Role of nitric oxide in renal hemodynamics.

abstract：:Macrophages have long been regarded as classic mediators of innate immunity because of their production of proinflammatory cytokines and their ability to induce apoptotic cell death. As a result of such activities and the detrimental long-term effect of kidney inflammation, macrophages principally have been regarded a...

journal_title：Seminars in nephrology

authors： Williams TM,Little MH,Ricardo SD

更新日期：2010-05-01 00:00:00

abstract：:The importance of hypertension as a cardiovascular risk factor increases progressively with aging, but diastolic blood pressure plateaus at age 50, which leads to a rise in pulse pressure in the elderly. Thus, isolated systolic hypertension with a widened pulse pressure is the most common type of hypertension seen in ...

journal_title：Seminars in nephrology

authors： Meeks WM

更新日期：2002-01-01 00:00:00

abstract：:In patients with chronic kidney disease, an impaired capacity of the kidney to excrete sodium is a major contributor to hypertension. We discuss the role of sodium restriction and diuretic therapy for resistant hypertension in chronic kidney disease. Independent of increasing blood pressure, a sustained high sodium in...

journal_title：Seminars in nephrology

authors： Sinnakirouchenan R,Kotchen TA

更新日期：2014-01-01 00:00:00

abstract：:The vacuolar H(+)-ATPase is a multisubunit protein consisting of a peripheral catalytic domain (V(1)) that binds and hydrolyzes adenosine triphosphate (ATP) and provides energy to pump H(+) through the transmembrane domain (V(0)) against a large gradient. This proton-translocating vacuolar H(+)-ATPase is present in bo...

journal_title：Seminars in nephrology

authors： Valles P,Lapointe MS,Wysocki J,Batlle D

更新日期：2006-09-01 00:00:00

abstract：:Necrosis is the predominant form of regulated cell death in acute kidney injury (AKI) and represents results in the formation of casts that appear in the urine sedimentation, referred to as muddy brown casts, which are part of the diagnosis of AKI. Pathologists referred to this typical feature as acute tubular necrosi...

journal_title：Seminars in nephrology

authors： Kers J,Leemans JC,Linkermann A

更新日期：2016-05-01 00:00:00

abstract：:Sphingolipids, including ceramides, glycosphingolipids, sphingomyelin, and sphingosine-1-phosphate, have been recognized as important molecules that regulate critical cellular functions. Although originally studied in the context of lysosomal storage diseases, the roles of these compounds in more common disorders invo...

journal_title：Seminars in nephrology

authors： Shayman JA

更新日期：2018-03-01 00:00:00

abstract：:Recent new insights into the determinants of the plasma water sodium concentration ([Na(+)](pw)) have played an important role in advancing our understanding of the pathogenesis and treatment of the dysnatremias. Central to these recent advances is the recognition of the full significance of the Edelman equation disco...

journal_title：Seminars in nephrology

authors： Nguyen MK

更新日期：2009-05-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by a combination of arterial and/or venous thrombosis, pregnancy morbidity, and the persistent presence of circulating antiphospholipid antibodies (aPL). APS has been described as primary APS when it occurs in the absence of any featur...

journal_title：Seminars in nephrology

authors： Sciascia S,Baldovino S,Schreiber K,Solfietti L,Roccatello D

更新日期：2015-09-01 00:00:00

abstract：:Mineralocorticoid hypertension is hypertension associated with the presence of hypokalemia, metabolic alkalosis, and suppression of plasma renin. Mineralocorticoid hypertension represents only 10% of patients with essential hypertension. However, its recognition is important because it is a potentially reversible caus...

journal_title：Seminars in nephrology

authors： Khosla N,Hogan D

更新日期：2006-11-01 00:00:00

abstract：:Cardio-Renal syndrome (CRS) is a common and complex clinical condition in which multiple causative factors are involved. The time window between renal insult and development of acute kidney injury (AKI) in acute heart failure (AHF) can be varied in different patients and AKI often is diagnosed too late, only when the ...

journal_title：Seminars in nephrology

authors： Ronco C,Cruz D,Noland BW

更新日期：2012-01-01 00:00:00

abstract：:Prolonged hyperuricemia is associated with the development of hypertension, renal arteriolosclerosis, glomerulosclerosis, and tubulointerstitial injury. It confers a greater risk than proteinuria for developing chronic renal disease and is associated with the development of hypertension. Mild chronic hyperuricemia wit...

journal_title：Seminars in nephrology

authors： Sánchez-Lozada LG,Tapia E,Rodríguez-Iturbe B,Johnson RJ,Herrera-Acosta J

更新日期：2005-01-01 00:00:00

abstract：:A complex pathophysiology, cardio-renal syndrome (CRS), has been redefined in recent years. One subtype is acute renocardiac CRS, or CRS type 3. This syndrome is intended to comprise situations in which acute kidney injury (AKI) results in acute cardiac injury or dysfunction. The pathophysiology of CRS type 3 is not w...

journal_title：Seminars in nephrology

authors： Chuasuwan A,Kellum JA

更新日期：2012-01-01 00:00:00

abstract：:Acute ingestion of protein and intravenous infusion of amino acids are known to stimulate increases in renal blood flow and glomerular filtration rate (GFR) in animals and humans. Although some investigators believe that these changes are mediated by a circulating hormonal factor, there is considerable evidence that i...

journal_title：Seminars in nephrology

authors： Woods LL

更新日期：1995-09-01 00:00:00

abstract：:This article summarizes physiological and molecular studies of the colonic H+,K+-ATPase and active potassium (K) absorption in the rat distal colon. Active K absorption is energized by an apical membrane H+,K+-ATPase that is a member of the gene family of P-type ATPases. Physiological experiments of active K absorptio...

journal_title：Seminars in nephrology

authors： Binder HJ,Sangan P,Rajendran VM

更新日期：1999-09-01 00:00:00

abstract：:Toxic nephropathies cause acute and chronic renal failure, primarily as a result of injury to renal tubular epithelium. There is a well-known capacity in the renal nephron for the synchronous occurrence of both apoptosis and necrosis in toxic nephropathies. This has engendered interest in the differing or complementar...

journal_title：Seminars in nephrology

authors： Gobe GC,Endre ZH

更新日期：2003-09-01 00:00:00

abstract：:Thrombotic microangiopathy represents the clinical picture of thrombocytopenia and hemolytic anemia in the setting of small blood vessel thrombosis, accompanied by varying degrees of organ dysfunction. Well known to both nephrologists and hematologists alike, among the most common and best-studied thrombotic microangi...

journal_title：Seminars in nephrology

authors： Motto D

更新日期：2012-03-01 00:00:00

abstract：:The prevalence of chronic or end-stage kidney disease in pediatric girls is lower than in boys, however, girls have unique morbidities that can have great effect on their quality of life. For female adolescents, creatinine excretion peaks at approximately 14 years of age and is significantly less than males, owing to ...

journal_title：Seminars in nephrology

authors： Diaz-Gonzalez De Ferris ME,Alvarez-Elías AC,Ferris MT,Medeiros M

更新日期：2017-07-01 00:00:00

abstract：:From the beginning of the first described hemodialysis in 1889, history has shown an exponential evolvement of systems that have resulted in greater safety, efficiency, and broader utilization. It took 60 years, 1947, for the technology to be used in a clinical setting in North America, treating acute renal failure. C...

journal_title：Seminars in nephrology

authors： Van Stone JC

更新日期：1997-05-01 00:00:00

abstract：:Mechanisms regulating the establishment of the glomerular endothelium and mesangium during glomerulogenesis are not understood. In this article, we discuss two different blood vessel growth processes: vasculogenesis and angiogenesis, with particular attention on how these processes might operate in the developing kidn...

journal_title：Seminars in nephrology

authors： Hyink DP,Abrahamson DR

更新日期：1995-07-01 00:00:00

abstract：:Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected syndromes that represent a global public health challenge. Organelles play essential roles in a vast range of cell functions, and their damage is related to several kidney diseases. Organelles launch the stress signal or trigger the stress r...

journal_title：Seminars in nephrology

authors： Maekawa H,Inagi R

更新日期：2019-11-01 00:00:00

abstract：:Although evidence has accumulated indicating a close relationship between inflammation and atherosclerosis, the relationship between inflammation and vascular calcification in patients with chronic renal failure is unclear. In the present study, the relationship between C-reactive protein (CRP) and vascular calcificat...

journal_title：Seminars in nephrology

authors： Ishimura E,Okuno S,Kitatani K,Maekawa K,Izumotani T,Yamakawa T,Jono S,Shoji T,Shioi A,Inaba M,Massry SG,Nishizawa Y

更新日期：2004-09-01 00:00:00

abstract：:Diabetes mellitus (DM) is becoming more common in the United States affecting an estimated 18.2 million Americans. Not only is the number of American's with DM staggering, but so are the medical and economic costs of DM. DM accounts for nearly 15% of all health care costs in the United States. The chronic hyperglycemi...

journal_title：Seminars in nephrology

authors： Daneshgari F,Moore C

更新日期：2006-03-01 00:00:00

abstract：:Several studies have shown an association between the hemodialysis session length (the t of Kt or Kt/V) and favorable outcomes for patients on maintenance hemodialysis. In a single randomized controlled trial that systematically varied hemodialysis session length, shorter session length was associated with an increase...

journal_title：Seminars in nephrology

authors： Kurella M,Chertow GM

更新日期：2005-03-01 00:00:00

abstract：:In recent years, it has become apparent that parietal epithelial cells (PECs) play an important role within the renal glomerulus, in particular in diseased conditions. In this review, we examine current knowledge about the role of PECs and their interactions with podocytes in development and under physiological condit...

journal_title：Seminars in nephrology

authors： Smeets B,Moeller MJ

更新日期：2012-07-01 00:00:00

abstract：:The complement system consists of 3 pathways and more than 30 proteins, including those with biological activity that directly or indirectly mediate the effects of this system, plus a set of regulatory proteins necessary to prevent injudicious complement activation on host tissue. The role for complement in the pathog...

journal_title：Seminars in nephrology

authors： Bao L,Quigg RJ

更新日期：2007-01-01 00:00:00

abstract：:Effectiveness of antihypertensive agents is assessed not only by systemic blood pressure levels, but by multiple parameters that reflect specific organ functions. Among antihypertensive agents, those which inhibit angiotensin actions show particular efficacy in ameliorating end organ damage. This efficacy likely refle...

journal_title：Seminars in nephrology

authors： Fogo A,Kon V

更新日期：1996-11-01 00:00:00

abstract：:Cigarette smoking (CS) has been associated with augmented progression of nephropathies responsible for the 4 major causes of end-stage renal disease (ESRD) in the United States. CS has well-described ways by which it causes tissue injury in other organ systems and the mechanisms by which it adversely affects nephropat...

journal_title：Seminars in nephrology

authors： Wesson DE

更新日期：2003-05-01 00:00:00

abstract：:By analogy to the findings with other transport disorders such as Bartter's or Liddle's syndrome, it might be expected that the various forms of renal tubular acidosis (RTA) could result from defects in H-ATPase or H-K-ATPase. However, the available data do not yet support such a simple explanation. With regard to dis...

journal_title：Seminars in nephrology

authors： Mujais SK

更新日期：1998-01-01 00:00:00

abstract：:Our understanding of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis has developed greatly since the discovery of ANCA, directed against neutrophil components, in 1982. Observations in human disease, and increasingly sophisticated studies in vitro and in rodent models in vivo, have allowed a nuanced u...

journal_title：Seminars in nephrology

authors： Hutton HL,Holdsworth SR,Kitching AR

更新日期：2017-09-01 00:00:00

abstract：:Nephrogenic systemic fibrosis is a new disease whose incidence has peaked and receded over the past decade. It occurs in the presence of significant renal impairment, either acute or chronic (MDRD creatinine clearance of <30 mL/min/1.73 m(2)), and is associated with the administration of gadolinium-based contrast (GBC...

journal_title：Seminars in nephrology

authors： Hellman RN

更新日期：2011-05-01 00:00:00