    更新日期:2016-09-01 00:00:00

  • Which time-to-peak threshold best identifies penumbral flow? A comparison of perfusion-weighted magnetic resonance imaging and positron emission tomography in acute ischemic stroke.

    abstract:BACKGROUND AND PURPOSE:In acute ischemic stroke, the hypoperfused but viable tissue is the main therapeutic target. In clinical routine, time-to-peak (TTP) maps are frequently used to estimate the hemodynamic compromise and to calculate the mismatch volume. We evaluated the accuracy of TTP maps to identify penumbral fl...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000147043.29399.f6

    authors: Sobesky J,Zaro Weber O,Lehnhardt FG,Hesselmann V,Thiel A,Dohmen C,Jacobs A,Neveling M,Heiss WD

    更新日期:2004-12-01 00:00:00

  • Stroke and stroke care in China: huge burden, significant workload, and a national priority.

    abstract::At the same time as the world recognizes the rapid economic development in China, Chinese healthcare system has also had significant improvement. However, this nation of 1.4 billion faces tough challenges in treating stroke, the leading cause of death in China. The recently completed Chinese National Stroke Registry h...

    journal_title:Stroke

    pub_type: 杂志文章,评审

    doi:10.1161/STROKEAHA.111.635755

    authors: Liu L,Wang D,Wong KS,Wang Y

    更新日期:2011-12-01 00:00:00

  • Analysis of reproducibility and sensitivity of atraumatic measurements of regional cerebral blood flow in cerebrovascular diseases.

    abstract::We tested the reproducibility of consecutive measurements of regional cerebral blood flow (rCBF) made in 13 areas of each hemisphere in patients with cerebrovascular diseases by the atraumatic 133Xe intravenous injection method. The data were analysed by a two-compartment model similar to that used in the Obrist inhal...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.1.82

    authors: Meric P,Luft A,Seylaz J,Mamo H

    更新日期:1983-01-01 00:00:00

  • High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA.

    abstract:BACKGROUND AND PURPOSE:Severe cerebral edema is associated with poor outcome in patients with acute stroke. Experimental studies suggest that astrocytic endothelin-1 (ET-1) has deleterious effects on water homeostasis, cerebral edema, and blood brain barrier (BBB) integrity, which contribute to more severe ischemic bra...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.495044

    authors: Moldes O,Sobrino T,Millán M,Castellanos M,Pérez de la Ossa N,Leira R,Serena J,Vivancos J,Dávalos A,Castillo J

    更新日期:2008-07-01 00:00:00

  • Hemorrhagic complications of thrombolytic therapy in experimental stroke.

    abstract::Recent success with thrombolytic therapy for acute myocardial infarction has stimulated interest in its use for stroke. To determine the hemorrhagic potential of thrombolytic therapy in experimental cerebral infarction, we compared a group of tissue plasminogen activator-treated rabbits (n = 4) with 2 groups of strept...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.18.6.1148

    authors: Slivka A,Pulsinelli W

    更新日期:1987-11-01 00:00:00

  • Pseudocontinuous arterial spin labeling quantifies relative cerebral blood flow in acute stroke.

    abstract:BACKGROUND AND PURPOSE:The aim of this study was to test whether arterial spin labeling (ASL) can detect significant differences in relative cerebral blood flow (rCBF) in the core, mismatch, and reverse-mismatch regions, and whether rCBF values measured by ASL in those areas differ from values obtained using dynamic su...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.111.635979

    authors: Hernandez DA,Bokkers RP,Mirasol RV,Luby M,Henning EC,Merino JG,Warach S,Latour LL

    更新日期:2012-03-01 00:00:00

  • Burden of Intracranial Atherosclerosis Is Associated With Long-Term Vascular Outcome in Patients With Ischemic Stroke.

    abstract:BACKGROUND AND PURPOSE:Ischemic stroke patients often have intracranial atherosclerosis (ICAS), despite heterogeneity in the cause of stroke. We tested the hypothesis that ICAS burden can independently reflect the risk of long-term vascular outcome. METHODS:This was a retrospective cohort study analyzing data from a p...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.117.017806

    authors: Kim BS,Chung PW,Park KY,Won HH,Bang OY,Chung CS,Lee KH,Kim GM

    更新日期:2017-10-01 00:00:00

  • Sympathetic nervous activity and myocardial damage immediately after subarachnoid hemorrhage in a unique animal model.

    abstract:BACKGROUND AND PURPOSE:Obvious cardiac dysfunction, including ECG abnormalities and left ventricular asynergy, is known to develop after subarachnoid hemorrhage (SAH). To clarify the close relationship between myocardial damage and sympathetic nervous activity immediately after SAH, a novel experimental animal model wa...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.0000016327.74392.02

    authors: Masuda T,Sato K,Yamamoto S,Matsuyama N,Shimohama T,Matsunaga A,Obuchi S,Shiba Y,Shimizu S,Izumi T

    更新日期:2002-06-01 00:00:00

  • Cerebral thromboembolism among young women and men in Denmark 1977-1982.

    abstract::In the period 1977-1982, the Danish National Patient Register recorded 1000 cases of cerebral thromboembolic attacks among women 15-44 years of age, and 971 cases among men of the same age. Cerebral infarction accounted for 70% of cases and transient ischemic attacks (TIA) for the remaining 30%. By analysing this mate...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.17.4.670

    authors: Lidegaard O,Soe M,Andersen MV

    更新日期:1986-07-01 00:00:00

  • Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population.

    abstract:BACKGROUND AND PURPOSE:Disruption of the endothelial layer is the first step in the atherogenic process. Experimental studies have shown that endothelial progenitor cells (EPCs) are involved in endothelial homeostasis and repair. Conversely, EPC depletion has been demonstrated in the setting of established atherosclero...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.STR.0000236064.19293.79

    authors: Fadini GP,Coracina A,Baesso I,Agostini C,Tiengo A,Avogaro A,de Kreutzenberg SV

    更新日期:2006-09-01 00:00:00

  • Osteogenic protein-1 protects against cerebral infarction induced by MCA ligation in adult rats.

    abstract:BACKGROUND AND PURPOSE:Osteogenic protein-1 (OP1) not only possesses trophic activity on bone tissue but also influences neuronal survival and differentiation in vitro. Specific receptors for OP1 are present in brain and spinal cord and can be upregulated during cerebral contusion. OP1 is a member of the transforming g...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.1.126

    authors: Lin SZ,Hoffer BJ,Kaplan P,Wang Y

    更新日期:1999-01-01 00:00:00

  • CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.

    abstract:BACKGROUND AND PURPOSE:Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibition has been hypothesized to provide neuroprotective efficacy after cerebral ischemia on the basis of the activity in experimental ischemia models of a variety of compounds with varying selectivity for AMPA over other...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.0000048216.90221.9c

    authors: Menniti FS,Buchan AM,Chenard BL,Critchett DJ,Ganong AH,Guanowsky V,Seymour PA,Welch WM

    更新日期:2003-01-01 00:00:00

  • beta-amyloid load is not influenced by the severity of cardiovascular disease in aged and demented patients.

    abstract:BACKGROUND AND PURPOSE:This study was conducted to analyze the association between reported risk factors for Alzheimer's disease, apolipoprotein E epsilon4 allele, and cardiovascular disease and neuropathological changes essential for the diagnosis of Alzheimer's disease. METHODS:Our data are based on clinical and pos...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.30.3.613

    authors: Irina A,Seppo H,Arto M,Paavo R Sr,Hilkka S

    更新日期:1999-03-01 00:00:00

  • Hypertensive putaminal hemorrhage: treatment and results. Is surgical treatment superior to conservative one?

    abstract::Seventy-four patients with hypertensive putaminal hemorrhage (HPH) were followed at least 6 months after treatment and estimated by ADL. They were graded according to the state of consciousness on admission. The grading consists of 6 grades: Grade 1, fully conscious; Grade 2, somnolent; Grade 3, stuporous; Grade 4, se...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.14.4.480

    authors: Waga S,Yamamoto Y

    更新日期:1983-07-01 00:00:00

  • Effects of fluoxetine and maprotiline on functional recovery in poststroke hemiplegic patients undergoing rehabilitation therapy.

    abstract:BACKGROUND AND PURPOSE:In animals, drugs that increase brain amine concentrations influence the rate and degree of recovery from cortical lesions. It is therefore conceivable that antidepressants may influence outcome after ischemic brain injury in humans. We evaluated the effects of the norepinephrine reuptake blocker...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.str.27.7.1211

    authors: Dam M,Tonin P,De Boni A,Pizzolato G,Casson S,Ermani M,Freo U,Piron L,Battistin L

    更新日期:1996-07-01 00:00:00

  • Intravoxel Incoherent Motion Imaging in Small Vessel Disease: Microstructural Integrity and Microvascular Perfusion Related to Cognition.

    abstract:BACKGROUND AND PURPOSE:Cerebral small vessel disease (SVD) is associated with cognitive impairment. This may be because of decreased microstructural integrity and microvascular perfusion, but data on these relationships are scarce. We determined the relationship between cognition and microvascular perfusion and microst...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.116.015084

    authors: Zhang CE,Wong SM,Uiterwijk R,Staals J,Backes WH,Hoff EI,Schreuder T,Jeukens CR,Jansen JF,van Oostenbrugge RJ

    更新日期:2017-03-01 00:00:00

  • Homocyst(e)ine and risk of cerebral infarction in a biracial population : the stroke prevention in young women study.

    abstract:BACKGROUND AND PURPOSE:Genetic enzyme variation and vitamin intake are important determinants of blood homocyst(e)ine levels. The prevalence of common genetic polymorphisms influencing homocyst(e)ine levels varies by race, and vitamin intake varies by socioeconomic status. Therefore, we examined the effect of vitamin i...

    journal_title:Stroke

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.str.30.8.1554

    authors: Kittner SJ,Giles WH,Macko RF,Hebel JR,Wozniak MA,Wityk RJ,Stolley PD,Stern BJ,Sloan MA,Sherwin R,Price TR,McCarter RJ,Johnson CJ,Earley CJ,Buchholz DW,Malinow MR

    更新日期:1999-08-01 00:00:00

  • Damage to the Left Precentral Gyrus Is Associated With Apraxia of Speech in Acute Stroke.

    abstract:BACKGROUND AND PURPOSE:Apraxia of speech (AOS) is a motor speech disorder, which is clinically characterized by the combination of phonemic segmental changes and articulatory distortions. AOS has been believed to arise from impairment in motor speech planning/programming and differentiated from both aphasia and dysarth...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.115.010402

    authors: Itabashi R,Nishio Y,Kataoka Y,Yazawa Y,Furui E,Matsuda M,Mori E

    更新日期:2016-01-01 00:00:00

  • Impact of anatomic features in the endovascular embolization of 181 anterior communicating artery aneurysms.

    abstract:BACKGROUND AND PURPOSE:We analyzed the impact of detailed anatomic characteristics on the results of endovascular coil embolization for anterior communicating artery (AcoA) aneurysms and developed a predictive model estimating the probability of successful endovascular treatment. METHODS:One hundred eighty-one AcoA an...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.107.505222

    authors: Gonzalez N,Sedrak M,Martin N,Vinuela F

    更新日期:2008-10-01 00:00:00

  • A prospective study of cerebral ischemia in the young. Analysis of pathogenic determinants. The National Research Council Study Group.

    abstract:BACKGROUND AND PURPOSE:The etiology of stroke in the young is different from that in older patients and remains unknown in almost one third of the cases. To gain further insight into both pathogenic and etiologic determinants, we prospectively studied a large number of consecutive young adults with focal cerebral ische...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.24.3.362

    authors: Carolei A,Marini C,Ferranti E,Frontoni M,Prencipe M,Fieschi C

    更新日期:1993-03-01 00:00:00

  • Dietary nonprotein calories and cerebral infarction size in rats.

    abstract:BACKGROUND AND PURPOSE:Conventional diets may cause hyperglycemia in patients with neurological injuries. The purpose of this study was to examine the effect on the severity of cerebral infarction of replacing carbohydrates as the primary dietary source of nonprotein calories. METHODS:Sixty-nine Long-Evans rats were e...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.23.4.564

    authors: Robertson C,Goodman JC,Grossman RG,Claypool M,White A

    更新日期:1992-04-01 00:00:00

  • The incidence of cerebral venous thrombosis: a cross-sectional study.

    abstract:BACKGROUND AND PURPOSE:The purpose of this study was to determine the incidence of adult cerebral venous thrombosis. METHODS:A retrospective cross-sectional study was conducted among all 19 hospitals located in 2 Dutch provinces serving 3.1 million people. Adult cerebral venous thrombosis cases diagnosed between Janua...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/STROKEAHA.112.671453

    authors: Coutinho JM,Zuurbier SM,Aramideh M,Stam J

    更新日期:2012-12-01 00:00:00

  • Effect of intracarotid prostaglandin E1 on regional cerebral blood flow in man.

    abstract::The effect of prostaglandin E1 on regional cerebral blood flow (rCBF) was studied with the intra-arterial 133Xe method in ten awake patients under local anesthesia. Measurements were taken from 16 areas of a hemisphere in seven patients, from 35 areas of a hemisphere in two patients and from 256 areas of a hemisphere ...

    journal_title:Stroke

    pub_type: 杂志文章

    doi:10.1161/01.str.7.6.566

    authors: Olesen J

    更新日期:1976-11-01 00:00:00