Abstract：
:Twenty-eight patients with multiple myeloma responding to prior melphalan-prednisone combinations, but without additional chemotherapy, were followed until relapse. Patients receiving no further treatment had a median survival time similar to that of those receiving indefinite courses of melphalan-prednisone or carmustine-prednisone. Prolonged periods of unmaintained remission occurred primarily in patients without extensive disease at the time of diagnosis or in whom the abnormal protein disappeared from the electrophoresis strip. The initial relapse after an unmaintained remission was controlled in 80% of patients with the resumption of melphalan-prednisone, but second remissions were usually less marked in degree and shorter in duration. Results supported the long-term evaluation without chemotherapy of selected patients with low numbers of plasma cells after treatment who were likely to experience long durations of disease stability and respond again to retreatment with melphalan-prednisone.
journal_name
Bloodjournal_title
Bloodauthors
Alexanian R,Gehan E,Haut A,Saiki J,Weick Jsubject
Has Abstractpub_date
1978-06-01 00:00:00pages
1005-11issue
6eissn
0006-4971issn
1528-0020journal_volume
51pub_type
杂志文章相关文献
BLOOD文献大全abstract：:In this issue of Blood, Wang et al describe the occurrence and pathogenetic relevance of IDH2R172 mutations in angioimmunoblastic T-cell lymphoma (AITL). ...
journal_title：Blood
pub_type： 评论,杂志文章
doi：10.1182/blood-2015-08-665075
更新日期：2015-10-08 00:00:00
abstract：:Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) were recently demonstrated in acute myeloid leukemia (AML), but their prevalence and prognostic impact remain to be explored in large extensively characterized AML series, and also in various other hematologic malignancies. Here, we demonstrate in 8...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2009-11-250878
更新日期：2010-09-23 00:00:00
abstract：:Despite multiple disparate prognostic risk analysis systems for evaluating clinical outcome for patients with myelodysplastic syndrome (MDS), imprecision persists with such analyses. To attempt to improve on these systems, an International MDS Risk Analysis Workshop combined cytogenetic, morphological, and clinical da...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-03-15 00:00:00
abstract：:Iron overload is common in patients undergoing allogeneic hematopoietic cell transplantation (HCT), but the mechanisms leading to overload are unknown. Here, we determined iron levels and the expression of iron regulatory proteins in the liver and gut of nonobese diabetic-severe combined immunodeficient (NOD/SCID) mic...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2008-09-178517
更新日期：2009-02-19 00:00:00
abstract：:Monoclonally-derived neoplastic T-cells from a patient with cutaneous T-cell lymphoma respond to multiple human HLA-D antigens in mixed lymphocyte culture. The implications of this phenomenon relevant to normal T-cell function and to malignancy are discussed. ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:Parasitic worms of the genus Schistosoma excrete relatively large amounts of immunogenic glycoproteins (circulating cathodic antigen [CCA]) that contain polysaccharide side chains with the trisaccharide Lewis-x (L(ex)) as a repeating unit. These carbohydrates evoke high titers of specific IgM antibodies that cross-rea...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1996-12-01 00:00:00
abstract：:To program pluripotent cells into blood, a knowledge of the locations of precursors during their journey through the embryo and the signals they experience would be informative. The anterior (a) and posterior (p) ventral blood islands (VBIs) in Xenopus are derived from opposite sides of the pregastrula embryo. The aVB...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2007-03-081323
更新日期：2008-02-01 00:00:00
abstract：:The epidemic form of the hemolytic uremic syndrome (HUS), beginning with an acute gastroenteritis, has been associated with a verocytotoxin-producing Escherichia coli infection. The endothelial cell is believed to play an important role in the pathogenesis of HUS. Endothelial cell damage by verocytotoxin-1 (VT-1) in v...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Multicentric Castleman disease (MCD) is a lymphoproliferative disorder associated with human herpesvirus 8 (HHV-8) infection among persons with human immunodeficiency virus (HIV) infection. Treatment often includes chemotherapy, and progression to non-Hodgkin lymphoma frequently occurs. MCD is characterized in part by...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2003-05-1721
更新日期：2004-03-01 00:00:00
abstract：:Multiple myeloma (MM) is characterized by accumulation and dissemination of malignant plasma cells (PCs) in the bone marrow (BM). Gene expression profiling of 2 MM cell lines (OH-2 and IH-1) indicated that expression of PRL-3, a metastasis-associated tyrosine phosphatase, was induced by several mitogenic cytokines. Cy...
journal_title：Blood
pub_type： 杂志文章,多中心研究
doi：10.1182/blood-2007-07-101139
更新日期：2008-01-15 00:00:00
abstract：:A20 is a stress response gene in endothelial cells (ECs). A20 serves a dual cytoprotective function, protecting from tumor necrosis factor (TNF)-mediated apoptosis and inhibiting inflammation via blockade of the transcription factor nuclear factor-kappaB (NF-kappaB). In this study, we evaluated the molecular basis of ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2003-02-0635
更新日期：2004-10-15 00:00:00
abstract：:Current monoclonal antibody therapies for multiple myeloma have had limited success, perhaps due to narrow target specificity. We have previously described the ability of polyclonal rabbit antithymocyte globulin (rATG) to induce caspase- and cathepsin-mediated apoptosis in human B and plasma cells. We now extend this ...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2005-06-2269
更新日期：2006-04-01 00:00:00
abstract：:Expression of B7 family costimulatory molecules on B cells defines their capacity to function as antigen presenting cells (APCs). B cells that do not express B7 costimulatory molecules induce T-cell tolerance. Therefore, the expression of B7 costimulatory molecules on malignant B cells might be critical for their reco...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:The relationship between the level of retinoblastoma protein (RB) expression and the survival of 113 newly diagnosed acute myelogenous leukemia (AML) patients was studied. Western blotting was used to determine the level of RB protein present in peripheral blood leukemia cells and results were confirmed in 26 patients...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:Human myeloma cells freshly isolated from 40 patients with IgG multiple myeloma (MM, 10 in stage I and 30 in stage III), were cultured for 48 hours with recombinant B cell stimulatory factor 2 (rBSF-2)/interleukin-6 (IL-6), which is considered a major growth factor for myeloma cells. Uptake of 3H-thymidine by these pu...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Factor IX (F.IX) is a vitamin K-dependent plasma protein, a deficiency of which results in hemophilia B. A canine model of hemophilia B exists; attempts to use this model for gene transfer experiments or characterization of the hemophilic defect require elucidation of normal canine F.IX structure. We report the isolat...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:Although hepatitis C virus (HCV) mainly affects hepatocytes, infection is widespread and involves immunologically privileged sites. Whether lymphoid cells represent further targets of early HCV infection, or whether other cells in the hematopoietic microenvironment may serve as a potential virus reservoir, is still un...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:Recent evidence suggests that proteolysis plays an important role in some forms of inherited and acquired von Willebrand disease (vWD). Because calpains and one or more enzymes released from polymorphonuclear leukocytes are known to proteolyze von Willebrand factor (vWF) in vitro with resultant loss of large multimers...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown to stimulate T-cell-dependent B-cell maturation, megakaryopoiesis, and various stages of myeloid differentiation, but to inhibit adipogenesis. Because stromal cells are essential for the main...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1992-09-01 00:00:00
abstract：:Patients referred to tertiary care centers occasionally may have their diagnostic procedures repeated and have a final diagnosis that differs from that of the referring center. The aim of this study was to evaluate discordance rates and their clinical implications in the diagnosis of patients with myelodysplastic synd...
journal_title：Blood
pub_type： 杂志文章
doi：10.1182/blood-2011-03-342642
更新日期：2011-10-27 00:00:00
abstract：:The regulatory function of recombinant human granulocyte-macrophage colony stimulating factor (rhGM-CSF) on granulocyte production in vivo was evaluated in an autologous bone marrow transplantation model using rhesus monkeys. Monkeys were exposed to 9.0 Gy total body irradiation and then transplanted with 5.0 x 10(7) ...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：:Type I interferons (IFNs-alpha and IFN-beta) bind to a common receptor to exert strong antiproliferative activity on a broad range of cell types, including interleukin-6 (IL-6)-dependent myeloma cells. In this study, we investigated the effect of IFN-beta pretreatment on IL-6-stimulated mitogenic signaling in the huma...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Interleukin-15 (IL-15) induces proliferation and promotes cell survival of human T and B lymphocytes, natural killer cells, and neutrophils. Here we report the constitutive expression of a functional IL-15 receptor (IL-15R) in 6 of 6 myeloma cell lines and in CD38(high)/CD45(low )plasma cells belonging to 14 of 14 pat...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：2000-01-15 00:00:00
abstract：:During the course of differentiation of early human myeloid cells toward monocytes and granulocytes, cell surface expression of the cell adhesion molecule, CD11b/CD18 (Mo1) increases dramatically and expression of myeloperoxidase (MPO), a bacteriocidal enzyme, decreases markedly. Using the inducible promyelocytic cell...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Genes of the major histocompatibility complex (MHC) are associated with susceptibility to different immune and nonimmune mediated diseases. We had reported that the drug adverse reaction, clozapine-induced agranulocytosis (CA), is associated with different HLA types and HSP70 variants in Ashkenazi Jewish and non-Jewis...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：:Peripheral blood and bone marrow mononuclear cells from patients with refractory anemia (RA) or RA with sideroblasts (defined according to the revised French-American-British classification with less than 5% blast cells in the bone marrow) were analyzed using a panel of monoclonal antibodies directed against leukocyte...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Hematide is an investigational pegylated synthetic peptide that stimulates erythropoiesis in animal models and is being developed for the treatment of anemia associated with chronic renal failure and cancer. This study evaluated the safety and pharmacodynamics of single, intravenous doses (0.025, 0.05, and 0.1 mg/kg) ...
journal_title：Blood
pub_type： 杂志文章,随机对照试验
doi：10.1182/blood-2006-04-015818
更新日期：2006-09-15 00:00:00
abstract：:Clonal chromosomal abnormalities in Philadelphia chromosome-negative (CCA/Ph-) metaphases emerge as patients with chronic phase chronic myeloid leukemia (CP-CML) are treated with tyrosine kinase inhibitors (TKIs). We assessed the characteristics and prognostic impact of 598 patients with CP-CML treated on clinical tri...
journal_title：Blood
pub_type： 临床试验,杂志文章
doi：10.1182/blood-2017-07-792143
更新日期：2017-11-09 00:00:00
abstract：:To determine whether the sensitivity of the human long-term culture-initiating cell (LTC-IC) assay could be increased, we have evaluated a spectrum of different fibroblast cell lines for their abilities to influence the number of cells detectable as LTC-IC, to influence LTC-IC maintenance, and/or to influence LTC-IC d...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1996-11-15 00:00:00
abstract：:We investigated the intracellular site of pro-von Willebrand factor (pro-vWF) cleavage and multimerization, as well as the fate of the propolypeptide (von Willebrand antigen II) after cleavage. Analysis of subcellular fractions of endothelial cells metabolically labeled with sulfate showed that both cleavage and coval...
journal_title：Blood
pub_type： 杂志文章
doi：
更新日期：1994-06-15 00:00:00
