An Overview of Pathways of Regulated Necrosis in Acute Kidney Injury.

abstract：:Overweight and obesity are associated with arterial hypertension. Given the large increase in the obesity prevalence worldwide, the number of obese patients with hypertension is likely to increase substantially in the near future. Overweight and obese patients are exposed to an important metabolic and cardiovascular r...

journal_title：Seminars in nephrology

authors： Vogt B,Bochud M,Burnier M

更新日期：2007-09-01 00:00:00

abstract：:In recent years, it has become apparent that parietal epithelial cells (PECs) play an important role within the renal glomerulus, in particular in diseased conditions. In this review, we examine current knowledge about the role of PECs and their interactions with podocytes in development and under physiological condit...

journal_title：Seminars in nephrology

authors： Smeets B,Moeller MJ

更新日期：2012-07-01 00:00:00

abstract：:Mechanisms regulating the establishment of the glomerular endothelium and mesangium during glomerulogenesis are not understood. In this article, we discuss two different blood vessel growth processes: vasculogenesis and angiogenesis, with particular attention on how these processes might operate in the developing kidn...

journal_title：Seminars in nephrology

authors： Hyink DP,Abrahamson DR

更新日期：1995-07-01 00:00:00

abstract：:Renal involvement is common in leptospirosis. Clinical manifestations vary from urinary sediment changes to acute renal failure. Renal failure is observed in 44% to 67% of patients. Hypokalemia frequently occurs. Severe hypotension is an important warning sign for the later development of renal and pulmonary complicat...

journal_title：Seminars in nephrology

authors： Sitprija V,Losuwanrak K,Kanjanabuch T

更新日期：2003-01-01 00:00:00

abstract：:Cardiovascular disease (CVD) is the major cause of morbidity and mortality in patients with renal failure. Patients with chronic kidney disease have significant CVD, and carry a high cardiovascular burden by the time they commence renal replacement therapy (RRT). The severity of CVD that has been observed in dialysis ...

journal_title：Seminars in nephrology

authors： Jaradat MI,Molitoris BA

更新日期：2002-11-01 00:00:00

abstract：:Initially described in 1984, human immunodeficiency virus-associated nephropathy (HIVAN) has now become a common disease within the HIV-seropositive population. It is a focal segmental glomerulosclerosis causing rapid deterioration of renal function. It is the most common cause of chronic renal disease in HIV patients...

journal_title：Seminars in nephrology

authors： Herman ES,Klotman PE

更新日期：2003-03-01 00:00:00

abstract：:Preeclampsia is a 2-stage disorder. Stage 1 is decreased placental perfusion and generates stage 2 of the disorder, the maternal syndrome characteristic of preeclampsia. How the 2 stages are linked has been a topic of intense investigation for many years. One candidate phenomenon, which includes many other suggested l...

journal_title：Seminars in nephrology

authors： Roberts JM,Speer P

更新日期：2004-11-01 00:00:00

abstract：:The first part of this article focuses on the risk of functional deterioration in subjects with solitary kidneys; the long-term clinical outcome of various subgroups of patients is reviewed. Thereafter, the pathophysiology of the renal functional reserve in subjects with a 50% reduction in renal parenchyma and the res...

journal_title：Seminars in nephrology

authors： Rugiu C,Oldrizzi L,Maschio G

更新日期：1995-09-01 00:00:00

abstract：:The identification of natriuretic peptides as key regulators of natriuresis and vasodilatation, and the appreciation that their secretion is under the control of cardiac hemodynamic and neurohumoral factors, has caused wide interest. The natriuretic peptides are structurally similar, but genetically distinct peptides ...

journal_title：Seminars in nephrology

authors： Dhingra H,Roongsritong C,Kurtzman NA

更新日期：2002-09-01 00:00:00

abstract：:Diabetes mellitus (DM) is becoming more common in the United States affecting an estimated 18.2 million Americans. Not only is the number of American's with DM staggering, but so are the medical and economic costs of DM. DM accounts for nearly 15% of all health care costs in the United States. The chronic hyperglycemi...

journal_title：Seminars in nephrology

authors： Daneshgari F,Moore C

更新日期：2006-03-01 00:00:00

abstract：:Studies in patients on maintenance hemodialysis have disclosed a high prevalence of sleeping disorders, which have been linked to various factors including blood urea levels, creatinine levels, parathyroid hormone levels, anemia, systolic and diastolic blood pressure, quality of life, disease intrusiveness, and comorb...

journal_title：Seminars in nephrology

authors： De Santo RM,Bartiromo M,Cesare MC,Di Iorio BR

更新日期：2006-01-01 00:00:00

abstract：:Autophagy is a ubiquitous intracellular catabolic process that contributes to homeostatic maintenance and regulates the balance between health and disease. Emerging evidence from both the immunology and renal literature suggests that important relationships exist between the immune system and renal autophagy that may ...

journal_title：Seminars in nephrology

authors： Leventhal JS,He JC,Ross MJ

更新日期：2014-01-01 00:00:00

abstract：:Traditionally, renal ischemia has been regarded as central to the pathogenesis of sepsis-associated acute kidney injury (SA-AKI). Accordingly, hemodynamic management of SA-AKI has emphasized restoration of renal perfusion, whereas, experimentally, ischemia reperfusion models have been emphasized. However, in human bei...

journal_title：Seminars in nephrology

authors： Prowle JR,Bellomo R

更新日期：2015-01-01 00:00:00

abstract：:In most countries the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in peritoneal dialysis (PD) patients is lower than in hemodialysis (HD) patients. Besides a history of blood transfusions, previous HD is an important risk factor for developing HCV infection in PD patients. Many HCV-posi...

journal_title：Seminars in nephrology

authors： Puttinger H,Vychytil A

更新日期：2002-07-01 00:00:00

abstract：:Hyperhomocysteinemia, highly prevalent in well-nourished patients with chronic renal failure and in uremia, causes toxic effects that can be envisioned in terms of cardiovascular risk increase. However, its effects on cellular metabolism and on gene expression, not to mention receptor regulation, only recently are bei...

journal_title：Seminars in nephrology

authors： Perna AF,Capasso R,Acanfora F,Satta E,Lombardi C,Ingrosso D,Violetti E,Romano MM,De Santo NG

更新日期：2006-01-01 00:00:00

abstract：:Kidney function declines with age in association with the development of age-associated glomerulosclerosis. The well-established structural and functional changes with age are reviewed briefly. The modification of aging pathology by calorie restriction is discussed. The role of the podocyte as a critical cell in the a...

journal_title：Seminars in nephrology

authors： Wiggins J

更新日期：2009-11-01 00:00:00

abstract：:Acute renal failure (ARF) is an important clinical syndrome. Despite the frequent occurrence of ARF, nephrologists have not made major therapeutic inroads in the treatment or prevention of ARF. This article will speculate as to why it has been so difficult to gain a substantial foothold in the ongoing battle against A...

journal_title：Seminars in nephrology

authors： Paller MS

更新日期：1998-09-01 00:00:00

abstract：:Chronic kidney disease mineral and bone disorder (MBD) encompasses changes in mineral ion and vitamin D metabolism that are widespread in the setting of chronic kidney disease and end-stage renal disease. MBD components associate with cardiovascular disease in many epidemiologic studies. Through impacts on hypertensio...

journal_title：Seminars in nephrology

authors： Lunyera J,Scialla JJ

更新日期：2018-11-01 00:00:00

abstract：:Red cell production in chronic kidney disease is usually too low to maintain a normal haemoglobin, and thus anaemia develops in a large proportion of patients. The ability to stimulate erythropoiesis in the bone marrow by the use of therapeutic agents has only been possible in the last 20 years, initially with recombi...

journal_title：Seminars in nephrology

authors： Macdougall IC

更新日期：2006-07-01 00:00:00

abstract：:Cigarette smoking (CS) has been associated with augmented progression of nephropathies responsible for the 4 major causes of end-stage renal disease (ESRD) in the United States. CS has well-described ways by which it causes tissue injury in other organ systems and the mechanisms by which it adversely affects nephropat...

journal_title：Seminars in nephrology

authors： Wesson DE

更新日期：2003-05-01 00:00:00

abstract：:Small lipids such as eicosanoids exert diverse and complex functions. In addition to their role in regulating normal kidney function, these lipids also play important roles in the pathogenesis of kidney diseases. Increased glomerular cyclooxygenase (COX)1 or COX2 expression has been reported in patients with nephritis...

journal_title：Seminars in nephrology

authors： Hao CM,Breyer MD

更新日期：2007-05-01 00:00:00

abstract：:Blood pressure increases with age in all US population groups that have been studies, but does so faster in African Americans. Evidence from extensive microscopic renal vascular studies at autopsy supports the view that blood pressure increases with age because of progressive fibroplasia of renal interlobular arteries...

journal_title：Seminars in nephrology

authors： Tracy RE

更新日期：1996-03-01 00:00:00

abstract：:This prospective multicenter study included 1,205 patients, who were referred for difficult-to-treat hypertension or analysis of possible secondary hypertension. After a standardized selection protocol based on sharply defined drug-resistant hypertension or renal function impairment during angiotensin-converting enzym...

journal_title：Seminars in nephrology

authors： van Jaarsveld BC,Krijnen P

更新日期：2000-09-01 00:00:00

abstract：:Goodpasture (GP) syndrome is a form of anti-glomerular basement membrane (GBM) disease, in which autoantibodies bind to alpha3(IV) collagen in GBM causing rapidly progressive glomerulonephritis and pulmonary hemorrhage. The conformational GP epitopes have been mapped to 2 regions within the noncollagenous (NC1) domain...

journal_title：Seminars in nephrology

authors： Borza DB,Neilson EG,Hudson BG

更新日期：2003-11-01 00:00:00

abstract：:The first aldosterone blocker, spironolactone, initially was used as a diuretic but was accompanied by a significant amount of side effects that necessitated the withdrawal of the drug in a relevant number of patients. The discovery of the many receptor-mediated actions of aldosterone in several different organs great...

journal_title：Seminars in nephrology

authors： Tamargo J,Solini A,Ruilope LM

更新日期：2014-05-01 00:00:00

abstract：:A number of antineoplastic chemotherapeutic drugs may produce fluid and electrolyte disturbances or nephrotoxic reactions extending across the clinical spectrum, from subclinical renal dysfunction to progressive chronic renal insufficiency to severe acute failure. Although some of the drugs that are highly nephrotoxic...

journal_title：Seminars in nephrology

authors： Berns JS,Ford PA

更新日期：1997-01-01 00:00:00

abstract：:Care of patients with type 1 diabetes (T1D) has changed during the past 30 years. Tools to control hyperglycemia have improved and it was shown that improvement in glycemic control diminished the risk of late diabetic complications, including nephropathy. Moreover, in patients with impaired renal function, aggressive ...

journal_title：Seminars in nephrology

authors： Krolewski AS,Bonventre JV

更新日期：2012-09-01 00:00:00

abstract：:Nitric oxide (NO) is a gaseous free radical that serves cell signaling, cellular energetics, host defense, and inflammatory functions in virtually all cells. In the kidney and vasculature, NO plays fundamental roles in the control of systemic and intrarenal hemodynamics, the tubuloglomerular feedback response, pressur...

journal_title：Seminars in nephrology

authors： Kone BC

更新日期：2004-07-01 00:00:00

abstract：:A complex pathophysiology, cardio-renal syndrome (CRS), has been redefined in recent years. One subtype is acute renocardiac CRS, or CRS type 3. This syndrome is intended to comprise situations in which acute kidney injury (AKI) results in acute cardiac injury or dysfunction. The pathophysiology of CRS type 3 is not w...

journal_title：Seminars in nephrology

authors： Chuasuwan A,Kellum JA

更新日期：2012-01-01 00:00:00

abstract：:As kidney function declines, chronic kidney disease (CKD) becomes an increasingly systemic disorder. Most patients with CKD eventually develop subclinical or clinical abnormalities in bone and mineral metabolism. Recent observational and basic scientific studies have led to a new emphasis on the changes in phosphorus ...

journal_title：Seminars in nephrology

authors： Williams ME

更新日期：2009-03-01 00:00:00