Abstract:
OBJECTIVES:Along with technological innovations for improving the efficiency of printing, nanoparticles have been added to the surface of toners, and there is concern about the harmful effects of those components. We investigated, through a long-term observation following intratracheal instillation using rats, whether exposure to a toner with external additives can cause tumorigenesis. METHODS:Female Wistar rats were intratracheally instilled with dispersed toner at low (1 mg/rat) and high (2 mg/rat) doses, and the rats were sacrificed at 24 months after exposure, after which we examined pulmonary inflammation, histopathological changes, and DNA damage in the lung. Rats that had deceased before 24 months were dissected at that time as well, to compare tumor development. RESULTS:Although alveolar macrophages with pigment deposition in the alveoli were observed in the 1 and 2 mg exposure groups, no significant lung inflammation/fibrosis or tumor was observed. Since immunostaining with 8-OHdG or γ-H2AX did not show a remarkable positive reaction, it is thought that toner did not cause severe DNA damage to lung tissue. CONCLUSION:These results suggest that toner with external additives may have low toxicity in the lung.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Tomonaga T,Izumi H,Yoshiura Y,Marui T,Wang KY,Nishida C,Yatera K,Morimoto Ydoi
10.1002/1348-9585.12146subject
Has Abstractpub_date
2020-01-01 00:00:00pages
e12146issue
1eissn
1341-9145issn
1348-9585journal_volume
62pub_type
杂志文章abstract:OBJECTIVES:Spinal pain is a significant occupational health issue. Whilst neck pain and low back pain have received considerable attention, thoracic spinal pain (TSP) has not. The objective of this study was to systematically identify and report the evidence describing the prevalence and correlates of TSP within occupa...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.k8007
更新日期:2009-01-01 00:00:00
abstract::This study prospectively examined the association between perceived noise exposure at work and cerebrovascular diseases among Japanese male workers. A baseline survey was conducted between 1988 and 1990, which involved 110,792 inhabitants (age range: 40-79 yr) from 45 areas throughout Japan. Subsequent causes of death...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.382
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:Occupational lead (Pb) exposure is still an important health problem in the world. Long-term Pb exposure causes several adverse effects. The aim of this study was to investigate the changes of inflammation markers with chronic Pb exposure by analyzing neopterin levels and kynurenine (Kyn) to tryptophan (Trp)...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.16-0273-OA
更新日期:2017-07-27 00:00:00
abstract:OBJECTIVES:The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after s...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0241-OA
更新日期:2016-05-25 00:00:00
abstract::To find the possible association of gene methylation of p16(INK4a) and O(6)-Methylguanine-DNA Methyltransferase (O(6)-MGMT) with occupational exposure to radon, 91 male miners from a uranium mine in China were divided into 4 groups according to the cumulative doses of radon exposure from 2 to 425 WLM (working-level mo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.261
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:We performed the current study to (1) understand the distribution of culturable airborne bacteria over a one-year monitoring period, (2) confirm places in stations where airborne bacteria are highly detected, (3) understand the factors that affect concentrations of airborne bacteria and (4) compare the distr...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0055-fs
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To investigate associations of work-related stressors and their changes over time with the risk of developing metabolic syndrome (MetS) among Japanese manufacturing workers. METHODS:Participants were 1,040 employees aged 19 to 68 years who were free from MetS at baseline and completed the three year-interval...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0298-OA
更新日期:2018-11-27 00:00:00
abstract:OBJECTIVES:Although many studies have examined locomotive syndrome (LS) among elderly people, few studies have examined LS in young- and middle-aged adults. This study aimed to provide basic data on the epidemiological characteristics of LS, including in young- and middle-aged adults. METHOD:We conducted a cross-secti...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12053
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:Arsine, a potent hemolytic agent, is widely used in the semiconductor industry. We report a case of arsine poisoning confirmed by arsenic speciation analysis in serum and urine that occurred in a recycling factory. CASE:A male worker in his twenties noticed hematuria 3 h after finishing work and was admitte...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l10108
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the efficacy of increased daily walking steps on the 6-month incidence of neck pain among office workers. METHODS:Healthy office workers with high risk of neck pain were recruited into a 6-month prospective cluster-randomized controlled trial. Participants were randomly assigned ...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1002/1348-9585.12106
更新日期:2020-01-01 00:00:00
abstract::With the immense economic growth and social development, China has gained worldwide attention. With the quick growth of industrialization, several international professionals are gaining interest in occupational management system and in the role of the Chinese Government in protecting the worker's health. The Law on P...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.17-0229-RA
更新日期:2018-03-27 00:00:00
abstract:OBJECTIVES:It is common to find doctors working long and odd hours and many at times without rest and sleep. Despite the evidence of adverse risk, jeopardizing patient safety under the hands of fatigue doctors under such working hours has not changed in many places. It has argued that with such training and subsequent ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12121
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:There is concern that sound via earphones and headphones attached to headsets used in workplaces may be a risk factor for noise-induced hearing loss (NIHL). Although there are some previous studies investigating exposure to noise from headphones, almost none have assessed the risks to workers who use earphon...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0285-oa
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Occupational diseases (OD) are among the most significant issues of work life, with economic, medical, social, and ethical aspects. The majority of studies concerning OD focus on the causes or medical outcomes of OD. There are a limited number of studies investigating the social and economic impacts of being ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0282-OA
更新日期:2018-11-27 00:00:00
abstract::Slovenia is a small, fast developing country in the EU with approximately 2,000,000 inhabitants and 700,000 employed. Occupational medicine has been present in Slovenia for as long as 500 yr. Today, 130 specialists of occupational medicine are in charge of health protection of the employed (including transport workers...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.47.193
更新日期:2005-05-01 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12153
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:In order to measure occupational exposure concentrations of ethyl tertiary-butyl ether (ETBE), we developed a diffusive sampling method for monitoring ETBE and performed an ETBE exposure assessment. METHODS:The applicability of diffusive samplers was examined by exposing the samplers to ETBE vapor in test c...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.11-0111-oa
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:Although well-being at work is important for occupational health, multi-dimensional workplace well-being measures do not exist for Japanese workers. The purpose of this study was to investigate the validity of the Japanese version of the Workplace PERMA-Profiler. METHODS:Japanese workers completed online su...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2018-0050-OA
更新日期:2018-09-26 00:00:00
abstract:OBJECTIVE:This cross-sectional study aimed to assess fire risk in fire hazardous zones (FHZ) at the dispenser areas of gasoline stations. METHODS:There were 47 stations chosen for fire risk assessment and two zones around the dispenser area of each station were assessed. The assessments were carried out by applying th...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12137
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Dental caries and periodontal disease are highly prevalent in the Japanese adult population. Oral examination is an effective method to find various oral health problems in their early stages. However, workplace oral examination is not common in Japan. The purpose of this study was to examine the relationshi...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.o10031
更新日期:2011-01-01 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.47.22
更新日期:2005-01-01 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0253-FS
更新日期:2017-01-24 00:00:00
abstract::The effort-reward imbalance is an important psychosocial factor which is related to poor health among employees. However, there are few studies that have evaluated effort-reward imbalance among medical residents. The present study was done to determine the association between psychosocial factors at work as defined by...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8043
更新日期:2008-01-01 00:00:00
abstract::Although the main hazard in cement processing is dust and respiratory tract disorders are the most important group of occupational diseases in this industry, evidence for associations between exposure to cement dust and either respiratory symptoms or functional impairment has not been conclusive. This study was, there...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.273
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Nurses are one of the population groups with the highest prevalence of musculoskeletal disorders (MSDs). At many sites, musculoskeletal symptoms (MS) represent a major health-care burden, adversely affecting nurses' quality of life and giving rise to mental health issues. OBJECTIVES:This study measured the ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12161
更新日期:2020-01-01 00:00:00
abstract::The purpose of this study was to assess the value and usefulness of high resolution computed tomography (HRCT) in the diagnostics of small opacities and complications of silicosis in mine machinery manufacturing workers, compared to conventional radiograms. The diagnosis of silicosis is mainly based on the radiologica...
journal_title:Journal of occupational health
pub_type: 杂志文章,随机对照试验
doi:10.1539/joh.l8015
更新日期:2008-01-01 00:00:00
abstract::Many dental health workers suffer from musculoskeletal disorders in the upper extremities. In addition to ergonomic factors, psychosocial work characteristics have been linked to musculoskeletal disorders. The present cross-sectional study aimed at investigating how musculoskeletal disorders in the upper extremities (...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.192
更新日期:2006-05-01 00:00:00
abstract::This study presents the results of an investigation of respiratory symptoms, pulmonary function and chest X-ray examinations, and analysis of antibodies to fungi of 197 tussah silk-processing workers and 40 control workers. An industrial hygiene survey and environmental mycological studies were also conducted. The dus...
journal_title:Journal of occupational health
pub_type: 临床试验,杂志文章
doi:10.1539/joh.46.418
更新日期:2004-09-01 00:00:00
abstract::Infrared Spectrophotometry (IR) is now widely used to determine crystalline silica in industrial dust samples. Though the IR method has many advantages when dealing with respirable dust samples, some serious analytical errors are often caused by interference minerals contamination. These minerals have a characteristic...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.94
更新日期:2003-03-01 00:00:00
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journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.o9022
更新日期:2010-01-01 00:00:00