Structure of vacuolar proton pumps.

abstract：:The mortality of end-stage renal disease (ESRD) patients, including those receiving long-term peritoneal dialysis (PD), has remained unacceptably high owing to the prevalence of cardiovascular disease. It is well recognized that both traditional Framingham risk factors and kidney disease-related risk factors may contr...

journal_title：Seminars in nephrology

authors： Wang AY

更新日期：2011-03-01 00:00:00

abstract：:Arrhythmia issues arise frequently in the renal disease population, spanning the spectrum from benign ectopy to sustained arrhythmias. Studies adding to our understanding of arrhythmias and advances in technology have revolutionized the way we deal with many arrhythmias. In dealing with ventricular tachyarrhythmias, r...

journal_title：Seminars in nephrology

authors： Kocheril AG

更新日期：2001-01-01 00:00:00

abstract：:Compared with Caucasians, African Americans have lower circulating concentrations of 25-hydroxyvitamin D (25(OH)D), the major storage form of vitamin D, leading to the widespread assumption that African Americans are at higher risk of vitamin D deficiency. However, the finding that African Americans maintain better in...

journal_title：Seminars in nephrology

authors： Saxena N,Gutiérrez OM

更新日期：2013-09-01 00:00:00

abstract：:Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by bone abnormalities, vascular calcification, and an array of laboratory abnormalities. The latter classically include disturbances in the parathyroid hormone/vitamin D axis. More recently, fibroblast growth factor 23 (FGF23) and klotho also ...

journal_title：Seminars in nephrology

authors： Evenepoel P,Rodriguez M,Ketteler M

更新日期：2014-03-01 00:00:00

abstract：:Studies performed over the last 10 years have evaluated the role of nitric oxide (NO) in the control of renal hemodynamics. This article reviews the effects of administration of nitric oxide synthase (NOS) blockers on renal function in experimental animals and human volunteers. These studies show that NOS blockade inc...

journal_title：Seminars in nephrology

authors： Gabbai FB,Blantz RC

更新日期：1999-05-01 00:00:00

abstract：:The association between increased uric acid (UA) levels and cardiovascular disease (CVD) has been observed and studied for many decades. The value of UA as an independent factor within the metabolic risk profile for prediction of CVD in the normal population remains an issue of ongoing discussion. In turn, increasing ...

journal_title：Seminars in nephrology

authors： Doehner W,Landmesser U

更新日期：2011-09-01 00:00:00

abstract：:The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by a combination of arterial and/or venous thrombosis, pregnancy morbidity, and the persistent presence of circulating antiphospholipid antibodies (aPL). APS has been described as primary APS when it occurs in the absence of any featur...

journal_title：Seminars in nephrology

authors： Sciascia S,Baldovino S,Schreiber K,Solfietti L,Roccatello D

更新日期：2015-09-01 00:00:00

abstract：:Although systemic hypertension is a common clinical condition, hypertensive emergencies are distinctly unusual in clinical practice. There are some situations, however, that qualify as hypertensive emergencies or urgencies. It is important, therefore, to diagnose these conditions because immediate treatment of severe ...

journal_title：Seminars in nephrology

authors： Fenves AZ,Ram CV

更新日期：2005-07-01 00:00:00

abstract：:In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary hyperparathyroidism. The increase in serum parathyroid hormone is associated with reduced serum calcium and calcitriol levels and/or increased serum fibroblast growth f...

journal_title：Seminars in nephrology

authors： Hénaut L,Chillon JM,Kamel S,Massy ZA

更新日期：2018-05-01 00:00:00

abstract：:It has been known for decades that urinary potassium excretion varies with a circadian pattern. In this review, we consider the historical evidence for this phenomenon and present an overview of recent developments in the field. Extensive evidence from the latter part of the past century clearly shows that circadian p...

journal_title：Seminars in nephrology

authors： Gumz ML,Rabinowitz L

更新日期：2013-05-01 00:00:00

abstract：:Goodpasture (GP) syndrome is a form of anti-glomerular basement membrane (GBM) disease, in which autoantibodies bind to alpha3(IV) collagen in GBM causing rapidly progressive glomerulonephritis and pulmonary hemorrhage. The conformational GP epitopes have been mapped to 2 regions within the noncollagenous (NC1) domain...

journal_title：Seminars in nephrology

authors： Borza DB,Neilson EG,Hudson BG

更新日期：2003-11-01 00:00:00

abstract：:One of the most important and lethal effects of animal venoms is nephrotoxicity. In Latin America, severe acute kidney injury has been reported after accidents with poisonous arthropods such as bees, caterpillars of the genus Lonomia, and spiders of the genus Loxosceles. In this article the characteristics of these ve...

journal_title：Seminars in nephrology

authors： Abdulkader RC,Barbaro KC,Barros EJ,Burdmann EA

更新日期：2008-07-01 00:00:00

abstract：:Our understanding of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis has developed greatly since the discovery of ANCA, directed against neutrophil components, in 1982. Observations in human disease, and increasingly sophisticated studies in vitro and in rodent models in vivo, have allowed a nuanced u...

journal_title：Seminars in nephrology

authors： Hutton HL,Holdsworth SR,Kitching AR

更新日期：2017-09-01 00:00:00

abstract：:Pancreas transplantation is being performed with increasing frequency and increasing technical success. The availability of new immunosuppressant agents has been associated with a reduction in the previously high rates of allograft rejection in recipients of simultaneous pancreas-kidney transplants. These lower reject...

journal_title：Seminars in nephrology

authors： Hricik DE

更新日期：2000-03-01 00:00:00

abstract：:Nitric oxide (NO) is a gaseous free radical that serves cell signaling, cellular energetics, host defense, and inflammatory functions in virtually all cells. In the kidney and vasculature, NO plays fundamental roles in the control of systemic and intrarenal hemodynamics, the tubuloglomerular feedback response, pressur...

journal_title：Seminars in nephrology

authors： Kone BC

更新日期：2004-07-01 00:00:00

abstract：:The rapid understanding of the cellular and molecular basis of organ function and disease processes will be translated in the next millennium into new therapeutic approaches to a wide range of clinical disorders, including acute and chronic renal failure. Central to these new therapies are the developing fields of gen...

journal_title：Seminars in nephrology

authors： Humes HD

更新日期：2000-01-01 00:00:00

abstract：:Diagnosis of aluminum-related bone disease in patients with renal failure often requires a bone biopsy. Percutaneous biopsy of the iliac crest has been safely carried out as an outpatient procedure in over 300 patients. No instances of significant bleeding or infection have occurred. The procedure was well accepted in...

journal_title：Seminars in nephrology

authors： Norris KC,Goodman WG,Howard N,Nugent ME,Coburn JW

更新日期：1986-12-01 00:00:00

abstract：:A review is presented of 164 nephrotic patients who were older than 60 years at the onset of their nephrotic syndrome, together with a review of more than 1,000 patients from the literature. The nephrotic syndrome in elderly patients is as common as in younger adults, but is often misdiagnosed as "heart failure" by pr...

journal_title：Seminars in nephrology

authors： Cameron JS

更新日期：1996-07-01 00:00:00

abstract：:Immune-mediated nephritis is a common complication of systemic lupus erythematosus (SLE). It is now clear that multiple and independent mechanisms contribute to disease onset and pathogenesis, which may explain the remarkable phenotypic and histopathological heterogeneity observed in human SLE. Identification and char...

journal_title：Seminars in nephrology

authors： Foster MH,Kelley VR

更新日期：1999-03-01 00:00:00

abstract：:Membranous nephropathy remains the most common cause of the nephrotic syndrome in adults. Most patients do well with long-term natural history studies reporting a 10-year renal survival of 70% to 90% but the remainder progress to end stage renal failure. This plus the associated morbidity of those with persistent high...

journal_title：Seminars in nephrology

authors： Geddes CC,Cattran DC

更新日期：2000-05-01 00:00:00

abstract：:Early diagnosis of acute kidney injury (AKI) is an important step to improve AKI outcome. In Asia, several distinct conditions of this region such as environment (tropical climate), socioeconomic status (high-resource and low-resource settings), process of care (shortage of nephrologists), exposure factors (specific t...

journal_title：Seminars in nephrology

authors： Srisawat N,Lumlertgul N,Kulvichit W,Thamrongsat N,Peerapornratana S,Eiam-Ong S,Tungsanga K

更新日期：2020-09-01 00:00:00

abstract：:This prospective multicenter study included 1,205 patients, who were referred for difficult-to-treat hypertension or analysis of possible secondary hypertension. After a standardized selection protocol based on sharply defined drug-resistant hypertension or renal function impairment during angiotensin-converting enzym...

journal_title：Seminars in nephrology

authors： van Jaarsveld BC,Krijnen P

更新日期：2000-09-01 00:00:00

abstract：:The identification of natriuretic peptides as key regulators of natriuresis and vasodilatation, and the appreciation that their secretion is under the control of cardiac hemodynamic and neurohumoral factors, has caused wide interest. The natriuretic peptides are structurally similar, but genetically distinct peptides ...

journal_title：Seminars in nephrology

authors： Dhingra H,Roongsritong C,Kurtzman NA

更新日期：2002-09-01 00:00:00

abstract：:Besides loss of life and property, natural disasters result in a number of renal challenges, either by the creation of rhabdomyolysis and crush-induced acute kidney injury or by the destruction of existing dialysis facilities, leaving chronic dialysis patients and kidney transplanted patients without access to their r...

journal_title：Seminars in nephrology

authors： Lameire N,Sever MS,Van Biesen W,Vanholder R

更新日期：2020-07-01 00:00:00

abstract：:The first part of this article focuses on the risk of functional deterioration in subjects with solitary kidneys; the long-term clinical outcome of various subgroups of patients is reviewed. Thereafter, the pathophysiology of the renal functional reserve in subjects with a 50% reduction in renal parenchyma and the res...

journal_title：Seminars in nephrology

authors： Rugiu C,Oldrizzi L,Maschio G

更新日期：1995-09-01 00:00:00

abstract：:A complex pathophysiology, cardio-renal syndrome (CRS), has been redefined in recent years. One subtype is acute renocardiac CRS, or CRS type 3. This syndrome is intended to comprise situations in which acute kidney injury (AKI) results in acute cardiac injury or dysfunction. The pathophysiology of CRS type 3 is not w...

journal_title：Seminars in nephrology

authors： Chuasuwan A,Kellum JA

更新日期：2012-01-01 00:00:00

abstract：:Monocytes/macrophages and activated (but not resting) lymphocytes as well as certain subsets of thymocytes express the VDR. This protein is indistinguishable from the classical 50-kDa VDR and is encoded by an mRNA with identical nucleotide sequence to that of the human intestinal VDR. Acting via the VDR, 1,25(OH)2D3 m...

journal_title：Seminars in nephrology

authors： Manolagas SC,Yu XP,Girasole G,Bellido T

更新日期：1994-03-01 00:00:00

abstract：:In humans, idiopathic hypercalciuria is associated with stone formation. To study the mechanisms that are responsible for the excess urine calcium excretion in ways that are difficult to impossible in humans, we have developed a rat model of idiopathic hypercalciuria. Hypercalciuric rats were successively inbred for m...

journal_title：Seminars in nephrology

authors： Bushinsky DA

更新日期：1996-09-01 00:00:00

abstract：:The prevalence of chronic or end-stage kidney disease in pediatric girls is lower than in boys, however, girls have unique morbidities that can have great effect on their quality of life. For female adolescents, creatinine excretion peaks at approximately 14 years of age and is significantly less than males, owing to ...

journal_title：Seminars in nephrology

authors： Diaz-Gonzalez De Ferris ME,Alvarez-Elías AC,Ferris MT,Medeiros M

更新日期：2017-07-01 00:00:00

abstract：:Patients with cirrhosis have significant abnormalities in their fluid and electrolyte balance, this is manifested mainly by the development of ascites and edema. Ascites is the most common complication of patients with cirrhosis and its development constitutes the first and most important manifestation of the disease....

journal_title：Seminars in nephrology

authors： Cárdenas A,Ginès P

更新日期：2001-05-01 00:00:00