Cardiovascular Disease Consequences of CKD.

abstract：:Cell-based therapy, designed to promote angiogenesis and improve organ function, has been under investigation for the treatment of ischemic heart disease for more than 10 years. Although believed to work primarily by repairing the microvasculature, this form of therapy has not been examined in the setting of chronic k...

journal_title：Seminars in nephrology

authors： Gilbert RE,Zhang Y,Yuen DA

更新日期：2012-09-01 00:00:00

abstract：:A number of antineoplastic chemotherapeutic drugs may produce fluid and electrolyte disturbances or nephrotoxic reactions extending across the clinical spectrum, from subclinical renal dysfunction to progressive chronic renal insufficiency to severe acute failure. Although some of the drugs that are highly nephrotoxic...

journal_title：Seminars in nephrology

authors： Berns JS,Ford PA

更新日期：1997-01-01 00:00:00

abstract：:A number of conditions can contribute to the development of the anemia that inevitably occurs with end-stage renal disease. The primary ones are decreased production of erythropoietin (EPO), decreased response to EPO by the bone marrow, and shortened red cell survival. Dialysis improves hematocrit levels by reducing p...

journal_title：Seminars in nephrology

authors： Korbet SM

更新日期：1989-03-01 00:00:00

abstract：:Our understanding of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis has developed greatly since the discovery of ANCA, directed against neutrophil components, in 1982. Observations in human disease, and increasingly sophisticated studies in vitro and in rodent models in vivo, have allowed a nuanced u...

journal_title：Seminars in nephrology

authors： Hutton HL,Holdsworth SR,Kitching AR

更新日期：2017-09-01 00:00:00

abstract：:Toxic nephropathies cause acute and chronic renal failure, primarily as a result of injury to renal tubular epithelium. There is a well-known capacity in the renal nephron for the synchronous occurrence of both apoptosis and necrosis in toxic nephropathies. This has engendered interest in the differing or complementar...

journal_title：Seminars in nephrology

authors： Gobe GC,Endre ZH

更新日期：2003-09-01 00:00:00

abstract：:Red cell production in chronic kidney disease is usually too low to maintain a normal haemoglobin, and thus anaemia develops in a large proportion of patients. The ability to stimulate erythropoiesis in the bone marrow by the use of therapeutic agents has only been possible in the last 20 years, initially with recombi...

journal_title：Seminars in nephrology

authors： Macdougall IC

更新日期：2006-07-01 00:00:00

abstract：:In chronic kidney disease the excessive production of parathyroid hormone increases the bone resorption rate and leads to histologic bone signs of secondary hyperparathyroidism. However, in other situations, the initial increase in parathyroid hormone and bone remodeling may be slowed down excessively by a multitude o...

journal_title：Seminars in nephrology

authors： Torres PU,Bover J,Mazzaferro S,de Vernejoul MC,Cohen-Solal M

更新日期：2014-11-01 00:00:00

abstract：:This prospective multicenter study included 1,205 patients, who were referred for difficult-to-treat hypertension or analysis of possible secondary hypertension. After a standardized selection protocol based on sharply defined drug-resistant hypertension or renal function impairment during angiotensin-converting enzym...

journal_title：Seminars in nephrology

authors： van Jaarsveld BC,Krijnen P

更新日期：2000-09-01 00:00:00

abstract：:The rapid understanding of the cellular and molecular basis of organ function and disease processes will be translated in the next millennium into new therapeutic approaches to a wide range of clinical disorders, including acute and chronic renal failure. Central to these new therapies are the developing fields of gen...

journal_title：Seminars in nephrology

authors： Humes HD

更新日期：2000-01-01 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) has revolutionized the treatment of anemia of chronic renal failure. RHuEPO has been shown to increase survival, decrease hospitalizations, improve brain and cognitive function, and improve quality of life for renal patients. Much has been learned about the normal and patholog...

journal_title：Seminars in nephrology

authors： Tong EM,Nissenson AR

更新日期：2001-03-01 00:00:00

abstract：:Antineutrophil cytoplasmic autoantibodies (ANCA) are the likely cause for necrotizing small-vessel vasculitis and crescentic glomerulonephritis. Unlike other forms of crescentic glomerulonephritis induced by immune complexes or anti-glomerular basement membrane antibodies that have conspicuous vessel wall immunoglobul...

journal_title：Seminars in nephrology

authors： Charles Jennette J,Xiao H,Hu P

更新日期：2013-11-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN), the single most common cause of end-stage renal failure in seropositive patients, has increased in incidence by 30% each year since 1991. Occurring almost exclusively in blacks, HIVAN became the third leading cause of ESRD in blacks, ages 20 to 64, in ...

journal_title：Seminars in nephrology

authors： Winston JA,Burns GC,Klotman PE

更新日期：1998-07-01 00:00:00

abstract：:Acid-base balance is critical for normal life. Acute and chronic disturbances impact cellular energy metabolism, endocrine signaling, ion channel activity, neuronal activity, and cardiovascular functions such as cardiac contractility and vascular blood flow. Maintenance and adaptation of acid-base homeostasis are most...

journal_title：Seminars in nephrology

authors： Wagner CA,Imenez Silva PH,Bourgeois S

更新日期：2019-07-01 00:00:00

abstract：:Early diagnosis of acute kidney injury (AKI) is an important step to improve AKI outcome. In Asia, several distinct conditions of this region such as environment (tropical climate), socioeconomic status (high-resource and low-resource settings), process of care (shortage of nephrologists), exposure factors (specific t...

journal_title：Seminars in nephrology

authors： Srisawat N,Lumlertgul N,Kulvichit W,Thamrongsat N,Peerapornratana S,Eiam-Ong S,Tungsanga K

更新日期：2020-09-01 00:00:00

abstract：:It has been known for decades that urinary potassium excretion varies with a circadian pattern. In this review, we consider the historical evidence for this phenomenon and present an overview of recent developments in the field. Extensive evidence from the latter part of the past century clearly shows that circadian p...

journal_title：Seminars in nephrology

authors： Gumz ML,Rabinowitz L

更新日期：2013-05-01 00:00:00

abstract：:Autophagy is a ubiquitous intracellular catabolic process that contributes to homeostatic maintenance and regulates the balance between health and disease. Emerging evidence from both the immunology and renal literature suggests that important relationships exist between the immune system and renal autophagy that may ...

journal_title：Seminars in nephrology

authors： Leventhal JS,He JC,Ross MJ

更新日期：2014-01-01 00:00:00

abstract：:Substantial progress has been made in the application of computer-driven methods to provide erythropoietic dosing information for patients with anemia resulting from chronic kidney disease. Initial solutions were simply computerized versions of traditional paper-based anemia management protocols. True personalization ...

journal_title：Seminars in nephrology

authors： Brier ME,Gaweda AE,Aronoff GR

更新日期：2018-07-01 00:00:00

abstract：:The mortality of end-stage renal disease (ESRD) patients, including those receiving long-term peritoneal dialysis (PD), has remained unacceptably high owing to the prevalence of cardiovascular disease. It is well recognized that both traditional Framingham risk factors and kidney disease-related risk factors may contr...

journal_title：Seminars in nephrology

authors： Wang AY

更新日期：2011-03-01 00:00:00

abstract：:Cerebrovascular disease and stroke are very common at all stages of chronic kidney disease (CKD), likely representing both shared risk factors as well as synergy among risk factors. More subtle ischemic brain lesions may be particularly common in the CKD population, with subtle manifestations including cognitive impai...

journal_title：Seminars in nephrology

authors： Dad T,Weiner DE

更新日期：2015-07-01 00:00:00

abstract：:Frailty is a distinct phenotype that is highly prevalent in chronic kidney disease (CKD) and appears to be more prevalent with decreasing glomerular filtration rate. Exercise training or intervention to increase physical activity may ameliorate poor physical functioning and frailty, and even may improve survival in pa...

journal_title：Seminars in nephrology

authors： Sheshadri A,Johansen KL

更新日期：2017-03-01 00:00:00

abstract：:A review is presented of 164 nephrotic patients who were older than 60 years at the onset of their nephrotic syndrome, together with a review of more than 1,000 patients from the literature. The nephrotic syndrome in elderly patients is as common as in younger adults, but is often misdiagnosed as "heart failure" by pr...

journal_title：Seminars in nephrology

authors： Cameron JS

更新日期：1996-07-01 00:00:00

abstract：:By analogy to the findings with other transport disorders such as Bartter's or Liddle's syndrome, it might be expected that the various forms of renal tubular acidosis (RTA) could result from defects in H-ATPase or H-K-ATPase. However, the available data do not yet support such a simple explanation. With regard to dis...

journal_title：Seminars in nephrology

authors： Mujais SK

更新日期：1998-01-01 00:00:00

abstract：:The Kidney Early Evaluation Program (KEEP) is a free, community-based, kidney disease screening program designed to detect chronic kidney disease (CKD) early and promote follow-up evaluation with clinicians to ultimately improve outcomes. This program screens individuals with diabetes, hypertension, or those with a fi...

journal_title：Seminars in nephrology

authors： Vassalotti JA,Li S,McCullough PA,Bakris GL

更新日期：2010-01-01 00:00:00

abstract：:Small lipids such as eicosanoids exert diverse and complex functions. In addition to their role in regulating normal kidney function, these lipids also play important roles in the pathogenesis of kidney diseases. Increased glomerular cyclooxygenase (COX)1 or COX2 expression has been reported in patients with nephritis...

journal_title：Seminars in nephrology

authors： Hao CM,Breyer MD

更新日期：2007-05-01 00:00:00

abstract：:Long-term continuous ambulatory peritoneal dialysis (CAPD) often causes peritoneal fibrosis and sclerosis with a loss of function, and some CAPD patients develop sclerosing encapsulating peritonitis. Glucose-based peritoneal dialysis fluids readily produce glucose degradation products by heat sterilization, and glucos...

journal_title：Seminars in nephrology

authors： Nakamura S,Niwa T

更新日期：2004-09-01 00:00:00

abstract：:Pancreas transplantation is being performed with increasing frequency and increasing technical success. The availability of new immunosuppressant agents has been associated with a reduction in the previously high rates of allograft rejection in recipients of simultaneous pancreas-kidney transplants. These lower reject...

journal_title：Seminars in nephrology

authors： Hricik DE

更新日期：2000-03-01 00:00:00

abstract：:The identification of natriuretic peptides as key regulators of natriuresis and vasodilatation, and the appreciation that their secretion is under the control of cardiac hemodynamic and neurohumoral factors, has caused wide interest. The natriuretic peptides are structurally similar, but genetically distinct peptides ...

journal_title：Seminars in nephrology

authors： Dhingra H,Roongsritong C,Kurtzman NA

更新日期：2002-09-01 00:00:00

abstract：:Chronic kidney disease-mineral and bone disorder (CKD-MBD) is characterized by bone abnormalities, vascular calcification, and an array of laboratory abnormalities. The latter classically include disturbances in the parathyroid hormone/vitamin D axis. More recently, fibroblast growth factor 23 (FGF23) and klotho also ...

journal_title：Seminars in nephrology

authors： Evenepoel P,Rodriguez M,Ketteler M

更新日期：2014-03-01 00:00:00

abstract：:The important role of hyperglycemia in the genesis of diabetic renal disease has been strengthened by tissue culture studies, experimental animal models, and clinical trials. A mechanistic understanding of the cellular and biochemical processes that link hyperglycemia with the development of diabetic nephropathy is in...

journal_title：Seminars in nephrology

authors： Sharma K,Ziyadeh FN

更新日期：1997-03-01 00:00:00

abstract：:Studies performed over the last 10 years have evaluated the role of nitric oxide (NO) in the control of renal hemodynamics. This article reviews the effects of administration of nitric oxide synthase (NOS) blockers on renal function in experimental animals and human volunteers. These studies show that NOS blockade inc...

journal_title：Seminars in nephrology

authors： Gabbai FB,Blantz RC

更新日期：1999-05-01 00:00:00