Abstract:
:The nature of Reed-Sternberg cells, the abnormal cells of Hodgkin's disease, is controversial. Morphological and immunologic marker studies suggested different cells of origin. To investigate a possible B or T cell origin, immunoglobulin and T cell receptor gene analyses were performed on tissues from 11 patients in early and late stages of Hodgkin's disease. In addition, the immunologic marker patterns of the Reed-Sternberg cells were determined. Rearrangements of immunoglobulin heavy- and light-chain genes were detected in tissues from five patients, particularly in late stages of the disease when lymphocyte depletion had occurred. No rearrangements of T cell receptor genes were found. The results indicate that clonal immunoglobulin gene rearrangements can be detected in tissues involved by Hodgkin's disease.
journal_name
Bloodjournal_title
Bloodauthors
Brinker MG,Poppema S,Buys CH,Timens W,Osinga J,Visser Lsubject
Has Abstractpub_date
1987-07-01 00:00:00pages
186-91issue
1eissn
0006-4971issn
1528-0020journal_volume
70pub_type
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