Abstract:
PURPOSE:Fabry disease retinal vascular involvement has been widely reported, with narrowing of the retinal arterioles, dilation and irregularity of the retinal veins, and exaggerated tortuosity of the retinal vessels. We evaluated retinal vessel diameter in Fabry disease, by means of a dedicated software, aiming to provide a quantitative marker of retinal vascular network abnormalities in Fabry disease patients. MATERIAL AND METHODS:Observational case-control study evaluating different branches of vessels, peripapillary vessels (group A), temporal vascular arcades (group B), and second-order collaterals of the temporal arcades (group C). We obtained the vessel diameters values from eye fundus digital images of eight Fabry disease patients and eight age-sex matched controls, using a semiautomatic software. Mann-Whitney test was used to compare the Fabry disease group versus the control group. RESULTS:The difference between the average diameters of all the types of vessels considered were significantly smaller in Fabry disease patients compared to healthy controls, resulting in a decrease in size (mm) of 10.9% for group A, 7.8% for group B, and 7.4% for group C. The most evident difference between Fabry disease patients and controls was found in the largest vessels. CONCLUSION:A computer-assisted analysis of retinal vessel diameter in Fabry disease by means of dedicated software showed narrower retinal arteries in Fabry disease patients than in controls. Our data support the use of semiautomatic assessment of retinal vessel attenuation as an objective and reproducible method to evaluate retinal vascular alterations in Fabry disease, providing a clinical non-invasive tool for early diagnosis and disease monitoring.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Sodi A,Nicolosi C,Vicini G,Lenzetti C,Virgili G,Rizzo Sdoi
10.1177/1120672119886985subject
Has Abstractpub_date
2021-01-01 00:00:00pages
173-178issue
1eissn
1120-6721issn
1724-6016journal_volume
31pub_type
杂志文章abstract:OBJECTIVE OF THE STUDY:Inborn lens opacity is the most frequent cause of childhood blindness. In this study, we aimed to define the presumed genetic cause of a congenital cataract present in a Mauritanian family over the last nine generations. METHODS:A family history of the disease and eye examination were carried ou...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
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abstract:PURPOSE:To present outcome data on low risk primary trabeculectomy augmented with low dose peroperative (0.1 mg/mL for 1 minute) mitomycin-C (MMC). METHODS:Retrospective case note review. All cases of trabeculectomy utilizing MMC augmentation at a concentration of 0.1 mg/mL with an application time of 1 minute and at ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
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abstract:INTRODUCTION:The aim of this study was to evaluate repeatability and reproducibility of newly calculated biomechanical parameters of the cornea, developed by our research group. METHODS:One eye from each of the 23 healthy subjects was measured three times consecutively, three times at different daytimes and on three d...
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journal_title:European journal of ophthalmology
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journal_title:European journal of ophthalmology
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-04-01 00:00:00
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journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-09-01 00:00:00