Apolipoprotein L1 Gene Effects on Kidney Transplantation.

abstract：:The important role of hyperglycemia in the genesis of diabetic renal disease has been strengthened by tissue culture studies, experimental animal models, and clinical trials. A mechanistic understanding of the cellular and biochemical processes that link hyperglycemia with the development of diabetic nephropathy is in...

journal_title：Seminars in nephrology

authors： Sharma K,Ziyadeh FN

更新日期：1997-03-01 00:00:00

abstract：:Acute kidney injury (AKI) is common in the setting of shock. Hemodynamic instability is a risk factor for the development of AKI, and pathophysiological mechanisms include loss of renal perfusion pressure and impaired microcirculation. Although restoration of mean arterial pressure (MAP) may mitigate the risk of AKI t...

journal_title：Seminars in nephrology

authors： Busse LW,Ostermann M

更新日期：2019-09-01 00:00:00

abstract：:Hypertension is growing in prevalence and most of this growth represents isolated systolic hypertension in the elderly. Attempts at prevention are critical but likely are ineffectual. Therefore, the delivery and acceptance of current medical regimens must be improved. ...

journal_title：Seminars in nephrology

authors： Kaplan NM

更新日期：2005-07-01 00:00:00

abstract：:Long-term continuous ambulatory peritoneal dialysis (CAPD) often causes peritoneal fibrosis and sclerosis with a loss of function, and some CAPD patients develop sclerosing encapsulating peritonitis. Glucose-based peritoneal dialysis fluids readily produce glucose degradation products by heat sterilization, and glucos...

journal_title：Seminars in nephrology

authors： Nakamura S,Niwa T

更新日期：2004-09-01 00:00:00

abstract：:In patients with chronic kidney disease, an impaired capacity of the kidney to excrete sodium is a major contributor to hypertension. We discuss the role of sodium restriction and diuretic therapy for resistant hypertension in chronic kidney disease. Independent of increasing blood pressure, a sustained high sodium in...

journal_title：Seminars in nephrology

authors： Sinnakirouchenan R,Kotchen TA

更新日期：2014-01-01 00:00:00

abstract：:The rapid understanding of the cellular and molecular basis of organ function and disease processes will be translated in the next millennium into new therapeutic approaches to a wide range of clinical disorders, including acute and chronic renal failure. Central to these new therapies are the developing fields of gen...

journal_title：Seminars in nephrology

authors： Humes HD

更新日期：2000-01-01 00:00:00

abstract：:Kidney disease has been shown to be highly prevalent in cancer patients in the IRMA studies (Renal Insufficiency and Anticancer Medications). Furthermore, anticancer drugs used in those patients, among which half have abnormal renal function, necessitate dosage adjustment in case of reduced renal function and/or is po...

journal_title：Seminars in nephrology

authors： Launay-Vacher V

更新日期：2010-11-01 00:00:00

abstract：:Membranous nephropathy is a relatively common glomerular disease found to underlie both nonnephrotic and nephrotic proteinuria. In adults, about 75% of cases are primary (idiopathic) and 25% are secondary to a wide variety of causes, including neoplasia, infections, autoimmunity, and drugs. Presenting features are not...

journal_title：Seminars in nephrology

authors： Glassock RJ

更新日期：2003-07-01 00:00:00

abstract：:Cardio-Renal syndrome (CRS) is a common and complex clinical condition in which multiple causative factors are involved. The time window between renal insult and development of acute kidney injury (AKI) in acute heart failure (AHF) can be varied in different patients and AKI often is diagnosed too late, only when the ...

journal_title：Seminars in nephrology

authors： Ronco C,Cruz D,Noland BW

更新日期：2012-01-01 00:00:00

abstract：:Neuroimmune interaction is an emerging concept, wherein the nervous system modulates the immune system and vice versa. This concept is gaining attention as a novel therapeutic target in various inflammatory diseases including acute kidney injury (AKI). Vagus nerve stimulation or treatment with pulsed ultrasound activa...

journal_title：Seminars in nephrology

authors： Tanaka S,Okusa MD

更新日期：2019-01-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on many systems, depending on the biologic setting. Retinoids are vitamin A derivatives that also have diverse effects in development, physiology, and disease. The interactions between thes...

journal_title：Seminars in nephrology

authors： Xu Q,Kopp JB

更新日期：2012-05-01 00:00:00

abstract：:Overweight and obesity are associated with arterial hypertension. Given the large increase in the obesity prevalence worldwide, the number of obese patients with hypertension is likely to increase substantially in the near future. Overweight and obese patients are exposed to an important metabolic and cardiovascular r...

journal_title：Seminars in nephrology

authors： Vogt B,Bochud M,Burnier M

更新日期：2007-09-01 00:00:00

abstract：:A complex pathophysiology, cardio-renal syndrome (CRS), has been redefined in recent years. One subtype is acute renocardiac CRS, or CRS type 3. This syndrome is intended to comprise situations in which acute kidney injury (AKI) results in acute cardiac injury or dysfunction. The pathophysiology of CRS type 3 is not w...

journal_title：Seminars in nephrology

authors： Chuasuwan A,Kellum JA

更新日期：2012-01-01 00:00:00

abstract：:Mechanisms regulating the establishment of the glomerular endothelium and mesangium during glomerulogenesis are not understood. In this article, we discuss two different blood vessel growth processes: vasculogenesis and angiogenesis, with particular attention on how these processes might operate in the developing kidn...

journal_title：Seminars in nephrology

authors： Hyink DP,Abrahamson DR

更新日期：1995-07-01 00:00:00

abstract：:Projected requirements for nephrology physicians indicate a need for an increase in the number of nephrology trainees. In addition, government regulations are creating the climate to diminish the entry of international medical graduates into all residency programs. To meet the needs of renal patients, especially those...

journal_title：Seminars in nephrology

authors： Levison SP

更新日期：1999-03-01 00:00:00

abstract：:At present the pathogenesis of diabetic nephropathy remains unresolved. Clearly lack of insulin, with its associated disorders of carbohydrate, protein, and/or lipid metabolism, initiates the process which eventually leads to the characteristic histologic picture of diabetic nephropathy. The disturbance in cellular me...

journal_title：Seminars in nephrology

authors： Castellino P,Shohat J,DeFronzo RA

更新日期：1990-05-01 00:00:00

abstract：:Membranous nephropathy remains the most common cause of the nephrotic syndrome in adults. Most patients do well with long-term natural history studies reporting a 10-year renal survival of 70% to 90% but the remainder progress to end stage renal failure. This plus the associated morbidity of those with persistent high...

journal_title：Seminars in nephrology

authors： Geddes CC,Cattran DC

更新日期：2000-05-01 00:00:00

abstract：:Antineutrophil cytoplasmic autoantibodies (ANCA) are the likely cause for necrotizing small-vessel vasculitis and crescentic glomerulonephritis. Unlike other forms of crescentic glomerulonephritis induced by immune complexes or anti-glomerular basement membrane antibodies that have conspicuous vessel wall immunoglobul...

journal_title：Seminars in nephrology

authors： Charles Jennette J,Xiao H,Hu P

更新日期：2013-11-01 00:00:00

abstract：:Recent breakthroughs in genomics have led to a critical reappraisal of factors once thought to initiate common complex forms of kidney disease. The tenet that diabetes mellitus and hypertension routinely initiate kidney disease whenever blood glucose concentrations or systemic blood pressures reach critical levels for...

journal_title：Seminars in nephrology

authors： Freedman BI,Parekh RS,Kao WH

更新日期：2010-03-01 00:00:00

abstract：:Premature menopause defined as secondary amenorrhea is common in women with kidney disease. Moreover, the aging population has resulted in increasing numbers of postmenopausal women with kidney disease. Though the pathophysiology is poorly understood, kidney transplantation and more frequent hemodialysis can restore m...

journal_title：Seminars in nephrology

authors： Ahmed SB

更新日期：2017-07-01 00:00:00

abstract：:Vascular remodeling and hypertrophy-hyperplasia of the heart and kidney are the hallmarks of hypertensions, being involved in the long-term maintenance of elevated blood pressure and the development of cardiovascular and renal hypertension. Both augmented proliferation and unscheduled programmed cell death (apoptosis)...

journal_title：Seminars in nephrology

authors： Orlov SN,Tremblay J,Deblois D,Hamet P

更新日期：2002-03-01 00:00:00

abstract：:There are emerging data that the skeleton is connected to systemic biological functions through the release of two osteoblast-/osteocyte-derived hormones, fibroblastic growth factor 23 (FGF23) and undercarboxylated osteocalcin (Ocn). FGF23 is important in the regulation of phosphate and vitamin D metabolism, whereas O...

journal_title：Seminars in nephrology

authors： Quarles LD

更新日期：2013-03-01 00:00:00

abstract：:Exposure is a critically important aspect to consider in the study and management of drug-induced kidney injury. Although blood concentrations of kidney toxicants often may provide a valid surrogate measure of kidney exposure, the kidney has several unique physiological and biochemical properties that lend themselves ...

journal_title：Seminars in nephrology

authors： Li Z,Fisher C,Gardner I,Ghosh A,Litchfield J,Maurer TS

更新日期：2019-03-01 00:00:00

abstract：:Compared with Caucasians, African Americans have lower circulating concentrations of 25-hydroxyvitamin D (25(OH)D), the major storage form of vitamin D, leading to the widespread assumption that African Americans are at higher risk of vitamin D deficiency. However, the finding that African Americans maintain better in...

journal_title：Seminars in nephrology

authors： Saxena N,Gutiérrez OM

更新日期：2013-09-01 00:00:00

abstract：:Although systemic hypertension is a common clinical condition, hypertensive emergencies are distinctly unusual in clinical practice. There are some situations, however, that qualify as hypertensive emergencies or urgencies. It is important, therefore, to diagnose these conditions because immediate treatment of severe ...

journal_title：Seminars in nephrology

authors： Fenves AZ,Ram CV

更新日期：2005-07-01 00:00:00

abstract：:An expanding proportion of people in the United States and worldwide are affected by kidney disease, leading to a growing concern over the public health implications. Despite the high prevalence and the considerable associated health risks of kidney disease, major gaps in our knowledge base hinder the delivery of opti...

journal_title：Seminars in nephrology

authors： Himmelfarb J,Shankland SJ

更新日期：2009-09-01 00:00:00

abstract：:Sonography has become integral to the evaluation and management of patients with renal disease. Although many of the procedures discussed in this issue are not feasible for all nephrologists, sonography clearly is. It is convenient and saves time, both for the physician and the patient, and the equipment is not expens...

journal_title：Seminars in nephrology

authors： O'Neill WC

更新日期：2002-05-01 00:00:00

abstract：:Cardiovascular disease (CVD) is the major cause of morbidity and mortality in patients with renal failure. Patients with chronic kidney disease have significant CVD, and carry a high cardiovascular burden by the time they commence renal replacement therapy (RRT). The severity of CVD that has been observed in dialysis ...

journal_title：Seminars in nephrology

authors： Jaradat MI,Molitoris BA

更新日期：2002-11-01 00:00:00

abstract：:The prevalence of chronic or end-stage kidney disease in pediatric girls is lower than in boys, however, girls have unique morbidities that can have great effect on their quality of life. For female adolescents, creatinine excretion peaks at approximately 14 years of age and is significantly less than males, owing to ...

journal_title：Seminars in nephrology

authors： Diaz-Gonzalez De Ferris ME,Alvarez-Elías AC,Ferris MT,Medeiros M

更新日期：2017-07-01 00:00:00

abstract：:The incidence of progressive kidney disease associated with diabetes continues to increase worldwide. Only partial renoprotection is achieved by current standard therapy with angiotensin-converting enzyme inhibitors and/or angiotensin-receptor blockers, increasing the need for novel therapeutic approaches. Experimenta...

journal_title：Seminars in nephrology

authors： Gagliardini E,Zoja C,Benigni A

更新日期：2015-03-01 00:00:00