Abstract:
PURPOSE:The purpose of this study is to test non-inferiority of a lower dose of crosslinked hyaluronic acid (CLHA) to a higher dose of carmellose eye drop in menopause patients receiving antidepressant treatments. METHODS:This prospective, double-blind, single-center study enrolled sixty female patients. Mean age was 63.25 ± 9.13 years. We examined patients with Schirmer I, breakup time (TBUT) and the ocular surface disease index (OSDI) at the first visit. Tear A eyedrops were formulated with crosslinked hyaluronic acid, coenzyme Q10 and vitamin E. Control tear B was formulated with carmellose sodium. Posology was two and five times, respectively. RESULTS:After 2 months of treatment, the tear A obtained 14.12 ± 7.47 score points for OSDI (t = 11.74, p < 0.01), and tear B obtained 19.46 ± 10.03 score points (t = 7.59, p < 0.01). The tear A obtained 13.77 ± 7.78 score points for Schirmer test (t = 0.88, p > 0.05), and tear B obtained 14.20 ± 8.62 score points (t = 2.92, p < 0.01). The tear A obtained 8.30 ± 2.08 s for TBUT (t = 15.50, p < 0.01), and tear B obtained 7.23 ± 2.40 s (t = 8.79, p < 0.01). CONCLUSION:Lower total daily dose of crosslinked hyaluronic acid eyedrops obtained similar efficacy results in terms of tear stability and subjective dry eye sensation than higher carmellose total daily dose. A lower total daily dose of crosslinked eyedrops was sufficient to achieve better dry eye disease management compared to carmellose.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Serrano-Morales JM,De-Hita-Cantalejo C,Sánchez-González MC,Bautista-Llamas MJ,Sánchez-González JMdoi
10.1177/1120672120972026subject
Has Abstractpub_date
2020-11-05 00:00:00pages
1120672120972026eissn
1120-6721issn
1724-6016pub_type
杂志文章abstract:PURPOSE:Fabry disease retinal vascular involvement has been widely reported, with narrowing of the retinal arterioles, dilation and irregularity of the retinal veins, and exaggerated tortuosity of the retinal vessels. We evaluated retinal vessel diameter in Fabry disease, by means of a dedicated software, aiming to pro...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672119886985
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To describe a patient who developed diplopia, lagophthalmos and exposure keratopathy due to a large subconjunctival emphysema. METHODS:A 24-year-old man sustained an injury in his left eye from a compressed air hose. The patient complained of pain and diplopia. He underwent slit-lamp examination, funduscopy an...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210301300113
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:To describe the use of silicone oil (SO) in combination with subretinal recombinant tissue plasminogen activator (rtPA) to achieve dislocation of large subretinal hemorrhage secondary to exudative age-related macular degeneration (AMD). METHODS:A single-eye 81-year-old woman, known for exudative AMD, presented...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120952349
更新日期:2020-08-18 00:00:00
abstract:PURPOSE:To report the unknown coexistence of bilateral optic disc pit and keratoconus. METHODS:A 23-year-old man with bilateral keratoconus underwent complete ophthalmology screening, with an unexpected detection of undiagnosed optic disc pit in both eyes. Computerized corneal topography (CT), Orbscan, corneal pachome...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800124
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To quantify the maximal level of temperature and the time the maximal temperature is achieved and correlate the temperature parameters to the mean rate of endothelial cell loss after standardized ultrasound delivery assisted with four viscoelastic substances or different temperature of balanced salt solution (B...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To report on the microperimetric evaluation of the central visual field in a patient with retinopathy due to membranoproliferative glomerulonephritis. METHODS:The central 20 degrees visual field was evaluated using fundus-related perimetry with (Nidek MP1) microperimeter in a patient with proven membranoprolif...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600425
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To identify factors that determined the outcome of eyes that underwent pars plana vitrectomy for retained lens fragments after phacoemulsification. METHODS:A retrospective review of the records of 63 eyes that underwent vitrectomy for retained lens fragments after phacoemulsification. Fragments were defined as...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2011.6483
更新日期:2011-11-01 00:00:00
abstract:PURPOSE:The authors wondered whether the spectrum of endophthalmitis and the type of therapy had changed. METHODS:Files of patients who were operated upon for endophthalmitis between 1988 and 2000 were retrospectively analyzed. They were divided into Group 1 (operated upon 1988 to 1994) and Group 2 (1995 to 2000). RE...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600217
更新日期:2006-03-01 00:00:00
abstract:PURPOSE:To assess the difference in best-corrected visual acuity (BCVA) at presentation between the first and second eye in patients with bilateral neovascular age-related macular degeneration (AMD). METHODS:We reviewed the charts of all patients who had a clinical examination for neovascular AMD at the University Eye...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000649
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Scleral buckling (SB) has been the first technique to repair a retinal detachment (RD) and it is still largely in use. Pars plana vitrectomy (PPV) is currently the most common technique, being more versatile and easier to approach. Here we report on a new SB variant, modified by using some of the latest te...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120945091
更新日期:2020-07-22 00:00:00
abstract:PURPOSE:To assess and investigate the relationship between diurnal variations in intraocular pressure (IOP) and biomechanical properties of cornea. METHODS:Sixty-two healthy volunteers were recruited. Corneal compensated IOP (IOPcc), Goldmann-correlated IOP (IOPg), corneal resistance factor (CRF), and corneal hysteres...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900518
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:Avastin (bevacizumab) intravitreal injections are widely used for treatment of diabetic retinopathy. The aim of our study was to analyze effect of 1.25 mg of intravitreal Avastin on serum concentration of vascular endothelial growth factor (VEGF) in diabetic patients. METHODS:Participants were 10 diabetic pati...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000118
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:To describe a rare presentation of pituitary apoplexy as unilateral abducens nerve palsy demonstrating the various presentations of the condition. METHODS:Case report. RESULTS:A 48-year-old man presented with isolated right abducens nerve palsy. Magnetic resonance imaging showed a large pituitary macroadenoma...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000136
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To evaluate the intraocular pressure-lowering effect, the safety profile, and the success rate of the XEN45 Gel Stent (Allergan, Dublin, Ireland) in patients with pseudoexfoliative glaucoma. METHODS:Retrospective study conducted on patients with pseudoexfoliative glaucoma, with or without cataract, who underwe...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118795063
更新日期:2019-05-01 00:00:00
abstract::We report a case of ocular drug toxicity consistent with bilateral Vogt-Koyanagi-Harada (VKH) like disease in a patient with cutaneous melanoma treated with Dabrafenib/Trametinib therapy. A 53-year-old man with a history of metastatic cutaneous melanoma, treated with Dabrafenib/Trametinib, developed a severe acute pan...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120962044
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To report a new family belonging to a previously non-investigated geographic are a with a rare form of lattice corneal dystrophy (LCD). METHODS:Detailed ophthalmologic analysis was carried out on a Bulgarian woman, enrolled for perforating keratoplasty. In order to obtain a final diagnosis both histology and g...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210501500624
更新日期:2005-11-01 00:00:00
abstract:PURPOSE:To identify a new cortical vitreous segmentation protocol for non invasive standardised investigation of Neovascularisation (NV) with detection of regression of NV activity in Proliferative Diabetic Retinopathy (PDR). DESIGN:Retrospective study. PARTICIPANTS:One hundred and eighty-six eyes of 93 consecutive d...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120944028
更新日期:2020-07-28 00:00:00
abstract:PURPOSE:To document incidence of and risk factors for development of retinopathy of prematurity (ROP) in a population of low birthweight infants (< 1500 g). METHODS:The authors registered clinical characteristics (birthweight, gestational age (GA), Clinical Risk Index for Babies (CRIB), Apgar score, respiratory charac...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672103013009-1009
更新日期:2003-11-01 00:00:00
abstract:PURPOSE:Mutations in the ABCA4 gene result in a broad spectrum of severe retinal degeneration, including Stargardt macular dystrophy, fundus flavimaculatus, autosomal recessive retinitis pigmentosa, and cone-rod dystrophy. In addition to the detection of well-characterized mutations, genetic testing frequently yields n...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5001019
更新日期:2018-01-01 00:00:00
abstract:PURPOSE::To evaluate the predictive value of magnetic resonance imaging in retinoblastoma for the likelihood of high-risk pathologic features. METHODS::A retrospective study of 64 eyes enucleated from 60 retinoblastoma patients. Contrast-enhanced magnetic resonance imaging was performed before enucleation. Main outcom...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118781200
更新日期:2019-03-01 00:00:00
abstract::Diseases of the optic nerve head involving changes in blood flow are common. However, the pathophysiology is not always fully understood. Several non-invasive methods for measuring optic nerve head blood flow are available, but currently no gold standard has been established. Methods for measuring blood flow in optic ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672119858891
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To identify complications associated with tumor-related lipid exudation (TRLE) after plaque radiotherapy of posterior uveal melanoma. METHODS:Comparative study including 294 patients with posterior uveal melanoma who developed TRLE after plaque radiotherapy (TRLE group) and 294 patients who did not develop ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000236
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To compare the inhibitory effects of a topical combination product, cromolyn sodium (DSCG) 4% with the antihistamine, chlorpheniramine, with those of topical ketotifen 0.05% on the clinical allergic reaction induced by the conjunctival allergen challenge (CAC). METHODS:Ten allergic but non-active patients were...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/112067210301300202
更新日期:2003-03-01 00:00:00
abstract::We sent questionnaires to 424 retina specialists in order to compile information on the use of fluorescein angiography in pregnant women. Four-hundred and three specialists responded. Of these, 313 (78%) had never performed fluorescein angiography on a pregnant woman. Ninety specialists (22%) had performed at least on...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:PURPOSE:To prospectively compare the clinical results of two cataract surgery procedures through a 4.0-mm incision, differing only in the wound location (superior or lateral). METHODS:168 eyes with cataract were randomly assigned to either procedure. Except for incision location, surgical methods were identical. Uncor...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1996-10-01 00:00:00
abstract:PURPOSE:To report the off-label use of systemic bevacizumab in a patient with stage 3 retinal angiomatous proliferation (RAP) associated with a vascularized pigmented epithelium detachment (PED). METHODS:Interventional case report. RESULTS:The patient was treated with systemic bevacizumab after obtaining fully inform...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700621
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:Preoperative and postoperative optical coherence tomography (OCT) of macular pathologies can be regarded as the gold standard diagnostic technique, providing detailed information on the microstructures of the macula for planning the surgical procedure and comparing improvements after surgery in the follow-up pe...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5001058
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:To report a case of a combined branch retinal artery and vein occlusion in a patient with hepatitis C treated with interferon and ribavirin. METHODS:A 29-year-old man with a 1-week history of sudden visual field defect and decrease of central visual acuity was examined. RESULTS:Ophthalmoscopy and fluorescein ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2008.4623
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:To investigate color perception and contrast sensitivity with and without additional glare in pseudophakic patients with a conventional intraocular lens (IOL) in one eye and a blue light-filtering IOL in the fellow eye. METHODS:Twenty-three bilaterally pseudophakic patients with a conventional IOL (AcrySof SA6...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900210
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To describe a new technique for remnant removal in cases of posterior capsular rupture during cataract surgery and Soemmering ring extraction during intraocular lens (IOL) removal. METHODS:An IOL injector, inserted into the anterior chamber, provides a new exit for residual lens fragments. Passive fluid flow, ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000962
更新日期:2017-06-26 00:00:00