Abstract：
:Preeclampsia is a 2-stage disorder. Stage 1 is decreased placental perfusion and generates stage 2 of the disorder, the maternal syndrome characteristic of preeclampsia. How the 2 stages are linked has been a topic of intense investigation for many years. One candidate phenomenon, which includes many other suggested linkages, is oxidative stress. This hypothesis predicts that the administration of antioxidants would decrease oxidative stress and modify stage 2. Experience with the treatment of preeclampsia including a small trial of antioxidants in women with manifest preeclampsia makes it clear that the use of any therapy once preeclampsia is evident will not be successful. Trials evaluating prophylactic aspirin and supplemental calcium from early pregnancy suggest that therapy before evident preeclampsia may be successful in selected populations. Guided by these concepts and by experience with antioxidant therapy in other settings, 1 small study (<80 women in the treatment arm) was very encouraging with an almost two-thirds reduction of the frequency of preeclampsia in high-risk women. Antioxidants currently are being evaluated in several larger trials in the United States, Canada, Mexico, England, and in several developing nations. These studies should definitively establish the efficacy and safety of this therapy for the mother and fetus.
journal_name
Semin Nephroljournal_title
Seminars in nephrologyauthors
Roberts JM,Speer Pdoi
10.1016/s0270-9295(04)00126-3subject
Has Abstractpub_date
2004-11-01 00:00:00pages
557-64issue
6eissn
0270-9295issn
1558-4488pii
S0270929504001263journal_volume
24pub_type
杂志文章,评审abstract：:A complex pathophysiology, cardio-renal syndrome (CRS), has been redefined in recent years. One subtype is acute renocardiac CRS, or CRS type 3. This syndrome is intended to comprise situations in which acute kidney injury (AKI) results in acute cardiac injury or dysfunction. The pathophysiology of CRS type 3 is not w...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2011.11.005
更新日期：2012-01-01 00:00:00
abstract：:Immune-mediated nephritis is a common complication of systemic lupus erythematosus (SLE). It is now clear that multiple and independent mechanisms contribute to disease onset and pathogenesis, which may explain the remarkable phenotypic and histopathological heterogeneity observed in human SLE. Identification and char...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：:Novel erythropoiesis stimulating protein (NESP) is a hyperglycosylated analogue of recombinant human erythropoietin (rHuEPO) that stimulates erythropoiesis by the same mechanism as the native hormone. The addition of two extra carbohydrate chains, however, gives NESP greater metabolic stability in vivo, and its termin...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2000-07-01 00:00:00
abstract：:The renal tubular epithelium maintains different sets of transport proteins in plasma membrane domains facing the lumenal and mucosal fluids and limits diffusion between these two compartments. This asymmetry is generated by directing transporters to the appropriate membrane domain, a process that requires both an int...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1998-03-01 00:00:00
abstract：:In recent years, it has become apparent that parietal epithelial cells (PECs) play an important role within the renal glomerulus, in particular in diseased conditions. In this review, we examine current knowledge about the role of PECs and their interactions with podocytes in development and under physiological condit...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2012.06.007
更新日期：2012-07-01 00:00:00
abstract：:Although evidence has accumulated indicating a close relationship between inflammation and atherosclerosis, the relationship between inflammation and vascular calcification in patients with chronic renal failure is unclear. In the present study, the relationship between C-reactive protein (CRP) and vascular calcificat...
journal_title：Seminars in nephrology
pub_type： 杂志文章
doi：10.1016/j.semnephrol.2004.06.008
更新日期：2004-09-01 00:00:00
abstract：:From the beginning of the first described hemodialysis in 1889, history has shown an exponential evolvement of systems that have resulted in greater safety, efficiency, and broader utilization. It took 60 years, 1947, for the technology to be used in a clinical setting in North America, treating acute renal failure. C...
journal_title：Seminars in nephrology
pub_type： 历史文章,杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:Membranous nephropathy is a relatively common glomerular disease found to underlie both nonnephrotic and nephrotic proteinuria. In adults, about 75% of cases are primary (idiopathic) and 25% are secondary to a wide variety of causes, including neoplasia, infections, autoimmunity, and drugs. Presenting features are not...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/s0270-9295(03)00049-4
更新日期：2003-07-01 00:00:00
abstract：:Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected syndromes that represent a global public health challenge. Organelles play essential roles in a vast range of cell functions, and their damage is related to several kidney diseases. Organelles launch the stress signal or trigger the stress r...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2019.10.007
更新日期：2019-11-01 00:00:00
abstract：:Overweight and obesity are associated with arterial hypertension. Given the large increase in the obesity prevalence worldwide, the number of obese patients with hypertension is likely to increase substantially in the near future. Overweight and obese patients are exposed to an important metabolic and cardiovascular r...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2007.07.009
更新日期：2007-09-01 00:00:00
abstract：:The search for an endogenous digitalis has led to the identification of the cardenolides ouabain and digoxin and the bufadienolide marinobufagenin in mammalian tissues and biological fluids. Ouabain's release from adrenal glands is under the control of epinephrine and angiotensin II; hence, its blood concentration cha...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2005.03.010
更新日期：2005-09-01 00:00:00
abstract：:An important component of nephrology research is the discovery of novel proteins that control cellular and molecular events that contribute to normal kidney cell biology and disease. Identifying perturbation of normal cellular protein expression and interactions within signaling networks is critical for understanding ...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2007.09.008
更新日期：2007-11-01 00:00:00
abstract：:In most countries the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in peritoneal dialysis (PD) patients is lower than in hemodialysis (HD) patients. Besides a history of blood transfusions, previous HD is an important risk factor for developing HCV infection in PD patients. Many HCV-posi...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2002-07-01 00:00:00
abstract：:Membranous nephropathy remains the most common cause of the nephrotic syndrome in adults. Most patients do well with long-term natural history studies reporting a 10-year renal survival of 70% to 90% but the remainder progress to end stage renal failure. This plus the associated morbidity of those with persistent high...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：:Studies performed over the last 10 years have evaluated the role of nitric oxide (NO) in the control of renal hemodynamics. This article reviews the effects of administration of nitric oxide synthase (NOS) blockers on renal function in experimental animals and human volunteers. These studies show that NOS blockade inc...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1999-05-01 00:00:00
abstract：:The identification of natriuretic peptides as key regulators of natriuresis and vasodilatation, and the appreciation that their secretion is under the control of cardiac hemodynamic and neurohumoral factors, has caused wide interest. The natriuretic peptides are structurally similar, but genetically distinct peptides ...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1053/snep.2002.35666
更新日期：2002-09-01 00:00:00
abstract：:Cytomegalovirus (CMV), human herpes virus (HHV)-6, and HHV-7 are ubiquitous β-herpesviruses that can cause opportunistic infection and disease in kidney transplant recipients. Active CMV infection and disease are associated with acute allograft failure and death, and HHV-6 and HHV-7 replication are associated with CMV...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2016.05.012
更新日期：2016-09-01 00:00:00
abstract：:Sphingolipids, including ceramides, glycosphingolipids, sphingomyelin, and sphingosine-1-phosphate, have been recognized as important molecules that regulate critical cellular functions. Although originally studied in the context of lysosomal storage diseases, the roles of these compounds in more common disorders invo...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2018.01.007
更新日期：2018-03-01 00:00:00
abstract：:Worldwide, more than 250,000 individuals who have received a liver, heart, lung, or intestinal transplant are living longer. Twenty percent to 25% of these recipients experience perioperative acute renal failure, with 10% to 15% requiring renal replacement therapy. Chronic kidney disease (CKD) is also highly prevalent...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2007.03.010
更新日期：2007-07-01 00:00:00
abstract：:Compared with Caucasians, African Americans have lower circulating concentrations of 25-hydroxyvitamin D (25(OH)D), the major storage form of vitamin D, leading to the widespread assumption that African Americans are at higher risk of vitamin D deficiency. However, the finding that African Americans maintain better in...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2013.07.006
更新日期：2013-09-01 00:00:00
abstract：:A review is presented of 164 nephrotic patients who were older than 60 years at the onset of their nephrotic syndrome, together with a review of more than 1,000 patients from the literature. The nephrotic syndrome in elderly patients is as common as in younger adults, but is often misdiagnosed as "heart failure" by pr...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1996-07-01 00:00:00
abstract：:Assessment of adiposity should include measurements of both body mass index and waist circumference. The prevalence of obesity, based on a body mass index of 30 kg/m(2) or greater, has increased substantially over the past 2 decades in Western societies. Obesity remains the number one preventable risk factor for chron...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2012.12.006
更新日期：2013-01-01 00:00:00
abstract：:An expanding proportion of people in the United States and worldwide are affected by kidney disease, leading to a growing concern over the public health implications. Despite the high prevalence and the considerable associated health risks of kidney disease, major gaps in our knowledge base hinder the delivery of opti...
journal_title：Seminars in nephrology
pub_type： 评论,杂志文章,评审
doi：10.1016/j.semnephrol.2009.06.002
更新日期：2009-09-01 00:00:00
abstract：:Calcium homeostasis is an important aspect of maternal and fetal physiology during gestation, and recent evidence implicates alterations in calcium metabolism in the pathogenesis of hypertension during pregnancy. Deficiencies in calcium intake have been linked to preeclampsia/eclampsia, and hypocalciuria and deviation...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：:In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary hyperparathyroidism. The increase in serum parathyroid hormone is associated with reduced serum calcium and calcitriol levels and/or increased serum fibroblast growth f...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2018.02.004
更新日期：2018-05-01 00:00:00
abstract：:The renal biopsy provides critical diagnostic and prognostic information to clinicians including cases of acute kidney injury, chronic kidney disease, and allograft dysfunction. Today, biopsy specimens are read using a combination of light microscopy, electron microscopy, and indirect immunofluorescence, with a limite...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2017.09.005
更新日期：2018-01-01 00:00:00
abstract：:Monocytes/macrophages and activated (but not resting) lymphocytes as well as certain subsets of thymocytes express the VDR. This protein is indistinguishable from the classical 50-kDa VDR and is encoded by an mRNA with identical nucleotide sequence to that of the human intestinal VDR. Acting via the VDR, 1,25(OH)2D3 m...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：
更新日期：1994-03-01 00:00:00
abstract：:Cigarette smoking (CS) has been associated with augmented progression of nephropathies responsible for the 4 major causes of end-stage renal disease (ESRD) in the United States. CS has well-described ways by which it causes tissue injury in other organ systems and the mechanisms by which it adversely affects nephropat...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/s0270-9295(03)00037-8
更新日期：2003-05-01 00:00:00
abstract：:Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by bone abnormalities, vascular calcification, and an array of laboratory abnormalities. The latter classically include disturbances in the parathyroid hormone/vitamin D axis. More recently, fibroblast growth factor 23 (FGF23) and klotho also ...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2014.02.007
更新日期：2014-03-01 00:00:00
abstract：:Mineralocorticoid hypertension is hypertension associated with the presence of hypokalemia, metabolic alkalosis, and suppression of plasma renin. Mineralocorticoid hypertension represents only 10% of patients with essential hypertension. However, its recognition is important because it is a potentially reversible caus...
journal_title：Seminars in nephrology
pub_type： 杂志文章,评审
doi：10.1016/j.semnephrol.2006.10.004
更新日期：2006-11-01 00:00:00
