Abstract:
OBJECTIVES:The aim of this study was to develop and validate a simple and reliable gas chromatography-mass spectrometry (GC-MS) method to simultaneously determine urinary 1-naphthol (1-NAP) and 2-naphthol (2-NAP) for biological monitoring of occupational exposure to naphthalene. METHODS:NAPs were derivatized in situ with acetic anhydride after enzymatic hydrolysis, extracted with n-hexane, and analyzed using GC-MS. Validation of the proposed method was conducted in accordance with US Food and Drug Administration guidance. A final validation was performed by analyzing a ClinChek® -Control for phenolic compounds. RESULTS:The linearity of calibration curves was indicated by a high correlation coefficient (>0.999) in the concentration range 1-100 μg/L for each NAP. The limits of detection and quantification for each NAP were 0.30 and 1.00 μg/L, respectively. The recovery was 90.8%-98.1%. The intraday and interday accuracies, expressed as the deviation from the nominal value, were 92.2%-99.9% and 93.4%-99.9%, respectively. The intraday and interday precision, expressed as the relative standard deviation, was 0.3%-3.9% and 0.4%-4.1%, respectively. The ClinChek® values obtained using our method were sufficiently accurate. CONCLUSIONS:The proposed method is simple, reliable, and appropriate for routine analyses, and is useful for biological monitoring of naphthalene exposure in occupational health practice.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Takeuchi A,Nakamura S,Namera A,Kondo T,Onuki H,Yamamoto S,Okamura S,Nishinoiri O,Endo Y,Miyauchi H,Endo Gdoi
10.1002/1348-9585.12144subject
Has Abstractpub_date
2020-01-01 00:00:00pages
e12144issue
1eissn
1341-9145issn
1348-9585journal_volume
62pub_type
杂志文章abstract:OBJECTIVE:To investigate associations of work-related stressors and their changes over time with the risk of developing metabolic syndrome (MetS) among Japanese manufacturing workers. METHODS:Participants were 1,040 employees aged 19 to 68 years who were free from MetS at baseline and completed the three year-interval...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0298-OA
更新日期:2018-11-27 00:00:00
abstract:OBJECTIVES:Agricultural use of neonicotinoid (NEO) insecticides has been increasing in recent years, but their biological monitoring methods have been scarcely reported. In this study, we developed and validated a rapid and sensitive method for quantifying urinary NEO concentrations using high-performance liquid chroma...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.14-0077-OA
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Arsine, a potent hemolytic agent, is widely used in the semiconductor industry. We report a case of arsine poisoning confirmed by arsenic speciation analysis in serum and urine that occurred in a recycling factory. CASE:A male worker in his twenties noticed hematuria 3 h after finishing work and was admitte...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l10108
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:We investigated the effects of fatigue on NK cell function and lymphocyte subpopulations in nurses performing shift work using a longitudinal design. METHODS:Fifty-seven female nurses engaged in shift work at a hospital in Japan were selected for our study cohort. The hospital used a counterclockwise rotati...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.10-0072-oa
更新日期:2011-01-01 00:00:00
abstract::Using workplaces as a unit for randomization, a randomized controlled trial was conducted to determine the effects of web-based supervisor training on the subject of worksite mental health on job stressors, supervisor support and psychological distress among subordinate workers. A total of eight workplaces of a sales ...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1539/joh.48.28
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:Despite the great impact the migration has had in economic, social and health-related fields, and the repercussions of alcohol consumption on them, few data exist concerning the extent of alcohol consumption in migrant workers. The aims of this study were to identify workers with a hazardous drinking problem...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0119-oa
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Along with technological innovations for improving the efficiency of printing, nanoparticles have been added to the surface of toners, and there is concern about the harmful effects of those components. We investigated, through a long-term observation following intratracheal instillation using rats, whether ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12146
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the efficacy of increased daily walking steps on the 6-month incidence of neck pain among office workers. METHODS:Healthy office workers with high risk of neck pain were recruited into a 6-month prospective cluster-randomized controlled trial. Participants were randomly assigned ...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1002/1348-9585.12106
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Spinal pain is a significant occupational health issue. Whilst neck pain and low back pain have received considerable attention, thoracic spinal pain (TSP) has not. The objective of this study was to systematically identify and report the evidence describing the prevalence and correlates of TSP within occupa...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.k8007
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to examine the effects of noise exposure on spatial learning and memory and associated mechanisms in the hippocampus (HIP). METHODS:Forty-eight male SD rats were grouped as: A, control; B, Morris water maze (MWM) training group; C, noise exposure group; and D, noise exposure fo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8084
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Allyl nitrile (3-butenenitrile) occurs naturally in the environment, in particular, in cruciferous vegetables, indicating a possible daily intake of the compound. There is no report on actual health effects of allyl nitrile in humans, although it is possible that individuals in the environment are at a risk ...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.16-0147-RA
更新日期:2017-03-28 00:00:00
abstract::The relationships between alcohol consumption, serum gamma-glutamyltransferase (GGT) levels, and the prevalence of major coronary risk factors were analyzed cross-sectionally in 2,399 male and 1,402 female middle-aged workers, to clarify the effects of moderate alcohol consumption on the development of the metabolic s...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.293
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:Professional drivers are exposed to diesel engine exhaust and outdoor air pollution while driving. Diesel engine exhaust and outdoor air pollution are known carcinogens causing lung cancer. However, previous epidemiological studies examining lung cancer risk in professional drivers have not shown a consisten...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.14-0222-OA
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Long working hours may impact human health. In Japan, teachers tend to work long hours. From 2002 to 2012, the number of leaves of absence due to diseases other than mental disorders, or mental disorders among public school teachers increased by 1.3 times (from 2,616 to 3,381), or 1.8 times (from 2,687 to 4,...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0053-OA
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The present study examined how job demands affect an intimate partner's well-being. We hypothesized that job demands have a negative influence on partner well-being through the experience of work-family conflict (WFC) and an impaired quality of the relationship (reduced social support and increased social un...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8160
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Although many studies have examined locomotive syndrome (LS) among elderly people, few studies have examined LS in young- and middle-aged adults. This study aimed to provide basic data on the epidemiological characteristics of LS, including in young- and middle-aged adults. METHOD:We conducted a cross-secti...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12053
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Petrochemical industries are known as sources of many toxic chemicals. Safety and health risks of the petrochemical workers employed at Map Ta Phut Industrial Estate, located in Rayong, Thailand, are potentially high. METHODS:The research materials consisted of documents emanating from statutory reports on ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.11-0091-oa
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. METHODS:B6C3F(1) mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m(3) or 13 wk a...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.10-0053-br
更新日期:2011-01-01 00:00:00
abstract::This Document, "Guidelines for personal exposure monitoring of chemicals" ("this Guideline"), has been prepared by "The Committee for Personal Exposure Monitoring" ("the Committee") of the Expert Division of Occupational Hygiene & Ergonomics, Japan Society for Occupational Health. Considering the background of the gro...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.17-0311-RA
更新日期:2018-03-27 00:00:00
abstract:OBJECTIVE:Working long hours is a potential health hazard. Although self-reporting of working hours in various time frames has been used in epidemiologic studies, its validity is unclear. The objective of this study was to examine the validity and reproducibility of self-reported working hours among Japanese male emplo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0260-OA
更新日期:2016-07-22 00:00:00
abstract::This study prospectively examined the association between perceived noise exposure at work and cerebrovascular diseases among Japanese male workers. A baseline survey was conducted between 1988 and 1990, which involved 110,792 inhabitants (age range: 40-79 yr) from 45 areas throughout Japan. Subsequent causes of death...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.382
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:This cross-sectional study aimed to assess fire risk in fire hazardous zones (FHZ) at the dispenser areas of gasoline stations. METHODS:There were 47 stations chosen for fire risk assessment and two zones around the dispenser area of each station were assessed. The assessments were carried out by applying th...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12137
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Numerous workers have participated in recovery efforts following the accident that occurred at the Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Power Plant after the Great East Japan Earthquake. These workers, belonging to various companies, have been engaged in various tasks since the acci...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.17-0150-CS
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:Healthcare workers are at high risk of infection from blood-borne pathogens, such as Hepatitis B and C Virus, and Human Immunodeficiency. Occupational exposure to needle-stick injuries (NSIs) continue to have a major health problem in the healthcare systems of developing countries. Thus, this review article ...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1002/1348-9585.12179
更新日期:2020-01-01 00:00:00
abstract::Due to the potential for an influenza pandemic, preparedness for infection control in healthcare settings is essential from the standpoint of occupational health for healthcare workers. We conducted questionnaire surveys among Japanese hospitals to assess preparedness at the individual and institutional levels and the...
journal_title:Journal of occupational health
pub_type: 杂志文章,多中心研究
doi:10.1539/joh.50.13
更新日期:2008-01-01 00:00:00
abstract::Slovenia is a small, fast developing country in the EU with approximately 2,000,000 inhabitants and 700,000 employed. Occupational medicine has been present in Slovenia for as long as 500 yr. Today, 130 specialists of occupational medicine are in charge of health protection of the employed (including transport workers...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.47.193
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:This study aimed to evaluate the effectiveness of supervised exercise among nurses conducting shift work for health promotion. METHODS:A total of 30 healthy female nurses conducting shift work participated in this study and they were randomly assigned to one of the following 2 groups: The supervised exercis...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1539/joh.16-0125-OA
更新日期:2017-07-27 00:00:00
abstract::The aim was to explore long-term changes in the perception of job characteristics--based on the Job Content Questionnaire (JCQ)--in view of the changing labor market in Western societies. A total number of 2,821 workers from nine companies were involved in the longitudinal Belstress-project. Data were gathered on two ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.339
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:The aim of this review was to summarize the lessons learned from the experience in protecting the health of workers engaged in operations following the accident at the Fukushima Daiichi Nuclear Power Plant (NPP). METHODS:We reviewed all types of scientific papers examining workers' health found in Medline a...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.15-0084-RA
更新日期:2015-01-01 00:00:00
abstract::This study presents the results of an investigation of respiratory symptoms, pulmonary function and chest X-ray examinations, and analysis of antibodies to fungi of 197 tussah silk-processing workers and 40 control workers. An industrial hygiene survey and environmental mycological studies were also conducted. The dus...
journal_title:Journal of occupational health
pub_type: 临床试验,杂志文章
doi:10.1539/joh.46.418
更新日期:2004-09-01 00:00:00