Abstract:
:Toxic nephropathies cause acute and chronic renal failure, primarily as a result of injury to renal tubular epithelium. There is a well-known capacity in the renal nephron for the synchronous occurrence of both apoptosis and necrosis in toxic nephropathies. This has engendered interest in the differing or complementary roles of these modes of cell death. Once thought to be mutually exclusive in incidence and morphologic and biochemical features, recent evidence in renal and other diseases indicates some blurring in the features of apoptosis and necrosis, particularly in the situations in which they are identified, in their molecular pathways, and in the role of inflammation in the processes. Definition of the heterogenic pathophysiologic response of the nephron should provide information useful for promoting the health of the kidney after injury, particularly in relation to controlling the extent and modalities of cell death via the associated renal-specific molecular features. This article indicates the significance and some problems of defining the types of cell death in toxic nephropathies.
journal_name
Semin Nephroljournal_title
Seminars in nephrologyauthors
Gobe GC,Endre ZHdoi
10.1016/s0270-9295(03)00085-8subject
Has Abstractpub_date
2003-09-01 00:00:00pages
416-24issue
5eissn
0270-9295issn
1558-4488pii
S0270929503000858journal_volume
23pub_type
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
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journal_title:Seminars in nephrology
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abstract::The catecholamines dopamine and norepinephrine, play a central role in the regulation of sodium homeostasis and blood pressure. Dopamine inhibits tubular Na+, K(+)-ATPase activity and increases sodium excretion. Norepinephrine stimulates Na+, K(+)-ATPase activity and decreases urinary sodium excretion. The signaling p...
journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 历史文章,杂志文章
doi:
更新日期:1997-05-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1995-07-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:
更新日期:2002-07-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章
doi:10.1016/j.semnephrol.2005.01.011
更新日期:2005-05-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:10.1016/j.semnephrol.2007.01.003
更新日期:2007-03-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:10.1053/snep.2001.21653
更新日期:2001-05-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章
doi:10.1016/j.semnephrol.2012.07.002
更新日期:2012-09-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:10.1016/j.semnephrol.2008.09.001
更新日期:2008-11-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:
更新日期:1986-12-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:10.1016/s0270-9295(03)00058-5
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journal_title:Seminars in nephrology
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
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journal_title:Seminars in nephrology
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journal_title:Seminars in nephrology
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
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journal_title:Seminars in nephrology
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journal_title:Seminars in nephrology
pub_type: 杂志文章
doi:10.1016/j.semnephrol.2004.06.013
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abstract::Monocytes/macrophages and activated (but not resting) lymphocytes as well as certain subsets of thymocytes express the VDR. This protein is indistinguishable from the classical 50-kDa VDR and is encoded by an mRNA with identical nucleotide sequence to that of the human intestinal VDR. Acting via the VDR, 1,25(OH)2D3 m...
journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:
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abstract::Worldwide, more than 250,000 individuals who have received a liver, heart, lung, or intestinal transplant are living longer. Twenty percent to 25% of these recipients experience perioperative acute renal failure, with 10% to 15% requiring renal replacement therapy. Chronic kidney disease (CKD) is also highly prevalent...
journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:10.1016/j.semnephrol.2007.03.010
更新日期:2007-07-01 00:00:00
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journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
doi:10.1053/snep.2001.20939
更新日期:2001-03-01 00:00:00
abstract::Premature menopause defined as secondary amenorrhea is common in women with kidney disease. Moreover, the aging population has resulted in increasing numbers of postmenopausal women with kidney disease. Though the pathophysiology is poorly understood, kidney transplantation and more frequent hemodialysis can restore m...
journal_title:Seminars in nephrology
pub_type: 杂志文章,评审
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