Abstract:
:We report a case of ocular drug toxicity consistent with bilateral Vogt-Koyanagi-Harada (VKH) like disease in a patient with cutaneous melanoma treated with Dabrafenib/Trametinib therapy. A 53-year-old man with a history of metastatic cutaneous melanoma, treated with Dabrafenib/Trametinib, developed a severe acute panuveitis with granulomatous anterior uveitis and multiple serous retinal detachments. The ocular inflammatory reaction was classified as a bilateral Vogt-Koyanagi-Harada disease. Intraocular inflammation resolved after discontinuation of chemotherapeutic agents and aggressive topical and systemic corticosteroid therapy. The present case outlines the importance of recognizing VKH-like syndrome as a possible consequence of therapy with dabrafenib and trametinib.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Brambati M,Giuffrè C,Marchese A,Bandello F,Modorati GM,Miserocchi Edoi
10.1177/1120672120962044subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1120672120962044eissn
1120-6721issn
1724-6016pub_type
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journal_title:European journal of ophthalmology
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doi:
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:2002-05-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
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journal_title:European journal of ophthalmology
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更新日期:2014-07-01 00:00:00
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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pub_type: 临床试验,杂志文章
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
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journal_title:European journal of ophthalmology
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