Abstract:
OBJECTIVES:Occupational lead (Pb) exposure is still an important health problem in the world. Long-term Pb exposure causes several adverse effects. The aim of this study was to investigate the changes of inflammation markers with chronic Pb exposure by analyzing neopterin levels and kynurenine (Kyn) to tryptophan (Trp) ratio that reflects indolamine 2,3-dioxygenase activity and to compare with healthy volunteers' parameters. METHODS:Blood lead levels (BLLs) were analyzed by atomic absorption spectrometry. Urinary neopterin and serum Kyn and Trp levels were analyzed by high-performance liquid chromatography. RESULTS:According to our results, mean BLL of the 29 workers was 20.4±9.6 μg/dl. Urinary neopterin levels, serum Kyn levels, and Kyn/Trp of Pb workers (188±52 μmol/mol creatinine, 2.70±0.66 μM, and 43.19±10.38 μmol/mmol, respectively) were significantly higher than controls (144±35 μmol/mol creatinine, 2.08±0.34 μM, and 32.24±7.69 μmol/mmol, respectively). Pb-exposed workers were divided into further three groups according to their BLLs: as 10-19 μg/dl (n=18), 20-29 μg/dl (n=8), and 30-49 μg/dl (n=3). Neopterin levels of the workers with BLL of 30-49 μg/dl were significantly higher than those of BLL with 10-29 μg/dl, while Trp levels decreased. Kyn/Trp of workers with BLL of 30-49 μg/dl were elevated significantly compared with the workers with BLL<30 μg/dl. In addition to neopterin, Kyn and Kyn/Trp levels were positively influenced by Pb exposure. CONCLUSIONS:Increased level of inflammation markers confirms the adverse effects of Pb even low BLLs, and we suggest that monitoring BLLs with inflammation markers could help to prevent serious occupational health problems.
journal_name
J Occup Healthjournal_title
Journal of occupational healthauthors
Sipahi H,Girgin G,Palabiyik SS,Tutkun E,Yilmaz OH,Baydar Tdoi
10.1539/joh.16-0273-OAsubject
Has Abstractpub_date
2017-07-27 00:00:00pages
345-351issue
4eissn
1341-9145issn
1348-9585journal_volume
59pub_type
杂志文章abstract::Objective of this study is to clarify the health-related conditions of Japanese male expatriates in Thailand. Records of Japanese male expatriates in their 30s to 50s who consulted outpatient clinics at Bangkok Hospital in 2005 were analyzed for number and type of outpatient visits then compared with data from the "Pa...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l7072
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To develop tools offering definite orientation for managers and employees to support their work improvement through occupational mental health. This research was a part of the Mental Health Improvement & Reinforcement Study (MIR study), conducted from October 2004 to March 2006. METHODS:We developed a trial...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8081
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after s...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0241-OA
更新日期:2016-05-25 00:00:00
abstract:OBJECTIVES:The aim of this study was to develop and validate a simple and reliable gas chromatography-mass spectrometry (GC-MS) method to simultaneously determine urinary 1-naphthol (1-NAP) and 2-naphthol (2-NAP) for biological monitoring of occupational exposure to naphthalene. METHODS:NAPs were derivatized in situ w...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12144
更新日期:2020-01-01 00:00:00
abstract::The concept of biological monitoring (BM) has gained the special interest of individual scientists and international organizations. Today, when analytical problems have almost ceased due to new laboratory techniques and quality assurance systems, the methods for interpretation of results have become the most important...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.47.22
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the association between skill underutilization, a psychological job stressor proposed in the NIOSH (National Institute for Occupational Safety and Health) job stress model, and the prevalence of hypertension. METHODS:We studied sitting blood pressure and fasting bloo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0146-br
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:It is common to find doctors working long and odd hours and many at times without rest and sleep. Despite the evidence of adverse risk, jeopardizing patient safety under the hands of fatigue doctors under such working hours has not changed in many places. It has argued that with such training and subsequent ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12121
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to examine sexual harassment (SH) among hospital staffs in Taiwan, in terms of three-month incidence rate, the frequency of each type and the perception of SH, perpetrated by coworkers, patients and patients' families and to investigate the gender differences for these issues. ME...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.11-0063-fs
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:The main objectives of this cross-sectional descriptive study were to identify the prevalence of musculoskeletal symptoms and workstation biomechanical risk levels for garment workers in Kandal Province, Cambodia. METHODS:This cross-sectional descriptive study used multistage sampling techniques to select 7...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.15-0100-FS
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:This report reviews the carcinogenicity of multi-walled carbon nanotubes (MWCNTs) in experimental animals, concentrating on MWNT-7, a straight fibrous MWCNT. METHODS:MWCNTs were administered to mice and rats by intraperitoneal injection, intrascrotal injection, subcutaneous injection, intratracheal instilla...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.17-0102-RA
更新日期:2018-01-25 00:00:00
abstract::To find the possible association of gene methylation of p16(INK4a) and O(6)-Methylguanine-DNA Methyltransferase (O(6)-MGMT) with occupational exposure to radon, 91 male miners from a uranium mine in China were divided into 4 groups according to the cumulative doses of radon exposure from 2 to 425 WLM (working-level mo...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.261
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVES:Presenteeism is undoubtedly a widespread phenomenon in organizations. Research on presenteeism has been conducted for decades in the broader workforce (eg, nurses, doctors, teachers, police officers). Occupational stress and turnover intention in occupational therapy have been extensively studied. However, t...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12153
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:We investigated the effects of fatigue on NK cell function and lymphocyte subpopulations in nurses performing shift work using a longitudinal design. METHODS:Fifty-seven female nurses engaged in shift work at a hospital in Japan were selected for our study cohort. The hospital used a counterclockwise rotati...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.10-0072-oa
更新日期:2011-01-01 00:00:00
abstract::This study was conducted on a thermal exposure chamber designed for assessing workers' thermal hazard. In order to assess the efficacy of the studied chamber, three environmental conditions were selected to simulate high, middle and low thermal impact situations, with air temperatures (Ta) of 43.12, 36.23 and 25.77 ma...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.153
更新日期:2003-05-01 00:00:00
abstract::The aim was to explore long-term changes in the perception of job characteristics--based on the Job Content Questionnaire (JCQ)--in view of the changing labor market in Western societies. A total number of 2,821 workers from nine companies were involved in the longitudinal Belstress-project. Data were gathered on two ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.48.339
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:Work-related psychosocial hazards are associated with adverse health outcomes among workers. The association between psychosocial hazards and physiological health outcomes among laboratory technicians has not been studied previously. The objective of this study was to measure the association between work-rel...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0050-fs
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:Spinal pain is a significant occupational health issue. Whilst neck pain and low back pain have received considerable attention, thoracic spinal pain (TSP) has not. The objective of this study was to systematically identify and report the evidence describing the prevalence and correlates of TSP within occupa...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1539/joh.k8007
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:This study investigated potential associations between having a person in need of nursing care at home and psychological distress amongst the Japanese working population, using a nationally representative sample. METHODS:We extracted data from the 2013 Comprehensive Survey of Living Conditions conducted by ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2017-0295-OA
更新日期:2018-11-27 00:00:00
abstract::The aim of this study was to investigate the usefulness of heart rate variability (HRV) and urinary catecholamines (CA) as objective indices of heat stress effect. We examined physiological responses, subjective symptoms, HRV and urinary CA to evaluate the effect of heat exposure on the autonomic nervous system. Six h...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.199
更新日期:2007-05-01 00:00:00
abstract::Cadmium fluoride (CdF2, CdF for short) is the most lethal and hepatotoxic of all Cd-containing compounds. The toxic effects of CdF appear to depend on its detoxification and elimination. This study was designed to determine the early dynamics of the absorption, systemic distribution, and metabolism of CdF. The kinetic...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8016
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:The present study examined how job demands affect an intimate partner's well-being. We hypothesized that job demands have a negative influence on partner well-being through the experience of work-family conflict (WFC) and an impaired quality of the relationship (reduced social support and increased social un...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l8160
更新日期:2009-01-01 00:00:00
abstract::Infrared Spectrophotometry (IR) is now widely used to determine crystalline silica in industrial dust samples. Though the IR method has many advantages when dealing with respirable dust samples, some serious analytical errors are often caused by interference minerals contamination. These minerals have a characteristic...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.45.94
更新日期:2003-03-01 00:00:00
abstract::Workplace violence, a possible cause of job stress, has recently become an important concern in occupational health. This study determined the prevalence of workplace violence and its risk factors for employees at a psychiatric hospital in Taiwan. A questionnaire developed by ILO/ICN/WHO/PSI was first translated and v...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.l7132
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:Along with technological innovations for improving the efficiency of printing, nanoparticles have been added to the surface of toners, and there is concern about the harmful effects of those components. We investigated, through a long-term observation following intratracheal instillation using rats, whether ...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1002/1348-9585.12146
更新日期:2020-01-01 00:00:00
abstract::The present study examined degrees of job-related stress factors as well as mental and physical symptoms among Japanese hospital nurses in various departments, and clarified associations of departments and job-related stress factors with those symptoms. A self-administered anonymous questionnaire was distributed to 1,...
journal_title:Journal of occupational health
pub_type: 杂志文章,多中心研究
doi:10.1539/joh.50.79
更新日期:2008-01-01 00:00:00
abstract::Although the main hazard in cement processing is dust and respiratory tract disorders are the most important group of occupational diseases in this industry, evidence for associations between exposure to cement dust and either respiratory symptoms or functional impairment has not been conclusive. This study was, there...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.49.273
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:Healthcare workers are at high risk of infection from blood-borne pathogens, such as Hepatitis B and C Virus, and Human Immunodeficiency. Occupational exposure to needle-stick injuries (NSIs) continue to have a major health problem in the healthcare systems of developing countries. Thus, this review article ...
journal_title:Journal of occupational health
pub_type: 杂志文章,评审
doi:10.1002/1348-9585.12179
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:We performed the current study to (1) understand the distribution of culturable airborne bacteria over a one-year monitoring period, (2) confirm places in stations where airborne bacteria are highly detected, (3) understand the factors that affect concentrations of airborne bacteria and (4) compare the distr...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.13-0055-fs
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:The purpose of the present study was to obtain knowledge for improvement of the housing and life among radiation decontamination workers by examining the effect of housing type on anxiety over lack of privacy. METHODS:This cross-sectional study comprised 544 male radiation decontamination workers in Fukushi...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.2018-0007-OA
更新日期:2018-09-26 00:00:00
abstract:OBJECTIVES:Professional drivers are exposed to diesel engine exhaust and outdoor air pollution while driving. Diesel engine exhaust and outdoor air pollution are known carcinogens causing lung cancer. However, previous epidemiological studies examining lung cancer risk in professional drivers have not shown a consisten...
journal_title:Journal of occupational health
pub_type: 杂志文章
doi:10.1539/joh.14-0222-OA
更新日期:2015-01-01 00:00:00