Diagnostic Challenges of Acute Kidney Injury in Asia.

abstract：:The very limited ability of adult podocytes to proliferate in vivo is clinically significant because podocytes form a vascular barrier that is functionally critical to the nephron, podocyte hypoplasia is a characteristic of disease, and inadequate regeneration of podocytes is a major cause of persistent podocyte hypop...

journal_title：Seminars in nephrology

authors： Shankland SJ,Pippin JW,Duffield JS

更新日期：2014-07-01 00:00:00

abstract：:Cerebrovascular disease and stroke are very common at all stages of chronic kidney disease (CKD), likely representing both shared risk factors as well as synergy among risk factors. More subtle ischemic brain lesions may be particularly common in the CKD population, with subtle manifestations including cognitive impai...

journal_title：Seminars in nephrology

authors： Dad T,Weiner DE

更新日期：2015-07-01 00:00:00

abstract：:The mortality of end-stage renal disease (ESRD) patients, including those receiving long-term peritoneal dialysis (PD), has remained unacceptably high owing to the prevalence of cardiovascular disease. It is well recognized that both traditional Framingham risk factors and kidney disease-related risk factors may contr...

journal_title：Seminars in nephrology

authors： Wang AY

更新日期：2011-03-01 00:00:00

abstract：:The apical membrane epithelial Na(+) channel subunit (ENaC) in series with the basolateral Na(+)/K(+)-adenosine triphosphatase mediates collecting duct Na(+) reabsorption. Aldosterone induces αENaC gene transcription, which appears to be rate limiting for ENaC activity in this segment. Although this response has long ...

journal_title：Seminars in nephrology

authors： Kone BC

更新日期：2013-07-01 00:00:00

abstract：:Hotspots of chronic kidney disease of unknown etiology (CKDu) have been identified throughout the globe, of which the Mesoamerican nephropathy in Central America is the most conspicuous example. It affects mainly agricultural workers, heat exposure during extenuating shifts leading to sudden dehydration and subsequent...

journal_title：Seminars in nephrology

authors： Aguilar DJ,Madero M

更新日期：2019-05-01 00:00:00

abstract：:The association between increased uric acid (UA) levels and cardiovascular disease (CVD) has been observed and studied for many decades. The value of UA as an independent factor within the metabolic risk profile for prediction of CVD in the normal population remains an issue of ongoing discussion. In turn, increasing ...

journal_title：Seminars in nephrology

authors： Doehner W,Landmesser U

更新日期：2011-09-01 00:00:00

abstract：:The incidence of progressive kidney disease associated with diabetes continues to increase worldwide. Only partial renoprotection is achieved by current standard therapy with angiotensin-converting enzyme inhibitors and/or angiotensin-receptor blockers, increasing the need for novel therapeutic approaches. Experimenta...

journal_title：Seminars in nephrology

authors： Gagliardini E,Zoja C,Benigni A

更新日期：2015-03-01 00:00:00

abstract：:Angiotensin II maintains extracellular volume homeostasis, in part, by regulating proximal tubule transport. Physiological doses of angiotensin II stimulate volume and solute transport in the proximal tubule independent of changes in the glomerular filtration rate. Stimulation of bicarbonate transport primarily occurs...

journal_title：Seminars in nephrology

authors： Quan A,Baum M

更新日期：1997-09-01 00:00:00

abstract：:The search for an endogenous digitalis has led to the identification of the cardenolides ouabain and digoxin and the bufadienolide marinobufagenin in mammalian tissues and biological fluids. Ouabain's release from adrenal glands is under the control of epinephrine and angiotensin II; hence, its blood concentration cha...

journal_title：Seminars in nephrology

authors： Schoner W,Scheiner-Bobis G

更新日期：2005-09-01 00:00:00

abstract：:The human nuclear genome consists of approximately 3 billion nucleotides. Human beings are 99% similar in DNA sequence to each other, but natural genetic variation in approximately 1% of the DNA sequence is responsible for interindividual differences, including determining who will develop disease and who will remain ...

journal_title：Seminars in nephrology

authors： Iyengar SK,Adler SG

更新日期：2007-03-01 00:00:00

abstract：:Although calcitriol has been shown to have an important role in the pathogenesis of hyperparathyroidism, its use as a therapeutic agent often has been limited by calcemic and phosphatemic toxicity. Vitamin D analogs and the synthetic prohormones, with the potential to have lesser effects on calcium and phosphorus, hav...

journal_title：Seminars in nephrology

authors： Martin KJ,González EA

更新日期：2004-09-01 00:00:00

abstract：:Long-term continuous ambulatory peritoneal dialysis (CAPD) often causes peritoneal fibrosis and sclerosis with a loss of function, and some CAPD patients develop sclerosing encapsulating peritonitis. Glucose-based peritoneal dialysis fluids readily produce glucose degradation products by heat sterilization, and glucos...

journal_title：Seminars in nephrology

authors： Nakamura S,Niwa T

更新日期：2004-09-01 00:00:00

abstract：:Nephritic edema results from the primary retention of salt. Acute glomerulonephritis is the prototypical form of the disorder. The stimulus for the salt retention arises within the kidney by an unknown mechanism. As effective arterial blood volume (EABV) was normal at the start of the disease process, it becomes expan...

journal_title：Seminars in nephrology

authors： Kurtzman NA

更新日期：2001-05-01 00:00:00

abstract：:Diagnosis of aluminum-related bone disease in patients with renal failure often requires a bone biopsy. Percutaneous biopsy of the iliac crest has been safely carried out as an outpatient procedure in over 300 patients. No instances of significant bleeding or infection have occurred. The procedure was well accepted in...

journal_title：Seminars in nephrology

authors： Norris KC,Goodman WG,Howard N,Nugent ME,Coburn JW

更新日期：1986-12-01 00:00:00

abstract：:Neuroimmune interaction is an emerging concept, wherein the nervous system modulates the immune system and vice versa. This concept is gaining attention as a novel therapeutic target in various inflammatory diseases including acute kidney injury (AKI). Vagus nerve stimulation or treatment with pulsed ultrasound activa...

journal_title：Seminars in nephrology

authors： Tanaka S,Okusa MD

更新日期：2019-01-01 00:00:00

abstract：:In chronic kidney disease the excessive production of parathyroid hormone increases the bone resorption rate and leads to histologic bone signs of secondary hyperparathyroidism. However, in other situations, the initial increase in parathyroid hormone and bone remodeling may be slowed down excessively by a multitude o...

journal_title：Seminars in nephrology

authors： Torres PU,Bover J,Mazzaferro S,de Vernejoul MC,Cohen-Solal M

更新日期：2014-11-01 00:00:00

abstract：:The complement system consists of 3 pathways and more than 30 proteins, including those with biological activity that directly or indirectly mediate the effects of this system, plus a set of regulatory proteins necessary to prevent injudicious complement activation on host tissue. The role for complement in the pathog...

journal_title：Seminars in nephrology

authors： Bao L,Quigg RJ

更新日期：2007-01-01 00:00:00

abstract：:A number of antineoplastic chemotherapeutic drugs may produce fluid and electrolyte disturbances or nephrotoxic reactions extending across the clinical spectrum, from subclinical renal dysfunction to progressive chronic renal insufficiency to severe acute failure. Although some of the drugs that are highly nephrotoxic...

journal_title：Seminars in nephrology

authors： Berns JS,Ford PA

更新日期：1997-01-01 00:00:00

abstract：:Cell-based therapy, designed to promote angiogenesis and improve organ function, has been under investigation for the treatment of ischemic heart disease for more than 10 years. Although believed to work primarily by repairing the microvasculature, this form of therapy has not been examined in the setting of chronic k...

journal_title：Seminars in nephrology

authors： Gilbert RE,Zhang Y,Yuen DA

更新日期：2012-09-01 00:00:00

abstract：:In aggregate, the evidence reviewed here supports a very important role for PDGF expression and action at local glomerular and interstitial sites in human kidney development and disease. PDGF delivered by platelets, or produced by endogenous cells of the kidney is capable of stimulating responses including proliferati...

journal_title：Seminars in nephrology

authors： Daniel TO,Kumjian DA

更新日期：1993-01-01 00:00:00

abstract：:Cigarette smoking (CS) has been associated with augmented progression of nephropathies responsible for the 4 major causes of end-stage renal disease (ESRD) in the United States. CS has well-described ways by which it causes tissue injury in other organ systems and the mechanisms by which it adversely affects nephropat...

journal_title：Seminars in nephrology

authors： Wesson DE

更新日期：2003-05-01 00:00:00

abstract：:Stephen Hales was the first to measure blood pressure directly in the horse (1733), and the definitive studies on human nephrins by Richard Bright followed much later (1836). The relation between high blood pressure and renal disease was established by Mahomed (1872). The discovery of renin and its possible link with ...

journal_title：Seminars in nephrology

authors： Peart S

更新日期：2000-09-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on many systems, depending on the biologic setting. Retinoids are vitamin A derivatives that also have diverse effects in development, physiology, and disease. The interactions between thes...

journal_title：Seminars in nephrology

authors： Xu Q,Kopp JB

更新日期：2012-05-01 00:00:00

abstract：:Projected requirements for nephrology physicians indicate a need for an increase in the number of nephrology trainees. In addition, government regulations are creating the climate to diminish the entry of international medical graduates into all residency programs. To meet the needs of renal patients, especially those...

journal_title：Seminars in nephrology

authors： Levison SP

更新日期：1999-03-01 00:00:00

abstract：:Preeclampsia is a 2-stage disorder. Stage 1 is decreased placental perfusion and generates stage 2 of the disorder, the maternal syndrome characteristic of preeclampsia. How the 2 stages are linked has been a topic of intense investigation for many years. One candidate phenomenon, which includes many other suggested l...

journal_title：Seminars in nephrology

authors： Roberts JM,Speer P

更新日期：2004-11-01 00:00:00

abstract：:We related 24-hour sodium and potassium excretion cross-sectionally to blood pressure and longitudinally to coronary events and deaths during follow-up in a representative sample of the Scottish population. A random sampling of men and women aged 40-59 in 1984 to 1987 produced 11,629 men and women who provided questio...

journal_title：Seminars in nephrology

authors： Tunstall-Pedoe H

更新日期：1999-09-01 00:00:00

abstract：:On completion of a Nephrology fellowship, I went back to the inner city community where I was raised to begin my practice. Filled with idealism, I believed that, by returning, I could slow the devastation that hypertension was imparting on the black community, and in doing so, prevent end-stage renal disease (ESRD). I...

journal_title：Seminars in nephrology

authors： Crawford PW

更新日期：2001-07-01 00:00:00

abstract：:Minimally invasive therapies for urolithiasis including extracorporeal shock wave lithotripsy, ureteroscopy, and percutaneous nephrostolithotomy are highly efficacious, yet expensive. Medical expulsive therapy offers a cost-effective, nonsurgical approach for appropriate patients with ureteral stones. The use of hormo...

journal_title：Seminars in nephrology

authors： Sterrett SP,Nakada SY

更新日期：2008-03-01 00:00:00

abstract：:Goodpasture (GP) syndrome is a form of anti-glomerular basement membrane (GBM) disease, in which autoantibodies bind to alpha3(IV) collagen in GBM causing rapidly progressive glomerulonephritis and pulmonary hemorrhage. The conformational GP epitopes have been mapped to 2 regions within the noncollagenous (NC1) domain...

journal_title：Seminars in nephrology

authors： Borza DB,Neilson EG,Hudson BG

更新日期：2003-11-01 00:00:00

abstract：:Chronic kidney disease, defined as reduced glomerular filtration rate (estimated using serum creatinine- and/or serum cystatin C-based equations) or excess urinary protein excretion, affects approximately 13% of adult Americans and is linked to a variety of clinical complications. Although persons with end-stage renal...

journal_title：Seminars in nephrology

authors： Go AS

更新日期：2016-07-01 00:00:00