Genetics of programmed cell death and proliferation.

abstract：:Hyperhomocysteinemia, highly prevalent in well-nourished patients with chronic renal failure and in uremia, causes toxic effects that can be envisioned in terms of cardiovascular risk increase. However, its effects on cellular metabolism and on gene expression, not to mention receptor regulation, only recently are bei...

journal_title：Seminars in nephrology

authors： Perna AF,Capasso R,Acanfora F,Satta E,Lombardi C,Ingrosso D,Violetti E,Romano MM,De Santo NG

更新日期：2006-01-01 00:00:00

abstract：:At the present time, knowledge of the structure of the proton-translocating ATPase responsible for urinary acidification is far from complete. Key issues awaiting resolution are full definition of subunit structure and an understanding of the interactions among functional domains of this complex hetero-oligomer. Such ...

journal_title：Seminars in nephrology

authors： Stone DK,Crider BP,Xie XS

更新日期：1990-03-01 00:00:00

abstract：:By analogy to the findings with other transport disorders such as Bartter's or Liddle's syndrome, it might be expected that the various forms of renal tubular acidosis (RTA) could result from defects in H-ATPase or H-K-ATPase. However, the available data do not yet support such a simple explanation. With regard to dis...

journal_title：Seminars in nephrology

authors： Mujais SK

更新日期：1998-01-01 00:00:00

abstract：:The first aldosterone blocker, spironolactone, initially was used as a diuretic but was accompanied by a significant amount of side effects that necessitated the withdrawal of the drug in a relevant number of patients. The discovery of the many receptor-mediated actions of aldosterone in several different organs great...

journal_title：Seminars in nephrology

authors： Tamargo J,Solini A,Ruilope LM

更新日期：2014-05-01 00:00:00

abstract：:Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected syndromes that represent a global public health challenge. Organelles play essential roles in a vast range of cell functions, and their damage is related to several kidney diseases. Organelles launch the stress signal or trigger the stress r...

journal_title：Seminars in nephrology

authors： Maekawa H,Inagi R

更新日期：2019-11-01 00:00:00

abstract：:A complex pathophysiology, cardio-renal syndrome (CRS), has been redefined in recent years. One subtype is acute renocardiac CRS, or CRS type 3. This syndrome is intended to comprise situations in which acute kidney injury (AKI) results in acute cardiac injury or dysfunction. The pathophysiology of CRS type 3 is not w...

journal_title：Seminars in nephrology

authors： Chuasuwan A,Kellum JA

更新日期：2012-01-01 00:00:00

abstract：:The apical membrane epithelial Na(+) channel subunit (ENaC) in series with the basolateral Na(+)/K(+)-adenosine triphosphatase mediates collecting duct Na(+) reabsorption. Aldosterone induces αENaC gene transcription, which appears to be rate limiting for ENaC activity in this segment. Although this response has long ...

journal_title：Seminars in nephrology

authors： Kone BC

更新日期：2013-07-01 00:00:00

abstract：:Organs are complex structures that consist of multiple tissues with different levels of gene expression. To achieve comprehensive coverage and accurate quantitation data, organs ideally should be separated into morphologic and/or functional substructures before gene or protein expression analysis. However, because of ...

journal_title：Seminars in nephrology

authors： Velic A,Macek B,Wagner CA

更新日期：2010-09-01 00:00:00

abstract：:Cardiovascular disease (CVD) is the major cause of morbidity and mortality in patients with renal failure. Patients with chronic kidney disease have significant CVD, and carry a high cardiovascular burden by the time they commence renal replacement therapy (RRT). The severity of CVD that has been observed in dialysis ...

journal_title：Seminars in nephrology

authors： Jaradat MI,Molitoris BA

更新日期：2002-11-01 00:00:00

abstract：:The Kidney Early Evaluation Program (KEEP) is a free, community-based, kidney disease screening program designed to detect chronic kidney disease (CKD) early and promote follow-up evaluation with clinicians to ultimately improve outcomes. This program screens individuals with diabetes, hypertension, or those with a fi...

journal_title：Seminars in nephrology

authors： Vassalotti JA,Li S,McCullough PA,Bakris GL

更新日期：2010-01-01 00:00:00

abstract：:Novel erythropoiesis stimulating protein (NESP) is a hyperglycosylated analogue of recombinant human erythropoietin (rHuEPO) that stimulates erythropoiesis by the same mechanism as the native hormone. The addition of two extra carbohydrate chains, however, gives NESP greater metabolic stability in vivo, and its termin...

journal_title：Seminars in nephrology

authors： Macdougall IC

更新日期：2000-07-01 00:00:00

abstract：:Mechanisms regulating the establishment of the glomerular endothelium and mesangium during glomerulogenesis are not understood. In this article, we discuss two different blood vessel growth processes: vasculogenesis and angiogenesis, with particular attention on how these processes might operate in the developing kidn...

journal_title：Seminars in nephrology

authors： Hyink DP,Abrahamson DR

更新日期：1995-07-01 00:00:00

abstract：:The vacuolar H(+)-ATPase is a multisubunit protein consisting of a peripheral catalytic domain (V(1)) that binds and hydrolyzes adenosine triphosphate (ATP) and provides energy to pump H(+) through the transmembrane domain (V(0)) against a large gradient. This proton-translocating vacuolar H(+)-ATPase is present in bo...

journal_title：Seminars in nephrology

authors： Valles P,Lapointe MS,Wysocki J,Batlle D

更新日期：2006-09-01 00:00:00

abstract：:Assessment of adiposity should include measurements of both body mass index and waist circumference. The prevalence of obesity, based on a body mass index of 30 kg/m(2) or greater, has increased substantially over the past 2 decades in Western societies. Obesity remains the number one preventable risk factor for chron...

journal_title：Seminars in nephrology

authors： Wickman C,Kramer H

更新日期：2013-01-01 00:00:00

abstract：:The association between increased uric acid (UA) levels and cardiovascular disease (CVD) has been observed and studied for many decades. The value of UA as an independent factor within the metabolic risk profile for prediction of CVD in the normal population remains an issue of ongoing discussion. In turn, increasing ...

journal_title：Seminars in nephrology

authors： Doehner W,Landmesser U

更新日期：2011-09-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) isoforms are profibrotic cytokines, par excellence, and have complex multifunctional effects on many systems, depending on the biologic setting. Retinoids are vitamin A derivatives that also have diverse effects in development, physiology, and disease. The interactions between thes...

journal_title：Seminars in nephrology

authors： Xu Q,Kopp JB

更新日期：2012-05-01 00:00:00

abstract：:Macrophages have long been regarded as classic mediators of innate immunity because of their production of proinflammatory cytokines and their ability to induce apoptotic cell death. As a result of such activities and the detrimental long-term effect of kidney inflammation, macrophages principally have been regarded a...

journal_title：Seminars in nephrology

authors： Williams TM,Little MH,Ricardo SD

更新日期：2010-05-01 00:00:00

abstract：:Although evidence has accumulated indicating a close relationship between inflammation and atherosclerosis, the relationship between inflammation and vascular calcification in patients with chronic renal failure is unclear. In the present study, the relationship between C-reactive protein (CRP) and vascular calcificat...

journal_title：Seminars in nephrology

authors： Ishimura E,Okuno S,Kitatani K,Maekawa K,Izumotani T,Yamakawa T,Jono S,Shoji T,Shioi A,Inaba M,Massry SG,Nishizawa Y

更新日期：2004-09-01 00:00:00

abstract：:Studies performed over the last 10 years have evaluated the role of nitric oxide (NO) in the control of renal hemodynamics. This article reviews the effects of administration of nitric oxide synthase (NOS) blockers on renal function in experimental animals and human volunteers. These studies show that NOS blockade inc...

journal_title：Seminars in nephrology

authors： Gabbai FB,Blantz RC

更新日期：1999-05-01 00:00:00

abstract：:Membranous nephropathy is a relatively common glomerular disease found to underlie both nonnephrotic and nephrotic proteinuria. In adults, about 75% of cases are primary (idiopathic) and 25% are secondary to a wide variety of causes, including neoplasia, infections, autoimmunity, and drugs. Presenting features are not...

journal_title：Seminars in nephrology

authors： Glassock RJ

更新日期：2003-07-01 00:00:00

abstract：:Antineutrophil cytoplasmic autoantibodies (ANCA) are the likely cause for necrotizing small-vessel vasculitis and crescentic glomerulonephritis. Unlike other forms of crescentic glomerulonephritis induced by immune complexes or anti-glomerular basement membrane antibodies that have conspicuous vessel wall immunoglobul...

journal_title：Seminars in nephrology

authors： Charles Jennette J,Xiao H,Hu P

更新日期：2013-11-01 00:00:00

abstract：:Hypertension is growing in prevalence and most of this growth represents isolated systolic hypertension in the elderly. Attempts at prevention are critical but likely are ineffectual. Therefore, the delivery and acceptance of current medical regimens must be improved. ...

journal_title：Seminars in nephrology

authors： Kaplan NM

更新日期：2005-07-01 00:00:00

abstract：:Membranous nephropathy (MN), the most common cause of adult-onset nephrotic syndrome (NS) in Caucasians, is associated commonly with the secondary complications of hyperlipidemia and hypercoagulability. These may increase the risk for cardiovascular disease, alter the rate of progression of renal disease, and raise th...

journal_title：Seminars in nephrology

authors： Nickolas TL,Radhakrishnan J,Appel GB

更新日期：2003-07-01 00:00:00

abstract：:Effectiveness of antihypertensive agents is assessed not only by systemic blood pressure levels, but by multiple parameters that reflect specific organ functions. Among antihypertensive agents, those which inhibit angiotensin actions show particular efficacy in ameliorating end organ damage. This efficacy likely refle...

journal_title：Seminars in nephrology

authors： Fogo A,Kon V

更新日期：1996-11-01 00:00:00

abstract：:Overweight and obesity are associated with arterial hypertension. Given the large increase in the obesity prevalence worldwide, the number of obese patients with hypertension is likely to increase substantially in the near future. Overweight and obese patients are exposed to an important metabolic and cardiovascular r...

journal_title：Seminars in nephrology

authors： Vogt B,Bochud M,Burnier M

更新日期：2007-09-01 00:00:00

abstract：:Preeclampsia is a 2-stage disorder. Stage 1 is decreased placental perfusion and generates stage 2 of the disorder, the maternal syndrome characteristic of preeclampsia. How the 2 stages are linked has been a topic of intense investigation for many years. One candidate phenomenon, which includes many other suggested l...

journal_title：Seminars in nephrology

authors： Roberts JM,Speer P

更新日期：2004-11-01 00:00:00

abstract：:Chronic kidney disease, defined as reduced glomerular filtration rate (estimated using serum creatinine- and/or serum cystatin C-based equations) or excess urinary protein excretion, affects approximately 13% of adult Americans and is linked to a variety of clinical complications. Although persons with end-stage renal...

journal_title：Seminars in nephrology

authors： Go AS

更新日期：2016-07-01 00:00:00

abstract：:A review is presented of 164 nephrotic patients who were older than 60 years at the onset of their nephrotic syndrome, together with a review of more than 1,000 patients from the literature. The nephrotic syndrome in elderly patients is as common as in younger adults, but is often misdiagnosed as "heart failure" by pr...

journal_title：Seminars in nephrology

authors： Cameron JS

更新日期：1996-07-01 00:00:00

abstract：:The very limited ability of adult podocytes to proliferate in vivo is clinically significant because podocytes form a vascular barrier that is functionally critical to the nephron, podocyte hypoplasia is a characteristic of disease, and inadequate regeneration of podocytes is a major cause of persistent podocyte hypop...

journal_title：Seminars in nephrology

authors： Shankland SJ,Pippin JW,Duffield JS

更新日期：2014-07-01 00:00:00

abstract：:The human nuclear genome consists of approximately 3 billion nucleotides. Human beings are 99% similar in DNA sequence to each other, but natural genetic variation in approximately 1% of the DNA sequence is responsible for interindividual differences, including determining who will develop disease and who will remain ...

journal_title：Seminars in nephrology

authors： Iyengar SK,Adler SG

更新日期：2007-03-01 00:00:00