Sulfane Sulfur is an intrinsic signal activating MexR-regulated antibiotic resistance in Pseudomonas aeruginosa.

abstract：:A hallmark of the biofilm architecture is the presence of microcolonies. However, little is known about the underlying mechanisms governing microcolony formation. In the pathogen Pseudomonas aeruginosa, microcolony formation is dependent on the two-component regulator MifR, with mifR mutant biofilms exhibiting an over...

journal_title：Molecular microbiology

authors： Petrova OE,Schurr JR,Schurr MJ,Sauer K

更新日期：2012-11-01 00:00:00

abstract：:The nucleotide sequence (6138 bp) of a microaerobically inducible region (hupV/VI) from the Rhizobium leguminosarum bv. viciae hydrogenase gene cluster has been determined. Six genes, arranged as a single operon, were identified, and designated hypA, B, F, C, D and E based on the sequence similarities of all of them, ...

journal_title：Molecular microbiology

authors： Rey L,Murillo J,Hernando Y,Hidalgo E,Cabrera E,Imperial J,Ruiz-Argüeso T

更新日期：1993-05-01 00:00:00

abstract：:The effect of the unc transcription terminator on expression of uncC, encoding the epsilon subunit of Escherichia coli F1-ATPase, from plasmids was studied. The cloned sequence in pTK1 included the uncC ribosome binding site, the uncC structural gene, and the unc transcription terminator. The cloned region in pSD37 wa...

journal_title：Molecular microbiology

authors： Patel AM,Dallmann HG,Skakoon EN,Kapala TD,Dunn SD

更新日期：1990-11-01 00:00:00

abstract：:The bacterial phosphoenolpyruvate-dependent phosphotransferase system (PTS) consists of a set of cytoplasmic energy-coupling proteins and various integral membrane permeases/sugar phosphotransferases, each specific for a different sugar. We have conducted biochemical analyses of three PTS permeases (enzymes II), the g...

journal_title：Molecular microbiology

authors： Aboulwafa M,Saier M Jr

更新日期：2003-04-01 00:00:00

abstract：:Magnetotactic bacteria contain nanometre-sized, membrane-bound organelles, called magnetosomes, which are tasked with the biomineralization of small crystals of the iron oxide magnetite allowing the organism to use geomagnetic field lines for navigation. A key player in this process is the HtrA/DegP family protease Ma...

journal_title：Molecular microbiology

authors： Quinlan A,Murat D,Vali H,Komeili A

更新日期：2011-05-01 00:00:00

abstract：:The UhpA protein is required for expression of the sugar phosphate transporter UhpT in Escherichia coli and is regulated by phosphate transfer from the transmembrane UhpBC sensor kinase complex. UhpA action requires the sensor kinase complex and the site of phosphorylation, Asp-54, under normal conditions, but not whe...

journal_title：Molecular microbiology

authors： Webber CA,Kadner RJ

更新日期：1997-06-01 00:00:00

abstract：:Chromosomal rearrangements are common in both clinical isolates and spontaneous mutants of Candida albicans. It appears that many of these rearrangements are caused by translocations around the major sequence repeat (MSR) that is present in all chromosomes except chromosome 3, suggesting that homologous recombination ...

journal_title：Molecular microbiology

authors： Ciudad T,Andaluz E,Steinberg-Neifach O,Lue NF,Gow NA,Calderone RA,Larriba G

更新日期：2004-08-01 00:00:00

abstract：:In order to identify molecules that might be responsible for the difference in pathogenicity between the two closely related protozoan parasites Entamoeba histolytica and Entamoeba dispar, we focussed on cysteine proteinases because this class of enzymes has been considered important for pathogenic tissue destruction....

journal_title：Molecular microbiology

authors： Bruchhaus I,Jacobs T,Leippe M,Tannich E

更新日期：1996-10-01 00:00:00

abstract：:Natural transformation is a potent driver for genetic diversification in bacterial populations. It involves exogenous DNA binding, uptake, transport and internalization into the cytoplasm, where DNA can be processed and integrated into the host chromosome. Direct visualisation of transforming DNA (tDNA) has been limit...

journal_title：Molecular microbiology

authors： Corbinais C,Mathieu A,Kortulewski T,Radicella JP,Marsin S

更新日期：2016-09-01 00:00:00

abstract：:Mycobacterium tuberculosis infects one-third of the world's population and causes two million deaths annually. The unusually low permeability of its cell wall contributes to the ability of M. tuberculosis to grow within host macrophages, a property required for pathogenesis of infection. Mycobacterium marinum is an es...

journal_title：Molecular microbiology

authors： Gao LY,Laval F,Lawson EH,Groger RK,Woodruff A,Morisaki JH,Cox JS,Daffe M,Brown EJ

更新日期：2003-09-01 00:00:00

abstract：:The bacterial actin homologue MreB forms a helix underneath the cytoplasmic membrane and was shown to be essential in the morphogenesis of the rod-shaped cells. Additionally, MreB was implicated to be involved in DNA segregation. However, in our hands the mreBCD deletion strain (PA340-678) grew without apparent DNA se...

journal_title：Molecular microbiology

authors： Karczmarek A,Martínez-Arteaga R,Alexeeva S,Hansen FG,Vicente M,Nanninga N,den Blaauwen T

更新日期：2007-07-01 00:00:00

abstract：:In this report we evaluate the role of catalase in the survival of Bordetella pertussis within human polymorphonuclear leukocytes (PMNs). Crude extracts of B. pertussis exhibited a single catalase activity when subjected to non-denaturing polyacrylamide gel electrophoresis and assayed for catalase activity. A plasmid ...

journal_title：Molecular microbiology

authors： DeShazer D,Wood GE,Friedman RL

更新日期：1994-10-01 00:00:00

abstract：:The Escherichia coli UvrD helicase (or helicase II) is known for its involvement in DNA repair. We report that UvrD is required for DNA replication of several different rolling-circle plasmids in E. coli, whereas its homologue, the Rep helicase, is not. Lack of UvrD helicase does not impair the first step of plasmid r...

journal_title：Molecular microbiology

authors： Bruand C,Ehrlich SD

更新日期：2000-01-01 00:00:00

abstract：:MexAB-OprM is a multidrug efflux system that contributes to intrinsic and acquired multidrug resistance in Pseudomonas aeruginosa, the latter as a result of mutational hyperexpression of the mexAB-oprM operon. While efflux gene hyperexpression typically results from mutations in the linked mexR repressor gene, it also...

journal_title：Molecular microbiology

authors： Cao L,Srikumar R,Poole K

更新日期：2004-09-01 00:00:00

abstract：:Release factors RF1 and RF2 are required in bacteria for the cleavage of peptidyl-tRNA. A single sequence motif, GGQ, is conserved in all eubacterial, archaebacterial and eukaryotic release factors and may mimic the CCA end of tRNA, although the position of the motif in the crystal structures of human eRF1 and Escheri...

journal_title：Molecular microbiology

authors： Mora L,Heurgué-Hamard V,Champ S,Ehrenberg M,Kisselev LL,Buckingham RH

更新日期：2003-01-01 00:00:00

abstract：:The chromosomes of the soil bacteria Streptomyces, unlike those of most other bacteria, are linear DNA molecules. Their telomeres contain long-terminal inverted repeats and covalently bound terminal proteins (TPs). These bacteria also harbour linear plasmids that share the same structural features. In this study, we d...

journal_title：Molecular microbiology

authors： Yang CC,Huang CH,Li CY,Tsay YG,Lee SC,Chen CW

更新日期：2002-01-01 00:00:00

abstract：:Like other bacterial species, Mycobacterium tuberculosis has multiple sigma (sigma) factors encoded in its genome. In previously published work, we and others have shown that mutations in some of these transcriptional activators render M. tuberculosis sensitive to various environmental stresses and, in some cases, cau...

journal_title：Molecular microbiology

authors： Manganelli R,Voskuil MI,Schoolnik GK,Dubnau E,Gomez M,Smith I

更新日期：2002-07-01 00:00:00

abstract：:When confronted with a stress factor, bacteria react with a specific stress response, a genetically encoded programme resulting in the transiently enhanced expression of a subset of genes. One of these stress factors is a sudden increase in the external pH. As a first step to understand the response of Bacillus subtil...

journal_title：Molecular microbiology

authors： Wiegert T,Homuth G,Versteeg S,Schumann W

更新日期：2001-07-01 00:00:00

abstract：:Fluorescent polyclonal antibodies specific for MukB have been used to study its localization in Escherichia coli. In wild-type cells, the MukB protein appeared as a limited number of oblong shapes embracing the nucleoid. MukB remained associated with the nucleoid in the absence of DNA replication. The centre of gravit...

journal_title：Molecular microbiology

authors： den Blaauwen T,Lindqvist A,Löwe J,Nanninga N

更新日期：2001-12-01 00:00:00

abstract：:Among enteric bacteria, the ability to grow on N-acetyl-galactosamine (GalNAc or Aga) and on D-galactosamine (GalN or Gam) differs. Thus, strains B, C and EC3132 of Escherichia coli are Aga+ Gam+ whereas E. coli K-12 is Aga- Gam-, similarly to Klebsiella pneumoniae KAY2026, Klebsiella oxytoca M5a1 and Salmonella typhi...

journal_title：Molecular microbiology

authors： Brinkkötter A,Klöss H,Alpert C,Lengeler JW

更新日期：2000-07-01 00:00:00

abstract：:To study the role of cell division in the process of nucleoid segregation, we measured the DNA content of individual nucleoids in isogenic Escherichia coli cell division mutants by image cytometry. In pbpB(Ts) and ftsZ strains growing as filaments at 42 degrees C, nucleoids contained, on average, more than two chromos...

journal_title：Molecular microbiology

authors： Huls PG,Vischer NO,Woldringh CL

更新日期：1999-09-01 00:00:00

abstract：:Chemoreceptors play a central role in chemotaxis, allowing bacteria to detect chemical gradients and bias their swimming behavior in order to navigate toward favorable environments. The genome of the kiwifruit pathogen, Pseudomonas syringae pv. actinidiae (Psa) strain NZ-V13 encodes 43 predicted chemoreceptors, none o...

journal_title：Molecular microbiology

authors： McKellar JL,Minnell JJ,Gerth ML

更新日期：2015-05-01 00:00:00

abstract：:The endophytic fungus Epichloë festucae systemically colonizes the intercellular spaces of cool-season grasses to establish a mutualistic symbiosis. Hyphal growth of the endophyte within the host plant is tightly regulated and synchronized with the growth of the host plant. A genetic screen to identify symbiotic genes...

journal_title：Molecular microbiology

authors： Tanaka A,Kamiya S,Ozaki Y,Kameoka S,Kayano Y,Saikia S,Akano F,Uemura A,Takagi H,Terauchi R,Maruyama JI,Hammadeh HH,Fleissner A,Scott B,Takemoto D

更新日期：2020-10-01 00:00:00

abstract：:Escherichia coli RNA polymerase is able to site-specifically melt 12 bp of promoter DNA at temperatures far below those normally associated with DNA melting. Here we consider several models to explain how RNA polymerase destabilizes duplex DNA. One popular model proposes that upon binding to the promoter, RNA polymera...

journal_title：Molecular microbiology

authors： deHaseth PL,Helmann JD

更新日期：1995-06-01 00:00:00

abstract：:PspF bound to the psp enhancer activates E sigma54 holoenzyme-dependent transcription of the Escherichia coli phage-shock protein (psp) operon and autogenously represses its own sigma70-dependent transcription, thereby keeping its concentration at a low level. It has been demonstrated previously that integration host ...

journal_title：Molecular microbiology

authors： Jovanovic G,Model P

更新日期：1997-08-01 00:00:00

abstract：:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is exposed on the surface of infected erythrocytes where it both acts as an important pathogenicity factor in malaria and undergoes antigenic variation as a means of immune evasion. Because the mammalian erythrocyte lacks a protein secretory machinery ther...

journal_title：Molecular microbiology

authors： Papakrivos J,Newbold CI,Lingelbach K

更新日期：2005-02-01 00:00:00

abstract：:Histidine kinases (HK) sense and transduce via phosphorylation events many intra- and extracellular signals in bacteria, archaea, slime moulds and plants. HK are also widespread in the fungal kingdom, but their precise roles in the regulation of physiological processes remain largely obscure. Expanding genomic resourc...

journal_title：Molecular microbiology

authors： Defosse TA,Sharma A,Mondal AK,Dugé de Bernonville T,Latgé JP,Calderone R,Giglioli-Guivarc'h N,Courdavault V,Clastre M,Papon N

更新日期：2015-03-01 00:00:00

abstract：:The SaPIs are chromosomal islands in staphylococci and other Gram-positive bacteria that carry genes for superantigens, virulence factors, resistance and certain metabolic functions. They have intimate relationships with certain temperate phages involving phage-induced excision, replication and efficient packaging in ...

journal_title：Molecular microbiology

authors： Ubeda C,Maiques E,Barry P,Matthews A,Tormo MA,Lasa I,Novick RP,Penadés JR

更新日期：2008-02-01 00:00:00

abstract：:The HPr kinase of Gram-positive bacteria is an ATP-dependent serine protein kinase, which phosphorylates the HPr protein of the bacterial phosphotransferase system (PTS) and is involved in the regulation of carbohydrate metabolism. The hprK gene from Enterococcus faecalis was cloned via polymerase chain reaction (PCR)...

journal_title：Molecular microbiology

authors： Kravanja M,Engelmann R,Dossonnet V,Blüggel M,Meyer HE,Frank R,Galinier A,Deutscher J,Schnell N,Hengstenberg W

更新日期：1999-01-01 00:00:00

abstract：:The location of FtsQ, an Escherichia coli protein essential for cell division, is, under physiological conditions, in the cytoplasmic membrane facing towards the periplasmic space. An amino-proximal hydrophobic domain is required for FtsQ to reach its location and for its activity in the cell. Overexpression of modifi...

journal_title：Molecular microbiology

authors： Dopazo A,Palacios P,Sánchez M,Pla J,Vicente M

更新日期：1992-03-01 00:00:00