Sepsis-associated acute kidney injury: macrohemodynamic and microhemodynamic alterations in the renal circulation.

abstract：:A review is presented of 164 nephrotic patients who were older than 60 years at the onset of their nephrotic syndrome, together with a review of more than 1,000 patients from the literature. The nephrotic syndrome in elderly patients is as common as in younger adults, but is often misdiagnosed as "heart failure" by pr...

journal_title：Seminars in nephrology

authors： Cameron JS

更新日期：1996-07-01 00:00:00

abstract：:The complement system consists of 3 pathways and more than 30 proteins, including those with biological activity that directly or indirectly mediate the effects of this system, plus a set of regulatory proteins necessary to prevent injudicious complement activation on host tissue. The role for complement in the pathog...

journal_title：Seminars in nephrology

authors： Bao L,Quigg RJ

更新日期：2007-01-01 00:00:00

abstract：:Renal involvement is common in leptospirosis. Clinical manifestations vary from urinary sediment changes to acute renal failure. Renal failure is observed in 44% to 67% of patients. Hypokalemia frequently occurs. Severe hypotension is an important warning sign for the later development of renal and pulmonary complicat...

journal_title：Seminars in nephrology

authors： Sitprija V,Losuwanrak K,Kanjanabuch T

更新日期：2003-01-01 00:00:00

abstract：:Nephrogenic systemic fibrosis is a new disease whose incidence has peaked and receded over the past decade. It occurs in the presence of significant renal impairment, either acute or chronic (MDRD creatinine clearance of <30 mL/min/1.73 m(2)), and is associated with the administration of gadolinium-based contrast (GBC...

journal_title：Seminars in nephrology

authors： Hellman RN

更新日期：2011-05-01 00:00:00

abstract：:A number of antineoplastic chemotherapeutic drugs may produce fluid and electrolyte disturbances or nephrotoxic reactions extending across the clinical spectrum, from subclinical renal dysfunction to progressive chronic renal insufficiency to severe acute failure. Although some of the drugs that are highly nephrotoxic...

journal_title：Seminars in nephrology

authors： Berns JS,Ford PA

更新日期：1997-01-01 00:00:00

abstract：:Several studies have shown an association between the hemodialysis session length (the t of Kt or Kt/V) and favorable outcomes for patients on maintenance hemodialysis. In a single randomized controlled trial that systematically varied hemodialysis session length, shorter session length was associated with an increase...

journal_title：Seminars in nephrology

authors： Kurella M,Chertow GM

更新日期：2005-03-01 00:00:00

abstract：:Remarkable advances have been made in the past decade in understanding the pathophysiology of idiopathic nephrotic syndrome. Although the initiating events leading to the onset of proteinuria still are not well defined, it has become increasingly clear that many glomerular diseases can be classified as podocytopathies...

journal_title：Seminars in nephrology

authors： Lane JC,Kaskel FJ

更新日期：2009-07-01 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) has revolutionized the treatment of anemia of chronic renal failure. RHuEPO has been shown to increase survival, decrease hospitalizations, improve brain and cognitive function, and improve quality of life for renal patients. Much has been learned about the normal and patholog...

journal_title：Seminars in nephrology

authors： Tong EM,Nissenson AR

更新日期：2001-03-01 00:00:00

abstract：:From the beginning of the first described hemodialysis in 1889, history has shown an exponential evolvement of systems that have resulted in greater safety, efficiency, and broader utilization. It took 60 years, 1947, for the technology to be used in a clinical setting in North America, treating acute renal failure. C...

journal_title：Seminars in nephrology

authors： Van Stone JC

更新日期：1997-05-01 00:00:00

abstract：:The prevalence of chronic or end-stage kidney disease in pediatric girls is lower than in boys, however, girls have unique morbidities that can have great effect on their quality of life. For female adolescents, creatinine excretion peaks at approximately 14 years of age and is significantly less than males, owing to ...

journal_title：Seminars in nephrology

authors： Diaz-Gonzalez De Ferris ME,Alvarez-Elías AC,Ferris MT,Medeiros M

更新日期：2017-07-01 00:00:00

abstract：:The pathogenesis of many common etiologies of nephropathy has been informed by recent molecular genetic breakthroughs. It now is apparent that the ethnic disparity in the risk for nondiabetic chronic kidney disease between African Americans and European Americans is explained largely by variation in the apolipoprotein...

journal_title：Seminars in nephrology

authors： Freedman BI,Locke JE,Reeves-Daniel AM,Julian BA

更新日期：2017-11-01 00:00:00

abstract：:Recent new insights into the determinants of the plasma water sodium concentration ([Na(+)](pw)) have played an important role in advancing our understanding of the pathogenesis and treatment of the dysnatremias. Central to these recent advances is the recognition of the full significance of the Edelman equation disco...

journal_title：Seminars in nephrology

authors： Nguyen MK

更新日期：2009-05-01 00:00:00

abstract：:Goodpasture (GP) syndrome is a form of anti-glomerular basement membrane (GBM) disease, in which autoantibodies bind to alpha3(IV) collagen in GBM causing rapidly progressive glomerulonephritis and pulmonary hemorrhage. The conformational GP epitopes have been mapped to 2 regions within the noncollagenous (NC1) domain...

journal_title：Seminars in nephrology

authors： Borza DB,Neilson EG,Hudson BG

更新日期：2003-11-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on many systems, depending on the biologic setting. Retinoids are vitamin A derivatives that also have diverse effects in development, physiology, and disease. The interactions between thes...

journal_title：Seminars in nephrology

authors： Xu Q,Kopp JB

更新日期：2012-05-01 00:00:00

abstract：:Cardiovascular disease (CVD) is the major cause of morbidity and mortality in patients with renal failure. Patients with chronic kidney disease have significant CVD, and carry a high cardiovascular burden by the time they commence renal replacement therapy (RRT). The severity of CVD that has been observed in dialysis ...

journal_title：Seminars in nephrology

authors： Jaradat MI,Molitoris BA

更新日期：2002-11-01 00:00:00

abstract：:This review emphasizes four major areas of pediatric hypertension. Because hypertension is the most common reason student athletes fail the sports pre-participation examinations, we have attempted to provide a rationale approach to the decision process to permit a hypertensive child to partake in leisure and competiti...

journal_title：Seminars in nephrology

authors： Feld LG,Springate JE,Waz WR

更新日期：1998-05-01 00:00:00

abstract：:Renal cell carcinoma (RCC) is increasing in incidence and one third of newly diagnosed cases already are metastatic. The metastatic spread of solid tumors renders RCC incurable by surgical resection and consequently more difficult to treat. New molecular-targeted therapies have played a pivotal role in RCC treatment. ...

journal_title：Seminars in nephrology

authors： Yang DC,Chen CH

更新日期：2020-01-01 00:00:00

abstract：:Thrombotic microangiopathy represents the clinical picture of thrombocytopenia and hemolytic anemia in the setting of small blood vessel thrombosis, accompanied by varying degrees of organ dysfunction. Well known to both nephrologists and hematologists alike, among the most common and best-studied thrombotic microangi...

journal_title：Seminars in nephrology

authors： Motto D

更新日期：2012-03-01 00:00:00

abstract：:Sphingolipids, including ceramides, glycosphingolipids, sphingomyelin, and sphingosine-1-phosphate, have been recognized as important molecules that regulate critical cellular functions. Although originally studied in the context of lysosomal storage diseases, the roles of these compounds in more common disorders invo...

journal_title：Seminars in nephrology

authors： Shayman JA

更新日期：2018-03-01 00:00:00

abstract：:It has been known for decades that urinary potassium excretion varies with a circadian pattern. In this review, we consider the historical evidence for this phenomenon and present an overview of recent developments in the field. Extensive evidence from the latter part of the past century clearly shows that circadian p...

journal_title：Seminars in nephrology

authors： Gumz ML,Rabinowitz L

更新日期：2013-05-01 00:00:00

abstract：:The Human Genome Project is rapidly producing insights into the molecular basis of human genetic disorders. The most immediate clinical benefit is the advent of new diagnostic methods. Molecular diagnostic tools are available for several genetic renal disorders and are in development for many more. Two general approac...

journal_title：Seminars in nephrology

authors： Korf BR

更新日期：1999-07-01 00:00:00

abstract：:Dent's disease and familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) are inherited diseases in which hypercalciuria, nephrocalcinosis, and renal failure are prominent features. Dent's disease resembles a Fanconi syndrome, with impaired reabsorption in the proximal tubule; FHHNC, with urinary los...

journal_title：Seminars in nephrology

authors： Knohl SJ,Scheinman SJ

更新日期：2004-01-01 00:00:00

abstract：:As kidney function declines, chronic kidney disease (CKD) becomes an increasingly systemic disorder. Most patients with CKD eventually develop subclinical or clinical abnormalities in bone and mineral metabolism. Recent observational and basic scientific studies have led to a new emphasis on the changes in phosphorus ...

journal_title：Seminars in nephrology

authors： Williams ME

更新日期：2009-03-01 00:00:00

abstract：:In recent years, it has become apparent that parietal epithelial cells (PECs) play an important role within the renal glomerulus, in particular in diseased conditions. In this review, we examine current knowledge about the role of PECs and their interactions with podocytes in development and under physiological condit...

journal_title：Seminars in nephrology

authors： Smeets B,Moeller MJ

更新日期：2012-07-01 00:00:00

abstract：:The mortality of end-stage renal disease (ESRD) patients, including those receiving long-term peritoneal dialysis (PD), has remained unacceptably high owing to the prevalence of cardiovascular disease. It is well recognized that both traditional Framingham risk factors and kidney disease-related risk factors may contr...

journal_title：Seminars in nephrology

authors： Wang AY

更新日期：2011-03-01 00:00:00

abstract：:The identification of natriuretic peptides as key regulators of natriuresis and vasodilatation, and the appreciation that their secretion is under the control of cardiac hemodynamic and neurohumoral factors, has caused wide interest. The natriuretic peptides are structurally similar, but genetically distinct peptides ...

journal_title：Seminars in nephrology

authors： Dhingra H,Roongsritong C,Kurtzman NA

更新日期：2002-09-01 00:00:00

abstract：:Blood pressure increases with age in all US population groups that have been studies, but does so faster in African Americans. Evidence from extensive microscopic renal vascular studies at autopsy supports the view that blood pressure increases with age because of progressive fibroplasia of renal interlobular arteries...

journal_title：Seminars in nephrology

authors： Tracy RE

更新日期：1996-03-01 00:00:00

abstract：:Cardio-Renal syndrome (CRS) is a common and complex clinical condition in which multiple causative factors are involved. The time window between renal insult and development of acute kidney injury (AKI) in acute heart failure (AHF) can be varied in different patients and AKI often is diagnosed too late, only when the ...

journal_title：Seminars in nephrology

authors： Ronco C,Cruz D,Noland BW

更新日期：2012-01-01 00:00:00

abstract：:Acute ingestion of protein and intravenous infusion of amino acids are known to stimulate increases in renal blood flow and glomerular filtration rate (GFR) in animals and humans. Although some investigators believe that these changes are mediated by a circulating hormonal factor, there is considerable evidence that i...

journal_title：Seminars in nephrology

authors： Woods LL

更新日期：1995-09-01 00:00:00

abstract：:Given the prohibitive costs of end-stage renal disease (ESRD) care for certain countries and the increasing incidence of ESRD worldwide, alternative methods of funding dialysis care are increasingly necessary. We describe the paradigm of the National Kidney Foundation of Singapore (NKF-S), the provider of subsidized d...

journal_title：Seminars in nephrology

authors： Ramirez SP,Hsu SI,Nandakumar M,Friedman EA,Durai TT,Owen WF Jr

更新日期：2001-07-01 00:00:00