Abstract:
:In controlled human infection (CHI) studies, investigators deliberately infect healthy individuals with pathogens in order to study mechanisms of disease or obtain preliminary efficacy data on investigational vaccines and medicines. CHI studies offer a fast and cost-effective way of generating new scientific insights, prioritizing investigational products for clinical testing, and reducing the risk that large numbers of people are exposed to ineffective or harmful substances in research or in practice. Yet depending on the pathogen, CHI studies can involve significant risks or burdens for participants, pose risks to individuals or communities not involved in the research, and lead to public controversy. It is therefore essential to ensure that the risks of CHI studies are justified by their social value-that is, their potential to generate benefits for society-and that public trust can be maintained. In this paper, we aim to clarify how research sponsors, research ethics committees and other reviewers should judge the social value of CHI studies. We develop a list of relevant considerations for making social value judgments based on the standard view of social value. We then use this list to discuss the example of potentially conducting dengue virus CHI studies in endemic settings. We argue that dengue virus CHI studies in endemic settings would fall on the higher end of the spectrum of social value, mostly because of their potential to redirect all fields of future dengue research. Drawing on this discussion, we derive several general recommendations for how reviewers should judge the social value of CHI studies.
journal_name
Bioethicsjournal_title
Bioethicsauthors
Rid A,Roestenberg Mdoi
10.1111/bioe.12794subject
Has Abstractpub_date
2020-10-01 00:00:00pages
749-763issue
8eissn
0269-9702issn
1467-8519journal_volume
34pub_type
杂志文章相关文献
BIOETHICS文献大全abstract::Funders (located primarily in high-income countries) and high-income country researchers have historically dominated decision-making within global health research collaborations: from setting agendas and research design to determining how data are collected and analysed and what happens with findings and outputs. The ...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12793
更新日期:2020-11-01 00:00:00
abstract::Is it ethical to market complementary and alternative medicines? Complementary and alternative medicines (CAM) are medical products and services outside the mainstream of medical practice. But they are not just medicines (or supposed medicines) offered and provided for the prevention and treatment of illness. They are...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12226
更新日期:2016-02-01 00:00:00
abstract::Jansen and Wall suggest a new way of defending hard paternalism in clinical research. They argue that non-therapeutic research exposing people to more than minimal risk should be banned on egalitarian grounds: in preventing poor decision-makers from making bad decisions, we will promote equality of welfare. We argue t...
journal_title:Bioethics
pub_type: 评论,杂志文章
doi:10.1111/j.1467-8519.2010.01816.x
更新日期:2012-02-01 00:00:00
abstract::This paper considers the disciplines of literature and history and the contributions each makes to the discourse of bioethics. In each case I note the pedagogic ends that can be enacted though the appropriate use of the each of these disciplines in the sphere of medical education, particularly in the medical ethics cl...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/j.1467-8519.2010.01818.x
更新日期:2011-02-01 00:00:00
abstract::Political communities across the world have recently sought to tackle rising rates of vaccine hesitancy and refusal, by implementing coercive immunization programs, or by making existing immunization programs more coercive. Many academics and advocates of public health have applauded these policy developments, and the...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12645
更新日期:2019-11-01 00:00:00
abstract::Women face extraordinary difficulty in seeking sterilization as physicians routinely deny them the procedure. Physicians defend such denials by citing the possibility of future regret, a well-studied phenomenon in women's sterilization literature. Regret is, however, a problematic emotion upon which to deny reproducti...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12431
更新日期:2018-06-01 00:00:00
abstract::As bioethics emerged in the 1960s and 1970s and began to have enormous impacts on the practice of medicine and research--fuelled, by broad socio-political changes that gave rise to the struggles of women, African Americans, gay men and lesbians, and the antiauthoritarianism impulse that characterised the New Left in d...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/j.1467-8519.2004.00412.x
更新日期:2004-11-01 00:00:00
abstract::A common strategy in bioethics is to posit a prima facie case in favour of one policy, and to then claim that the burden of proof (that this policy should be rejected) falls on those with opposing views. If the burden of proof is not met, it is claimed, then the policy in question should be accepted. This article illu...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12194
更新日期:2015-11-01 00:00:00
abstract::This article introduces questions in psychiatric ethics regarding the substantial field of qualitative and quantitative research into 'posttraumatic growth', which investigates how, after devastating experiences, individuals can come to feel that they have developed warmer relationships, increased spirituality, or a c...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12164
更新日期:2015-11-01 00:00:00
abstract::Over the past 10 years, John Harris has made important contributions to thinking about distributive justice in health care. In his latest work, Harris controversially argues that clinicians should stop prioritising patients according to prognosis. He argues that the good or benefit of health care is providing each ind...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/1467-8519.00109
更新日期:1998-07-01 00:00:00
abstract::Western studies of national differences in pain have indicated that pain tolerance is higher in white than in Asian patients. The authors' clinical experiences in China seem to contradict this conclusion, and they have investigated the incidence or prevalence of some pain syndromes and have made comparisons with West...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/j.1467-8519.1989.tb00343.x
更新日期:1989-07-01 00:00:00
abstract::This article reports the results of a survey, by mailed questionnaire, of the attitudes, values and practices of doctors in Singapore with respect to the doctor-patient relationship. Questionnaires were sent to a random sample of 475 doctors (261 general practitioners and 214 medical specialists), out of which 249 (52...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/1467-8519.00180
更新日期:2000-01-01 00:00:00
abstract::In 2017 and 2019, two research teams claimed 'proof of principle' for artificial womb technology (AWT). AWT has long been a subject of speculation in bioethical literature, with broad consensus that it is a welcome development. Despite this, little attention is afforded to more immediate ethical problems in the develo...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12701
更新日期:2020-05-01 00:00:00
abstract::Fatness stigma is pervasive. Being fat is widely regarded a bad thing, and fat persons suffer numerous social and material disadvantages in virtue of their weight being regarded that way. Despite the seriousness of this problem, it has received relatively little attention from analytic philosophers. In this paper, I s...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12560
更新日期:2019-06-01 00:00:00
abstract::Is it ethical to pay patients for selecting cheaper medical treatments? The healthcare system in the United States is notoriously profligate, at least in part because when insurers foot the bill, patients have little incentive to avoid wasteful treatments. One familiar means for dealing with this problem is for insure...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12267
更新日期:2016-10-01 00:00:00
abstract::This discussion paper continues the debate over risk-related standards of mental competence which appears in Bioethics 5. Dan Brock there defends an approach to mental competence in patients which defines it as being relative to differing standards, more or less rigorous depending on the degree of risk involved in pro...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/1467-8519.00081
更新日期:1997-10-01 00:00:00
abstract::Joona Räsänen has argued that pro-life arguments against the permissibility of infanticide are not persuasive, and fail to show it to be immoral. We responded to Räsänen's arguments, concluding that his critique of pro-life arguments was misplaced. Räsänen has recently replied in 'Why pro-life arguments still are not ...
journal_title:Bioethics
pub_type: 评论,杂志文章
doi:10.1111/bioe.12646
更新日期:2019-10-01 00:00:00
abstract::Many people have moral qualms about embryo research, feeling that embryos must deserve some kind of protection, if not so much as is afforded to persons. This paper will show that these qualms serve to camouflage motives that are really prudential, at the cost of also obscuring the real ethical issues at play in the d...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/j.1467-8519.2008.00639.x
更新日期:2008-05-01 00:00:00
abstract::An educated guess about the future of academic bioethics can only be made on the basis of the historical conditions of its success. According to its official history, which attributes its success primarily to the service it has done for the patient, it should be safe at least as long as the patient still needs its ser...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/j.1467-8519.2010.01807.x
更新日期:2010-06-01 00:00:00
abstract::CIOMS has been criticised for not adequately consulting stakeholders about its revised ethical guidelines regarding medical research. Political and logistical issues that arise in democratic processes and open exchange of information probably contributed to this exclusion. What might CIOMS have done to be more inclusi...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/j.1467-8519.2004.00395.x
更新日期:2004-06-01 00:00:00
abstract::Germline genome editing is often disapproved of at the international policy level because of its possible threats to human dignity. However, from a critical perspective the relationship between this emerging technology and human dignity is relatively understudied. We explore the main principles that are referred to wh...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12607
更新日期:2020-01-01 00:00:00
abstract::Do biological relations ground responsibilities between biological fathers and their offspring? Few think biological relations ground either necessary or sufficient conditions for responsibility. Nevertheless, many think biological relations ground responsibility at least partially. Various scenarios, such as cases co...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12213
更新日期:2016-06-01 00:00:00
abstract::This paper considers Habermas' model of a post-secular political order in the light of the debate on male circumcision that arose in Germany after a court ruled that male circumcision was an unjustifiable act of bodily harm. Central to this model is the idea that religious reasons can only become effective in central ...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12526
更新日期:2019-05-01 00:00:00
abstract::Scientists seeking to conduct research with human subjects must first submit their proposals to research ethics committees (Institutional Review Boards [IRBs], in the United States). Some of these studies pose risks to "bystanders," i.e., people who may be affected by the research but who are not enrolled as study sub...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12823
更新日期:2020-11-01 00:00:00
abstract::As Tom Tomlinson's study indicates, there is considerable misunderstanding and confusion among physicians and nurses working in the area. Brain death is often not well-understood by healthcare professionals and hence inadequately explained to relatives, leaving them confused as to whether their loved-one is alive or ...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/j.1467-8519.1990.tb00088.x
更新日期:1990-07-01 00:00:00
abstract::The assumption that people have a right to have children is considered in relation to the question of whether society has an obligation to allocate resources to make clinical in vitro fertilization available, at least to married couples where the woman is infertile and the couple provides the ovum and sperm. The auth...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/j.1467-8519.1987.tb00010.x
更新日期:1987-07-01 00:00:00
abstract::In this paper we consider the three categories offered by Howard Brody for understanding power in medicine. In his book The Healer's Power, Brody separates out power in medicine into the categories of Aesculapian, Social, and Charismatic power. We examine these three categories and then apply them to a case. In this c...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/1467-8519.00065
更新日期:1997-07-01 00:00:00
abstract::Are fetuses, at any stage of their development, capable of feeling pain? In his paper, "Locating the Beginnings of Pain," Stuart Derbyshire argues that they are not. We argue that he reaches this conclusion by way of conceptual confusion, a misreading of the available scientific data and the inclusion of irrelevant da...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/1467-8519.00212
更新日期:2001-02-01 00:00:00
abstract::In democratic theory, "legitimacy" refers to the set of conditions that must be in place in order for the claims to authority of somebody to be deemed appropriate, and for their claims to compliance to be warranted. Though criteria of legitimacy have been elaborated in the context of democratic states, there is no rea...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/bioe.12489
更新日期:2019-03-01 00:00:00
abstract::In recent years philosophers and bioethicists have given considerable attention to the concept of care. Thus we have seen important work on questions such as: whether there is a uniquely female approach to ethics, whether ethics should be partial or impartial, and whether care must be supplemented by justice. Despite ...
journal_title:Bioethics
pub_type: 杂志文章
doi:10.1111/1467-8519.00318
更新日期:2003-02-01 00:00:00