Dengue virus inhibits the production of type I interferon in primary human dendritic cells.

abstract：:Fluorescent retroviral envelope (Env) proteins were developed for direct visualization of viral particles. By fusing the enhanced green fluorescent protein (eGFP) to the N terminus of the amphotropic 4070A envelope protein, extracellular presentation of eGFP was achieved. Viruses incorporated the modified Env protein ...

journal_title：Journal of virology

authors： Spitzer D,Dittmar KE,Rohde M,Hauser H,Wirth D

更新日期：2003-05-01 00:00:00

abstract：:Here we present the first complete genomic sequence of Marek's disease virus serotype 3 (MDV3), also known as turkey herpesvirus (HVT). The 159,160-bp genome encodes an estimated 99 putative proteins and resembles alphaherpesviruses in genomic organization and gene content. HVT is very similar to MDV1 and MDV2 within ...

journal_title：Journal of virology

authors： Afonso CL,Tulman ER,Lu Z,Zsak L,Rock DL,Kutish GF

更新日期：2001-01-01 00:00:00

abstract：:Paired immunoglobulin (Ig)-like type 2 receptor alpha (PILRalpha) and PILRbeta are paired receptors that are highly homologous to each other. When engaged by ligand, PILRalpha is inhibitory whereas PILRbeta is activating. PILRalpha is a newly identified herpes simplex virus type 1 (HSV-1) glycoprotein B (gB) receptor ...

journal_title：Journal of virology

authors： Fan Q,Longnecker R

更新日期：2010-09-01 00:00:00

abstract：:When influenza virus monoclonal antibody-resistant (mar) mutants are selected by incubation in vitro with excess antibody, 90 to 99% of the mutants are not detectable. This observation may be explained by encapsidation of mar mutant RNAs within phenotypically wild-type envelopes. This phenotypic hiding can be revealed...

journal_title：Journal of virology

authors： Valcárcel J,Ortín J

更新日期：1989-09-01 00:00:00

abstract：:Herpes simplex virus (HSV) virion host shutoff protein (vhs) destabilizes cellular and viral mRNAs. Previous work from several laboratories has indicated that vhs accelerates the turnover of most host mRNAs and provided evidence that at least some of these are degraded via endonucleolytic cleavage near regions of tran...

journal_title：Journal of virology

authors： Hsu WL,Saffran HA,Smiley JR

更新日期：2005-04-01 00:00:00

abstract：:By superinfection of human immunodeficiency virus type 2 (HIV-2) strain HIV-2ben-infected macaques with simian immunodeficiency virus (SIV) strain SIVmac, we investigated the mutual influences of an apathogenic and a pathogenic virus in vivo. Four rhesus and two cynomolgus monkeys were infected with HIV-2ben in 1988 a...

journal_title：Journal of virology

authors： Petry H,Dittmer U,Stahl-Hennig C,Coulibaly C,Makoschey B,Fuchs D,Wachter H,Tolle T,Morys-Wortmann C,Kaup FJ

更新日期：1995-03-01 00:00:00

abstract：:Herpes simplex virus establishes latent infections in the nuclei of sensory neurons. These infections are characterized by the abundant expression of a series of 5' coterminal transcripts termed the latency-associated transcripts (LATs). Available evidence indicates that LAT expression is specifically regulated in lat...

journal_title：Journal of virology

authors： Frazier DP,Cox D,Godshalk EM,Schaffer PA

更新日期：1996-11-01 00:00:00

abstract：:Vaccinia virus J1R protein is required for virion morphogenesis (W. L. Chiu and W. Chang, J. Virol. 76:9575-9587, 2002). In this work, we further characterized the J1R protein of wild-type vaccinia virus and compared it with the protein encoded by the temperature-sensitive mutant virus Cts45. The mutant Cts45 was foun...

journal_title：Journal of virology

authors： Chiu WL,Szajner P,Moss B,Chang W

更新日期：2005-07-01 00:00:00

abstract：:HIV-1 infectivity is strongly restricted by TRIM5α from certain primate species but has been described as being only marginally susceptible to human TRIM5α. In this study, we evaluated the effects of the modulation of human TRIM5α activity (pretreatment of target cells with alpha interferon, expression of a pre-miRNA ...

journal_title：Journal of virology

authors： Battivelli E,Lecossier D,Matsuoka S,Migraine J,Clavel F,Hance AJ

更新日期：2010-11-01 00:00:00

abstract：UNLABELLED:Many coxsackievirus B (CVB) isolates bind to human decay-accelerating factor (DAF) as well as to the coxsackievirus and adenovirus receptor (CAR). However, the virus does not interact with murine DAF. To understand why CVB3 binds specifically to human DAF, we constructed a series of chimeric molecules in whi...

journal_title：Journal of virology

authors： Pan J,Zhang L,Organtini LJ,Hafenstein S,Bergelson JM

更新日期：2015-01-15 00:00:00

abstract：:Phosphorylation of the βC1 protein encoded by the betasatellite of tomato yellow leaf curl China virus (TYLCCNB-βC1) by SNF1-related protein kinase 1 (SnRK1) plays a critical role in defense of host plants against geminivirus infection in Nicotiana benthamiana However, how phosphorylation of TYLCCNB-βC1 impacts its pa...

journal_title：Journal of virology

authors： Zhong X,Wang ZQ,Xiao R,Cao L,Wang Y,Xie Y,Zhou X

更新日期：2017-07-27 00:00:00

abstract：:The segment of simian virus 40 (SV40) genome which is recognized as the BC domain encodes for the COOH-terminal end of the SV40 major capsid protein VP1. Mutations in this domain lead to the synthesis of a thermosensitive VP1 which fails to assemble mature SV40 at the nonpermissive temperature. We determined the DNA s...

journal_title：Journal of virology

authors： Ng SC,Behm M,Bina M

更新日期：1985-05-01 00:00:00

abstract：:We have examined the pattern of RNA transcription on the L (late) DNA strand late in the simian virus 40 virus infectious cycle by separating pulse-labeled RNA chains according to size and hybridizing to an ordered series of DNA fragments obtained by restriction enzyme digestion. From this analysis, the 5' end of the ...

journal_title：Journal of virology

authors： Ford JP,Hsu MT

更新日期：1978-12-01 00:00:00

abstract：:Levels of the p53 tumor suppressor protein are increased in human cytomegalovirus (HCMV)-infected cells and may be important for HCMV pathogenesis. In normal cells p53 levels are kept low due to an autoregulatory feedback loop where p53 activates the transcription of mdm2 and mdm2 binds and ubiquitinates p53, targetin...

journal_title：Journal of virology

authors： Zhang Z,Evers DL,McCarville JF,Dantonel JC,Huong SM,Huang ES

更新日期：2006-04-01 00:00:00

abstract：:Enhancins are metalloproteinases, first identified in granuloviruses, that can enhance nucleopolyhedrovirus (NPV) potency. We had previously identified two enhancin genes (E1 and E2) in the Lymantria dispar multinucleocapsid NPV (LdMNPV) and showed that both were functional. For this study, we have extended our analys...

journal_title：Journal of virology

authors： Slavicek JM,Popham HJ

更新日期：2005-08-01 00:00:00

abstract：:The processes that facilitate transport of integral membrane proteins though the secretory pathway and subsequently target them to particular cellular membranes are relevant to almost every field of biology. These transport processes involve integration of proteins into the membrane of the endoplasmic reticulum (ER), ...

journal_title：Journal of virology

authors： Brock SC,Heck JM,McGraw PA,Crowe JE Jr

更新日期：2005-10-01 00:00:00

abstract：:Multimerization of the Hantaan virus nucleocapsid protein (NP) in Hantaan virus-infected Vero E6 cells was observed in a competitive enzyme-linked immunosorbent assay (ELISA). Recombinant and truncated NPs of Hantaan, Seoul, and Dobrava viruses lacking the N-terminal 49 amino acids were also detected as multimers. Alt...

journal_title：Journal of virology

authors： Yoshimatsu K,Lee BH,Araki K,Morimatsu M,Ogino M,Ebihara H,Arikawa J

更新日期：2003-01-01 00:00:00

abstract：:The control of human immunodeficiency virus type 1 (HIV-1) associated with particular HLA class I alleles suggests that some CD8(+) T-cell responses may be more effective than others at containing HIV-1. Unfortunately, substantial diversities in the breadth, magnitude, and function of these responses have impaired our...

journal_title：Journal of virology

authors： Wang YE,Li B,Carlson JM,Streeck H,Gladden AD,Goodman R,Schneidewind A,Power KA,Toth I,Frahm N,Alter G,Brander C,Carrington M,Walker BD,Altfeld M,Heckerman D,Allen TM

更新日期：2009-02-01 00:00:00

abstract：:Infectious pancreatic necrosis virus (IPNV) is a bisegmented, double-stranded RNA (dsRNA) virus of the Birnaviridae family that causes widespread disease in salmonids. Its two genomic segments are encapsulated together with the viral RNA-dependent RNA polymerase, VP1, and the assumed internal protein, VP3, in a single...

journal_title：Journal of virology

authors： Pedersen T,Skjesol A,Jørgensen JB

更新日期：2007-06-01 00:00:00

abstract：:We introduced various mutations into the activation and RNA binding domains of human immunodeficiency virus type 1 (HIV-1) Tat in order to develop a novel and potent transdominant Tat protein and to characterize its mechanism of action. The different mutant Tat proteins were characterized for their abilities to activa...

journal_title：Journal of virology

authors： Orsini MJ,Debouck CM

更新日期：1996-11-01 00:00:00

abstract：:The mammalian APOBEC3 family of cytidine deaminases includes members that can act as potent inhibitors of retroviral infectivity and retrotransposon mobility. Here, we have examined whether the alpharetrovirus Rous sarcoma virus (RSV) is susceptible to inhibition by a range of human APOBEC3 proteins. We report that RS...

journal_title：Journal of virology

authors： Wiegand HL,Cullen BR

更新日期：2007-12-01 00:00:00

abstract：:The stimulation of host macromolecular synthesis and induction into the cell cycle of serum-deprived G0-G1-arrested mouse embryo fibroblasts were examined after infection of resting cells with wild-type simian virus 40 or with viral mutants affecting T antigen (tsA58) or small t antigen (dl884). At various times after...

journal_title：Journal of virology

authors： Hiscott JB,Defendi V

更新日期：1981-02-01 00:00:00

abstract：:We developed antigen microarrays to profile the breadth, strength, and kinetics of epitope-specific antiviral antibody responses in vaccine trials with a simian-human immunodeficiency virus (SHIV) model for human immunodeficiency virus (HIV) infection. These arrays contained 430 distinct proteins and overlapping pepti...

journal_title：Journal of virology

authors： Neuman de Vegvar HE,Amara RR,Steinman L,Utz PJ,Robinson HL,Robinson WH

更新日期：2003-10-01 00:00:00

abstract：:Porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV), a positive-strand RNA virus that belongs to the Arteriviridae family of Nidovirales, has been identified as the causative agent of PRRS. Nsp1alpha is the amino (N)-terminal protein in a polyprotein encoded by the PRRSV genome and is reported to be cru...

journal_title：Journal of virology

authors： Sun Y,Xue F,Guo Y,Ma M,Hao N,Zhang XC,Lou Z,Li X,Rao Z

更新日期：2009-11-01 00:00:00

abstract：:Murine models have suggested that CD8+ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8+ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8+ T-ce...

journal_title：Journal of virology

authors： Norbeck O,Isa A,Pöhlmann C,Broliden K,Kasprowicz V,Bowness P,Klenerman P,Tolfvenstam T

更新日期：2005-09-01 00:00:00

abstract：:The binding of a recombinant soluble form of the measles virus (MV) hemagglutinin (sH) to cells expressing hybrid CD46/CD4 proteins was compared to that of purified virus. For binding of both ligands, both CD46 external short consensus repeats I and II (SCR I and II) in the natural order were essential. The addition o...

journal_title：Journal of virology

authors： Devaux P,Buchholz CJ,Schneider U,Escoffier C,Cattaneo R,Gerlier D

更新日期：1997-05-01 00:00:00

abstract：:Borna disease virus (BDV) is an enveloped virus with a genome organization characteristic of Mononegavirales. However, based on its unique features, BDV is considered the prototypic member of a new virus family, Bornaviridae, within the order Mononegavirales. We have described the establishment of a reverse genetics s...

journal_title：Journal of virology

authors： Rosario D,Perez M,de la Torre JC

更新日期：2005-05-01 00:00:00

abstract：:Infection with human papillomavirus (HPV) is a critical factor in the pathogenesis of most cervical cancers and some aerodigestive cancers. The HPV E6 oncoprotein from high-risk HPV types contributes to the immortalization and transformation of cells by multiple mechanisms, including degradation of p53, transcriptiona...

journal_title：Journal of virology

authors： James MA,Lee JH,Klingelhutz AJ

更新日期：2006-06-01 00:00:00

abstract：:A series of contiguous 30-bp deletions were introduced into the regions upstream of the p19 and p40 promoters of adeno-associated virus (AAV), and the effects of these deletions on induction of AAV transcription by the rep gene products was evaluated. A novel complementation system was devised for supplying wild-type ...

journal_title：Journal of virology

authors： McCarty DM,Christensen M,Muzyczka N

更新日期：1991-06-01 00:00:00

abstract：:The NS5A nonstructural protein of hepatitis C virus (HCV) has been shown to inhibit the cellular interferon (IFN)-induced protein kinase R (PKR). PKR mediates the host IFN-induced antiviral response at least in part by inhibiting mRNA translation initiation through phosphorylation of the alpha subunit of eukaryotic in...

journal_title：Journal of virology

authors： He Y,Tan SL,Tareen SU,Vijaysri S,Langland JO,Jacobs BL,Katze MG

更新日期：2001-06-01 00:00:00