Nephrotoxicity of insect and spider venoms in Latin America.

abstract：:Organs are complex structures that consist of multiple tissues with different levels of gene expression. To achieve comprehensive coverage and accurate quantitation data, organs ideally should be separated into morphologic and/or functional substructures before gene or protein expression analysis. However, because of ...

journal_title：Seminars in nephrology

authors： Velic A,Macek B,Wagner CA

更新日期：2010-09-01 00:00:00

abstract：:Long-term continuous ambulatory peritoneal dialysis (CAPD) often causes peritoneal fibrosis and sclerosis with a loss of function, and some CAPD patients develop sclerosing encapsulating peritonitis. Glucose-based peritoneal dialysis fluids readily produce glucose degradation products by heat sterilization, and glucos...

journal_title：Seminars in nephrology

authors： Nakamura S,Niwa T

更新日期：2004-09-01 00:00:00

abstract：:The search for an endogenous digitalis has led to the identification of the cardenolides ouabain and digoxin and the bufadienolide marinobufagenin in mammalian tissues and biological fluids. Ouabain's release from adrenal glands is under the control of epinephrine and angiotensin II; hence, its blood concentration cha...

journal_title：Seminars in nephrology

authors： Schoner W,Scheiner-Bobis G

更新日期：2005-09-01 00:00:00

abstract：:The apical membrane epithelial Na(+) channel subunit (ENaC) in series with the basolateral Na(+)/K(+)-adenosine triphosphatase mediates collecting duct Na(+) reabsorption. Aldosterone induces αENaC gene transcription, which appears to be rate limiting for ENaC activity in this segment. Although this response has long ...

journal_title：Seminars in nephrology

authors： Kone BC

更新日期：2013-07-01 00:00:00

abstract：:Kidney disease has been shown to be highly prevalent in cancer patients in the IRMA studies (Renal Insufficiency and Anticancer Medications). Furthermore, anticancer drugs used in those patients, among which half have abnormal renal function, necessitate dosage adjustment in case of reduced renal function and/or is po...

journal_title：Seminars in nephrology

authors： Launay-Vacher V

更新日期：2010-11-01 00:00:00

abstract：:Stephen Hales was the first to measure blood pressure directly in the horse (1733), and the definitive studies on human nephrins by Richard Bright followed much later (1836). The relation between high blood pressure and renal disease was established by Mahomed (1872). The discovery of renin and its possible link with ...

journal_title：Seminars in nephrology

authors： Peart S

更新日期：2000-09-01 00:00:00

abstract：:Necrosis is the predominant form of regulated cell death in acute kidney injury (AKI) and represents results in the formation of casts that appear in the urine sedimentation, referred to as muddy brown casts, which are part of the diagnosis of AKI. Pathologists referred to this typical feature as acute tubular necrosi...

journal_title：Seminars in nephrology

authors： Kers J,Leemans JC,Linkermann A

更新日期：2016-05-01 00:00:00

abstract：:Frailty is a distinct phenotype that is highly prevalent in chronic kidney disease (CKD) and appears to be more prevalent with decreasing glomerular filtration rate. Exercise training or intervention to increase physical activity may ameliorate poor physical functioning and frailty, and even may improve survival in pa...

journal_title：Seminars in nephrology

authors： Sheshadri A,Johansen KL

更新日期：2017-03-01 00:00:00

abstract：:The rapid understanding of the cellular and molecular basis of organ function and disease processes will be translated in the next millennium into new therapeutic approaches to a wide range of clinical disorders, including acute and chronic renal failure. Central to these new therapies are the developing fields of gen...

journal_title：Seminars in nephrology

authors： Humes HD

更新日期：2000-01-01 00:00:00

abstract：:Minimally invasive therapies for urolithiasis including extracorporeal shock wave lithotripsy, ureteroscopy, and percutaneous nephrostolithotomy are highly efficacious, yet expensive. Medical expulsive therapy offers a cost-effective, nonsurgical approach for appropriate patients with ureteral stones. The use of hormo...

journal_title：Seminars in nephrology

authors： Sterrett SP,Nakada SY

更新日期：2008-03-01 00:00:00

abstract：:Cell-based therapy, designed to promote angiogenesis and improve organ function, has been under investigation for the treatment of ischemic heart disease for more than 10 years. Although believed to work primarily by repairing the microvasculature, this form of therapy has not been examined in the setting of chronic k...

journal_title：Seminars in nephrology

authors： Gilbert RE,Zhang Y,Yuen DA

更新日期：2012-09-01 00:00:00

abstract：:Kidney function declines with age in association with the development of age-associated glomerulosclerosis. The well-established structural and functional changes with age are reviewed briefly. The modification of aging pathology by calorie restriction is discussed. The role of the podocyte as a critical cell in the a...

journal_title：Seminars in nephrology

authors： Wiggins J

更新日期：2009-11-01 00:00:00

abstract：:Vascular remodeling and hypertrophy-hyperplasia of the heart and kidney are the hallmarks of hypertensions, being involved in the long-term maintenance of elevated blood pressure and the development of cardiovascular and renal hypertension. Both augmented proliferation and unscheduled programmed cell death (apoptosis)...

journal_title：Seminars in nephrology

authors： Orlov SN,Tremblay J,Deblois D,Hamet P

更新日期：2002-03-01 00:00:00

abstract：:Given the prohibitive costs of end-stage renal disease (ESRD) care for certain countries and the increasing incidence of ESRD worldwide, alternative methods of funding dialysis care are increasingly necessary. We describe the paradigm of the National Kidney Foundation of Singapore (NKF-S), the provider of subsidized d...

journal_title：Seminars in nephrology

authors： Ramirez SP,Hsu SI,Nandakumar M,Friedman EA,Durai TT,Owen WF Jr

更新日期：2001-07-01 00:00:00

abstract：:Numerous pathological processes are involved in the renal tubulointerstitial fibrogenic reaction that occurs after ureteral ligation. Central to these maladaptive events is a florid interstitial monocytic infiltration of the tubulointerstitium, which is preceded by a proximal tubular up-regulation of macrophage chemoa...

journal_title：Seminars in nephrology

authors： Diamond JR,Ricardo SD,Klahr S

更新日期：1998-11-01 00:00:00

abstract：:In aggregate, the evidence reviewed here supports a very important role for PDGF expression and action at local glomerular and interstitial sites in human kidney development and disease. PDGF delivered by platelets, or produced by endogenous cells of the kidney is capable of stimulating responses including proliferati...

journal_title：Seminars in nephrology

authors： Daniel TO,Kumjian DA

更新日期：1993-01-01 00:00:00

abstract：:At present the pathogenesis of diabetic nephropathy remains unresolved. Clearly lack of insulin, with its associated disorders of carbohydrate, protein, and/or lipid metabolism, initiates the process which eventually leads to the characteristic histologic picture of diabetic nephropathy. The disturbance in cellular me...

journal_title：Seminars in nephrology

authors： Castellino P,Shohat J,DeFronzo RA

更新日期：1990-05-01 00:00:00

abstract：:At the present time, knowledge of the structure of the proton-translocating ATPase responsible for urinary acidification is far from complete. Key issues awaiting resolution are full definition of subunit structure and an understanding of the interactions among functional domains of this complex hetero-oligomer. Such ...

journal_title：Seminars in nephrology

authors： Stone DK,Crider BP,Xie XS

更新日期：1990-03-01 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) has revolutionized the treatment of anemia of chronic renal failure. RHuEPO has been shown to increase survival, decrease hospitalizations, improve brain and cognitive function, and improve quality of life for renal patients. Much has been learned about the normal and patholog...

journal_title：Seminars in nephrology

authors： Tong EM,Nissenson AR

更新日期：2001-03-01 00:00:00

abstract：:There are emerging data that the skeleton is connected to systemic biological functions through the release of two osteoblast-/osteocyte-derived hormones, fibroblastic growth factor 23 (FGF23) and undercarboxylated osteocalcin (Ocn). FGF23 is important in the regulation of phosphate and vitamin D metabolism, whereas O...

journal_title：Seminars in nephrology

authors： Quarles LD

更新日期：2013-03-01 00:00:00

abstract：:Nephritic edema results from the primary retention of salt. Acute glomerulonephritis is the prototypical form of the disorder. The stimulus for the salt retention arises within the kidney by an unknown mechanism. As effective arterial blood volume (EABV) was normal at the start of the disease process, it becomes expan...

journal_title：Seminars in nephrology

authors： Kurtzman NA

更新日期：2001-05-01 00:00:00

abstract：:The catecholamines dopamine and norepinephrine, play a central role in the regulation of sodium homeostasis and blood pressure. Dopamine inhibits tubular Na+, K(+)-ATPase activity and increases sodium excretion. Norepinephrine stimulates Na+, K(+)-ATPase activity and decreases urinary sodium excretion. The signaling p...

journal_title：Seminars in nephrology

authors： Meister B,Aperia A

更新日期：1993-01-01 00:00:00

abstract：:Amiloride is a prototypic inhibitor of epithelial sodium channels. Rapid progress has been made in our understanding of the structure of the sodium channel and related cation-selective channels. This work, coupled with experiments examining how selected sodium channel mutations affect amiloride binding, provides criti...

journal_title：Seminars in nephrology

authors： Kleyman TR,Sheng S,Kosari F,Kieber-Emmons T

更新日期：1999-11-01 00:00:00

abstract：:Preeclampsia is a 2-stage disorder. Stage 1 is decreased placental perfusion and generates stage 2 of the disorder, the maternal syndrome characteristic of preeclampsia. How the 2 stages are linked has been a topic of intense investigation for many years. One candidate phenomenon, which includes many other suggested l...

journal_title：Seminars in nephrology

authors： Roberts JM,Speer P

更新日期：2004-11-01 00:00:00

abstract：:Arrhythmia issues arise frequently in the renal disease population, spanning the spectrum from benign ectopy to sustained arrhythmias. Studies adding to our understanding of arrhythmias and advances in technology have revolutionized the way we deal with many arrhythmias. In dealing with ventricular tachyarrhythmias, r...

journal_title：Seminars in nephrology

authors： Kocheril AG

更新日期：2001-01-01 00:00:00

abstract：:Neuroimmune interaction is an emerging concept, wherein the nervous system modulates the immune system and vice versa. This concept is gaining attention as a novel therapeutic target in various inflammatory diseases including acute kidney injury (AKI). Vagus nerve stimulation or treatment with pulsed ultrasound activa...

journal_title：Seminars in nephrology

authors： Tanaka S,Okusa MD

更新日期：2019-01-01 00:00:00

abstract：:As kidney function declines, chronic kidney disease (CKD) becomes an increasingly systemic disorder. Most patients with CKD eventually develop subclinical or clinical abnormalities in bone and mineral metabolism. Recent observational and basic scientific studies have led to a new emphasis on the changes in phosphorus ...

journal_title：Seminars in nephrology

authors： Williams ME

更新日期：2009-03-01 00:00:00

abstract：:Peritoneal dialysis (PD) may be a feasible, safe, and complementary alternative to hemodialysis not only in the chronic setting, but also in the acute setting. It previously was widely accepted for acute kidney injury (AKI) treatment, but its practice decreased in favor of other types of extracorporeal therapies. The ...

journal_title：Seminars in nephrology

authors： Ponce D,Balbi A,Cullis B

更新日期：2017-01-01 00:00:00

abstract：:Calcium homeostasis is an important aspect of maternal and fetal physiology during gestation, and recent evidence implicates alterations in calcium metabolism in the pathogenesis of hypertension during pregnancy. Deficiencies in calcium intake have been linked to preeclampsia/eclampsia, and hypocalciuria and deviation...

journal_title：Seminars in nephrology

authors： Hojo M,August P

更新日期：1995-11-01 00:00:00

abstract：:Nephrogenic systemic fibrosis is a new disease whose incidence has peaked and receded over the past decade. It occurs in the presence of significant renal impairment, either acute or chronic (MDRD creatinine clearance of <30 mL/min/1.73 m(2)), and is associated with the administration of gadolinium-based contrast (GBC...

journal_title：Seminars in nephrology

authors： Hellman RN

更新日期：2011-05-01 00:00:00